Live viruses in cancer treatment.

An Adenovirus Mutant That Replicates Selectively in p53- Deficient Human Tumor Cells

1996 • 1,735 citations

ARF Promotes MDM2 Degradation and Stabilizes p53: ARF-INK4a Locus Deletion Impairs Both the Rb and p53 Tumor Suppression Pathways

1998 • 1,584 citations

A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer

2000 • 1,092 citations

Experimental Therapy of Human Glioma by Means of a Genetically Engineered Virus Mutant

1991 • 994 citations

ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents

1997 • 945 citations

STUDIES ON THE PROPAGATION IN VITRO OF POLIOMYELITIS VIRUSES

1953 • 821 citations

Attenuated multi–mutated herpes simplex virus–1 for the treatment of malignant gliomas

1995 • 800 citations

An Adenovirus Vector for Gene Transfer into Neurons and Glia in the Brain

1993 • 746 citations

Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis.

1993 • 677 citations

Association between Cigarette Smoking and Mutation of the p53 Gene in Squamous-Cell Carcinoma of the Head and Neck

1995 • 664 citations

Virus Entry into Animal Cells

1989 • 625 citations

Adenoviruses in the immunocompromised host

1992 • 575 citations

p53 Mutation and MDM2 amplification in human soft tissue sarcomas.

1993 • 535 citations

Induction of chemosensitivity in human lung cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene.

1994 • 465 citations

A phase I study of Onyx-015, an E1B attenuated adenovirus, administered intratumorally to patients with recurrent head and neck cancer.

2000 • 426 citations

A Defective HSV-1 Vector Expresses Escherichia coli β-Galactosidase in Cultured Peripheral Neurons

1988 • 417 citations

Selective replication and oncolysis in p53 mutant tumors with ONYX-015, an E1B-55kD gene-deleted adenovirus, in patients with advanced head and neck cancer: a phase II trial.

2000 • 407 citations

REGRESSION OF BURKITT'S LYMPHOMA IN ASSOCIATION WITH MEASLES INFECTION

1971 • 399 citations

Adenovirus proteins from both E1B reading frames are required for transformation of rodent cells by viral infection and DNA transfection

1987 • 394 citations

Thymidine kinase-negative herpes simplex virus mutants establish latency in mouse trigeminal ganglia but do not reactivate.

1989 • 360 citations

The pathogenicity of thymidine kinase-deficient mutants of herpes simplex virus in mice

1978 • 337 citations

Studies on the use of viruses in the treatment of carcinoma of the cervix

1956 • 329 citations

Adenovirus-Mediated p53 Gene Transfer in Sequence With Cisplatin to Tumors of Patients With Non–Small-Cell Lung Cancer

2000 • 322 citations

INFECTIONS IN 18, 000 INFANTS AND CHILDREN IN A CONTROLLED STUDY OF RESPIRATORY TRACT DISEASE. I. ADENOVIRUS PATHOGENICITY IN RELATION TO SEROLOGIC TYPE AND ILLNESS SYNDROME1

1969 • 292 citations

p53 and DNA polymerase α compete for binding to SV40 T antigen

1987 • 291 citations

Human papillomavirus E6 proteins bind p53 in vivo and abrogate p53-mediated repression of transcription.

1992 • 272 citations

p53-Independent and -Dependent Requirements for E1B-55K in Adenovirus Type 5 Replication

1999 • 260 citations

Adenovirus-mediated transfer of the muscle glycogen phosphorylase gene into hepatocytes confers altered regulation of glycogen metabolism.

1992 • 248 citations

Newcastle disease virus selectively kills human tumor cells

1992 • 235 citations

p53-dependent cell death/apoptosis is required for a productive adenovirus infection

1998 • 231 citations

Newcastle disease virus as an antineoplastic agent

1965 • 214 citations

Treatment of human cancer with mumps virus

1974 • 207 citations

Intravenous administration of ONYX-015, a selectively replicating adenovirus, induces antitumoral efficacy.

1999 • 190 citations

Biochemical Studies on the Herpes Simplex Virus-specified Deoxypyrimidine Kinase Activity

1974 • 190 citations

Clinical studies of viruses as antineoplastic agents, with particular reference to egypt 101 virus

1952 • 184 citations

A phase II study on the postsurgical management of stage II malignant melanoma with a Newcastle disease virus oncolysate

1983 • 171 citations

In Situ Cancer Vaccination: An IL-12 Defective Vector/Replication-Competent Herpes Simplex Virus Combination Induces Local and Systemic Antitumor Activity

1998 • 160 citations

Systemic Gene Therapy with p53 Reduces Growth and Metastases of a Malignant Human Breast Cancer in Nude Mice

1995 • 145 citations

Treatment of human malignant meningiomas by G207, a replication-competent multimutated herpes simplex virus 1.

1995 • 141 citations

Treatment of Human Breast Cancer in a Brain Metastatic Model by G207, a Replication-Competent Multimutated Herpes Simplex Virus 1

1998 • 138 citations

The early region 1B 55-kilodalton oncoprotein of adenovirus relieves growth restrictions imposed on viral replication by the cell cycle

1997 • 127 citations

The Replicative Capacities of Large E1B-Null Group A and Group C Adenoviruses Are Independent of Host Cell p53 Status

1999 • 122 citations

Remissions in leukemia of childhood following acute infectious disease. Staphylococcus and streptococcus, varicella, and feline panleukopenias

1953 • 120 citations

Efficacy of p53 adenovirus-mediated gene therapy against human breast cancer xenografts.

1997 • 113 citations

A ten-year follow-up on stage II Malignant Melanoma patients treated postsurgically with newcastle disease virus oncolysate

1992 • 113 citations

ONYX-015 works synergistically with chemotherapy in lung cancer cell lines and primary cultures freshly made from lung cancer patients.

2000 • 111 citations

Attenuated veterinary virus vaccine for the treatment of cancer.

1993 • 111 citations

DIVISION OF MICROBIOLOGY: PRESENT STATUS OF ONCOLYTIC VIRUS STUDIES*

1960 • 110 citations

Prevention of metastatic spread by postoperative immunotherapy with virally modified autologous tumor cells. I. Parameters for optimal therapeutic effects

1986 • 109 citations

Treatment of Experimental Intracranial Murine Melanoma with a Neuroattenuated Herpes Simplex Virus 1 Mutant

1995 • 108 citations

Active specific immunotherapy with Newcastle-diseasevirus-modified autologous tumor cells following resection of liver metastases in colorectal cancer

1992 • 107 citations

Phase I Study of a Recombinant Adenovirus-Mediated Gene Transfer in Lung Cancer Patients

1996 • 97 citations

Herpes simplex virus-mediated human hypoxanthine-guanine phosphoribosyltransferase gene transfer into neuronal cells.

1988 • 88 citations

Chemical modification of an ecotropic murine leukemia virus results in redirection of its target cell specificity

1991 • 86 citations

Mechanisms of c-erbB2/neu oncogene-induced metastasis and repression of metastatic properties by adenovirus 5 E1A gene products.

1992 • 85 citations

Simultaneous Administration of Live, Enteric-Coated Adenovirus Types 4,7, and 21 Vaccines: Safety and Immunogenicity

1979 • 82 citations

Cellular promoters incorporated into the adenovirus genome: cell specificity of albumin and immunoglobulin expression.

1986 • 77 citations

Selective Destruction of Gliomas in Immunocompetent Rats by Thymidine Kinase-Defective Herpes Simplex Virus Type 1

1994 • 72 citations

A southeastern cancer study group phase I/II trial with vaccinia melanoma oncolysates

1986 • 65 citations

Studies in Hodgkin's syndrome; nitrogen mustard therapy.

1948 • 63 citations

A new approach in specific, active immunotherapy

1977 • 63 citations

Active Immunotherapy of Human Melanoma Exploiting the Immunopotentiating Effects of Cyclophosphamide

1988 • 63 citations

Cyclophosphamide and abrogation of tumor-induced suppressor T cell activity

1990 • 59 citations

Replicating vectors for gene therapy of cancer: risks, limitations and prospects

1994 • 56 citations

Positive Relationship of Clinical and Serologic Responses to Vaccinia Melanoma Oncolysate

1987 • 55 citations

IMMUNOHISTOCHEMICAL STUDIES ON THE INTERACTION BETWEEN EHRLICH ASCITES TUMOR CELLS AND NEWCASTLE DISEASE VIRUS

1957 • 53 citations

p53 Gene Mutations as Markers of Tumor Spread in Synchronous Oral Cancers

1994 • 53 citations

Viral oncolysate in the management of malignant melanoma.I. Preparation of the oncolysate and measurement of immunologic responses

1977 • 53 citations

Remission of Chronic Lymphocytic Leukemia After Smallpox Vaccination

1978 • 52 citations

Modification of tumor cells by a low dose of Newcastle Disease Virus.

1988 • 51 citations

Propagation of Newcastle Disease Virus in Ehrlich Ascites Cells In Vitro and In vivo.

1955 • 50 citations

Adjuvant treatment of locally advanced renal cancer with autologous virus-modified tumor vaccines

1995 • 47 citations

Augmented Immunogenicity of Tumor Cell Homogenates Infected with Influenza Virus

1974 • 46 citations

Studies on the use of mumps virus for treatment of human cancer.

1978 • 44 citations

Inhibition of growth of five transplantable mouse tumors by the virus of Russian far east encephalitis

1951 • 41 citations

Viral oncolysates in patients with advanced ovarian cancer

1988 • 39 citations

Preferential cytotoxic effect of Newcastle disease virus on lymphoma cells

1996 • 37 citations

Immunotherapy of advanced gynecologic cancer patients utilizing mumps virus.

1988 • 35 citations

A New Host-Virus System.

1952 • 33 citations

Vaccinia Virus for Human Gene Therapy

1998 • 29 citations

Lymphosarcoma

1969 • 27 citations

T-cell functions in ovarian cancer patients treated with viral oncolysates: I. Increased helper activity to immunoglobulins production.

1990 • 23 citations

Bispecific antibodies increase T-cell stimulatory capacity in vitro of human autologous virus-modified tumor vaccine.

1998 • 22 citations

Active specific immunotherapy with vaccinia melanoma oncolysate.

1992 • 19 citations

Immunogenicity increase of autologous tumor cell vaccines by virus infection and attachment of bispecific antibodies

1996 • 17 citations

Relationship between viral neurotropism and oncolysis.I. Study of vaccinia virus

1967 • 17 citations

MULTIPLE MYELOMA: REPORT OF A CASE SHOWING UNUSUAL REMISSION LASTING TWO YEARS FOLLOWING SEVERE HEPATITIS

1955 • 15 citations

Studies on the biological characteristics of the newcastle disease virus (NDV) adapted to the brain of newborne mice

1957 • 12 citations

Active Specific Adjuvant Immunotherapy with Vaccinia Melanoma Oncolysate

1992 • 8 citations

Oncogenes-antioncogenes and virus therapy of cancer.

1989 • 6 citations