Attenuated multi–mutated herpes simplex virus–1 for the treatment of malignant gliomas

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Current protocols in molecular biology

1988 • 7,584 citations

Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue.

1980 • 3,822 citations

Experimental Therapy of Human Glioma by Means of a Genetically Engineered Virus Mutant

1991 • 994 citations

Mapping of Herpes Simplex Virus-1 Neurovirulence to γ ₁ 34.5, a Gene Nonessential for Growth in Culture

1990 • 705 citations

Herpes simplex virus type 1-induced ribonucleotide reductase activity is dispensable for virus growth and DNA synthesis: isolation and characterization of an ICP6 lacZ insertion mutant

1988 • 394 citations

National survey of patterns of care for brain-tumor patients

1989 • 385 citations

Thymidine kinase-negative herpes simplex virus mutants establish latency in mouse trigeminal ganglia but do not reactivate.

1989 • 360 citations

Two new species of night monkeys, genus Aotus (Cebidae, platyrrhini): A preliminary report on Aotus taxonomy

1983 • 270 citations

Herpes simplex virus type 1 deletion variants 1714 and 1716 pinpoint neurovirulence-related sequences in Glasgow strain 17+ between immediate early gene 1 and the 'a' sequence

1991 • 256 citations

Treatment of malignant gliomas using ganciclovir-hypersensitive, ribonucleotide reductase-deficient herpes simplex viral mutant.

1994 • 236 citations

Herpes simplex virus genomes in human nervous system tissue analyzed by polymerase chain reaction

1994 • 232 citations

The maintenance and identification of mouse cerebellar granule cells in monolayer culture

1977 • 230 citations

Factor(s) present in herpes simplex virus type 1-infected cells can compensate for the loss of the large subunit of the viral ribonucleotide reductase: characterization of an ICP6 deletion mutant

1988 • 226 citations

A herpes simplex virus ribonucleotide reductase deletion mutant is defective for productive acute and reactivatable latent infections of mice and for replication in mouse cells

1989 • 225 citations

Replication, establishment of latency, and induced reactivation of herpes simplex virus gamma 1 34.5 deletion mutants in rodent models.

1993 • 187 citations

Reduction and Elimination of Encephalitis in an Experimental Glioma Therapy Model with Attenuated Herpes Simplex Mutants that Retain Susceptibility to Acyclovir

1993 • 177 citations

In Vivo Behavior of Genetically Engineered Herpes Simplex Viruses R7017 and R7020. II. Studies in Immunocompetent and Immunosuppressed Owl Monkeys (Aotus trivirgatus)

1990 • 154 citations

ICP34.5 mutants of herpes simplex virus type 1 strain 17syn+ are attenuated for neurovirulence in mice and for replication in confluent primary mouse embryo cell cultures

1994 • 152 citations

The terminal a sequence of the herpes simplex virus genome contains the promoter of a gene located in the repeat sequences of the L component

1986 • 149 citations

Ribonucleotide Reductase Encoded by Herpes Simplex Virus Is a Determinant of the Pathogenicity of the Virus in Mice and a Valid Antiviral Target

1988 • 147 citations

Antitumor activity and reporter gene transfer into rat brain neoplasms inoculated with herpes simplex virus vectors defective in thymidine kinase or ribonucleotide reductase.

1994 • 116 citations

Identification of a Herpes Simplex Virus Type 1 Polypeptide Which Is a Component of the Virus-induced Ribonucleotide Reductase

1984 • 111 citations

Expression of a functional foreign gene in adult mammalian brain following in Vivo transfer via a herpes simplex virus type 1 defective viral vector

1991 • 101 citations

The Pathogenicity of Ribonucleotide Reductase-Null Mutants of Herpes Simplex Virus Type 1 in Mice

1991 • 85 citations

Molecular Genetics of Herpes Simplex Virus VI. Characterization of a Temperature-Sensitive Mutant Defective in the Expression of All Early Viral Gene Products

1981 • 83 citations

Selective Destruction of Gliomas in Immunocompetent Rats by Thymidine Kinase-Defective Herpes Simplex Virus Type 1

1994 • 72 citations

Mutant herpes simplex virus induced regression of tumors growing in immunocompetent rats

1994 • 66 citations

A Phase II Clinical Trial of Recombinant Human Tissue-type Plasminogen Activator against Cerebral Vasospasm after Aneurysmal Subarachnoid Hemorrhage

1994 • 65 citations

Herpes simplex virus ribonucleotide reductase mutants are hypersensitive to acyclovir

1989 • 55 citations

Natural herpes simplex infection in the owl monkey (Aotus trivirgatus).

1969 • 51 citations

Status of the ICP34.5 gene in herpes simplex virus type 1 strain 17

1992 • 46 citations

Experimental Herpes Simplex Infection in the Owl Monkey.

1967 • 38 citations

Changes in ganglioside composition and morphological features during the development of cultured astrocytes from rat brain

1989 • 20 citations

Herpesvirus simplex Infection

1993 • 11 citations