Oral Calcitriol With Ketoconazole in CRPC

NCT03261336

PHASE2INTERVENTIONAL

Donald Trump, MD

1 participants

Started 2017-01-06 · Completed 2018-02-28

Status: Terminated (as of 12-23-2025)

Conditions

Castration-resistant Prostate Cancer

Interventions

DRUG: Calcitriol, Ketoconazole, Hydrocortisone

Linked Papers (from SciSciNet-V2)

Total Papers95

Background

10

Result

0

Derived

0

Unknown

85

View on ClinicalTrials.gov

Total Citations Per Year

Brief Summary

The aim of this study is to estimate the PSA response rate with the use of ketoconazole (400mg QD + hydrocortisone 20mg AM, 10 mg PM) among men with CRPC in whom disease has progressed despite abiraterone

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Background Papers20

The Steroid and Thyroid Hormone Receptor Superfamily

7,590 citations

The Steroid and Thyroid Hormone Receptor Superfamily

7,590 citations

1,25-Dihydroxyvitamin D3-induced differentiation in a human promyelocytic leukemia cell line (HL-60): receptor-mediated maturation to macrophage-like cells.

1,25-Dihydroxyvitamin D3-induced differentiation in a human promyelocytic leukemia cell line (HL-60): receptor-mediated maturation to macrophage-like cells.

Intestinal Calcium Absorption in Exogenous Hypercortisonism

Steroid hormone receptors and their regulation by phosphorylation

Intestinal Calcium Absorption in Exogenous Hypercortisonism

Steroid hormone receptors and their regulation by phosphorylation

Effect of cortisone treatment on the active transport of calcium by the small intestine

Effect of cortisone treatment on the active transport of calcium by the small intestine

Genomic mechanisms involved in the pleiotropic actions of 1,25-dihydroxyvitamin D3

Genomic mechanisms involved in the pleiotropic actions of 1,25-dihydroxyvitamin D3

1,25-Dihydroxyvitamin D3 up-regulates the 1,25-dihydroxyvitamin D3 receptor in vivo.

1,25-Dihydroxyvitamin D3 up-regulates the 1,25-dihydroxyvitamin D3 receptor in vivo.

Cisplatin Induces the Proapoptotic Conformation of Bak in a ΔMEKK1-Dependent Manner

Cisplatin Induces the Proapoptotic Conformation of Bak in a ΔMEKK1-Dependent Manner

Androgen Receptor Expression and Cellular Proliferation During Transition from Androgen-Dependent to Recurrent Growth after Castration in the CWR22 Prostate Cancer Xenograft

Androgen Receptor Expression and Cellular Proliferation During Transition from Androgen-Dependent to Recurrent Growth after Castration in the CWR22 Prostate Cancer Xenograft

Alfacalcidol as a modulator of growth of low grade non-Hodgkin's lymphomas.

Alfacalcidol as a modulator of growth of low grade non-Hodgkin's lymphomas.

Result Papers0

No result papers linked

Derived Papers0

No derived papers linked

Unknown Papers85

Inhibitors of mammalian G1 cyclin-dependent kinases.

3,258 citations

Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis.

1,888 citations

Signal Transduction through MAP Kinase Cascades

1,762 citations

Chemotherapy with mitoxantrone plus prednisone or prednisone alone for symptomatic hormone-resistant prostate cancer: a Canadian randomized trial with palliative end points.

1,584 citations

Structure-Function Relationships in the Vitamin D Endocrine System*

1,182 citations

Analysis of gene function in somatic mammalian cells using small interfering RNAs

1,108 citations

Transcriptional activation of the Cdk inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937.

Hydrocortisone With or Without Mitoxantrone in Men With Hormone-Refractory Prostate Cancer: Results of the Cancer and Leukemia Group B 9182 Study

In Vivo Cross-Linking and Immunoprecipitation for Studying Dynamic Protein:DNA Associations in a Chromatin Environment

The p53/p63/p73 family of transcription factors: overlapping and distinct functions

ICE Family Proteases: Mediators of All Apoptotic Cell Death?

RU486 (MIFEPRISTONE): Mechanisms of Action and Clinical Uses

Stress-activated Protein Kinases: Activation, Regulation and Function

Cyclin-dependent kinase inhibitor p27 as a mediator of the G1-S phase block induced by 1,25-dihydroxyvitamin D3 in HL60 cells.

Vitamin D, Calcium, and Epidermal Differentiation*

1,25-Dihydroxyvitamin D3: in vivo and in vitro effects on human preleukemic and leukemic cells.

Effects of synthetic vitamin d analogues on breast cancer cell proliferation in vivo and in vitro

Vitamin D receptor expression, 24-hydroxylase activity, and inhibition of growth by 1alpha,25-dihydroxyvitamin D3 in seven human prostatic carcinoma cell lines.

1,25(OH)2-vitamin D3, a steroid hormone that produces biologic effects via both genomic and nongenomic pathways

Ketoconazole and Other Imidazole Derivatives as Inhibitors of Steroidogenesis

Calcitriol (1,25-dihydroxycholecalciferol) enhances paclitaxel antitumor activity in vitro and in vivo and accelerates paclitaxel-induced apoptosis.

1,25-Dihydroxyvitamin D3 induces morphological and biochemical markers of apoptosis in MCF-7 breast cancer cells

Vitamin D-regulated gene expression.

A Phase I trial of calcitriol (1,25-dihydroxycholecalciferol) in patients with advanced malignancy.

1,25-Dihydroxyvitamin D3 receptor as a marker of human colon carcinoma cell line differentiation and growth inhibition.

Inhibition of Phosphorylation of BAD and Raf-1 by Akt Sensitizes Human Ovarian Cancer Cells to Paclitaxel

Liarozole Acts Synergistically with 1α,25-Dihydroxyvitamin D₃to Inhibit Growth of DU 145 Human Prostate Cancer Cells by Blocking 24-Hydroxylase Activity¹

Overexpression of p21WAF1/CIP1 induces growth arrest, giant cell formation and apoptosis in human breast carcinoma cell lines.

1,25-Dihydroxycholecalciferol (1,25-D3) inhibits the growth of squamous cell carcinoma and down-modulates p21(Waf1/Cip1) in vitro and in vivo.

Nuclear Coactivator-62 kDa/Ski-interacting Protein Is a Nuclear Matrix-associated Coactivator That May Couple Vitamin D Receptor-mediated Transcription and RNA Splicing

Repressors of Androgen and Progesterone Receptor Action

Potential Mechanism for the Effects of Dexamethasone on Growth of Androgen-Independent Prostate Cancer

Vitamin D3-induced Apoptosis of Murine Squamous Cell Carcinoma Cells

25-Hydroxy-Vitamin D Metabolism in Human Colon Cancer Cells during Tumor Progression

The effects of 1,25-dihydroxyvitamin D3 on human T lymphocyte activation and proliferation: a cell cycle analysis.

A Phase I trial of pulse calcitriol in patients with refractory malignancies: pulse dosing permits substantial dose escalation.

Pharmacokinetics of high-dose oral calcitriol: Results from a phase 1 trial of calcitriol and paclitaxel

Parathyroid Hormone Down-Regulates 1,25-Dihydroxyvitamin D Receptors (VDR) and VDR Messenger Ribonucleic Acidin Vitroand Blocks Homologous Up-Regulation of VDRin Vivo

Direct Activation of Protein Kinase C by 1α,25-Dihydroxyvitamin D3

Potentiation of cisplatin antitumor activity using a vitamin D analogue in a murine squamous cell carcinoma model system.

Transactivation-deficient p73α (p73Δexon2) inhibits apoptosis and competes with p53

Combination of 1alpha,25-dihydroxyvitamin D(3) with dexamethasone enhances cell cycle arrest and apoptosis: role of nuclear receptor cross-talk and Erk/Akt signaling.

Signaling pathways for vitamin D-induced differentiation: implications for therapy of proliferative and neoplastic diseases.

Evidence for Involvement of Protein Kinase C and Cyclic Adenosine 3’,5’ Monophosphate-Dependent Protein Kinase in the 1,25-Dihydroxy-Vitamin D₃-Mediated Rapid Stimulation of Intestinal Calcium Transport, (Tr anscaltachia)*

Enhancement of 1,25-Dihydroxyvitamin D3-Mediated Antitumor Activity With Dexamethasone

Regulation of vitamin D-1alpha-hydroxylase and -24-hydroxylase expression by dexamethasone in mouse kidney

Activation of Raf—Mitogen–Activated Protein Kinase Signaling Pathway by 1,25-Dihydroxyvitamin D3 in Normal Human Keratinocytes

The bcl-2 oncogene and apoptosis.

Pharmacologic interruption of the mitogen-activated extracellular-regulated kinase/mitogen-activated protein kinase signal transduction pathway: potential role in promoting cytotoxic drug action.

Retinoic acid stimulates 1,25-dihydroxyvitamin D3 binding in rat osteosarcoma cells.

Vitamin D receptor and nuclear receptor coactivators: crucial interactions in vitamin D-mediated transcription

Cisplatin potentiates 1,25-dihydroxyvitamin D3-induced apoptosis in association with increased mitogen-activated protein kinase kinase kinase 1 (MEKK-1) expression.

Enhancement of VDR-Mediated Transcription by Phosphorylation: Correlation with Increased Interaction Between the VDR and DRIP205, a Subunit of the VDR-Interacting Protein Coactivator Complex

1,25-Dihydroxyvitamin D3 Protects HL60 Cells against Apoptosis but Down-regulates the Expression of the bcl-2 Gene

High-dose ketoconazole in advanced hormone-refractory prostate cancer: endocrinologic and clinical effects.

Overview of regulatory cytochrome P450 enzymes of the vitamin D pathway

Preclinical Activity of Ketoconazole in Combination With Calcitriol or the Vitamin D Analogue Eb 1089 in Prostate Cancer Cells

Androgen Receptor Up-Regulates Insulin-Like Growth Factor Binding Protein-5 (IGFBP-5) Expression in a Human Prostate Cancer Xenograft*

Glucocorticoid regulation of 1,25(OH)2-vitamin D3 receptors in cultured mouse bone cells.

Selective inhibition of vitamin D hydroxylases in human keratinocytes11Abbreviations: VD: vitamin D3; 25(OH)D3: 25-hydroxyvitamin D3; 3H-25(OH)D3: [26,27n-3H] 25-hydroxyvitamin D3; 1α,25(OH)2D3: 1α,25-dihydroxyvitamin D3; 1α,25(OH)2-3epi-D3: 1α,25-dihydroxyvitamin-3-epi-D3; 1α,24(R),25(OH)3D3: 1α,24(R),25-trihydroxyvitamin D3, 1α,25(OH)2-24oxo-D3: 1α,25-dihydroxy-24oxo-vitamin D3; 1α,23(S),25(OH)3-24oxo-D3: 1α,23(S),25-trihydroxy-24oxo-vitamin D3; calcitroic acid: 1α-hydroxy-23-carboxy-24,25,26…

Induction of Endothelial Nitric-oxide Synthase Phosphorylation by the Raloxifene Analog LY117018 Is Differentially Mediated by Akt and Extracellular Signal-regulated Protein Kinase in Vascular Endothelial Cells

Glucocorticoids and treatment of prostate cancer: a preclinical and clinical review

Secondary hormonal therapies in the treatment of prostate cancer

Identification of differentially expressed genes associated with androgen‐independent growth of prostate cancer

Calcitriol (1,25-Dihydroxycholecalciferol) Potentiates Activity of Mitoxantrone/Dexamethasone in an Androgen Independent Prostate Cancer Model

Recent Advances in the Molecular Biology of Vitamin D Action

Expression of Annexin I, II and VII Proteins in Androgen Stimulated and Recurrent Prostate Cancer

Inhibitors of cyclin-dependent kinase and cancer

Ketoconazole inhibits self-induced metabolism of 1,25-dihydroxyvitamin D3 and amplifies 1,25-dihydroxyvitamin D3 receptor up-regulation in rat osteosarcoma cells

A dual block to cell cycle progression in HL60 cells exposed to analogues of vitamin D,

The 25(OH)D3/1α,25(OH)2D3-24R-hydroxylase: a catabolic or biosynthetic enzyme?

1,25(OH)2-vitamin D3 signal transduction in chick myoblasts involves phosphatidylcholine hydrolysis.

Dexamethasone Enhances Vitamin D-24-Hydroxylase Expression in Osteoblastic (UMR-106) and Renal (LLC-PK1) Cells Treated with 1α,25-Dihydroxyvitamin D<sub>3</sub>

The Retinoid X Receptor Agonist 9-cis-Retinoic Acid and the 24-Hydroxylase Inhibitor Ketoconazole Increase Activity of 1,25-Dihydroxyvitamin D3 in Human Skin In Vivo

In vitro study of effects of 1,25 dihydroxyvitamin D3 on the morphology of human breast cancer cell line BT.20

Agonist-triggered Modulation of the Activated and Silent State of the Vitamin D3 Receptor by Interaction with Co-repressors and Co-activators

Enhancement of antiproliferative activity of 1α,25-dihydroxyvitamin D3 (analogs) by cytochrome P450 enzyme inhibitors is compound- and cell-type specific

Induction of cytosolic receptors for 1α,25-dihydroxyvitamin D3 in the immature rat uterus by oestradiol

Glucocorticoids down-regulate the number of 1,25-dihydroxyvitamin D3 receptors in mouse intestine

The role of protein kinase-C alpha in the activation of particulate guanylate cyclase by 1 alpha,25-dihydroxyvitamin D3 in CaCo-2 cells.

Apoptosis levels increase after castration in the CWR22 human prostate cancer xenograft

Metabolism of 26,26,26,27,27,27-F6-1α,25-dihydroxyvitamin D3 by CYP24: species-based difference between humans and rats

Effects of Subcutaneous Calcitriol Administration on Plasma Calcium An D Parathyroid Hormone Concentrations in Continuous Ambulatory Peritoneal Dialysis Uremic Patients

Mdm2 sensitizes MCF7 breast cancer cells to cisplatin or carboplatin

Interleukin-1α synergistic in vivo enhancement of cyclophosphamide- and carboplatin-mediated antitumor activity