Stress-activated Protein Kinases: Activation, Regulation and Function

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1994 • 3,285 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells

1994 • 2,659 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases

1995 • 2,441 citations

Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2

1995 • 2,308 citations

Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine

1995 • 2,238 citations

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1

1995 • 2,080 citations

cPLA2 is phosphorylated and activated by MAP kinase

1993 • 1,858 citations

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis

1996 • 1,784 citations

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

1994 • 1,684 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms

1995 • 1,562 citations

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

1994 • 1,520 citations

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1995 • 1,499 citations

Transcription Factor ATF2 Regulation by the JNK Signal Transduction Pathway

1995 • 1,453 citations

Selective interaction of JNK protein kinase isoforms with transcription factors.

1996 • 1,333 citations

Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-β Signal Transduction

1995 • 1,318 citations

Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity.

1991 • 1,300 citations

MKK3- and MKK6-Regulated Gene Expression Is Mediated by the p38 Mitogen-Activated Protein Kinase Signal Transduction Pathway

1996 • 1,286 citations

NF-κB: A lesson in family values

1995 • 1,266 citations

An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G ₁

1995 • 1,142 citations

Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK

1994 • 1,092 citations

A Divergence in the MAP Kinase Regulatory Network Defined by MEK Kinase and Raf

1993 • 1,086 citations

MAP kinase pathways in yeast: For mating and more

1995 • 1,009 citations

Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun

1994 • 978 citations

MAPKs: new JNK expands the group

1994 • 949 citations

Integration of MAP Kinase Signal Transduction Pathways at the Serum Response Element

1995 • 935 citations

An essential role for Rac in Ras transformation

1995 • 895 citations

Stress-Induced Phosphorylation and Activation of the Transcription Factor CHOP (GADD153) by p38 MAP Kinase

1996 • 893 citations

Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of hsp27

1994 • 866 citations

Identification of a Dual Specificity Kinase That Activates the Jun Kinases and p38-Mpk2

1995 • 775 citations

Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1

1995 • 733 citations

Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1

1994 • 706 citations

The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor.

1996 • 650 citations

Cdc42 and PAK-mediated Signaling Leads to Jun Kinase and p38 Mitogen-activated Protein Kinase Activation

1995 • 639 citations

FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2.

1996 • 633 citations

Modulation of Cellular Thermoresistance and Actin Filament Stability Accompanies Phosphorylation-Induced Changes in the Oligomeric Structure of Heat Shock Protein 27

1995 • 631 citations

Ceramide: an intracellular signal for apoptosis

1995 • 604 citations

ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents.

1995 • 603 citations

An Osmosensing Signal Transduction Pathway in Mammalian Cells

1994 • 584 citations

TAB1: An Activator of the TAK1 MAPKKK in TGF-β Signal Transduction

1996 • 582 citations

Stimulation of the Stress-Activated Mitogen-Activated Protein Kinase Subfamilies in Perfused Heart

1996 • 531 citations

Characterization of the Structure and Function of a Novel MAP Kinase Kinase (MKK6)

1996 • 519 citations

ATF-2 contains a phosphorylation-dependent transcriptional activation domain.

1995 • 504 citations

c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases.

1994 • 463 citations

Persistent Activation of c-Jun N-terminal Kinase 1 (JNK1) in γ Radiation-induced Apoptosis

1996 • 460 citations

A Novel Kinase Cascade Mediated by Mitogen-activated Protein Kinase Kinase 6 and MKK3

1996 • 443 citations

Regulation of Human Leukocyte p21-Activated Kinases Through G Protein—Coupled Receptors

1995 • 415 citations

Role of CSBP/p38/RK stress response kinase in LPS and cytokine signaling mechanisms

1996 • 396 citations

Identification of a Mouse p21Cdc42/Rac Activated Kinase

1995 • 395 citations

Ceramide Activates the Stress-activated Protein Kinases

1995 • 367 citations

A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20.

1995 • 365 citations

Signal Transduction Pathways Regulated by Mitogen-activated/Extracellular Response Kinase Kinase Kinase Induce Cell Death

1996 • 346 citations

Identification of Mitogen-activated Protein (MAP) Kinase-activated Protein Kinase-3, a Novel Substrate of CSBP p38 MAP Kinase

1996 • 346 citations

Ras-dependent growth factor regulation of MEK kinase in PC12 cells

1994 • 322 citations

Endotoxin induces rapid protein tyrosine phosphorylation in 70Z/3 cells expressing CD14.

1993 • 302 citations

Role for p38 Mitogen-activated Protein Kinase in Platelet Aggregation Caused by Collagen or a Thromboxane Analogue

1996 • 287 citations

Actions of Rho Family Small G Proteins and p21-Activated Protein Kinases on Mitogen-Activated Protein Kinase Family Members

1996 • 275 citations

Different requirements for formation of Jun: Jun and Jun: Fos complexes.

1989 • 272 citations

The Ras superfamily of GTPases ¹

1996 • 269 citations

The regulation of tyrosine kinase signalling pathways by growth factor and G-protein-coupled receptors

1995 • 267 citations

pp54 microtubule-associated protein 2 kinase. A novel serine/threonine protein kinase regulated by phosphorylation and stimulated by poly-L-lysine.

1990 • 256 citations

A non-enzymatic p21 protein inhibitor of stress-activated protein kinases

1996 • 248 citations

Mechanical stretch activates the stress‐activated protein kinase in cardiac myocytes

1996 • 247 citations

Signaling from G Protein-coupled Receptors to c-Jun Kinase Involves βγ Subunits of Heterotrimeric G Proteins Acting on a Ras and Rac1-dependent Pathway

1996 • 246 citations

Molecular Cloning of Mitogen-activated Protein/ERK Kinase Kinases (MEKK) 2 and 3

1996 • 227 citations

UV Irradiation and Heat Shock Mediate JNK Activation via Alternate Pathways

1995 • 223 citations

Isolation of MEK5 and Differential Expression of Alternatively Spliced Forms

1995 • 221 citations

Activation of the SAPK pathway by the human STE20 homologue germinal centre kinase

1995 • 214 citations

Transforming G Protein-coupled Receptors Potently Activate JNK (SAPK)

1995 • 211 citations

Thrombin Induces Activation of p38 MAP Kinase in Human Platelets

1995 • 209 citations

MEK Kinase Is Involved in Tumor Necrosis Factor α-Induced NF-κB Activation and Degradation of IκB-α

1996 • 197 citations

Cloning and Characterization of MEK6, a Novel Member of the Mitogen-activated Protein Kinase Kinase Cascade

1996 • 193 citations

Ceramide: an endogenous regulator of apoptosis and growth suppresion

1995 • 181 citations

Stimulation of c-Jun Kinase and Mitogen-Activated Protein Kinase by Ischemia and Reperfusion in the Perfused Rat Heart

1996 • 180 citations

SAP kinase‐3, a new member of the family of mammalian stress‐activated protein kinases

1996 • 159 citations

Activation of Protein Kinase Cascades by Osmotic Shock

1995 • 154 citations

Angiotensin II Stimulates Calcium-Dependent Activation of c-Jun N-Terminal Kinase

1995 • 149 citations

JNK, but not MAPK, activation is associated with Fas‐mediated apoptosis in human T cells

1996 • 142 citations

Activation of the JNK pathway by distantly related protein kinases, MEKK and MUK.

1996 • 130 citations

Cellular Stresses and Cytokines Activate Multiple Mitogen‐Activated‐Protein Kinase Kinase Homologues in PC12 and KB Cells

1996 • 123 citations

Ischemia and Reperfusion Enhance ATF-2 and c-Jun Binding to cAMP Response Elements and to an AP-1 Binding Site from the c-jun Promoter

1995 • 118 citations

Evidence for Multiple Activators for Stress-activated Protein Kinases/c-Jun Amino-terminal Kinases.

1995 • 114 citations

Inhibition of p38 Mitogen-activated Protein Kinase by Insulin in Cultured Fetal Neurons

1996 • 109 citations

Sphingolipid metabolites differentially regulate extracellular signal-regulated kinase and stress-activated protein kinase cascades

1996 • 106 citations

c-Jun N-terminal Kinase but Not Mitogen-activated Protein Kinase Is Sensitive to cAMP Inhibition in T Lymphocytes

1995 • 106 citations

Activation of Mitogen-activated Protein Kinase Cascades by p21-activated Protein Kinases in Cell-free Extracts of Xenopus Oocytes

1995 • 98 citations

The activation of distinct mitogen-activated protein kinase cascades is required for the stimulation of 2-deoxyglucose uptake by interleukin-1 and insulin-like growth factor-1 in KB cells

1995 • 91 citations

Activation of the MAP kinase homologue RK requires the phosphorylation of Thr‐180 and Tyr‐182 and both residues are phosphorylated in chemically stressed KB cells

1995 • 81 citations

Activation of the serum response factor by p65/NF-kappaB.

1996 • 66 citations