Recent Advances in the Molecular Biology of Vitamin D Action

Vitamin D

1979 • 3,814 citations

Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors

1991 • 1,725 citations

Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling

1992 • 1,514 citations

Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA

1991 • 1,501 citations

RXRβ: A coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements

1991 • 1,241 citations

Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-α

1995 • 1,179 citations

Cloning and expression of full-length cDNA encoding human vitamin D receptor.

1988 • 961 citations

Differential Recognition of Target Genes by Nuclear Receptor Monomers, Dimers, and Heterodimers*

1994 • 789 citations

The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: How receptors discriminate between their response elements

1993 • 745 citations

Photosynthesis of Previtamin D ₃ in Human Skin and the Physiologic Consequences

1980 • 742 citations

A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR

1991 • 672 citations

Solution Structure of the Glucocorticoid Receptor DNA-Binding Domain

1990 • 609 citations

The orientation and spacing of core DNA-binding motifs dictate selective transcriptional responses to three nuclear receptors

1991 • 603 citations

Two nuclear signalling pathways for vitamin D

1993 • 559 citations

The vitamin D story: a collaborative effort of basic science and clinical medicine ¹

1988 • 531 citations

Regulation of 25-Hydroxycholecalciferol-1-Hydroxylase Activity in Kidney by Parathyroid Hormone

1973 • 525 citations

Molecular Cloning of Complementary DNA Encoding the Avian Receptor for Vitamin D

1987 • 516 citations

The retinoid signaling pathway: molecular and genetic analyses

1994 • 508 citations

Identification of a DNA sequence responsible for binding of the 1,25-dihydroxyvitamin D3 receptor and 1,25-dihydroxyvitamin D3 enhancement of mouse secreted phosphoprotein 1 (SPP-1 or osteopontin) gene expression.

1990 • 467 citations

1,25-Dihydroxyvitamin D-Responsive Element and Glucocorticoid Repression in the Osteocalcin Gene

1989 • 418 citations

All-trans and 9-cis retinoic acid induction of CRABPII transcription is mediated by RAR-RXR heterodimers bound to DR1 and DR2 repeated motifs

1992 • 417 citations

Determinants for selective RAR and TR recognition of direct repeat HREs.

1993 • 403 citations

Sequences in the human parathyroid hormone gene that bind the 1,25-dihydroxyvitamin D3 receptor and mediate transcriptional repression in response to 1,25-dihydroxyvitamin D3.

1992 • 395 citations

Progesterone-binding Components of Chick Oviduct

1972 • 372 citations

Differential orientations of the DNA-binding domain and carboxy-terminal dimerization interface regulate binding site selection by nuclear receptor heterodimers.

1993 • 369 citations

Regulation of Serum 1α,25-Dihydroxyvitamin D ₃ by Calcium and Phosphate in the Rat

1975 • 369 citations

Regulation of Progesterone Receptor-Mediated Transcription by Phosphorylation

1990 • 365 citations

Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II).

1992 • 354 citations

Oestrogen and glucocorticoid responsive elements are closely related but distinct

1987 • 353 citations

The A and B isoforms of the human progesterone receptor operate through distinct signaling pathways within target cells.

1994 • 343 citations

Hormonal control of the renal conversion of 25-hydroxycholecalciferol to 1,25-dihydroxycholecalciferol

1972 • 332 citations

Interaction of human thyroid hormone receptor beta with transcription factor TFIIB may mediate target gene derepression and activation by thyroid hormone.

1993 • 328 citations

DNA sequences in the rat osteocalcin gene that bind the 1,25-dihydroxyvitamin D3 receptor and confer responsiveness to 1,25-dihydroxyvitamin D3.

1990 • 322 citations

The vitamin D-responsive element in the human osteocalcin gene. Association with a nuclear proto-oncogene enhancer.

1990 • 313 citations

Isolation and characterization of a novel cDNA from HL-60 cells treated with 1,25-dihydroxyvitamin D-3

1994 • 313 citations

Structure of the Retinoid X Receptor α DNA Binding Domain: a Helix Required for Homodimeric DNA Binding

1993 • 296 citations

Cloning of the human 1α,25-dihydroxyvitamin D-3 24-hydroxylase gene promoter and identification of two vitamin D-responsive elements

1995 • 281 citations

Retinoid X receptors stimulate and 9-cis retinoic acid inhibits 1,25-dihydroxyvitamin D3-activated expression of the rat osteocalcin gene.

1993 • 272 citations

Vitamin D3 Receptors: Structure and Function in Transcription

1991 • 271 citations

The estrogen-responsive element as an inducible enhancer: DNA sequence requirements and conversion to a glucocorticoid-responsive element.

1987 • 268 citations

The Response of Intestinal Calcium Transport to 25-Hydroxy and 1,25-Dihydroxy Vitamin D in Nephrectomized Rats

1972 • 241 citations

In SituPhotolinked Nuclear Progesterone Receptors of Human Breast Cancer Cells: Subunit Molecular Weights after Transformation and Translocation*

1983 • 238 citations

Cloning and expression of cDNA encoding 25‐hydroxyvitamin D₃ 24‐hydroxylase

1991 • 232 citations

Identification of a vitamin D-responsive element in the 5'-flanking region of the rat 25-hydroxyvitamin D3 24-hydroxylase gene.

1994 • 231 citations

Up-regulation of the vitamin D receptor in response to 1,25-dihydroxyvitamin D3 results from ligand-induced stabilization.

1992 • 224 citations

The patterns of binding of RAR, RXR and TR homo- and heterodimers to direct repeats are dictated by the binding specificites of the DNA binding domains.

1993 • 218 citations

Regulation of the hydroxylation of 25-hydroxyvitamin D3 in vivo and in primary cultures of chick kidney cells.

1979 • 213 citations

Transcription factor TFIIB and the vitamin D receptor cooperatively activate ligand-dependent transcription.

1995 • 212 citations

Stimulation of 25-hydroxyvitamin D3-1alpha-hydroxylase by phosphate depletion.

1976 • 191 citations

Identification of a 1,25-dihydroxyvitamin D3-response element in the 5'-flanking region of the rat calbindin D-9k gene.

1992 • 191 citations

Two Vitamin D Response Elements Function in the Rat 1,25-Dihydroxyvitamin D 24-Hydroxylase Promoter

1995 • 190 citations

Parathyroid hormone inhibits 25-hydroxyvitamin D3-24-hydroxylase mRNA expression stimulated by 1 alpha,25-dihydroxyvitamin D3 in rat kidney but not in intestine.

1992 • 186 citations

Regulation of Metabolism of 25-Hydroxycholecalciferol by Kidney Tissue in vitro by Dietary Calcium

1972 • 183 citations

Nongenomic Activation of the Calcium Message System by Vitamin D Metabolites in Osteoblast-like Cells

1990 • 179 citations

Control of renal vitamin D hydroxylases in birds by sex hormones.

1976 • 176 citations

Interaction between retinoic acid and vitamin D signaling pathways.

1993 • 171 citations

1,25-Dihydroxycholecalciferol: Metabolite of Vitamin D ₃ Active on Bone in Anephric Rats

1972 • 171 citations

Mechanism of Action and Metabolic Fate of Vitamin D

1967 • 168 citations

The Vitamin D Receptor Interacts with General Transcription Factor IIB

1995 • 166 citations

Identification of sequence elements in mouse calbindin-D28k gene that confer 1,25-dihydroxyvitamin D3- and butyrate-inducible responses.

1993 • 165 citations

Identification of a vitamin D-response element in the rat calcidiol (25-hydroxyvitamin D3) 24-hydroxylase gene.

1994 • 164 citations

Evidence That 1,25-Dihydroxyvitamin D₃Is the Physiologically Active Metabolite of Vitamin D₃*

1985 • 157 citations

Further Oxidation of Hydroxycalcidiol by Calcidiol 24‐Hydroxylase

1994 • 153 citations

Vitamin D3-thyroid hormone receptor heterodimer polarity directs ligand sensitivity of transactivation

1994 • 147 citations

Regulation of the metabolism of 25-hydroxyvitamin D3 in primary cultures of chick kidney cells.

1979 • 144 citations

Studies on Calciferol Metabolism

1974 • 141 citations

Natural Vitamin D₃ Response Elements Formed by Inverted Palindromes: Polarity-Directed Ligand Sensitivity of Vitamin D₃ Receptor-Retinoid X Receptor Heterodimer-Mediated Transactivation

1995 • 139 citations

Ligand modulates the conversion of DNA-bound vitamin D3 receptor (VDR) homodimers into VDR-retinoid X receptor heterodimers.

1994 • 137 citations

In VivoEvidence for the Intermediary Role of 3′,5′-Cyclic AMP in Parathyroid Hormone-Induced Stimulation of lα,25-Dihydroxy vitamin D₃Synthesis in Rats

1977 • 131 citations

Baculovirus-mediated expression of the human vitamin D receptor. Functional characterization, vitamin D response element interactions, and evidence for a receptor auxiliary factor.

1991 • 128 citations

Direct Activation of Protein Kinase C by 1α,25-Dihydroxyvitamin D3

1995 • 125 citations

Molecular cloning of cDNA for vitamin D₃ 25‐hydroxylase from rat liver mitochondria

1990 • 125 citations

Monoclonal antibodies to the porcine intestinal receptor for 1,25-dihydroxyvitamin D3: interaction with distinct receptor domains

1986 • 122 citations

Structure and regulation of the rat 1,25-dihydroxyvitamin D3 receptor.

1988 • 117 citations

DNA target selectivity by the vitamin D3 receptor: mechanism of dimer binding to an asymmetric repeat element.

1993 • 110 citations

A 55-Kilodalton Accessory Factor Facilitates Vitamin D Receptor DNA Binding

1991 • 109 citations

Isolation and characterization of a cytochrome P-450 from rat kidney mitochondria that catalyzes the 24-hydroxylation of 25-hydroxyvitamin D3

1991 • 107 citations

Evidence for Involvement of Protein Kinase C and Cyclic Adenosine 3’,5’ Monophosphate-Dependent Protein Kinase in the 1,25-Dihydroxy-Vitamin D₃-Mediated Rapid Stimulation of Intestinal Calcium Transport, (Tr anscaltachia)*

1990 • 106 citations

The C-terminal region of the vitamin D receptor is essential to form a complex with a receptor auxiliary factor required for high affinity binding to the vitamin D-responsive element.

1994 • 105 citations

Purification of chicken intestinal receptor for 1,25-dihydroxyvitamin D.

1979 • 105 citations

1,25-Dihydroxyvitamin D3 up-regulates the 1,25-dihydroxyvitamin D3 receptor in vivo.

1989 • 103 citations

Properties of a reconstituted vitamin D3 25-hydroxylase from rat liver mitochondria.

1980 • 101 citations

The 24-hydroxylation of 1,25-dihydroxyvitamin D3.

1977 • 101 citations

Immunocytology with microwave-fixed fibroblasts shows 1 alpha,25-dihydroxyvitamin D3-dependent rapid and estrogen-dependent slow reorganization of vitamin D receptors.

1990 • 99 citations

Dietary phosphate deprivation increases 1,25-dihyroxyvitamin D3 synthesis in rat kidney in vitro.

1983 • 97 citations

A nuclear protein essential for binding of rat 1,25-dihydroxyvitamin D3 receptor to its response elements.

1992 • 94 citations

Stabilization of the vitamin D receptor in rat osteosarcoma cells through the action of 1,25-dihydroxyvitamin D3.

1993 • 93 citations

Rapid Effects of 1,25-Dihydroxyvitamin D₃and Extracellular Ca²⁺on Phospholipid Metabolism in Dispersed Porcine Parathyroid Cells

1990 • 92 citations

Phosphorylation of the 1,25-dihydroxyvitamin D3 receptor. A primary event in 1,25-dihydroxyvitamin D3 action.

1990 • 92 citations

Activation of Renal 1,25-Dihydroxyvitamin D₃Synthesis by Phosphate Deprivation: Evidence for a Role for Growth Hormone*

1985 • 90 citations

Nuclear and cytoplasmic binding components for vitamin D metabolites

1975 • 83 citations

Dimerization interfaces of thyroid hormone, retinoic acid, vitamin D, and retinoid X receptors

1993 • 83 citations

INSULIN PERMITS PARATHYROID HORMONE STIMULATION OF 1,25-DIHYDROXYVITAMIN D₃PRODUCTION IN CULTURED KIDNEYCELLS

1981 • 82 citations

Cloning and sequencing of the gene encoding the mouse vitamin D receptor

1995 • 82 citations

In Vitro Stimulation of 25-Hydroxycholecalciferol lα- Hydroxylation by Parathyroid Hormone in Chick Kidney Slices: Evidence for a Role for Adenosine 3′,5′- Monophosphate *

1981 • 78 citations

Mutations that alter ligand-induced switches and dimerization activities in the retinoid X receptor.

1994 • 77 citations

Differential effect of forms A and B of human progesterone receptor on estradiol-dependent transcription.

1994 • 77 citations

Purification and characterization of vitamin D 25-hydroxylase from rat liver mitochondria.

1988 • 74 citations

Ordered binding of retinoic acid and retinoid-X receptors to asymmetric response elements involves determinants adjacent to the DNA-binding domain.

1994 • 72 citations

25-hydroxylation of C27-steroids and vitamin D3 by a constitutive cytochrome P-450 from rat liver microsomes.

1983 • 72 citations

Synergistic Effect of Progesterone, Testosterone, and Estradiol in the Stimulation of Chick Renal 25- Hydroxyvitamin D₃-lα-Hydroxylase*

1978 • 70 citations

Ligand and DNA-dependent phosphorylation of human progesterone receptor in vitro.

1992 • 69 citations

Effects of 1,25-dihydroxyvitamin D3 and phorbol ester on 25-hydroxyvitamin D3 24-hydroxylase cytochrome P450 messenger ribonucleic acid levels in primary cultures of rat renal cells.

1993 • 68 citations

Sex differences in cytochrome P-450-dependent 25-hydroxylation of C27-steroids and vitamin D3 in rat liver microsomes.

1986 • 68 citations

Expression of human vitamin D receptor in Saccharomyces cerevisiae. Purification, properties, and generation of polyclonal antibodies.

1990 • 67 citations

1,25-Dihydroxyvitamin D3 translocates protein kinase C beta to nucleus and enhances plasma membrane association of protein kinase C alpha in renal epithelial cells.

1994 • 66 citations

Ligand occupancy is not required for vitamin D receptor and retinoid receptor-mediated transcriptional activation.

1995 • 66 citations

Mouse primary osteoblasts express vitamin D3 25-hydroxylase mRNA and convert 1 alpha-hydroxyvitamin D3 into 1 alpha,25-dihydroxyvitamin D3.

1995 • 65 citations

Response element selectivity for heterodimerization of vitamin D receptors with retinoic acid and retinoid X receptors

1994 • 64 citations

Inhibition of Rad3 DNA helicase activity by DNA adducts and abasic sites: implications for the role of a DNA helicase in damage-specific incision of DNA

1993 • 61 citations

Chicken progesterone receptor is phosphorylated by a DNA-dependent protein kinase during in vitro transcription assays.

1992 • 60 citations

Isolation of a Cytochrome P-450 That Catalyzes the 25-Hydroxylation of Vitamin D3 from Rat Liver Microsomes1

1986 • 59 citations

Positive regulation of the vitamin D receptor by its cognate ligand in heterologous expression systems.

1993 • 59 citations

Evidence for the functional involvement of protein kinase C in the action of 1,25-dihydroxyvitamin D3 in bone.

1992 • 58 citations

Unique property of liver mitochondrial P450 to catalyze the two physiologically important reactions involved in both cholesterol catabolism and vitamin D activation

1990 • 58 citations

Molecular Biology of Vitamin D Action

1994 • 58 citations

Subcellular localization of vitamin D3 25-hydroxylase in human liver.

1984 • 56 citations

Phosphorylation is involved in transcriptional activation by the 1,25-dihydroxyvitamin D3 receptor

1993 • 54 citations

Expression of 25‐hydroxyvitamin D 24‐hydroxylase cytochrome P450 in kidney and intestine Effect of 1,25‐dihydroxyvitamin D and age

1991 • 54 citations

Mouse primary osteoblasts express vitamin D3 25-hydroxylase mRNA and convert 1α-hydroxyvitamin D3 into 1α,25-dihydroxyvitamin D3

1995 • 54 citations

Regulation of messenger ribonucleic acid expression of 1 alpha,25-dihydroxyvitamin D3-24-hydroxylase in rat osteoblasts.

1994 • 53 citations

1,25-Dihydroxyvitamin D3 Regulation of c-myc Protooncogene Transcription

1989 • 52 citations

1,25-Dihydroxyvitamin D3 activates Raf kinase and Raf perinuclear translocation via a protein kinase C-dependent pathway.

1993 • 48 citations

1,25(OH)2-vitamin D3 signal transduction in chick myoblasts involves phosphatidylcholine hydrolysis.

1994 • 48 citations

Evidence for two structurally related progesterone receptors in chick oviduct cytosol

1983 • 47 citations

The avian vitamin D receptors: primary structures and their origins.

1994 • 47 citations

Parathyroidectomy reduces 25-hydroxyvitamin D3-1 alpha-hydroxylase activity in the hypocalcemic vitamin D-deficient chick.

1977 • 46 citations

Purification of chicken intestinal receptor for 1 alpha, 25-dihydroxyvitamin D3 to apparent homogeneity.

1982 • 46 citations

25-Hydroxyvitamin D3-24-hydroxylase in rat kidney mitochondria.

1983 • 43 citations

Overproduction of rat 1,25-dihydroxyvitamin D3 receptor in insect cells using the baculovirus expression system.

1991 • 41 citations

Identification and Characterization of a Vitamin D₃Response Element of Chicken Carbonic Anhydrase-II

1994 • 41 citations

Expression of rat liver vitamin D₃ 25‐hydroxylase cDNA in Saccharomyces cerevisiae

1991 • 41 citations

The C-terminal region of the vitamin D receptor is essential to form a complex with a receptor auxiliary factor required for high affinity binding to the vitamin D-responsive element

1994 • 40 citations

Vitamin D-influenced gene expression via a ligand-independent, receptor-DNA complex intermediate.

1993 • 38 citations

Positive regulation of the vitamin D receptor by its cognate ligand in heterologous expression systems

1993 • 37 citations

Vitamin D receptor contains multiple dimerization interfaces that are functionally different

1995 • 36 citations

Structure-function requirements of parathyroid hormone for stimulation of 1,25-dihydroxyvitamin D3 production by rat renal proximal tubules.

1993 • 36 citations

Localization of the human vitamin D 24-hydroxylase gene (CYP24) to chromosome 20q13.2→q13.3

1993 • 35 citations

Protein kinase C is involved in 24‐hydroxylase gene expression induced by 1,25(OH)₂D₃ in rat intestinal epithelial cells

1994 • 35 citations

An immunoradiometric assay for 1,25-dihydroxyvitamin D3 receptor

1989 • 32 citations

Vitamin D receptor zinc finger region binds to a direct repeat as a dimer and discriminates the spacing number between each half-site.

1993 • 32 citations

Characterization and regulation of the vitamin D hydroxylases

1992 • 30 citations

Ordered binding of retinoic acid and retinoid-X receptors to asymmetric response elements involves determinants adjacent to the DNA-binding domain

1994 • 30 citations

Transcriptional control of the osteocalcin gene by 1,25-dihydroxyvitamin D-2 and its 24-epimer in rat osteosarcoma cells

1995 • 30 citations

In vivo regulation of rat intestinal 24-hydroxylase: potential new role of calcitonin.

1994 • 30 citations

Ligand occupancy is not required for vitamin D receptor and retinoid receptor-mediated transcriptional activation

1995 • 25 citations

Stabilization of the vitamin D receptor in rat osteosarcoma cells through the action of 1,25-dihydroxyvitamin D3

1993 • 25 citations

Chicken progesterone receptor is phosphorylated by a DNA-dependent protein kinase during in vitro transcription assays

1992 • 25 citations

Evidence that activation of protein kinase-C can stimulate 1,25-dihydroxyvitamin D3 secretion by rat proximal tubules.

1992 • 18 citations

1,25-Dihydroxycholecalciferol rapidly activates rat colonic particulate guanylate cyclase via a protein kinase C-dependent mechanism.

1993 • 17 citations

Overexpression of the Human Vitamin D₃Receptor in Mammalian Cells using Recombinant Adenovirus Vectors

1991 • 17 citations

NMR Assignments and Secondary Structure of the Retinoid X Receptor α DNA‐binding Domain

1994 • 16 citations

Effects of 1,25-dihydroxyvitamin D3 and phorbol ester on 25- hydroxyvitamin D3 24-hydroxylase cytochrome P450 messenger ribonucleic acid levels in primary cultures of rat renal cells

1993 • 14 citations

cDNA cloning and characterization of a vitamin D3 hydroxylase-associated protein.

1994 • 11 citations

The phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate stimulates the dephosphorylation of mitochondrial ferredoxin in cultured chick kidney cells.

1993 • 9 citations

Structure-function requirements of parathyroid hormone for stimulation of 1,25-dihydroxyvitamin D3 production by rat renal proximal tubules

1993 • 9 citations

Regulation of messenger ribonucleic acid expression of 1 alpha,25- dihydroxyvitamin D3-24-hydroxylase in rat osteoblasts

1994 • 9 citations

1,25-Dihydroxycholecalciferol rapidly activates rat colonic particulate guanylate cyclase via a protein kinase C-dependent mechanism

1993 • 7 citations

In vivo regulation of rat intestinal 24-hydroxylase: potential new role of calcitonin

1994 • 7 citations

The phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate stimulates the dephosphorylation of mitochondrial ferredoxin in cultured chick kidney cells

1993 • 6 citations

Evidence that activation of protein kinase-C can stimulate 1,25- dihydroxyvitamin D3 secretion by rat proximal tubules

1992 • 3 citations