Enzymology of bioreductive drug activation.

Mitomycins and Porfiromycin: Chemical Mechanism of Activation and Cross-linking of DNA

1964 • 565 citations

NADPH cytochrome P-450 reductase activation of quinone anticancer agents to free radicals.

1979 • 492 citations

Mitomycin C: a review

1976 • 441 citations

Regulatory mechanisms of monofunctional and bifunctional anticarcinogenic enzyme inducers in murine liver.

1988 • 408 citations

One-electron-transfer reactions in biochemical systems V. Difference in the mechanism of quinone reduction by the NADH dehydrogenase and the NAD(P)H dehydrogenase (DT-diaphorase)

1970 • 335 citations

[30] DT-diaphorase: Purification, properties, and function

1990 • 316 citations

NAD(P)H:quinone oxidoreductase gene expression in human colon carcinoma cells: characterization of a mutation which modulates DT-diaphorase activity and mitomycin sensitivity.

1992 • 313 citations

Antioxidant and prooxidant functions of DT-diaphorase in quinone metabolism

1995 • 273 citations

On the mechanisms of induction of cancer-protective enzymes: a unifying proposal.

1985 • 262 citations

Cytosolic NAD(P)H:(Quinone‐acceptor)oxidoreductase in human normal and tumor tissue: Effects of cigarette smoking and alcohol

1990 • 261 citations

Metabolism of mitomycin C by DT-diaphorase: role in mitomycin C-induced DNA damage and cytotoxicity in human colon carcinoma cells.

1990 • 222 citations

Reductive activation of mitomycin C and mitomycin C metabolites catalyzed by NADPH-cytochrome P-450 reductase and xanthine oxidase.

1984 • 214 citations

Potential bioreductive alkylating agents. 1. Benzoquinone derivatives

1972 • 200 citations

High levels of expression of the NAD(P)H:Quinone oxidoreductase (NQO1) gene in tumor cells compared to normal cells of the same origin

1991 • 197 citations

DT-diaphorase in activation and detoxification of quinones

1993 • 188 citations

The mechanism of the degradation of DNA by streptonigrin

1976 • 187 citations

Role of NADPH:cytochrome c reductase and DT-diaphorase in the biotransformation of mitomycin C1.

1984 • 178 citations

Human dioxin-inducible cytosolic NAD(P)H:menadione oxidoreductase. cDNA sequence and localization of gene to chromosome 16.

1988 • 174 citations

DT-diaphorase-catalysed reduction of 1,4-naphthoquinone derivatives and glutathionyl-quinone conjugates. Effect of substituents on autoxidation rates

1989 • 170 citations

Elevated DT-diaphorase activity and messenger RNA content in human non-small cell lung carcinoma: Relationship to the response of lung tumor xenografts to mitomycin C

1993 • 161 citations

Bioreductive activation of mitomycin C by DT-diaphorase

1992 • 158 citations

Relationship of the single-electron reduction potential of quinones to their reduction by flavoproteins

1980 • 154 citations

Molecular mechanisms for the hypoxiadependent activation of 3-amino-1,2,4-benzotriazine-1, 4-dioxide (SR 4233)

1988 • 152 citations

The nitroreductase enzyme in walker cells that activates 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) to 5-(aziridin-1-YL)-4-hydroxylamino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase (quinone) (EC 1.6.99.2)

1988 • 147 citations

Nucleotide and deduced amino acid sequence of a human cDNA (NQO2) corresponding to a second member of the NAD(P)H:quinone oxidoreductase gene family. Extensive polymorphism at the NQO2 gene locus on chromosome 6

1990 • 127 citations

Enzyme-directed bioreductive drug development revisited: a commentary on recent progress and future prospects with emphasis on quinone anticancer agents and quinone metabolizing enzymes, particularly DT-diaphorase.

1994 • 127 citations

The Role of NAD(P)H: Quinone Reductase (EC 1.6.99.2, DT-Diaphorase) in the Reductive Bioactivation of the Novel Indoloquinone Antitumor Agent E09

1991 • 122 citations

Human NAD(P)H:quinone oxidoreductase2. Gene structure, activity, and tissue-specific expression.

1994 • 117 citations

Reductive activation of mitomycin C by NADH:cytochrome b5 reductase.

1993 • 116 citations

Generation of hydroxyl radical by anticancer quinone drugs, carbazilquinone, mitomycin C, aclacinomycin A and adriamycin, in the presence of NADPH-cytochrome P-450 reductase

1982 • 113 citations

Mitomycin C: a prototype bioreductive agent.

1994 • 112 citations

The differences in kinetics of rat and human DT diaphorase result in a differential sensitivity of derived cell lines to CB 1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide)

1991 • 109 citations

Bioactivation of quinones by DT-diaphorase, molecular, biochemical, and chemical studies.

1994 • 106 citations

Activation of mitomycin C by NADPH:cytochrome P-450 reductase.

1990 • 102 citations

Metabolism of bioreductive antitumor compounds by purified rat and human DT-diaphorases.

1994 • 99 citations

On the catalytic function of heart flavoprotein

1939 • 93 citations

Decreased NADPH:cytochrome P-450 reductase activity and impaired drug activation in a mammalian cell line resistant to mitomycin C under aerobic but not hypoxic conditions.

1990 • 85 citations

Human FAD-dependent NAD(P)H diaphorase

1980 • 83 citations

The one-electron reduction potential of several substrates can be related to their reduction rates by cytochrome P-450 reductase

1993 • 82 citations

pH dependence of mitomycin C-induced cross-linking activity in EMT6 tumor cells.

1985 • 78 citations

The sensitivity of human tumour cells to quinone bioreductive drugs: What role for DT-diaphorase?

1992 • 77 citations

Rat liver cytosolic azoreductase. Electron transport properties and the mechanism of dicumarol inhibition of the purified enzyme.

1979 • 76 citations

Bioactivation of CB 1954: Reaction of the active 4-hydroxylamino derivative with thioesters to form the ultimate DNA-DNA interstrand crosslinking species

1991 • 76 citations

Factors affecting sensitivity to EO9 in rodent and human tumour cells in vitro: DT-diaphorase activity and hypoxia

1994 • 76 citations

Coenzyme factor—a new oxidation catalyst

1938 • 75 citations

Relationship between DT-diaphorase-mediated metabolism of a series of aziridinylbenzoquinones and DNA damage and cytotoxicity.

1992 • 75 citations

Anaerobic reduction of nitroimidazoles by reduced flavin mononucleotide and by xanthine oxidase

1980 • 72 citations

Enhancement of mitomycin C cytotoxicity to hypoxic tumor cells by dicoumarol in vivo and in vitro.

1985 • 71 citations

Bioactivation of Mitomycin C by Xanthine Dehydrogenase From EMT6 Mouse Mammary Carcinoma Tumors

1992 • 67 citations

Preclinical phase II studies in human tumor xenografts: A European multicenter follow-up study

1994 • 67 citations

Unusually marked hypoxic sensitization to indoloquinone E09 and mitomycin C in a human colon‐tumour cell line that lacks DT‐diaphorase activity

1994 • 66 citations

Nitroimidazoles as anaerobic electron acceptors for xanthine oxidase

1982 • 65 citations

Deficient activation by a human cell strain leads to mitomycin resistance under aerobic but not hypoxic conditions

1989 • 64 citations

DT-diaphorase protects cells from the hypoxic cytotoxicity of indoloquinone EO9

1994 • 57 citations

Increased sensitivity of quinone resistant cells to mitomycin C

1989 • 57 citations

Chinese hamster ovary cell lines resistant to mitomycin C under aerobic but not hypoxic conditions are deficient in DT-diaphorase.

1991 • 54 citations

Alteration in DNA cross-linking and sequence selectivity of a series of aziridinylbenzoquinones after enzymic reduction by DT-diaphorase

1992 • 52 citations

Effects of hypoxia on detoxicating enzyme activity and expression in HT29 colon adenocarcinoma cells.

1994 • 50 citations

Studies on the mechanism of resistance to mitomycin C and porfiromycin in a human cell strain derived from a cancer-prone individual

1991 • 43 citations

Genomic sequence and expression of a cloned human carbonyl reductase gene with daunorubicin reductase activity.

1991 • 41 citations

Chemosensitivity to the indoloquinone EO9 is correlated with DT-diaphorase activity and its gene expression

1994 • 37 citations

Indoloquinone EO9: DNA interstrand cross-linking upon reduction by DT-diaphorase or xanthine oxidase

1995 • 36 citations

DT-diaphorase activity and mitomycin C sensitivity in non-transformed cell strains derived from members of a cancer-prone family

1991 • 36 citations

Expression of NAD(P)H: quinone oxidoreductase and glutathione S-transferases α and π in human renal cell carcinoma and in kidney cancer-derived cell lines

1994 • 35 citations

Modification of the metabolism and cytotoxicity of bioreductive alkylating agents by dicoumarol in aerobic and hypoxic murine tumor cells.

1989 • 34 citations

Pharmacokinetics and bioreductive metabolism of the novel benzotriazine di-N-oxide hypoxic cell cytotoxin tirapazamine (WIN 59075; SR 4233; NSC 130181) in mice.

1993 • 33 citations

pH-dependent inactivation of DT-diaphorase by mitomycin C and porfiromycin.

1993 • 33 citations

Enhancement of xanthine dehydrogenase mediated mitomycin C metabolism by dicumarol.

1992 • 32 citations

Characterization of L5178Y murine lymphoblasts resistant to quinone antitumor agents.

1988 • 30 citations

Increased activity and expression of NAD(P)H:quinone acceptor oxidoreductase in confluent cell cultures and within multicellular spheroids.

1994 • 29 citations

Use of quinones in brain‐tumor therapy: Preliminary results of preclinical laboratory investigations

1985 • 28 citations

The Case for Mitomycin in Non-Small Cell Lung Cancer

1993 • 25 citations

The role of DT-diaphorase in determining the sensitivity of human tumor cells to tirapazamine (SR 4233)

1994 • 24 citations

Enzymatic and pH modulation of mitomycin C-induced DNA damage in mitomycin C-resistant HCT 116 human colon cancer cells.

1993 • 23 citations

Establishment and Characterization of Non‐small Cell Lung Cancer Cell Lines Resistant to Mitomycin C under Aerobic Conditions

1995 • 11 citations