The sensitivity of human tumour cells to quinone bioreductive drugs: What role for DT-diaphorase?

Effects of the pH dependence of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide-formazan absorption on chemosensitivity determined by a novel tetrazolium-based assay.

1989 • 580 citations

Regulatory mechanisms of monofunctional and bifunctional anticarcinogenic enzyme inducers in murine liver.

1988 • 408 citations

Oxygen Radicals in Biology and Medicine

1988 • 293 citations

DT-diaphorase and cancer chemotherapy

1992 • 284 citations

Metabolism of mitomycin C by DT-diaphorase: role in mitomycin C-induced DNA damage and cytotoxicity in human colon carcinoma cells.

1990 • 222 citations

Role of NADPH:cytochrome c reductase and DT-diaphorase in the biotransformation of mitomycin C1.

1984 • 178 citations

The nitroreductase enzyme in walker cells that activates 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) to 5-(aziridin-1-YL)-4-hydroxylamino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase (quinone) (EC 1.6.99.2)

1988 • 147 citations

The Role of NAD(P)H: Quinone Reductase (EC 1.6.99.2, DT-Diaphorase) in the Reductive Bioactivation of the Novel Indoloquinone Antitumor Agent E09

1991 • 122 citations

Selective Activation of Drugs by Redox Processes

1990 • 111 citations

The differential hypoxic cytotoxicity of bioreductive agents determined in vitro by the MTT assay

1989 • 80 citations

Molecular enzymology of the reductive bioactivation of hypoxic cell cytotoxins

1989 • 70 citations

Deficient activation by a human cell strain leads to mitomycin resistance under aerobic but not hypoxic conditions

1989 • 64 citations

Cytotoxicity and DNA lesions produced by mitomycin C and porfiromycin in hypoxic and aerobic EMT6 and Chinese hamster ovary cells.

1986 • 60 citations

Enzyme-Directed Bioreductive Drug Development

1990 • 58 citations

Increased sensitivity of quinone resistant cells to mitomycin C

1989 • 57 citations

Modification of the cytotoxic activity of mitomycin C by oxygen and ascorbic acid in Chinese hamster ovary cells and a repair-deficient mutant.

1986 • 55 citations

Chinese hamster ovary cell lines resistant to mitomycin C under aerobic but not hypoxic conditions are deficient in DT-diaphorase.

1991 • 54 citations

Studies on the mechanism of resistance to mitomycin C and porfiromycin in a human cell strain derived from a cancer-prone individual

1991 • 43 citations

The role of human and rodent DT-diaphorase in the reductive metabolism of hypoxic cell cytotoxins

1992 • 43 citations

Bioreductive drugs as post-irradiation sensitizers: Comparison of dual function agents with SR 4233 and the mitomycin C analogue EO9

1992 • 40 citations

Oxygen and exposure kinetics as factors influencing the cytotoxicity of porfiromycin, a mitomycin C analogue, in Chinese hamster ovary cells.

1988 • 39 citations

In vitro and in vivo evaluation of the indoloquinone EO-9 (NSC 382 459) against human small cell carcinoma of the lung

1989 • 23 citations

Keynote address: Concepts and developments in radiosensitization of mammalian cells

1992 • 16 citations

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