Chapter 9 Amplicon-Based Herpes Simplex Virus Vectors

A segment of the 5' nontranslated region of encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation

1988 • 1,325 citations

An Adenovirus Vector for Gene Transfer into Neurons and Glia in the Brain

1993 • 746 citations

Mapping of Herpes Simplex Virus-1 Neurovirulence to γ ₁ 34.5, a Gene Nonessential for Growth in Culture

1990 • 705 citations

Isolation and characterization of deletion mutants of herpes simplex virus type 1 in the gene encoding immediate-early regulatory protein ICP4

1985 • 702 citations

Cerebral hypoxia: some new approaches and unanswered questions

1990 • 674 citations

The herpes simplex virus amplicon: A new eucaryotic defective-virus cloning-amplifying vector

1982 • 507 citations

Initiation of protein synthesis by internal entry of ribosomes into the 5' nontranslated region of encephalomyocarditis virus RNA in vivo

1989 • 417 citations

A Defective HSV-1 Vector Expresses Escherichia coli β-Galactosidase in Cultured Peripheral Neurons

1988 • 417 citations

The gamma 1(34.5) gene of herpes simplex virus 1 precludes neuroblastoma cells from triggering total shutoff of protein synthesis characteristic of programed cell death in neuronal cells.

1992 • 396 citations

Cytotoxicity of a replication-defective mutant of herpes simplex virus type 1

1992 • 296 citations

Herpes simplex virus mutants defective in the virion-associated shutoff of host polypeptide synthesis and exhibiting abnormal synthesis of alpha (immediate early) viral polypeptides

1983 • 293 citations

A latent, nonpathogenic HSV-1-derived vector stably expresses β-galactosidase in mouse neurons

1990 • 264 citations

Effects of Defective Interfering Viruses on Virus Replication and Pathogenesis In Vitro and In Vivo

1991 • 233 citations

Sequence and structural elements that contribute to efficient encephalomyocarditis virus RNA translation

1992 • 229 citations

Structure and role of the herpes simplex virus DNA termini in inversion, circularization and generation of virion DNA

1982 • 225 citations

Cloning, sequencing, and functional analysis of oriL, a herpes simplex virus type 1 origin of DNA synthesis.

1985 • 222 citations

Detection of herpes simplex virus-specific DNA sequences in latently infected mice and in humans

1986 • 218 citations

Physical state of the latent herpes simplex virus genome in a mouse model system: Evidence suggesting an episomal state

1987 • 216 citations

Anatomy of Herpes Simplex Virus DNA XII. Accumulation of Head-to-Tail Concatemers in Nuclei of Infected Cells and Their Role in the Generation of the Four Isomeric Arrangements of Viral DNA

1979 • 204 citations

Expression of nerve growth factor in vivo from a defective herpes simplex virus 1 vector prevents effects of axotomy on sympathetic ganglia.

1992 • 203 citations

Characterization of the TRs/IRS origin of DNA replication of herpes simplex virus Type 1

1983 • 202 citations

Molecular engineering of the herpes simplex virus genome: Insertion of a second L-S junction into the genome causes additional genome inversions

1980 • 185 citations

Functional domains within the a sequence involved in the cleavage-packaging of herpes simplex virus DNA

1986 • 174 citations

Herpes simplex virus latent RNA (LAT) is not required for latent infection in the mouse.

1989 • 167 citations

Herpes simplex virus for gene delivery to neurons.

1991 • 161 citations

Altering central nervous system physiology with a defective herpes simplex virus vector expressing the glucose transporter gene.

1993 • 150 citations

The terminal a sequence of the herpes simplex virus genome contains the promoter of a gene located in the repeat sequences of the L component

1986 • 149 citations

A noninverting genome of a viable herpes simplex virus 1: presence of head-to-tail linkages in packaged genomes and requirements for circularization after infection

1985 • 147 citations

Transfer and expression of the lacZ gene in rat brain neurons mediated by herpes simplex virus mutants.

1990 • 145 citations

Site-specific cleavage/packaging of herpes simplex virus DNA and the selective maturation of nucleocapsids containing full-length viral DNA

1982 • 138 citations

The herpes simplex virus amplicon: analyses of cis-acting replication functions.

1985 • 136 citations

HSV-1 vector-mediated gene transfer of the human nerve growth factor receptor p75hNGFR defines high-affinity NGF binding

1993 • 127 citations

Latent herpes simplex virus type 1 DNA contains two copies of the virion DNA joint region

1985 • 121 citations

The octamer-binding protein Oct-2 represses HSV immediate-early genes in cell lines derived from latently infectable sensory neurons

1991 • 120 citations

Octamer motif mediates transcriptional repression of HSV immediate-early genes and octamer-containing cellular promoters in neuronal cells

1990 • 109 citations

Identification and characterization of the virion-induced host shutoff product of herpes simplex virus gene UL41

1992 • 103 citations

Expression of a functional foreign gene in adult mammalian brain following in Vivo transfer via a herpes simplex virus type 1 defective viral vector

1991 • 101 citations

Temperature-sensitive mutants of herpes simplex virus type 1 defective in lysis but not in transformation

1975 • 100 citations

Herpes simplex virus amplicon: cleavage of concatemeric DNA is linked to packaging and involves amplification of the terminally reiterated a sequence

1986 • 99 citations

Long-term increases in neurotransmitter release from neuronal cells expressing a constitutively active adenylate cyclase from a herpes simplex virus type 1 vector.

1993 • 98 citations

Herpes simplex virus vectors overexpressing the glucose transporter gene protect against seizure-induced neuron loss.

1995 • 95 citations

DNA of human cytomegalovirus: size heterogeneity and defectiveness resulting from serial undiluted passage

1979 • 91 citations

Human cytomegalovirus origin of DNA replication (oriLyt) resides within a highly complex repetitive region.

1992 • 89 citations

Isomerization of herpes simplex virus 1 genome: identification of the cis-acting and recombination sites within the domain of the a sequence

1985 • 89 citations

A Prominent Serine-rich Region in Vmw175, the Major Transcriptional Regulator Protein of Herpes Simplex Virus Type 1, is not Essential for Virus Growth in Tissue Culture

1990 • 86 citations

Transsynaptic neuronal loss induced in hippocampal slice cultures by a herpes simplex virus vector expressing the GluR6 subunit of the kainate receptor.

1993 • 85 citations

Effects of gene transfer into cultured CNS neurons with a replication-defective herpes simplex virus type 1 vector

1992 • 72 citations

Elements in the transcriptional regulatory region flanking herpes simplex virus type 1 oriS stimulate origin function

1991 • 67 citations

Herpes simplex virus amplicon: effect of size on replication of constructed defective genomes containing eucaryotic DNA sequences

1984 • 61 citations

Expression of an immediate early polypeptide and activation of a viral origin of DNA replication in cells containing a fragment of herpes simplex virus DNA

1985 • 61 citations

Herpes simplex virus vector system: analysis of its in vivo and in vitro cytopathic effects

1995 • 56 citations

Gene delivery to neurons: Is herpes simplex virus the right tool for the job?

1993 • 48 citations

Biological and biochemical properties of defective interfering particles of equine herpesvirus type 1

1979 • 47 citations

The herpes simplex virus amplicon IV. Efficient expression of a chimeric chicken ovalbumin gene amplified within defective virus genomes

1985 • 44 citations

Herpes simplex virus-based vectors

1995 • 29 citations

Activity of the simian virus 40 early promoter-enhancer in herpes simplex virus type 1 vectors is dependent on its position, the infected cell type, and the presence of Vmw175

1991 • 27 citations

Effect of genomic location on expression of beta-galactosidase mRNA controlled by the herpes simplex virus type 1 UL38 promoter

1992 • 26 citations

Infection of sympathetic and sensory neurones with herpes simplex virus does not elicit a shut-off of cellular protein synthesis: implications for viral latency and herpes vectors

1994 • 24 citations

Herpes simplex virus DNA synthesis at a preformed replication fork in vitro

1990 • 23 citations