Herpes simplex virus-based vectors

RNA Complementary to a Herpesvirus α Gene mRNA Is Prominent in Latently Infected Neurons

1987 • 902 citations

Isolation and characterization of deletion mutants of herpes simplex virus type 1 in the gene encoding immediate-early regulatory protein ICP4

1985 • 702 citations

The herpes simplex virus amplicon: A new eucaryotic defective-virus cloning-amplifying vector

1982 • 507 citations

A Defective HSV-1 Vector Expresses Escherichia coli β-Galactosidase in Cultured Peripheral Neurons

1988 • 417 citations

A deletion mutant of the latency-associated transcript of herpes simplex virus type 1 reactivates from the latent state with reduced frequency

1989 • 341 citations

Long-Term Behavioral Recovery in Parkinsonian Rats by an HSV Vector Expressing Tyrosine Hydroxylase

1994 • 333 citations

The structure and isomerization of herpes simplex virus genomes

1979 • 331 citations

An Improved Technique for Obtaining Enhanced Infectivity with Herpes Simplex Virus Type 1 DNA

1976 • 304 citations

During latency, herpes simplex virus type 1 DNA is associated with nucleosomes in a chromatin structure

1989 • 301 citations

Cytotoxicity of a replication-defective mutant of herpes simplex virus type 1

1992 • 296 citations

Herpes simplex virus latency-associated transcript is a stable intron.

1991 • 289 citations

A latent, nonpathogenic HSV-1-derived vector stably expresses β-galactosidase in mouse neurons

1990 • 264 citations

Herpes simplex virus 1 mutant deleted in the alpha 22 gene: growth and gene expression in permissive and restrictive cells and establishment of latency in mice

1985 • 243 citations

Identification of the latency-associated transcript promoter by expression of rabbit beta-globin mRNA in mouse sensory nerve ganglia latently infected with a recombinant herpes simplex virus

1989 • 237 citations

Construction and characterization of a herpes simplex virus type 1 mutant unable to transinduce immediate-early gene expression

1989 • 232 citations

Herpesvirus vector gene transfer and expression of β–glucuronidase in the central nervous system of MRS VII mice

1992 • 207 citations

In Vivo Expression of β-Galactosidase in Hippocampal Neurons by HSV-Mediated Gene Transfer

1992 • 204 citations

An efficient deletion mutant packaging system for defective herpes simplex virus vectors: potential applications to human gene therapy and neuronal physiology.

1990 • 203 citations

Expression of nerve growth factor in vivo from a defective herpes simplex virus 1 vector prevents effects of axotomy on sympathetic ganglia.

1992 • 203 citations

Structure and assembly of herpesviruses

1993 • 193 citations

Activity of herpes simplex virus type 1 latency-associated transcript (LAT) promoter in neuron-derived cells: evidence for neuron specificity and for a large LAT transcript

1990 • 188 citations

A novel latency-active promoter is contained within the herpes simplex virus type 1 UL flanking repeats

1994 • 178 citations

A herpes simplex virus type 1 mutant containing a nontransinducing Vmw65 protein establishes latent infection in vivo in the absence of viral replication and reactivates efficiently from explanted trigeminal ganglia

1990 • 170 citations

Herpes simplex virus latent RNA (LAT) is not required for latent infection in the mouse.

1989 • 167 citations

Preproenkephalin promoter yields region-specific and long-term expression in adult brain after direct in vivo gene transfer via a defective herpes simplex viral vector.

1994 • 157 citations

The virion transactivator of herpes simplex virus

1993 • 155 citations

Altering central nervous system physiology with a defective herpes simplex virus vector expressing the glucose transporter gene.

1993 • 150 citations

Ribonucleotide Reductase Encoded by Herpes Simplex Virus Is a Determinant of the Pathogenicity of the Virus in Mice and a Valid Antiviral Target

1988 • 147 citations

Infection of cultured central nervous system neurons with a defective herpes simplex virus 1 vector results in stable expression of Escherichia coli beta-galactosidase.

1990 • 146 citations

Pathways of viral gene expression during acute neuronal infection with HSV-1

1992 • 142 citations

In vivo and in vitro reactivation impairment of a herpes simplex virus type 1 latency-associated transcript variant in a rabbit eye model

1991 • 133 citations

Expression of human HPRT mRNA in brains of mice infected with a recombinant herpes simplex virus-1 vector

1989 • 127 citations

Regulation and cell-type-specific activity of a promoter located upstream of the latency-associated transcript of herpes simplex virus type 1

1990 • 127 citations

Improved cell survival by the reduction of immediate-early gene expression in replication-defective mutants of herpes simplex virus type 1 but not by mutation of the virion host shutoff function

1994 • 124 citations

Relationship between polyadenylated and nonpolyadenylated herpes simplex virus type 1 latency-associated transcripts

1991 • 118 citations

β-galactosidase as a marker in the peripheral and neural tissues of the herpes simplex virus-infected mouse

1988 • 116 citations

Expression of a functional foreign gene in adult mammalian brain following in Vivo transfer via a herpes simplex virus type 1 defective viral vector

1991 • 101 citations

Role of herpes simplex virus type 1 UL46 and UL47 in alpha TIF-mediated transcriptional induction: characterization of three viral deletion mutants

1991 • 100 citations

Long-term increases in neurotransmitter release from neuronal cells expressing a constitutively active adenylate cyclase from a herpes simplex virus type 1 vector.

1993 • 98 citations

Long-term promoter activity during herpes simplex virus latency

1994 • 97 citations

Herpes simplex virus-mediated human hypoxanthine-guanine phosphoribosyltransferase gene transfer into neuronal cells.

1988 • 88 citations

Determination of the Sequence Alteration in the DNA of the Herpes Simplex Virus Type 1 Temperature-sensitive Mutant ts K

1984 • 75 citations

Hexamethylene bisacetamide stimulates herpes simplex virus immediate early gene expression in the absence of trans-induction by Vmw65

1992 • 70 citations

Decreased Reporter Gene Expression during Latent Infection with HSV LAT Promoter Constructs

1993 • 65 citations

Localization of cis-acting sequence requirements in the promoter of the latency-associated transcript of herpes simplex virus type 1 required for cell-type-specific activity

1992 • 58 citations

Transfer of the nerve growth factor gene into cell lines and cultured neurons using a defective Herpes Simplex virus vector. Transfer of the NGF gene into cells by a HSV-1 vector

1994 • 53 citations

The herpes simplex virus amplicon IV. Efficient expression of a chimeric chicken ovalbumin gene amplified within defective virus genomes

1985 • 44 citations

In vivo deletion analysis of the herpes simplex virus type 1 latency-associated transcript promoter

1995 • 41 citations

Expression of the growth-associated protein B-50/GAP43 via a defective herpes-simplex virus vector results in profound morphological changes in non-neuronal cells

1994 • 38 citations

Peripheral replication and latency reactivation kinetics of the non-neurovirulent herpes simplex virus type 1 variant 1716

1992 • 33 citations

The human herpesviruses — An interdisciplinary perspective

1982 • 32 citations

Neuron-specific restriction of a herpes simplex virus recombinant maps to the UL5 gene

1994 • 30 citations

Inhibition of herpes simplex virus infection by ectopic expression of neuronal splice variants of the Oct-2 transcription factor

1994 • 23 citations

The herpesvirus protein kinase: a new departure in protein phosphorylation?

1988 • 21 citations

Expression of the E. coli Lac Z gene from a defective HSV‐1 vector in various human normal, cancer‐prone and tumor cells

1989 • 17 citations

Linear dimeric interleukin-2 obtained by the use of a defective herpes simplex viral vector: conformation-activity relationship

1994 • 4 citations