Effects of gene transfer into cultured CNS neurons with a replication-defective herpes simplex virus type 1 vector

GERM-LINE TRANSFORMATION OF MICE

1986 • 1,165 citations

A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirus

1985 • 1,155 citations

Initial interaction of herpes simplex virus with cells is binding to heparan sulfate

1989 • 913 citations

The herpes simplex virus amplicon: A new eucaryotic defective-virus cloning-amplifying vector

1982 • 507 citations

A Defective HSV-1 Vector Expresses Escherichia coli β-Galactosidase in Cultured Peripheral Neurons

1988 • 417 citations

Human herpesviruses: a consideration of the latent state

1989 • 279 citations

A latent, nonpathogenic HSV-1-derived vector stably expresses β-galactosidase in mouse neurons

1990 • 264 citations

Lipofection of cDNAs in the embryonic vertebrate central nervous system

1990 • 262 citations

Fibroblast growth factors stimulate nerve growth factor synthesis and secretion by astrocytes

1991 • 245 citations

Identification of the latency-associated transcript promoter by expression of rabbit beta-globin mRNA in mouse sensory nerve ganglia latently infected with a recombinant herpes simplex virus

1989 • 237 citations

Grafting genetically modified cells to the brain: Possibilities for the future

1987 • 206 citations

Molecular engineering of the herpes simplex virus genome: Insertion of a second L-S junction into the genome causes additional genome inversions

1980 • 185 citations

Activities of herpes simplex virus type 1 (HSV-1) ICP4 genes specifying nonsense peptides

1987 • 183 citations

Herpes simplex virus latent RNA (LAT) is not required for latent infection in the mouse.

1989 • 167 citations

Infection of cultured central nervous system neurons with a defective herpes simplex virus 1 vector results in stable expression of Escherichia coli beta-galactosidase.

1990 • 146 citations

Transfer and expression of the lacZ gene in rat brain neurons mediated by herpes simplex virus mutants.

1990 • 145 citations

Fibroblast Growth Factor Receptor Is a Portal of Cellular Entry for Herpes Simplex Virus Type 1

1990 • 133 citations

Expression of human HPRT mRNA in brains of mice infected with a recombinant herpes simplex virus-1 vector

1989 • 127 citations

Genetic Engineering of Novel Genomes of Large DNA Viruses

1985 • 125 citations

β-galactosidase as a marker in the peripheral and neural tissues of the herpes simplex virus-infected mouse

1988 • 116 citations

Grafting genetically modified cells into the rat brain: characteristics of E. coli β-galactosidase as a reporter gene

1989 • 108 citations

Human herpesviruses: a consideration of the latent state.

1989 • 101 citations

A Prominent Serine-rich Region in Vmw175, the Major Transcriptional Regulator Protein of Herpes Simplex Virus Type 1, is not Essential for Virus Growth in Tissue Culture

1990 • 86 citations

Expression of hepatitis B virus S gene by herpes simplex virus type 1 vectors carrying alpha- and beta-regulated gene chimeras.

1984 • 80 citations

Effects of altered expression of the neural cell adhesion molecule, N-CAM, on early neural development in Xenopus embryos

1988 • 65 citations

Isolation of a herpes simplex virus type 1 mutant deleted for the essential UL42 gene and characterization of its null phenotype

1991 • 63 citations

Gene transfer into the nervous system

1987 • 24 citations

Subcultured astrocytes suppress the proliferation of neuroblasts in vitro

1986 • 20 citations