Herpes simplex virus vectors overexpressing the glucose transporter gene protect against seizure-induced neuron loss.

Oxidative Stress, Glutamate, and Neurodegenerative Disorders

1993 • 3,746 citations

Limbic seizure and brain damage produced by kainic acid: Mechanisms and relevance to human temporal lobe epilepsy

1985 • 1,730 citations

Glutamate becomes neurotoxic via the N-methyl-d-aspartate receptor when intracellular energy levels are reduced

1988 • 972 citations

Isolation and characterization of deletion mutants of herpes simplex virus type 1 in the gene encoding immediate-early regulatory protein ICP4

1985 • 702 citations

The cytosensor microphysiometer: biological applications of silicon technology

1992 • 631 citations

A light and electron microscopic analysis of the mossy fibers of the rat dentate gyrus

1986 • 489 citations

A Defective HSV-1 Vector Expresses Escherichia coli β-Galactosidase in Cultured Peripheral Neurons

1988 • 417 citations

Biological differences between ischemia, hypoglycemia, and epilepsy

1988 • 331 citations

Glucocorticoid toxicity in the hippocampus: reversal by supplementation with brain fuels

1986 • 288 citations

Kainic acid neurotoxicity toward hippocampal formation: Dependence on specific excitatory pathways

1980 • 286 citations

Metabolic factors during prolonged seizures and their relation to nerve cell death.

1983 • 192 citations

Kainic acid selectively stimulates the release of endogenous excitatory acidic amino acids.

1983 • 184 citations

Altering central nervous system physiology with a defective herpes simplex virus vector expressing the glucose transporter gene.

1993 • 150 citations

Evidence that the Loss of the Voltage‐Dependent Mg²⁺ Block at the N‐Methyl‐D‐Aspartate Receptor Underlies Receptor Activation During Inhibition of Neuronal Metabolism

1992 • 137 citations

HSV-1 vector-mediated gene transfer of the human nerve growth factor receptor p75hNGFR defines high-affinity NGF binding

1993 • 127 citations

β-galactosidase as a marker in the peripheral and neural tissues of the herpes simplex virus-infected mouse

1988 • 116 citations

Long-term increases in neurotransmitter release from neuronal cells expressing a constitutively active adenylate cyclase from a herpes simplex virus type 1 vector.

1993 • 98 citations

Neurochemical characterization of excitotoxin lesions in the cerebral cortex

1991 • 94 citations

Comparison of delayed administration of competitive and uncompetitive antagonists in preventing NMDA receptor‐mediated neuronal death

1990 • 92 citations

Ischemic injury induces brain glucose transporter gene expression.

1993 • 87 citations

Transsynaptic neuronal loss induced in hippocampal slice cultures by a herpes simplex virus vector expressing the GluR6 subunit of the kainate receptor.

1993 • 85 citations

Expression of hepatitis B virus S gene by herpes simplex virus type 1 vectors carrying alpha- and beta-regulated gene chimeras.

1984 • 80 citations

Effects of Kainic Acid in Rat Brain Synaptosomes: The Involvement of Calcium

1984 • 80 citations

A defective HSV-1 vector expresses Escherichia coli beta-galactosidase in cultured peripheral neurons

1988 • 78 citations

Chapter 9 Amplicon-Based Herpes Simplex Virus Vectors

1994 • 75 citations

Alteration in Neuronal‐Glial Metabolism of Glutamate by the Neurotoxin Kainic Acid

1982 • 72 citations

Glucose deprivation depolarizes plasma membrane of cultured astrocytes and collapses transmembrane potassium and glutamate gradients

1988 • 72 citations

Inhibition of ascorbic acid transport in human neutrophils by glucose.

1992 • 66 citations

Kainic Acid Inhibits the Synaptosomal Plasma Membrane Glutamate Carrier and Allows Glutamate Leakage from the Cytoplasm but Does Not Affect Glutamate Exocytosis

1988 • 66 citations

Herpes simplex virus vector system: analysis of its in vivo and in vitro cytopathic effects

1995 • 56 citations

Effects of excitotoxin exposure on metabolic rate of primary hippocampal cultures: application of silicon microphysiometry to neurobiology

1992 • 45 citations

Status epilepticus-induced hippocampal damage is modulated by glucose availability

1989 • 38 citations

Influence of Reduced Oxygen Availability on Cerebral Metabolic Changes during Bicuculline-Induced Seizures in Rats

1985 • 32 citations