The Importance of Cytochrome P450 3A Enzymes in Drug Metabolism

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

1994 • 2,716 citations

Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes

1991 • 997 citations

Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism.

1986 • 734 citations

Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines.

1989 • 643 citations

Interaction of citrus juices with felodipine and nifedipine

1991 • 595 citations

Cyclosporine metabolism in human liver: Identification of a cytochrome P-450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs

1988 • 539 citations

Oxidation of midazolam and triazolam by human liver cytochrome P450IIIA4.

1989 • 528 citations

Enzymatic Metabolism of Drugs and other Foreign Compounds

1958 • 501 citations

Cytochrome P-450 hPCN3, a Novel Cytochrome P-450 IIIA Gene Product That Is Differentially Expressed in Adult Human Liver

1989 • 480 citations

Estimation of isozymes of microsomal cytochrome P-450 in rats, rabbits, and humans using immunochemical staining coupled with sodium dodecyl sulfate-polyacrylamide gel electrophoresis

1982 • 422 citations

Human liver microsomal steroid metabolism: Identification of the major microsomal steroid hormone 6β-hydroxylase cytochrome P-450 enzyme

1988 • 413 citations

Cytochrome P450 enzymes involved in acetaminophen activation by rat and human liver microsomes and their kinetics

1993 • 410 citations

Studies on the expression and metabolic capabilities of human liver cytochrome P450IIIA5 (HLp3).

1990 • 402 citations

Cytochrome P-450 3A enzymes are responsible for biotransformation of FK506 and rapamycin in man and rat.

1992 • 382 citations

Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450. Studies in rats and patients.

1989 • 349 citations

Expression of Modified Human Cytochrome P450 3A4 in Escherichia coli and Purification and Reconstitution of the Enzyme

1993 • 341 citations

The increase in urinary excretion of 6 beta‐hydroxycortisol as a marker of human hepatic cytochrome P450IIIA induction.

1989 • 334 citations

Steroid hormone hydroxylase specificities of eleven cDNA-expressed human cytochrome P450s

1991 • 326 citations

Identification of an inducible form of cytochrome P-450 in human liver.

1985 • 320 citations

Human anti-endoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome P-450 that hydroxylates the drug.

1987 • 320 citations

Oxidation of 4-aryl- and 4-alkyl-substituted 2,6-dimethyl-3,5-bis(alkoxycarbonyl)-1,4-dihydropyridines by human liver microsomes and immunochemical evidence for the involvement of a form of cytochrome P-450

1986 • 318 citations

Metabolism of cyclosporin A. IV. Purification and identification of the rifampicin-inducible human liver cytochrome P-450 (cyclosporin A oxidase) as a product of P450IIIA gene subfamily.

1989 • 303 citations

Evidence for cytochrome P-450NF, the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver.

1989 • 303 citations

Oxidation of quinidine by human liver cytochrome P-450.

1986 • 296 citations

Metabolism of 2-acetylaminofluorene and benzo(a)pyrene and activation of food-derived heterocyclic amine mutagens by human cytochromes P-450.

1990 • 291 citations

Activation and inhibition of benzo(a)pyrene and aflatoxin B1 metabolism in human liver microsomes by naturally occurring flavonoids.

1981 • 290 citations

Metabolism of taxol by human hepatic microsomes and liver slices: participation of cytochrome P450 3A4 and an unknown P450 enzyme.

1994 • 282 citations

Human liver microsomal cytochrome P-450 enzymes involved in the bioactivation of procarcinogens detected by umu gene response in Salmonella typhimurium TA 1535/pSK1002.

1989 • 265 citations

Lidocaine metabolism in human liver microsomes by cytochrome P450IIIA4

1989 • 264 citations

Oxidation of dihydropyridine calcium channel blockers and analogs by human liver cytochrome P-450 IIIA4

1991 • 262 citations

Separation, purification, and characterization of a novel form of hepatic cytochrome P-450 from rats treated with pregnenolone-16 alpha-carbonitrile.

1980 • 256 citations

Comparison of levels of several human microsomal cytochrome P-450 enzymes and epoxide hydrolase in normal and disease states using immunochemical analysis of surgical liver samples.

1991 • 255 citations

In vitro inhibition of dihydropyridine oxidation and aflatoxin B₁ activation in human liver microsomes by naringenin and other flavonoids

1990 • 247 citations

Antibodies against human cytochrome P-450db1 in autoimmune hepatitis type II.

1988 • 237 citations

Taxol metabolism by human liver microsomes: identification of cytochrome P450 isozymes involved in its biotransformation.

1994 • 231 citations

Grapefruit juice–felodipine interaction: Mechanism, predictability, and effect of naringin

1993 • 230 citations

Oxidation of 17 alpha-ethynylestradiol by human liver cytochrome P-450.

1988 • 229 citations

Oxidation of the antihistaminic drug terfenadine in human liver microsomes. Role of cytochrome P-450 3A(4) in N-dealkylation and C-hydroxylation.

1993 • 225 citations

Identification of a polymorphically expressed member of the human cytochrome P-450III family.

1989 • 224 citations

Roles of individual human cytochrome P-450 enzymes in the bioactivation of benzo(a)pyrene, 7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene, and other dihydrodiol derivatives of polycyclic aromatic hydrocarbons.

1989 • 221 citations

THE METABOLISM OF METHYLATED AMINOAZO DYES

1954 • 214 citations

Catalytic activities of human liver cytochrome P-450 IIIA4 expressed in Saccharomyces cerevisiae

1990 • 207 citations

Fetus-specific expression of a form of cytochrome P-450 in human livers

1990 • 205 citations

Identification by molecular cloning of an autoantigen associated with Addison's disease as steroid 17α-hydroxylase

1992 • 201 citations

Anti-liver endoplasmic reticulum autoantibodies are directed against human cytochrome P-450IA2. A specific marker of dihydralazine-induced hepatitis.

1990 • 200 citations

Biotransformation of lovastatin

1991 • 195 citations

Purification and characterization of six cytochrome P-450 isozymes from human liver microsomes

1983 • 192 citations

Pregnenolone-16α-carbonitrile: A new type of inducer of drug-metabolizing enzymes

1972 • 188 citations

Measurement of urinary 6-?-hydroxycortisol excretion as an in vivo parameter in the clinical assessment of the microsomal enzyme-inducing capacity of antipyrine, phenobarbitone and rifampicin

1979 • 186 citations

Variability in nifedipine pharmacokinetics and dynamics: A new oxidation polymorphism in man

1984 • 182 citations

Induction of cytochrome P-450 by glucocorticoids in rat liver. II. Evidence that glucocorticoids regulate induction of cytochrome P-450 by a nonclassical receptor mechanism.

1984 • 182 citations

Metabolism of cyclosporine.

1985 • 172 citations

Major pathway of imipramine metabolism is catalyzed by cytochromes P-450 1A2 and P-450 3A4 in human liver.

1993 • 168 citations

P-450 HFLa, a form of cytochrome P-450 purified from human fetal livers, is the 16 alpha-hydroxylase of dehydroepiandrosterone 3-sulfate.

1987 • 160 citations

Isolation and sequence determination of a cDNA clone related to human cytochrome P-450 nifedipine oxidase.

1986 • 158 citations

Expression of cytochrome P‐450 enzymes in cultured human hepatocytes

1990 • 157 citations

A predictive model for substrates of cytochrome P450-debrisoquine (2D6)

1992 • 152 citations

Identification of human liver cytochrome P450 isoforms mediating secondary omeprazole metabolism.

1994 • 144 citations

Modulation of rabbit and human hepatic cytochrome P-450-catalyzed steroid hydroxylations by alpha-naphthoflavone.

1988 • 143 citations

Development of a pharmacophore for inhibition of human liver cytochrome P-450 2D6: molecular modeling and inhibition studies

1993 • 143 citations

Complete cDNA sequence of a cytochrome P-450 inducible by glucocorticoids in human liver.

1986 • 142 citations

Lidocaine metabolism by human cytochrome P-450s purified from hepatic microsomes: comparison of those with rat hepatic cytochrome P-450s.

1990 • 141 citations

The development of a human cell line stably expressing human CYP3A4: role in the metabolic activation of aflatoxin B₁ and comparison to CYP1A2 and CYP2A3

1991 • 141 citations

Comparison of urinary 6-β-cortisol and the erythromycin breath test as measures of hepatic P450IIIA (CYP3A) activity

1992 • 138 citations

Effect of rifampicin.treatment on the metabolism of oestradiol and 17?-ethinyloestradiol by human liver microsomes

1975 • 138 citations

Purification and properties of cytochrome P-450 from homogenates of human fetal livers

1985 • 137 citations

Expression of a human liver cytochrome P-450 protein with tolbutamide hydroxylase activity in Saccharomyces cerevisiae

1989 • 134 citations

THE METABOLISM OF METHYLATED AMINOAZO DYES

1953 • 128 citations

Role of phospholipids in reconstituted cytochrome P 450 3A form and mechanism of their activation of catalytic activity

1992 • 124 citations

Characterization of mRNA Species Related to Human Liver Cytochrome P-450 Nifedipine Oxidase and the Regulation of Catalytic Activity

1989 • 123 citations

Oxidation of substituted N,N-dimethylanilines by cytochrome P-450: estimation of the effective oxidation-reduction potential of cytochrome P-450

1989 • 121 citations

Molecular Cloning and Sequence Analysis of cDNA Containing the Entire Coding Region for Human Fetal Liver Cytochrome P-4501

1989 • 118 citations

Differential inhibition of individual human liver cytochromes P-450 by cimetidine

1991 • 118 citations

Oxidation of aflatoxins and sterigmatocystin by human liver microsomes: significance of aflatoxin Q1 as a detoxication product of aflatoxin B1

1992 • 118 citations

Induction of drug metabolism in man after rifampicin treatment measured by increased hexobarbital and tolbutamide clearance

1975 • 117 citations

Identification of the fetal liver cytochrome CYP3A7 in human endometrium and placenta.

1993 • 116 citations

Steroid 21‐hydroxylase is a major autoantigen involved in adult onset autoimmune Addison's disease

1992 • 111 citations

In vitro metabolism of FK-506 in rat, rabbit, and human liver microsomes: Identification of a major metabolite and of cytochrome P450 3A as the major enzymes responsible for its metabolism

1992 • 110 citations

High-level expression in Escherichia coli of enzymatically active fusion proteins containing the domains of mammalian cytochromes P450 and NADPH-P450 reductase flavoprotein.

1992 • 110 citations

Characterization of cytochrome P-450 2B6 in human liver microsomes.

1993 • 107 citations

Lidocaine Metabolite Formation as a Measure of Liver Function in Patients with Cirrhosis

1990 • 106 citations

Identification of the Pharmacogenetic Determinants of Alfentanil Metabolism

1992 • 104 citations

Nifedipine: Kinetics and hemodynamic effects in patients with liver cirrhosis after intravenous and oral administration

1986 • 103 citations

INTERACTION OF RIFAMPICIN TREATMENT WITH PHARMACOKINETICS AND METABOLISM OF ETHINYLOESTRADIOL IN MAN

1977 • 96 citations

Roles of human liver cytochrome P4502C and 3A enzymes in the 3-hydroxylation of benzo(a)pyrene.

1992 • 93 citations

Role of cytochrome P450IIIA4 in the metabolism of the pyrrolizidine alkaloid senecionine in human liver

1991 • 93 citations

Expression of human liver cytochrome P450 IIIA4 in yeast

1990 • 91 citations

Lack of bimodality in nifedipine plasma kinetics in a large population of healthy subjects

1988 • 90 citations

A three-dimensional molecular template for substrates of human cytochrome P450 involved in debrisoquine 4-hydroxylation

1991 • 89 citations

Inhibitors of P450-dependent steroid biosynthesis: From research to medical treatment

1992 • 89 citations

Optimization of yeast‐expressed human liver cytochrome P450 3A4 catalytic activities by coexpressing NADPH‐cytochrome P450 reductase and cytochrome b₅

1992 • 88 citations

Ueber die nach Einführung von Brombenzol und Chlorbenzol im Organismus entstehenden schwefelhaltigen Säuren

1879 • 87 citations

Ueber Bromphenylmercaptursäure

1879 • 85 citations

Effects of clarithromycin on cytochrome P-450. Comparison with other macrolides.

1989 • 81 citations

Isolation and characterization of human fetal liver cytochrome P450HLp2: A third member of the P450III gene family

1989 • 81 citations

Human liver microsomal N-hydroxylation of dapsone by cytochrome P-4503A4.

1992 • 80 citations

Reconstitution of testosterone oxidation by purified rat cytochrome P450p (IIIA1)

1990 • 76 citations

Accessibility of cytochrome P450 in microsomal membranes: inhibition of metabolism by antibodies to cytochrome P450.

1977 • 75 citations

Comparison of monooxygenase activities and cytochrome P-450 isozyme concentrations in human liver microsomes.

1986 • 70 citations

7,8-Benzoflavone stimulates the metabolic activation of aflatoxin B1 to mutagens by human liver

1978 • 68 citations

Atypical Metabolism of Deprenyl and Its Enantiomer, (S)-(+)-N,.alpha.-Dimethyl-N-Propynylphenethylamine, by Cytochrome P450 2D6

1994 • 63 citations

Assessment of urinary 6 beta‐hydroxycortisol as an in vivo index of mixed‐function oxygenase activity.

1981 • 61 citations

Metabolic activation of aflatoxin B1 and 2-amino-3-methylimidazo[4,5-f]-quinoline by human adult and fetal livers.

1990 • 55 citations

Pharmacokinetics of felodipine in patients with liver disease

1989 • 53 citations

Inactivation of cytochrome P-450 by a troleandomycin metabolite. Protective role of glutathione.

1983 • 52 citations

Genomic organization of human fetal specific P-450IIIA7(cytochrome P-450HFLa)-related gene(s) and interaction of transcriptional regulatory factor with its DNA element in the 5′ flanking region

1992 • 50 citations

Ueber Verwandlung der Benzoësäure in Hippursäure

1842 • 45 citations

Pharmacokinetics and pharmacodynamics of oral contraceptive steroids: Factors influencing steroid metabolism

1990 • 42 citations

Roles of human hepatic and pulmonary cytochrome P450 enzymes in the metabolism of the environmental carcinogen 6-nitrochrysene.

1993 • 41 citations

Partial purification and properties of cytochrome P450 from homogenates of human fetal livers

1979 • 36 citations

Roles of different forms of cytochrome P450 in the activation of the promutagen 6-aminochrysene to genotoxic metabolites in human liver microsomes

1993 • 36 citations

The metabolism of 1-nitropyrene by human cytochromes P450

1990 • 36 citations

Inactivation of 1,3-, 1,6-, and 1,8-dinitropyrene by cytochrome P-450 enzymes in human and rat liver microsomes.

1990 • 33 citations

Mutagenic activation of aflatoxin B1 by P-450 HFLa in human fetal livers

1989 • 33 citations

Contributions of human liver cytochrome P450 enzymes to the N-oxidation of 4,4′-methylene-bis(2-chloroaniline)

1992 • 33 citations

Stable expression of cytochrome P450IIIA7 cDNA in human breast cancer cell line MCF-7 and its application to cytotoxicity testing

1992 • 29 citations

Induction by Triacetyloleandomycin and partial purification of a LM3 form of cytochrome P-450 from rabbit liver microsomes

1982 • 26 citations

Pharmacokinetics of Nifedipine After Oral Administration in Chronic Liver Disease

1987 • 20 citations

Catalytic properties of the liver microsomal hydroxylase system in reconstituted phospholipid vesicles

1979 • 12 citations

Mechanisms of Enhancement and Inhibition of Cytochrome-P450 Catalytic Activities

1994 • 10 citations