Metabolism of 2-acetylaminofluorene and benzo(a)pyrene and activation of food-derived heterocyclic amine mutagens by human cytochromes P-450.

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1951 • 319,299 citations

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1970 • 253,849 citations

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1982 • 1,559 citations

The molecular biology of cytochrome P450s.

1988 • 1,294 citations

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1979 • 576 citations

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1986 • 389 citations

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1985 • 320 citations

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1985 • 319 citations

Radioactive assay for aryl hydrocarbon hydroxylase. Improved method and biological importance

1977 • 265 citations

Human liver microsomal cytochrome P-450 enzymes involved in the bioactivation of procarcinogens detected by umu gene response in Salmonella typhimurium TA 1535/pSK1002.

1989 • 265 citations

Identification of the mutagens in cooked beef.

1986 • 244 citations

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1988 • 236 citations

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1985 • 233 citations

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1984 • 199 citations

Structural gene products of the Ah locus. Genetic and immunochemical evidence for two forms of mouse liver cytochrome P-450 induced by 3-methylcholanthrene.

1979 • 166 citations

Metabolic oxidation of the carcinogens 4-aminobiphenyl and 4,4'-methylene-bis(2-chloroaniline) by human hepatic microsomes and by purified rat hepatic cytochrome P-450 monooxygenases.

1989 • 154 citations

Metabolic oxidation of carcinogenic arylamines by rat, dog, and human hepatic microsomes and by purified flavin-containing and cytochrome P-450 monooxygenases.

1985 • 148 citations

Modulation of rabbit and human hepatic cytochrome P-450-catalyzed steroid hydroxylations by alpha-naphthoflavone.

1988 • 143 citations

Differential induction of two 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible forms of cytochrome P-450 in extrahepatic versus hepatic tissues.

1984 • 127 citations

Characterization of mRNA Species Related to Human Liver Cytochrome P-450 Nifedipine Oxidase and the Regulation of Catalytic Activity

1989 • 123 citations

Specificity in the activation and inhibition by flavonoids of benzo[a]pyrene hydroxylation by cytochrome P-450 isozymes from rabbit liver microsomes.

1981 • 119 citations

Identification of the major cytochrome P-450 form transplacentally induced in neonatal rabbits by 3,3,7,8-tetrachlorodibenzo-p-dioxin.

1978 • 113 citations

Structure and drug inducibility of the human cytochrome P-450c gene

1986 • 106 citations

The human cytochrome Cyp1A2 gene contains regulatory elements responsive to 3-methylcholanthrene.

1989 • 90 citations

Metabolism of 2-acetylaminofluorene by eight different forms of cytochrome P-450 isolated from rat liver

1985 • 89 citations

Studies on the mechanism of activation of microsomal benzo[a]pyrene hydroxylation by flavonoids.

1981 • 81 citations

Human cytochrome P-450 4 mRNA and gene: part of a multigene family that contains Alu sequences in its mRNA.

1986 • 65 citations

Comparison of aryl hydrocarbon hydroxylase and acetanilide 4-hydroxylase induction by polycyclic aromatic compounds in human and mouse cell lines

1985 • 62 citations

Catalysis of divergent pathways of 2-acetylaminofluorene metabolism by multiple forms of cytochrome P-450.

1980 • 61 citations

Developmental and tissue-specific differential regulation of the mouse dioxin-inducible P1-450 and P3-450 genes

1985 • 61 citations

Identification of human cytochromes P-450 analogous to forms induced by phenobarbital and 3-methylcholanthrene in the rat

1985 • 60 citations

Activation of the food-derived mutagen 2-amino-1-methyl-6-phenylimidazo[4, 5-b]pyridine by rabbit and human liver microsomes and purified forms of cytochrome P-450

1989 • 59 citations

Differential induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin of multiple forms of rabbit microsomal cytochrome P-450: evidence for tissue specificity.

1980 • 53 citations

Correlation of placental microsomal activities with protein detected by antibodies to rabbit cytochrome P-450 isozyme 6 in preparations from humans exposed to polychlorinated biphenyls, quaterphenyls, and dibenzofurans.

1986 • 46 citations

Metabolic Activation of Pyrolysate Arylamines by Human Liver Microsomes; Possible Involvement of a P‐448‐H Type Cytochrome P‐450

1988 • 44 citations

Metabolic processing of 2-acetylaminofluorene by microsomes and six highly purified cytochrome P-450 forms from rabbit liver

1984 • 36 citations

Relationship between oxidative metabolism of 2-acetylaminofluorene, debrisoquine, bufuralol, and aldrin in human liver microsomes.

1984 • 20 citations

Kinetic evidence for the involvement of multiple forms of human liver cytochrome P-450 in the metabolism of acetylaminofluorene

1983 • 16 citations