Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450. Studies in rats and patients.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Applied Linear Statistical Models.

1986 • 4,926 citations

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 3,435 citations

POLYMORPHIC HYDROXYLATION OF DEBRISOQUINE IN MAN

1977 • 1,196 citations

The P450 Gene Superfamily: Recommended Nomenclature

1987 • 812 citations

Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism.

1986 • 734 citations

Characterization of the common genetic defect in humans deficient in debrisoquine metabolism

1988 • 717 citations

Cyclosporine metabolism in human liver: Identification of a cytochrome P-450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs

1988 • 539 citations

Preparation and Properties of Partially Purified Cytochrome P-450 and Reduced Nicotinamide Adenine Dinucleotide Phosphate-Cytochrome P-450 Reductase from Rabbit Liver Microsomes

1974 • 518 citations

Human liver microsomal steroid metabolism: Identification of the major microsomal steroid hormone 6β-hydroxylase cytochrome P-450 enzyme

1988 • 413 citations

Identification of an inducible form of cytochrome P-450 in human liver.

1985 • 320 citations

Purification and characterization of the human liver cytochromes P-450 involved in debrisoquine 4-hydroxylation and phenacetin O-deethylation, two prototypes for genetic polymorphism in oxidative drug metabolism.

1985 • 319 citations

Isolation, complementary DNA sequence, and regulation of rat hepatic lauric acid omega-hydroxylase (cytochrome P-450LA omega). Identification of a new cytochrome P-450 gene family.

1987 • 317 citations

Identification of the cytochrome P-450 induced by macrolide antibiotics in rat liver as the glucocorticoid responsive cytochrome P-450p

1985 • 301 citations

Pregnenolone 16 alpha-carbonitrile-inducible P-450 gene family: gene conversion and differential regulation.

1986 • 299 citations

Oxidation of quinidine by human liver cytochrome P-450.

1986 • 296 citations

Purification, characterization and regulation of five rat hepatic microsomal cytochrome P-450 isozymes

1982 • 265 citations

Separation, purification, and characterization of a novel form of hepatic cytochrome P-450 from rats treated with pregnenolone-16 alpha-carbonitrile.

1980 • 256 citations

Regulation of cytochrome P-450j, a high-affinity N-nitrosodimethylamine demethylase, in rat hepatic microsomes

1987 • 201 citations

Assessment of Aminopyrine Metabolism in Man by Breath Analysis after Oral Administration of¹⁴C-Aminopyrine

1974 • 199 citations

Demonstration in multiple species of inducible hepatic cytochromes P-450 and their mRNAs related to the glucocorticoid-inducible cytochrome P-450 of the rat.

1985 • 194 citations

Purification and characterization of six cytochrome P-450 isozymes from human liver microsomes

1983 • 192 citations

Macrolide antibiotics inhibit the degradation of the glucocorticoid-responsive cytochrome P-450p in rat hepatocytes in vivo and in primary monolayer culture.

1986 • 177 citations

Isolation and sequence determination of a cDNA clone related to human cytochrome P-450 nifedipine oxidase.

1986 • 158 citations

Complete cDNA sequence of a cytochrome P-450 inducible by glucocorticoids in human liver.

1986 • 142 citations

Immunochemical evidence for induction of a common form of hepatic cytochrome P-450 in rats treated with pregnenolone-16 alpha-carbonitrile or other steroidal or non-steroidal agents.

1982 • 132 citations

MPTP, the neurotoxin inducing parkinson's disease, is a potent competitive inhibitor of human and rat cytochrome P450 isozymes (P450bufI, P450db1) catalyzing debrisoquine 4-hydroxylation

1987 • 130 citations

Regulation of cytochrome P-450p by phenobarbital and phenobarbital-like inducers in adult rat hepatocytes in primary monolayer culture and in vivo

1986 • 130 citations

Intersubject and dose‐related variability after intravenous administration of erythromycin.

1980 • 112 citations

Phenotyping of cytochromes P -450 in human tissues with monoclonal antibodies

1982 • 94 citations

Genetically determined polymorphisms in drug oxidation

1986 • 88 citations

Comparative Structures of P-450 Cytochromes

1986 • 86 citations

Effect of rifampicin treatment on hepatic drug metabolism and serum bile acids in patients with primary biliary cirrhosis

1985 • 75 citations

Regulation of bile acid synthesis in man. Presence of a diurnal rhythm.

1983 • 73 citations

Test for Alcoholic Cirrhosis by Conversion of [14C] or [13C]Galactose to Expired CO2

1976 • 73 citations

Comparison of monooxygenase activities and cytochrome P-450 isozyme concentrations in human liver microsomes.

1986 • 70 citations

Studies on the pregnenolone-16α-carbonitrile-inducible form of rat liver microsomal cytochrome P-450 and UDP-glucuronosyltransferase

1987 • 63 citations

Purification of a human liver cytochrome P-450 immunochemically related to several cytochromes P-450 purified from untreated rats.

1987 • 61 citations

Clinical Utility of Breath Tests for the Assessment of Hepatic Function

1983 • 59 citations

Immunochemical evidence for multiple steroid-inducible hepatic cytochromes P-450 in the rat

1987 • 55 citations

Debrisoquine‐type polymorphism of drug oxidation: purification from human liver of a cytochrome P450 isozyme with high activity for bufuralol hydroxylation

1984 • 55 citations

Demethylation of erythromycins by rabbit tissues in vitro

1965 • 42 citations

P450 Genes: Evolution, Regulation, and Relationship To Human Cancer and Pharmacogenetics

1986 • 41 citations

Pregnenolone 16 Alpha-Carbonitrile-Inducible P-450 Gene Family: Gene Conversion and Differential Regulation

1986 • 35 citations

The [14C]‐aminopyrine breath test. A comparison of different forms of analysis.

1979 • 30 citations

The excretory products of N-methyl-C14-erythromycin in rats.

1956 • 13 citations

The 14CO2 breath test: facilities and limitations of a rapid and noninvasive method for in vivo evaluation of modified hepatic cytochrome P-450 ? a critique

1987 • 10 citations