Differential inhibition of individual human liver cytochromes P-450 by cimetidine

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 11,832 citations

The colorimetric estimation of formaldehyde by means of the Hantzsch reaction

1953 • 4,357 citations

Cytochrome P-450: Structure, Mechanism, and Biochemistry

1986 • 2,703 citations

Ethoxyresorufin: direct fluorimetric assay of a microsomal O-dealkylation which is preferentially inducible by 3-methylcholanthrene.

1974 • 1,562 citations

Transformation of yeast by a replicating hybrid plasmid

1978 • 1,362 citations

Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism.

1986 • 734 citations

Computer Programmes for Processing Enzyme Kinetic Data

1963 • 655 citations

Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines.

1989 • 643 citations

The P450 Superfamily: Updated Listing of All Genes and Recommended Nomenclature for the Chromosomal Loci

1989 • 609 citations

Cyclosporine metabolism in human liver: Identification of a cytochrome P-450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs

1988 • 539 citations

Cytochrome P-450 hPCN3, a Novel Cytochrome P-450 IIIA Gene Product That Is Differentially Expressed in Adult Human Liver

1989 • 480 citations

Delayed Clearance of Diazepam Due to Cimetidine

1980 • 336 citations

CIMETIDINE: INTERACTION WITH ORAL ANTICOAGULANTS IN MAN

1979 • 321 citations

Purification and characterization of the human liver cytochromes P-450 involved in debrisoquine 4-hydroxylation and phenacetin O-deethylation, two prototypes for genetic polymorphism in oxidative drug metabolism.

1985 • 319 citations

Lidocaine metabolism in human liver microsomes by cytochrome P450IIIA4

1989 • 264 citations

Inhibition of Cytochrome P450 Enzymes

2015 • 258 citations

Human liver microsomal cytochrome P-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism. Purification and characterization of two similar forms involved in the reaction.

1986 • 258 citations

Oxidation of 17 alpha-ethynylestradiol by human liver cytochrome P-450.

1988 • 229 citations

Anti-liver endoplasmic reticulum autoantibodies are directed against human cytochrome P-450IA2. A specific marker of dihydralazine-induced hepatitis.

1990 • 200 citations

Evidence that isoniazid and ethanol induce the same microsomal cytochrome P-450 in rat liver, an isozyme homologous to rabbit liver cytochrome P-450 isozyme 3a

1986 • 158 citations

Isolation and sequence determination of a cDNA clone related to human cytochrome P-450 nifedipine oxidase.

1986 • 158 citations

Drug metabolism by rat and human hepatic microsomes in response to interaction with H2-receptor antagonists

1982 • 145 citations

Expression of a human liver cytochrome P-450 protein with tolbutamide hydroxylase activity in Saccharomyces cerevisiae

1989 • 134 citations

Modulation of cytochrome P450 isozymes in human liver, by ethanol and drug intake

1989 • 131 citations

Cimetidine impairs the elimination of theophylline and antipyrine

1981 • 131 citations

Hepatic metabolism of tolbutamide: characterization of the form of cytochrome P-450 involved in methyl hydroxylation and relationship to in vivo disposition.

1987 • 130 citations

Substrate specificity of human liver cytochrome P-450 debrisoquine 4-hydroxylase probed using immunochemical inhibition and chemical modeling.

1985 • 124 citations

Alteration of Theophylline Clearance and Half-life by Cimetidine in Normal Volunteers

1981 • 123 citations

CUSUM CHARTS

1974 • 117 citations

Purification and characterization of ethanol-inducible human hepatic cytochrome P-450HLj

1987 • 112 citations

Molecular dimensions of the substrate binding site of cytochrome P-448

1986 • 111 citations

Cimetidine Potentiation of the Hypoprothrombinemic Effect of Warfarin

1979 • 95 citations

Determinants of acetaminophen metabolism: Effect of inducers and inhibitors of drug metabolism on acetaminophen's metabolic pathways

1984 • 91 citations

Cloning and sequence determination of a complementary DNA related to human liver microsomal cytochrome P-450 S-mephenytoin 4-hydroxylase

1987 • 91 citations

Genetically determined polymorphisms in drug oxidation

1986 • 88 citations

Cimetidine decreases theophylline clearance.

1981 • 88 citations

Cimetidine Decreases Theophylline Clearance

1981 • 87 citations

The Effects of Cimetidine on the Oxidative Metabolism of Estradiol

1989 • 81 citations

Oxidative metabolism of hexobarbital in human liver: relationship to polymorphic S-mephenytoin 4-hydroxylation.

1988 • 80 citations

Influence of enzyme induction and inhibition on the oxidation of nifedipine, sparteine, mephenytoin and antipyrine in humans as assessed by a "cocktail" study design.

1989 • 67 citations

Cimetidine increases steady state plasma levels of propranolol.

1981 • 65 citations

In Vivo Interactions Between H2-Receptor Antagonists and Ethanol Metabolism in Man and in Rats

1984 • 65 citations

Immunochemical evidence for multiple steroid-inducible hepatic cytochromes P-450 in the rat

1987 • 55 citations

Lack of effect of cimetidine on acetaminophen disposition in humans

1989 • 31 citations

Polymorphism of human cytochrome P-450

1987 • 30 citations

Cimetidine Kinetics and Dynamics in Patients with Severe Liver Disease

2007 • 27 citations

Low kinetic hydrogen isotope effects in the dehydrogenation of 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester (nifedipine) by cytochrome P-450 enzymes are consistent with an electron/proton/electron transfer mechanism

1990 • 21 citations

Aniline hydroxylase microassay suitable for needle biopsy specimens: effects of phosphate and pyrophosphate on aniline hydroxylation.

1972 • 18 citations

The effect of cimetidine on hepatic drug elimination in cirrhosis

1985 • 17 citations

The effects of ranitidine and cimetidine on the pharmacokinetics and pharmacodynamics of metoprolol

1988 • 11 citations