Effectiveness of theophylline to increase cyclic AMP levels and force of contraction in electrically paced guinea-pig auricles. Comparison with isoprenaline, calcium and ouabain

A Protein Binding Assay for Adenosine 3′:5′-Cyclic Monophosphate

1970 • 3,269 citations

Adenosine 3‘,5‘-Phosphate in Biological Materials

1962 • 2,102 citations

Eine einfache Technik der extrem schnellen Abk�hlung gr��erer Gewebest�cke

1960 • 866 citations

The Relationship between Caffeine Contracture of Intact Muscle and the Effect of Caffeine on Reticulum

1968 • 683 citations

The role of cyclic-3',5'-AMP in responses to catecholamines and other hormones.

1966 • 573 citations

Divalent cations as charge carriers in excitable membranes

1973 • 516 citations

The regulation of the calcium conductance of cardiac muscle by adrenaline.

1977 • 475 citations

[A simple technic for extremely rapid freezing of large pieces of tissue].

1960 • 453 citations

Localization of beta adrenergic receptors, and effects of noradrenaline and cyclic nucleotides on action potentials, ionic currents and tension in mammalian cardiac muscle

1974 • 422 citations

Cyclic AMP Mediates the Effects of Adrenaline on Cardiac Purkinje Fibres

1972 • 346 citations

A study of the ion selectivity and the kinetic properties of the calcium dependent slow inward current in mammalian cardiac muscle.

1977 • 344 citations

Ion fluxes in cardiac excitation and contraction and their relation to myocardial contractility.

1968 • 314 citations

A metabolic control mechanism for calcium ion influx that may protect the ventricular myocardial cell

1976 • 270 citations

Influence of Caffeine and other Methylxanthines on Mechanical Properties of Isolated Mammalian Heart Muscle: EVIDENCE FOR A DUAL MECHANISM OF ACTION

1972 • 262 citations

Heart: Excitation-Contraction Coupling

1973 • 234 citations

Die Wirkung von Pharmaka auf die Elimination von Noradrenalin aus der Perfusionsfl�ssigkeit und die Noradrenalinaufnahme in das isolierte Herz

1964 • 184 citations

Cyclic Adenosine Monophosphate Modulation of Slow Calcium Influx Channels in Guinea Pig Hearts

1974 • 173 citations

Slow Ca2+ and Na+ responses induced by isoproterenol and methylxanthines in isolated perfused guinea pig hearts exposed to elevated K+

1975 • 172 citations

Cyclic adenosine 3′,5′-monophosphate-dependent protein kinase stimulation of calcium uptake by canine cardiac microsomes

1972 • 170 citations

Calcium Current Channels Induced by Catecholamines in Chick Embryonic Hearts Whose Fast Sodium Channels are Blocked by Tetrodotoxin or Elevated Potassium

1972 • 165 citations

Some Properties of Fragmented Frog Sarcoplasmic Reticulum with Particular Reference to Its Response to Caffeine*

1970 • 143 citations

Calcium exchange in cardiac muscle: A basic mechanism of drug action

1967 • 141 citations

The effect of methylxanthines and local anesthetics on fragmented sarcoplasmic reticulum.

1969 • 131 citations

The time course of the effects of ?-and ?-adrenoceptor stimulation by isoprenaline and methoxamine on the contractile force and cAMP level of the isolated rabbit papillary muscle

1975 • 130 citations

Sensitivity changes in the dog heart to norepinephrine, calcium and aminophyline resulting from pretreatment with reserpine.

1968 • 91 citations

Cyclic Adenosine Monophosphate and Cardiac Contractility

1973 • 87 citations

Inotropic stimuli and systolic transmembrane calcium flow in depolarized guinea-pig atria.

1974 • 82 citations

Adenyl Cyclase and Cyclic AMP

1971 • 76 citations

The role of cyclic adenosine 3', 5'-monophosphate and calcium in the regulation of contractility and glycogen phosphorylase activity in guinea pig papillary muscle.

1976 • 71 citations

Effect of catecholamines, histamine and oxyfedrine on isotonic contraction and cyclic AMP in the guinea-pig heart

1973 • 67 citations

Effects of theophylline on myocardial mechanics

1972 • 67 citations

Membrane currents and tension in cat ventricular muscle treated with cardiac glycosides.

1975 • 65 citations

Inhibition of sarcotubular calcium transport by caffeine: Species and temperature dependence

1969 • 59 citations

Stimulatory effects of DB-c-AMP and adrenaline on myocardial contraction and 45Ca exchange. Experiments at reduced calcium concentration and low frequencies of stimulation

1973 • 54 citations

The action of imidazole on the effects of methyl-xanthines and catecholamines on cardiac contraction and phosphorylase activity.

1967 • 50 citations

Electromechanical studies on the inotropic effects of acetylstrophanthidin in ventricular muscle.

1975 • 49 citations

Control of cardiac sarcolemmal adenylate cyclase and sodium, potassium-activated adenosinetriphosphatase activities.

1975 • 48 citations

Structural and Functional Characterization of Dog Heart Microsomes

1969 • 48 citations

Die Aufnahme von ?-Methylnoradrenalin in das isolierte Kaninchenherz und seine Freisetzung durch Reserpin und Guanethidin in vivo

1965 • 46 citations

Possible role of cyclic AMP in the relaxation process of mammalian heart: Effects of dibutyryl cyclic AMP and theophylline on potassium contractures in cat papillary muscles

1976 • 43 citations

Quantitative relations between cyclic AMP and contraction as affected by stimulators of adenylate cyclase and inhibitors of phosphodiesterase.

1975 • 41 citations

The positive inotropic effect of cyclic AMP.

1972 • 37 citations

Hormonal regulation of myocardial adenosine 3′,5′-monophosphate

1969 • 36 citations

Glucagon: effect on adenosine 3', 5'-monophosphate in the rat heart

1968 • 35 citations

Effect of psychotropic drugs on phosphodiesterase and cyclic AMP level in rat brainin vivo

1973 • 34 citations

The effect of theophylline on amine-induced cardiac phosphorylase activation and cardiac contractility.

1969 • 33 citations

Changes in mechanical events and adenosine 3',5'-monophosphate levels induced by enantiomers of isoproterenol in isolated rat atria and uteri.

1975 • 23 citations

Adenosine 3‘, 5’‐cyclic Monophosphate in Perfused Rat Hearts Exposed to Isoprenaline and Dopamine

1976 • 21 citations

�ber den Mechanismus der positiv inotropen Wirkung von Theophyllin am Warmbl�terherzen

1971 • 21 citations

Lack of Interaction between Norepinephrine or Histamine and Theophylline on Cardiac Cyclic AMP

1974 • 19 citations

EFFECT OF TEMPERATURE ON CAFFEINE-INDUCED CALCIUM RELEASE FROM ISOLATED RETICULUM IN FROG SKELETAL MUSCLE

1970 • 18 citations

Effect of theophylline on myocardial adenylate cyclase activity

1978 • 16 citations

�ber den Mechanismus der positiv inotropen Wirkung von Theophyllin am Warmbl�terherzen

1971 • 15 citations

�ber den Mechanismus der positiv inotropen Wirkung von Theophyllin am Warmbl�terherzen

1971 • 15 citations

RELATIONSHIP BETWEEN THEOPHYLLINE UPTAKE AND INOTROPIC EFFECT IN THE GUINEA‐PIG HEART

1974 • 14 citations

The effect of theophylline on amine-induced cardiac cyclic AMP and cardiac contractile force

1977 • 13 citations

[Mechanism of the positive ionotropic action of theophylline on the mammalian heart. 3. Effect of theophylline on contraction and Ca dependent changes in membrane potentials].

1971 • 11 citations

[Mechanism of the positive ionotropic action of theophylline on the mammalian heart. 2. Effect of theophylline on the uptake and release of 45 Ca].

1971 • 9 citations

[Mechanism of the positive ionotropic action of theophylline on the mamalian heart. I. Influence of extracellular Ca, Na and K concentrations and of reserpine].

1971 • 9 citations

Effect of theophylline on calcium exchangeability in ventricular myocardium

1976 • 8 citations

Calcium-dependent depolarizations and contractions in ventricular myocardial fibers: effects of adrenaline and cardiac glycosides.

1975 • 7 citations

Caffeine and KCl contracture in cat myocardium

1976 • 6 citations

Ca-abh�ngige Membranpotential�nderungen und Kontraktion am Herzen unter dem Einflu\ von Adrenalin und Digitoxigenin

1970 • 2 citations

[Ca-dependent changes in membrane potential and cardiac contraction under the influence of adrenaline and digitoxigenin].

1970 • 2 citations

Proceedings: Cyclic AMP and alterations in inotropic state in isolated guinea pig auricles.

1975 • 1 citations