Different Roles for Plasminogen Activators and Metalloproteinases in Melanoma Metastasis

Matrix metalloproteinases and their inhibitors in connective tissue remodeling

1991 • 3,309 citations

Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation

1991 • 2,774 citations

Plasminogen Activators, Tissue Degradation, and Cancer

1985 • 2,584 citations

A matrix metalloproteinase expressed on the surface of invasive tumour cells

1994 • 2,561 citations

Tumor Cell Interactions with the Extracellular Matrix During Invasion and Metastasis

1993 • 1,523 citations

The matrix‐degrading metalloproteinases

1992 • 1,383 citations

Biology and biochemistry of proteinases in tumor invasion

1993 • 1,264 citations

Regulation of development and differentiation by the extracellular matrix

1993 • 1,216 citations

The plasminogen activator/plasmin system.

1991 • 1,196 citations

Purification and characterization of the plasminogen activator secreted by human melanoma cells in culture.

1981 • 792 citations

Tumor invasion through the human amniotic membrane: Requirement for a proteinase cascade

1986 • 764 citations

Antibodies to plasminogen activator inhibit human tumor metastasis

1983 • 651 citations

Caveolae, caveolin and caveolin-rich membrane domains: a signalling hypothesis

1994 • 646 citations

Caveolae: where incoming and outgoing messengers meet.

1993 • 616 citations

Role of cell-surface lysines in plasminogen binding to cells: identification of .alpha.-enolase as a candidate plasminogen receptor

1991 • 544 citations

An endothelial cell receptor for plasminogen/tissue plasminogen activator. I. Identity with annexin II.

1994 • 509 citations

Integrin alpha v beta 3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen.

1994 • 447 citations

Inhibition of invasion and metastasis in cells transfected with an inhibitor of metalloproteinases.

1992 • 429 citations

Role of the alpha v beta 3 integrin in human melanoma cell invasion.

1992 • 414 citations

Urokinase and urokinase receptor: A paracrine/autocrine system regulating cell migration and invasiveness

1993 • 402 citations

Prevention of metastasis by inhibition of the urokinase receptor.

1993 • 387 citations

Effects of inhibitors of plasminogen activator, serine proteinases, and collagenase IV on the invasion of basement membranes by metastatic cells

1988 • 352 citations

Heparanases and tumor metastasis

1988 • 303 citations

Inhibition of angiogenesis by tissue inhibitor of metalloproteinase

1994 • 299 citations

Tumour progression and the nature of cancer

1991 • 273 citations

Tissue inhibitor of metalloproteinases (TIMP, aka EPA): Structure, control of expression and biological functions

1993 • 270 citations

Matrix metalloproteinase inhibitor BB-94 (batimastat)inhibits human colon tumor growth and spread in a patient-like orthotopic model in nude mice.

1994 • 254 citations

Extracellular Matrix Assembly

1988 • 250 citations

A potential marker protease of invasiveness, seprase, is localized on invadopodia of human malignant melanoma cells.

1994 • 242 citations

Modulation of metastatic potential by cell surface urokinase of murine melanoma cells.

1988 • 223 citations

Regulation of Matrix Metalloproteinase Activity^a

1994 • 221 citations

Suppression of the Tumorigenic and Metastatic Abilities of Murine B16-F10 Melanoma Cells In Vivo by the Overexpression of the Tissue Inhibitor of the Metalloproteinases-1

1994 • 221 citations

Inhibition of the metastatic spread and growth of B16‐BL6 murine melanoma by a synthetic matrix metalloproteinase inhibitor

1994 • 218 citations

The urokinase-type plasminogen activator receptor, a GPI-linked protein, is localized in caveolae.

1995 • 196 citations

Characterization of a highly invasive and spontaneously metastatic human malignant melanoma cell line

1991 • 191 citations

The plasminogen-plasmin system in malignancy

1992 • 190 citations

Cathepsin B and its endogenous inhibitors: the role in tumor malignancy

1990 • 187 citations

Inhibition of urokinase-type plasminogen activator by antibodies: the effect on dissemination of a human tumor in the nude mouse.

1991 • 179 citations

Basement membrane type IV collagen degradation: evidence for the involvement of a proteolytic cascade independent of metalloproteinases.

1990 • 173 citations

Effect of tissue inhibitor of the matrix metalloproteinases-2 expression on the growth and spontaneous metastasis of a human melanoma cell line.

1994 • 168 citations

The Urokinase Receptor: Involvement in Cell Surface Proteolysis and Cancer Invasion

1992 • 165 citations

Overexpression of metalloproteinase inhibitor in B16F10 cells does not affect extravasation but reduces tumor growth.

1994 • 160 citations

The role of urokinase-type plasminogen activator in aggressive tumor cell behavior

1990 • 158 citations

Metastatic behavior of human melanoma cell lines in nude mice correlates with urokinase-type plasminogen activator, its type-1 inhibitor, and urokinase-mediated matrix degradation.

1991 • 156 citations

Binding of urokinase to its receptor promotes migration and invasion of human melanoma cells in vitro.

1994 • 155 citations

Plasminogen activators, their inhibitors, and urokinase receptor emerge in late stages of melanocytic tumor progression.

1994 • 150 citations

The 72 kDa type IV collagenase is modulated via differential expression of alpha v beta 3 and alpha 5 beta 1 integrins during human melanoma cell invasion.

1993 • 147 citations

Suppression of Invasion by Inducible Expression of Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) in B 16-F10 Melanoma Cells

1992 • 137 citations

Biochemical and functional characterization of aminopeptidase N expressed by human melanoma cells.

1993 • 135 citations

Protease inhibitors: Role and potential therapeutic use in human cancer

1994 • 134 citations

Overexpression of plasminogen activator inhibitor 2 in human melanoma cells inhibits spontaneous metastasis in scid/scid mice.

1995 • 131 citations

Retinoic acid inhibition of human melanoma cell invasion through a reconstituted basement membrane and its relation to decreases in the expression of proteolytic enzymes and motility factor receptor.

1990 • 126 citations

A 170-kDa membrane-bound protease is associated with the expression of invasiveness by human malignant melanoma cells.

1990 • 125 citations

Expression of Human Recombinant Plasminogen Activators Enhances Invasion and Experimental Metastasis of H-ras-Transformed NIH 3T3 Cells

1989 • 120 citations

Invasion of connective tissue by human carcinoma cell lines: requirement for urokinase, urokinase receptor, and interstitial collagenase.

1992 • 106 citations

A metalloproteinase inhibitor as an inhibitor of neovascularization

1991 • 106 citations

Melanoma-mediated dissolution of extracellular matrix: contribution of urokinase-dependent and metalloproteinase-dependent proteolytic pathways.

1993 • 106 citations

The 92-kDa gelatinase B is expressed by advanced stage melanoma cells: suppression by somatic cell hybridization with early stage melanoma cells.

1995 • 102 citations

Relationship between secreted urokinase plasminogen activator activity and metastatic potential in murine B16 cells transfected with human urokinase sense and antisense genes.

1990 • 99 citations

Suppression of spontaneous melanoma metastasis in scid mice with an antibody to the epidermal growth factor receptor.

1991 • 98 citations

Expression of human recombinant plasminogen activators enhances invasion and experimental metastasis of H-ras-transformed NIH 3T3 cells.

1989 • 95 citations

Functional inhibition of endogenously produced urokinase decreases cell proliferation in a human melanoma cell line.

1989 • 91 citations

Mechanisms of Invasion and Metastasis

1991 • 86 citations

Urokinase-type and tissue-type plasminogen activators are essential for in vitro invasion of human melanoma cells

1991 • 85 citations

Membrane-associated cathepsin L: A role in metastasis of melanomas

1989 • 84 citations

Inhibition of invasion of HT1080 sarcoma cells expressing recombinant plasminogen activator inhibitor 2.

1993 • 78 citations

Up-regulation of TIMP-1 expression in B16-F10 melanoma cells suppresses their metastatic ability in chick embryo

1992 • 76 citations

Generation of cell surface-bound plasmin by cell-associated urokinase-type or secreted tissue-type plasminogen activator: A key event in melanoma cell invasiveness in vitro

1992 • 49 citations

Plasminogen activation in melanocytic neoplasia.

1994 • 42 citations

A possible role for cysteine proteinase and its inhibitors in motility of malignant melanoma and other tumour cells

1992 • 36 citations

Chromosomal abnormalities in human breast cancer

1990 • 35 citations

Binding of tissue‐type plasminogen activator to human melanoma cells

1993 • 28 citations

Characterization of a cathepsin‐H‐like enzyme from a human melanoma cell line

1991 • 27 citations

TIMP‐2 Expression Modulates Human Melanoma Cell Adhesion and Motility

1994 • 26 citations

Connective tissue degradation by invasive rat bladder carcinomas: action of nonspecific proteinases on collagenous matrices.

1986 • 23 citations

Characterization of seven human melanoma cell lines: Melanogenesis and secretion of plasminogen activators

1986 • 23 citations

Inactive cathepsin B-like enzyme in human melanoma culture medium

1992 • 5 citations

α₂‐Macroglobulin in the Regulation of Pericellular Plasminogen Activation of Human Tumor Cells

1994 • 3 citations