The Urokinase Receptor: Involvement in Cell Surface Proteolysis and Cancer Invasion

Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation

1991 • 2,774 citations

Plasminogen Activators, Tissue Degradation, and Cancer

1985 • 2,584 citations

A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas

1990 • 1,140 citations

MOLECULAR ORGANIZATION AND FUNCTION OF THE COMPLEMENT SYSTEM

1988 • 831 citations

Tumor invasion through the human amniotic membrane: Requirement for a proteinase cascade

1986 • 764 citations

A cellular binding site for the Mr 55,000 form of the human plasminogen activator, urokinase.

1985 • 731 citations

Cloning and expression of the receptor for human urokinase plasminogen activator, a central molecule in cell surface, plasmin dependent proteolysis.

1990 • 624 citations

Cellular receptor for urokinase plasminogen activator. Carboxyl-terminal processing and membrane anchoring by glycosyl-phosphatidylinositol

1991 • 578 citations

COFACTOR PROTEINS IN THE ASSEMBLY AND EXPRESSION OF BLOOD CLOTTING ENZYME COMPLEXES

1988 • 535 citations

The glycosyl-phosphatidylinositol anchor of membrane proteins

1989 • 520 citations

Plasminogen activation by receptor-bound urokinase. A kinetic study with both cell-associated and isolated receptor

1991 • 509 citations

Proteolytic degradation of extracellular matrix in tumor invasion

1987 • 484 citations

The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes.

1990 • 480 citations

The receptor-binding sequence of urokinase. A biological function for the growth-factor module of proteases.

1987 • 479 citations

The plasminogen system and cell surfaces: evidence for plasminogen and urokinase receptors on the same cell type.

1986 • 466 citations

Differentiation-enhanced binding of the amino-terminal fragment of human urokinase plasminogen activator to a specific receptor on U937 monocytes.

1985 • 450 citations

Fibrinolysis Associated with Oncogenic Transformation

1974 • 444 citations

Urokinase-type plasminogen activator is expressed in stromal cells and its receptor in cancer cells at invasive foci in human colon adenocarcinomas.

1991 • 440 citations

The activation of pro-urokinase by plasma kallikrein and its inactivation by thrombin.

1986 • 391 citations

The major Fc receptor in blood has a phosphatidylinositol anchor and is deficient in paroxysmal nocturnal haemoglobinuria

1988 • 387 citations

Receptor-mediated internalization and degradation of urokinase is caused by its specific inhibitor PAI-1.

1990 • 374 citations

Cathepsin B efficiently activates the soluble and the tumor cell receptor-bound form of the proenzyme urokinase-type plasminogen activator (Pro-uPA).

1991 • 347 citations

Growth factors in the regulation of pericellular proteolysis: a review.

1989 • 342 citations

Plasminogen Activation Initiated by Single-chain Urokinase-type Plasminogen Activator

1989 • 341 citations

Localization of messenger RNA for Mr 72,000 and 92,000 type IV collagenases in human skin cancers by in situ hybridization.

1992 • 331 citations

Activation of pro-urokinase and plasminogen on human sarcoma cells: a proteolytic system with surface-bound reactants.

1989 • 329 citations

Ultrastructural localization of plasma membrane-associated urokinase-type plasminogen activator at focal contacts.

1988 • 312 citations

Distinct localizations of urokinase-type plasminogen activator and its type 1 inhibitor under cultured human fibroblasts and sarcoma cells

1987 • 295 citations

Urokinase-plasminogen activator, a new and independent prognostic marker in breast cancer.

1990 • 294 citations

The human receptor for urokinase plasminogen activator. NH2-terminal amino acid sequence and glycosylation variants.

1990 • 278 citations

A 55,000-60,000 Mr receptor protein for urokinase-type plasminogen activator. Identification in human tumor cell lines and partial purification.

1988 • 275 citations

In vivo invasion of modified chorioallantoic membrane by tumor cells: the role of cell surface-bound urokinase.

1988 • 273 citations

Inhibition of receptor-bound urokinase by plasminogen-activator inhibitors.

1990 • 272 citations

Purification of zymogen to plasminogen activator from human glioblastoma cells by affinity chromatography with monoclonal antibody

1982 • 269 citations

The ligand-binding domain of the cell surface receptor for urokinase-type plasminogen activator.

1991 • 256 citations

Characterization of the Cellular Binding Site for the Urokinase-type Plasminogen Activator

1989 • 248 citations

One-chain urokinase-type plasminogen activator from human sarcoma cells is a proenzyme with little or no intrinsic activity.

1988 • 237 citations

Macrophage fibrinolytic activity: Identification of two pathways of plasmin formation by intact cells and of a plasminogen activator inhibitor

1982 • 225 citations

Surface receptors for urokinase plasminogen activator

1988 • 222 citations

In vivo paracrine interaction between urokinase and its receptor: effect on tumor cell invasion.

1991 • 216 citations

Plasminogen Activation by Receptor-Bound Urokinase

1991 • 214 citations

Cell‐induced potentiation of the plasminogen activation system is abolished by a monoclonal antibody that recognizes the NH₂‐terminal domain of the urokinase receptor

1991 • 194 citations

Binding of single-chain prourokinase to the urokinase receptor of human U937 cells.

1986 • 191 citations

Urokinase-type plasminogen activator (u-PA) antigen is a predictor of early relapse in breast cancer

1990 • 189 citations

Phosphatidylinositol-linked proteins and paroxysmal nocturnal hemoglobinuria

1990 • 189 citations

Plasminogen activator dependent pathways inthe dissemination of human tumor cells in the chick embryo

1988 • 181 citations

Distribution of urokinase-type plasminogen activator immunoreactivity in the mouse.

1984 • 181 citations

Localization of urokinase-type plasminogen activator in stromal cells in adenocarcinomas of the colon in humans.

1991 • 179 citations

Inhibition of urokinase-type plasminogen activator by antibodies: the effect on dissemination of a human tumor in the nude mouse.

1991 • 179 citations

Immunocytochemical localization of urokinase-type plasminogen activator in Lewis lung carcinoma.

1984 • 173 citations

Receptor Mediated Binding of the Fibrinolytic Components, Plasminogen and Urokinase, to Peripheral Blood Cells

1987 • 165 citations

Association of a protease (plasminogen activator) with a specific membrane fraction isolated from transformed cells.

1976 • 163 citations

Plasminogen receptors: Ubiquitous sites for cellular regulation of fibrinolysis

1988 • 161 citations

Linkage of extracellular plasminogen activator to the fibroblast cytoskeleton: colocalization of cell surface urokinase with vinculin.

1988 • 158 citations

Metastatic behavior of human melanoma cell lines in nude mice correlates with urokinase-type plasminogen activator, its type-1 inhibitor, and urokinase-mediated matrix degradation.

1991 • 156 citations

The plasminogen activation system in human colon cancer: messenger RNA for the inhibitor PAI-1 is located in endothelial cells in the tumor stroma.

1991 • 147 citations

Inhibition of cell surface receptor-bound plasmin by alpha 2-antiplasmin and alpha 2-macroglobulin

1991 • 143 citations

The receptor for urokinase-type plasminogen activator is deficient on peripheral blood leukocytes in patients with paroxysmal nocturnal hemoglobinuria

1992 • 136 citations

Determination of the levels of urokinase and its receptor in human colon carcinoma cell lines.

1988 • 128 citations

Effects of the DNA intercalators 4'-(9-acridinylamino)methanesulfon-m-anisidide and 2-methyl-9-hydroxyellipticinium on topoisomerase II mediated DNA strand cleavage and strand passage

1985 • 127 citations

Plasminogen activator and mouse spermatozoa: urokinase synthesis in the male genital tract and binding of the enzyme to the sperm cell surface.

1987 • 125 citations

Role of the urokinase receptor in facilitating extracellular matrix invasion by cultured colon cancer.

1991 • 123 citations

Protein Structure and Membrane Anchorage of the Cellular Receptor for Urokinase-Type Plasminogen Activator

1991 • 117 citations

Urokinase-receptor biosynthesis, mRNA level and gene transcription are increased by transforming growth factor beta 1 in human A549 lung carcinoma cells.

1991 • 117 citations

Two alternatively spliced mouse urokinase receptor mRNAs with different histological localization in the gastrointestinal tract.

1991 • 110 citations

Human Ovarian Tumor-associated Trypsin

1989 • 105 citations

Plasminogen activation by single-chain urokinase in functional isolation. A kinetic study.

1987 • 103 citations

Mouse L cells expressing human prourokinase-type plasminogen activator: effects on extracellular matrix degradation and invasion.

1989 • 99 citations

Functional characteristics of receptor-bound urokinase on human monocytes: catalytic efficiency and susceptibility to inactivation by plasminogen activator inhibitors

1989 • 99 citations

Localization of urokinase-type plasminogen activator messenger RNA in the normal mouse by in situ hybridization.

1991 • 97 citations

Complementation between urokinase-producing and receptor-producing cells in extracellular matrix degradation.

1991 • 87 citations

Localization of plasminogen activators in human colon cancer by immunoperoxidase staining.

1985 • 86 citations

A soluble form of the glycolipid‐anchored receptor for urokinase‐type plasminogen activator is secreted from peripheral blood leukocytes from patients with paroxysmal nocturnal hemoglobinuria

1992 • 75 citations

Sensitive and specific enzyme-linked immunosorbent assay for urokinase-type plasminogen activator and its application to plasma from patients with breast cancer.

1988 • 73 citations

Cryptic urokinase binding sites on human foreskin fibroblasts

1985 • 71 citations

Activation of pro‐urokinase by the human T cell‐associated serine proteinase HuTSP‐1

1990 • 67 citations

Urokinase receptors in human monocytes

1990 • 63 citations

Dynamics of the multidomain fibrinolytic protein urokinase from two-dimensional NMR

1989 • 62 citations

Identification and characterization of the murine cell surface receptor for the urokinase‐type plasminogen activator

1992 • 62 citations

Cathepsin D in breast cancer: from molecular and cellular biology to clinical applications.

1990 • 50 citations

Bimodal relationship between invasion of the amniotic membrane and plasminogen activator activity

1990 • 45 citations

The plasmin system in human adenocarcinomas and their metastases. A comparative immunofluorescence study

1987 • 39 citations

Transformation-dependent activation of urokinase-type plasminogen activator by a plasmin-independent mechanism: involvement of cell surface membranes.

1991 • 24 citations

Conformation of one- and two-chain high molecular weight urokinase analyzed by small-angle neutron scattering and vacuum ultraviolet circular dichroism

1991 • 15 citations

Stimulation of Cell Surface Plasminogen Activation by Heparin and Related Polyionic Substances

1991 • 7 citations