Coordinate Interactions of Cyclic Nucleotide and Phospholipid Metabolizing Pathways in Calcium-Dependent Cellular Processes

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

Prostaglandins and Thromboxanes

1978 • 1,310 citations

Phospholipid Methylation and Biological Signal Transmission

1980 • 1,101 citations

Intracellular phospholipases A

1980 • 989 citations

Macrocortin: a polypeptide causing the anti-phospholipase effect of glucocorticoids

1980 • 925 citations

A phospholipase A2 inhibitory protein in rabbit neutrophils induced by glucocorticoids.

1980 • 841 citations

Calcium-mobilizing receptors, polyphosphoinositides, and the generation of second messengers.

1986 • 831 citations

Eicosonoid metabolism and beta-adrenergic mechanisms in coronary arterial smooth muscle: potential compartmentation of cAMP

1986 • 795 citations

Cyclic GMP Metabolism and Involvement in Biological Regulation

1977 • 629 citations

A Potential Second Messenger Role for Unsaturated Fatty Acids: Activation of Ca ²⁺ -Dependent Protein Kinase

1984 • 618 citations

Mechanisms of Lysosomal Enzyme Release from Human Leukocytes II. EFFECTS OF cAMP AND cGMP, AUTONOMIC AGONISTS, AND AGENTS WHICH AFFECT MICROTUBULE FUNCTION

1974 • 567 citations

Identification of a calcium-binding protein as a calcium-dependent regulator of brain adenylate cyclase.

1975 • 546 citations

The mechanism of catecholamine release from the adrenal medulla and the role of calcium in stimulus—secretion coupling

1963 • 507 citations

Evidence that the Rous sarcoma virus transforming gene product phosphorylates phosphatidylinositol and diacylglycerol.

1984 • 476 citations

Studies on the mechanism of membrane fusion: evidence for an intermembrane calcium(2+) ion-phospholipid complex, synergism with magnesium(2+) ion, and inhibition by spectrin

1979 • 470 citations

The regulation of lipomodulin, a phospholipase inhibitory protein, in rabbit neutrophils by phosphorylation.

1981 • 424 citations

Phospholipase A2 and phospholipase C are activated by distinct GTP-binding proteins in response to alpha 1-adrenergic stimulation in FRTL5 thyroid cells.

1986 • 424 citations

Inhibition of receptor-mediated release of arachidonic acid by pertussis toxin

1984 • 418 citations

Activation of protein kinase C potentiates isoprenaline-induced cyclic AMP accumulation in rat pinealocytes

1985 • 415 citations

n-Tetradecanoyl is the NH2-terminal blocking group of the catalytic subunit of cyclic AMP-dependent protein kinase from bovine cardiac muscle.

1982 • 395 citations

Insulin-Stimulated Hydrolysis of a Novel Glycolipid Generates Modulators of cAMP Phosphodiesterase

1986 • 383 citations

Signal transduction by guanine nucleotide binding proteins

1987 • 362 citations

Enzymatic methylation of phosphatidylethanolamine increases erythrocyte membrane fluidity

1978 • 356 citations

Activation and attenuation of adenylate cyclase. The role of GTP-binding proteins as macromolecular messengers in receptor–cyclase coupling

1981 • 322 citations

Regulation Of Carbohydrate Metabolism

2018 • 316 citations

Studies of the characterisation of prostanoid receptors: A proposed classification

1982 • 305 citations

Metabolism of arachidonic acid in ionophore-stimulated neutrophils. Esterification of a hydroxylated metabolite into phospholipids.

1979 • 297 citations

Direct activation of purified protein kinase C by unsaturated fatty acids (oleate and arachidonate) in the absence of phospholipids and Ca²⁺

1985 • 293 citations

Smooth Muscle: An assessment of current knowledge

1981 • 288 citations

Phospholipase A2 and phospholipase C activities of platelets. Differential substrate specificity, Ca2+ requirement, pH dependence, and cellular localization.

1980 • 287 citations

Cyclic guanosine monophosphate inhibition of contraction may be mediated through inhibition of phosphatidylinositol hydrolysis in rat aorta.

1986 • 282 citations

Cyclic adenosine 3',5'-monophosphate inhibits the availability of arachidonate to prostaglandin synthetase in human platelet suspensions.

1977 • 279 citations

Message Transmission: Receptor Controlled Adenylate Cyclase System

1984 • 275 citations

UNSATURATED LIPIDE OXIDATION CATALYZED BY HEMATIN COMPOUNDS

1955 • 268 citations

Acetylcholine increases the breakdown of triphosphoinositide of rabbit iris muscle prelabelled with [32P] phosphate

1977 • 256 citations

Phosphorylation of the calcium antagonist receptor of the voltage-sensitive calcium channel by cAMP-dependent protein kinase.

1985 • 253 citations

Receptor-mediated inhibition of adenylate cyclase and stimulation of arachidonic acid release in 3T3 fibroblasts. Selective susceptibility to islet-activating protein, pertussis toxin.

1985 • 245 citations

Leukotriene B4 and phosphatidic acid are calcium ionophores. Studies employing arsenazo III in liposomes.

1982 • 241 citations

Regulation of arachidonic acid production: role of phospholipases C and A2

1982 • 239 citations

Platelet activation—a role for a 40K anti-phospholipase A2 protein indistinguishable from lipocortin

1986 • 233 citations

Cyclic GMP directly regulates a cation conductance in membranes of bovine rods by a cooperative mechanism.

1985 • 230 citations

The phosphatidylinositol cycle and the regulation of arachidonic acid production

1981 • 230 citations

Activation of guanylate cyclase from rat liver and other tissues by sodium azide.

1975 • 228 citations

Hormonal regulation of hormone-sensitive lipase in intact adipocytes: identification of phosphorylated sites and effects on the phosphorylation by lipolytic hormones and insulin.

1984 • 227 citations

Characterization of particulate and soluble guanylate cyclases from rat lung

1975 • 223 citations

The Ca2+-pumping ATPase of plasma membranes purification, reconstitution and properties

1982 • 221 citations

Phosphatidic acid may stimulate membrane receptors mediating adenylate cyclase inhibition and phospholipid breakdown in 3T3 fibroblasts.

1987 • 219 citations

Calcium and Cellular Secretion

1982 • 216 citations

Reduced Triphosphopyridine Nucleotide Oxidase-catalyzed Alterations of Membrane Phospholipids

1968 • 213 citations

Arachidonic acid stimulates the formation of 1,2-diacylglycerol and phosphatidic acid in human platelets. Degree of phospholipase C activation correlates with protein phosphorylation, platelet shape change, serotonin release, and aggregation.

1983 • 205 citations

Cyclic adenosine 3′,5′-monophosphate and prostacyclin inhibit membrane phospholipase activity in platelets

1977 • 204 citations

Mode of coupling between hormone receptors and adenylate cyclase elucidated by modulation of membrane fluidity

1978 • 202 citations

Studies on the hepatic calcium-mobilizing activity of aluminum fluoride and glucagon. Modulation by cAMP and phorbol myristate acetate.

1986 • 198 citations

Activation of Thyroid Membrane Adenylate Cyclase by Purine Nucleotides

1973 • 189 citations

Light activation of phospholipase A2 in rod outer segments of bovine retina and its modulation by GTP-binding proteins.

1987 • 186 citations

Characterization of the adrenergic receptors mediating a rise in cyclic 3'-5'-adenosine monophosphate in rat cerebral cortex.

1973 • 184 citations

The Role of Acidic Phospholipids in Glucagon Action on Rat Liver Adenylate Cyclase

1973 • 182 citations

Lysophosphatidic acids. Influence on platelet aggregation and intracellular calcium flux.

1979 • 169 citations

Smooth Muscle: An Assessment of Current Knowledge

1982 • 169 citations

Requirement for Guanosine Triphosphate in the Prostaglandin Activation of Adenylate Cyclase of Platelet Membranes

1972 • 166 citations

Insulin-stimulated diacylglycerol production results from the hydrolysis of a novel phosphatidylinositol glycan.

1987 • 166 citations

Inhibitory effect of prostaglandin E2, forskolin, and dibutyryl cAMP on arachidonic acid release and inositol phospholipid metabolism in guinea pig neutrophils.

1986 • 164 citations

Alamethicin pore formation: Voltage-dependent flip-flop of ?-helix dipoles

1983 • 161 citations

Restoration of Norepinephrine Responsiveness of Solubilized Myocardial Adenylate Cyclase by Phosphatidylinositol

1971 • 161 citations

The activation by Ca2+ of platelet phospholipase A2

1978 • 159 citations

Modulation of phosphatidylinositol-specific phospholipase C activity by phospholipid interactions, diglycerides, and calcium ions.

1982 • 158 citations

Regulation of endothelial cell cyclic nucleotide metabolism by prostacyclin.

1981 • 155 citations

cGMP-dependent protein kinase enhances Ca2+ current and potentiates the serotonin-induced Ca2+ current increase in snail neurones

1986 • 154 citations

Melittin and a chemically modified trichotoxin form alamethicin-type multi-state pores

1983 • 154 citations

Phosphorylation at a tyrosine residue of lipomodulin in mitogen-stimulated murine thymocytes.

1984 • 153 citations

Mepacrine blocks beta-adrenergic agonist-induced desensitization in astrocytoma cells.

1980 • 151 citations

Regulation of guanylate and adenylate cyclase activities by lysolecithin.

1976 • 150 citations

Influence of phosphatidylserine on (Na+ + K+)-stimulated ATPase and acetylcholinesterase activities of dog brain synaptosomal plasma membranes

1984 • 149 citations

Low concentrations of indomethacin inhibit phospholipase A2 of rabbit polymorphonuclear leukocytes.

1978 • 146 citations

A model for the regulation of the calmodulin-dependent enzymes erythrocyte Ca2+-transport ATPase and brain phosphodiesterase by activators and inhibitors

1982 • 144 citations

Effects of serotonin, carbamylcholine, and ascorbic acid on leukocyte cyclic GMP and chemotaxis.

1975 • 144 citations

Cyclic AMP inhibits synthesis of prostaglandin endoperoxide (PGG2) in human platelets

1976 • 142 citations

Insulin Generates an Enzyme Modulator from Hepatic Plasma Membranes: Regulation of Adenosine 3′, 5′-Monophosphate Phosphodiesterase, Pyruvate Dehydrogenase, and Adenylate Cyclase*

1987 • 142 citations

Calcium-dependent cyclic nucleotide phosphodiesterase from brain: Identification of phospholipids as calcium-independent activators

1976 • 141 citations

Cyclic Nucleotides

1971 • 140 citations

Biochemistry of Arachidonic Acid Metabolism

1985 • 138 citations

Inhibitory action of cyclic GMP on secretion, polyphosphoinositide hydrolysis and calcium mobilization in thrombin-stimulated human platelets

1986 • 136 citations

Stimulation of guanylate cyclase of fibroblasts by free fatty acids.

1976 • 134 citations

Ionophores stimulate prostaglandin and thromboxane biosynthesis

1977 • 133 citations

Platelet activating factor and U44069 stimulate a GTPase activity in human platelets which is distinct from the guanine nucleotide regulatory proteins, Ns and Ni

1986 • 132 citations

Fluoronorepinephrines: specific agonists for the activation of alpha and beta adrenergic-sensitive cyclic AMP-generating systems in brain slices.

1980 • 125 citations

Lipoxygenase Pathway in Islet Endocrine Cells. OXIDATIVE METABOLISM OF ARACHIDONIC ACID PROMOTES INSULIN RELEASE

1983 • 125 citations

Asymmetry of the phospholipid bilayer of rat liver endoplasmic reticulum

1977 • 121 citations

Serum-coated zymosan stimulates the synthesis of leukotriene B4 in human polymorphonuclear leukocytes. Inhibition by cyclic AMP

1981 • 114 citations

Characterization of the relationship between gamma-aminobutyric acid B agonists and transmitter-coupled cyclic nucleotide-generating systems in rat brain.

1985 • 113 citations

Unique aspects of the modulation of human neutrophil function by 12-L-hydroperoxy-5,8,10,14-eicosatetraenoic acid

1980 • 112 citations

Lipid peroxidation increases the molecular order of microsomal membranes

1984 • 111 citations

Fatty acid stimulation of membrane phosphatidylinositol hydrolysis by brain phosphatidylinositol phosphodiesterase

1979 • 110 citations

Cyclic Nucleotide Changes in Human Neutrophils Induced by Chemoattractants and Chemotactic Modulators

1977 • 108 citations

Increased membrane acyl chain ordering activates adenylate cyclase.

1979 • 107 citations

Modification of adenylate cyclase activity in LM cells by manipulation of the membrane phospholipid composition in vivo.

1976 • 106 citations

AGEPC (platelet activating factor) induced stimulation of rabbit platelets: Effects on phosphatidylinositol, DI- and TRI-phosphoinositides and phosphatidic acid metabolism

1982 • 105 citations

Effect of membrane phospholipid compositional changes on adenylate cyclase in LM cells

1978 • 105 citations

Characterization and regulation of prostaglandin and leukotriene receptors: An overview

1986 • 103 citations

An activator of protein kinase C (phorbol‐12‐myristate‐13‐acetate) augments 2‐chloroadenosine‐elicited accumulation of cyclic AMP in guinea pig cerebral cortical particulate preparations

1985 • 102 citations

Liver plasma membranes from essential fatty acid-deficient rats

1976 • 102 citations

Adenylate cyclase-coupled beta adrenergic receptors effect of membrane lipid-perturbing agents on receptor binding and enzyme stimulation by catecholamines.

1976 • 101 citations

Cellular Regulation of Secretion and Release

1982 • 98 citations

Localization of particulate guanylate cyclase in plasma membranes and microsomes of rat liver.

1975 • 98 citations

An Examination of the Involvement of Phospholipases A₂ and C in the α‐Adrenergic and γ‐Aminobutyric Acid Receptor Modulation of Cyclic AMP Accumulation in Rat Brain Slices

1986 • 97 citations

Interaction of Brain Synaptic Vesicles Induced by Endogenous Ca ²⁺ -Dependent Phospholipase A ₂

1982 • 92 citations

The Calcium‐Dependent Phosphatidylinositol‐Phosphodiesterase of Rat Brain

1979 • 92 citations

Die hämolytischen Eigenschaften der membranmodifizierenden Peptidantibiotika Alamethicin, Suzukacillin und Trichotoxin

1977 • 91 citations

PLASMA MEMBRANE Ca²⁺‐PUMPING ATPases*

1982 • 91 citations

Leukotriene D4 treatment of bovine aortic endothelial cells and murine smooth muscle cells in culture results in an increase in phospholipase A2 activity.

1986 • 90 citations

Interaction of antibiotics with membranes: Polymyxin B and gramicidin S

1972 • 90 citations

Neurotensin Stimulates Inositol Phospholipid Metabolism and Calcium Mobilization in Murine Neuroblastoma Clone N1E‐115

1986 • 89 citations

Elevated membrane cholesterol concentrations inhibit glucagon-stimulated adenylate cyclase

1983 • 88 citations

Effect of cyclic AMP-dependent hormones and Ca2+-mobilizing hormones on the Ca2+ influx and polyphosphoinositide metabolism in isolated rat hepatocytes

1986 • 87 citations

Accumulation of inositol phosphates and cyclic AMP in guinea-pig cerebral cortical preparations

1985 • 83 citations

Effect of liposomes containing cholesterol on adenylate cyclase activity of cultured mammalian fibroblasts

1978 • 83 citations

Evidence for a catalytic role of phospholipase A in phorbol diester- and zymosan-induced mobilization of arachidonic acid in mouse peritoneal macrophages

1986 • 82 citations

Mechanisms of adenosine triphosphate-, thrombin-, and trypsin-induced relaxation of rat thoracic aorta.

1984 • 82 citations

Polyphosphoinositide metabolism in adrenal glomerulosa cells

1985 • 82 citations

Nuclear magnetic resonance studies of the polypeptide alamethicin and its interaction with phospholipids

1970 • 80 citations

Extrusion of cyclic AMP from pigeon erythrocytes.

1979 • 79 citations

The Activity of Adenylate Cyclase Is Regulated by the Nature of Its Lipid Environment

1983 • 78 citations

Pertussis toxin differentiates between two mechanisms of attenuation of cyclic AMP accumulation by muscarinic cholinergic receptors.

1984 • 78 citations

Guanine nucleotide-sensitive, high affinity binding of carbachol to muscarinic cholinergic receptors of 1321N1 astrocytoma cells is insensitive to pertussis toxin.

1985 • 78 citations

The enzymology of stimulated inositol lipid turnover

1982 • 77 citations

Activation of soluble guanylate cyclase by arachidonic acid and 15-lipoxygenase products

1986 • 77 citations

Activation of adenylate cyclase of rat brain by lipid peroxidation.

1981 • 75 citations

Adenylate Cyclase Activity in Fibroblasts Transformed by Kirsten or Moloney Sarcoma Viruses

1974 • 75 citations

Inositol 1,4,5-trisphosphate induces cyclic GMP formation in Dictyosteliumdiscoideum

1985 • 74 citations

Selective release of plasma-membrane enzymes from rat hepatocytes by a phosphatidylinositol-specific phospholipase C

1980 • 73 citations

Evidence for multiple metabolic pools of phosphatidylinositol in stimulated platelets.

1982 • 73 citations

Identification and characterization of both the cytosolic and particulate forms of cyclic GMP-stimulated cyclic AMP phosphodiesterase from rat liver

1986 • 73 citations

Inhibition of Prostaglandin E Synthesis Augments Glucose-induced Insulin Secretion in Cultured Pancreas

1981 • 72 citations

Inhibition of platelet and neutrophil phospholipase A2 by hydroxyeicosatetraenoic acids (HETEs) A novel pharmacological mechanism for regulating free fatty acid release

1985 • 72 citations

Receptor-Mediated Adenylate Cyclase—Coupled Mechanism for PGE2 Inhibition of Insulin Secretion in HIT Cells

1987 • 72 citations

Interrelationships between Ca2+ and adenylate and guanylate cyclases in the control of platelet secretion and aggregation.

1976 • 71 citations

Activation of sperm respiration by a low molecular weight egg factor and by 8-bromoguanosine 3‘,5‘-monophosphate.

1979 • 71 citations

Receptor regulation: evidence for a relationship between phospholipid metabolism and neurotransmitter receptor-mediated cAMP formation in brain

1987 • 70 citations

The role of calcium ions in accumulation of cyclic adenosine monophosphate elicited by alpha and beta adrenergic agonists in rat brain slices.

1977 • 69 citations

Characterization of the forward and reverse reactions catalyzed by CDP-diacylglycerol: Inositol transferase in rabbit lung tissue

1979 • 69 citations

Phosphatidic acid releases calcium from a platelet membrane fraction in vitro

1978 • 67 citations

Phenobarbital selectively modulates the glucagon-stimulated activity of adenylate cyclase by depressing the lipid phase separation occurring in the outer half of the bilayer of liver plasma membranes

1981 • 67 citations

Effects of cations on guanylate cyclase of sea urchin sperm

1975 • 65 citations

Endogenous activating factor for guanylate cyclase in synaptosomal-soluble fraction of rat brain.

1977 • 63 citations

Angiotensin II and guanine nucleotides stimulate formation of inositol 1,4,5-trisphosphate and its metabolites in permeabilized adrenal glomerulosa cells.

1988 • 62 citations

Phytohemagglutinin stimulation of guanylate cyclase in human lymphocytes.

1981 • 61 citations

Phosphatidylcholine-promoted interaction of the catalytic and regulatory proteins of adenylate cyclase.

1982 • 60 citations

The role of phosphatidylserine in the hormonal control of adenylate cyclase of rat liver plasma membranes

1972 • 60 citations

Quasi‐Lipoxygenase Activity of Haemoglobin

1981 • 58 citations

See‐Saw Signal Processing in Pinealocytes Involves Reciprocal Changes in the α₁‐Adrenergic Component of the Cyclic GMP Response and the β‐Adrenergic Component of the Cyclic AMP Response

1986 • 58 citations

Adenylate cyclase is inhibited upon depletion of plasma-membrane cholesterol

1983 • 58 citations

Thyrotropin and Cyclic Nucleotide Effects on Prostaglandin Levels in Isolated Thyroid Cells

1973 • 57 citations

Effects of phospholipase A2 and filipin on the activation of adenylate cyclase

1979 • 56 citations

The role of calcium in the control of adrenal adenylate cyclase. Enhancement of enzyme activation by guanyl-5'-yl imidodiphosphate.

1980 • 55 citations

Prostaglandin synthesis in rabbit graafian follicles in vitro. Effect of luteinizing hormone and cyclic AMP

1974 • 55 citations

Fatty Acid Incorporation into Phospholipids of Isolated Pancreatic Islets of the Rat: Relationship to Insulin Release

1983 • 55 citations

Inhibitory action of guanosine 3′,5′-monophosphate on thrombin-induced calcium mobilization in human platelets

1984 • 54 citations

Modulation of adenylate cyclase activity of fibroblasts by free fatty acids and phospholipids

1977 • 53 citations

Potassium depolarisation markedly enhances muscarinic receptor stimulated inositol tetrakisphosphate accumulation in rat cerebral cortical slices

1986 • 53 citations

Specific phospholipids are required to reconstitute adenylate cyclase solubilized from rat brain.

1981 • 52 citations

Guanosine cyclic 3',5'-monophosphate and guanylate cyclase activity in guinea pig lung: effects of acetylcholine and cholinesterase inhibitors.

1974 • 51 citations

Calcium-induced release from platelet membranes of fatty acids that modulate soluble guanylate cyclase.

1983 • 51 citations

Solubilized myocardial adenylate cyclase

1972 • 51 citations

Parathyroid Hormone and Adenosine-3′,5′-Monophosphate Acutely Increase Phospholipids of the Phosphatidate-Polyphosphoinositide Pathway in Rabbit Kidney Cortex Tubulesin Vitroby a Cycloheximide-Sensitive Process*

1981 • 51 citations

Possible role of a cAMP-dependent phosphorylation in the calcium release mediated by inositol 1,4,5-trisphosphate in human platelet membrane vesicles

1987 • 50 citations

Membrane Phospholipid Turnover, Receptor Function and Protein Phosphorylation

1982 • 49 citations

Further evidence that muscarinic cholinergic receptors of 1321N1 astrocytoma cells couple to a guanine nucleotide regulatory protein that is not Ni

1985 • 48 citations

A mechanism in the control of intracellular cAMP level: the activation of a calmodulin-sensitive phosphodiesterase by a rise of intracellular free calcium

1985 • 48 citations

Oxygen and cyclic nucleotides in human umbilical artery.

1975 • 48 citations

Diacylglycerol induces deacylation of phosphatidylinositol and mobilization of arachidonic acid in mouse macrophages Comparison with induction by phorbol diester

1986 • 47 citations

Guanylate Cyclase: Regulation of Cyclic GMP Metabolism

1982 • 46 citations

Glucagon-stimulated adenylate cyclase detects a selective perturbation of the inner half of the liver plasma-membrane bilayer achieved by the local anaesthetic prilocaine

1980 • 46 citations

Effect of prostaglandins E1, E2 and F2α on neutrophil aggregation

1979 • 45 citations

The inhibition of diacylglycerol-stimulated intracellular phospholipases by phospholipids with a phosphocholine-containing polar group. A possible physiological role for sphingomyelin

1985 • 45 citations

Lateral mobility of phospholipids in turkey erythrocytes. Implications for adenylate cyclase activation.

1982 • 43 citations

Regulation of Ca2+-dependent cyclic AMP accumulation and Ca2+ metabolism in intact pituitary tumor cells by modulators of prolactin production.

1983 • 43 citations

Existence of two pools of prostaglandins during stimulation of the thyroid by TSH

1974 • 42 citations

Regulation of cyclic nucleotide phosphodiesterases in cultured hepatoma cells by dexamethasone and N6,O2'-dibutyryl adenosine 3':k'-monophosphate.

1977 • 42 citations

Role of Phospholipids in Coupling of Adenosine and Dopamine Receptors to Striatal Adenylate Cyclase

1981 • 42 citations

Nuclear magnetic resonance studies of interactions of phospholipids with cyclic antibiotics

1969 • 41 citations

Catecholamine stimulated myocardial adenylate cyclase: Effects of phospholipase digestion and the role of membrane lipids

1975 • 41 citations

Agents that elevate platelet cAMP stimulate the formation of phosphatidylinositol 4‐phosphate in intact human platelets

1986 • 41 citations

Cyclic AMP Concentrations in Rat Neocortex and Hippocampus During and Following Incomplete Ischemia: Effects of Central Noradrenergic Neurons, Prostaglandins, and Adenosine

1985 • 41 citations

Further Studies on the Mechanisms Controlling Prostaglandin Biosynthesis in the Cat Adrenal Cortex: The Role of Calcium and Cyclic AMP

1977 • 41 citations

Phospholipase a and lysophospholipase activities in isolated fat cells: Effect of cyclic 3'.5'-AMP

1972 • 40 citations

Effect of lysolecithin on guanylate and adenylate cyclase activities in neuroblastoma cells in culture

1976 • 40 citations

Modulation by Unsaturated Fatty Acids of Norepinephrine‐ and Adenosine‐Induced Formation of Cyclic AMP in Brain Slices

1984 • 39 citations

Phorbol Esters Increase GTP‐Dependent Adenylate Cyclase Activity in Rat Brain Striatal Membranes

1986 • 39 citations

Prostaglandin modification of membrane-bound enzyme activity: A possible mechanism of action?

1973 • 39 citations

Thymocyte cyclic AMP and cyclic GMP response to treatment with metabolites issued from the lipoxygenase pathway.

1985 • 38 citations

Inhibition of hormone-stimulated adenylate cyclase activity after altering turkey erythrocyte phospholipid composition with a nonspecific lipid transfer protein. Phosphatidylinositol uncouples catecholamine binding from adenylate cyclase activation.

1983 • 38 citations

Effect of lipid environment on the motion of a spin-label covalently bound to myelin basic protein

1980 • 38 citations

Variable interaction of spin-labeled human myelin basic protein with different acidic lipids

1980 • 38 citations

Prostaglandins, leukotrienes, and lipoxins : biochemistry, mechanism of action, and clinical applications

1985 • 38 citations

Physical Studies of Phospholipid/Alamethicin Interactions

1969 • 37 citations

Incorporation of synthetic 1,2‐diacylglycerol into platelet phosphatidylinositol is increased by cyclic AMP

1986 • 37 citations

Prostaglandin F_2αInhibits 3',5'-Adenosine Monophosphate Accumulation and Parathyroid Hormone Release from Dispersed Bovine Parathyroid Cells*

1979 • 37 citations

Altered physiological responsiveness and decreased cyclic AMP levels in rat atria after dietary cod liver oil supplementation and its possible association with an increased membrane phospholipid n−3n−6 fatty acid ratio

1986 • 35 citations

Pancreatic islet arachidonic acid turnover and metabolism and insulin release in response to delta-9-tetrahydrocannabinol

1986 • 35 citations

Prostaglandin F_2αandα-Adrenergic Agonists Regulate Parathyroid Cell Function via the Inhibitory Guanine Nucleotide Regulatory Protein

1986 • 34 citations

Regulation of synthesis of guanosine 3′:5′-cyclic monophosphate in neuroblastoma cells

1978 • 34 citations

Prostaglandins and cyclic AMP stimulate creatine kinase synthesis but not fusion in cultured embryonic chick muscle cells

1984 • 34 citations

Lysophosphatidylcholines can modulate the activity of the glucagon-stimulated adenylate cyclase from rat liver plasma membranes

1979 • 34 citations

Interactions Between the Hormone-Sensitive Adenylate Cyclase System and the Phosphoinositide-Metabolizing Pathway in Human Platelets

1986 • 33 citations

Diets Varying in Linoleic and Linolenic Acid Content Alter Liver Plasma Membrane Lipid Composition and Glucagon-Stimulated Adenylate Cyclase Activity

1986 • 33 citations

Prostaglandin F_2α and E₁ regulation of proliferation in primary cultures of rabbit endometrial cells

1986 • 33 citations

Biosynthesis of cyclic AMP antagonist in hepatocytes from rats after adrenalin‐ or insulin‐stimulation

1981 • 32 citations

Effects of Hydroxyeicosatetraenoic Acids on Fatty Acid Esterification in Phospholipids and Insulin Secretion in Pancreatic Islets*

1985 • 31 citations

Effects on adenylate cyclase activities of unsaturated fatty acid incorporation into rat liver plasma membrane phospholipids specific modulation by linoleate

1980 • 30 citations

Effect of Calcium on Adenylate Cyclase of Rat Anterior Pituitary Gland

1987 • 29 citations

Receptor-mediated regulation of calcium mobilization and cyclic GMP synthesis in neuroblastoma cells

1984 • 29 citations

Proposed mechanisms of stimulation and inhibition of guanylate cyclase with reference to the actions of chlorpromazine, phospholipases and triton X-100

1975 • 29 citations

Phosphorylation of hormone‐sensitive lipase by cyclic GMP‐dependent protein kinase

1985 • 28 citations

The protein kinase C activator, 12-O-tetradecanoylphorbol-13-acetate (TPA), inhibits muscarinic (M1) receptor-mediated inositol phosphate release and cyclic GMP formation in murine neuroblastoma cells (clone N1E-115)

1986 • 27 citations

The relationship between pertussis-toxin-induced ADP-ribosylation of a plasma-membrane protein and reversal of muscarinic inhibition of prolactin secretion in GH3 cells

1984 • 26 citations

Lysophosphatidic acids. II. Interaction of the effects of adenosine diphosphate and lysophosphatidic acids in dog, rabbit, and human platelets.

1979 • 26 citations

Stimulation of phosphoinositide hydrolysis and inhibition of cyclic AMP formation by muscarinic agonists in developing chick heart

1985 • 26 citations

The relationship between the carbachol stimulatory effect on cyclic GMP content and activation by fatty acid hydroperoxides of a soluble guanylate cyclase in the guinea pig myometrium.

1982 • 26 citations

Studies of the Regulation of Basal Adenylate Cyclase Activity by Membrane Polyunsaturated Fatty Acids in Cultured Neuroblastoma

1986 • 26 citations

Calcium, Calmodulin, and Cycle Adenosine Monophosphate Modulate Prostaglandin E₂Release from Isolated Human Gastric Mucosal Cells*

1986 • 25 citations

Cyclic AMP‐dependent protein kinase and Ca²⁺‐calmodulin stimulate the formation of polyphosphoinositjdes in a sarcoplasmic reticulum preparation of rabbit heart

1984 • 22 citations

Membrane fatty acids, lipid peroxidation and adenylate cyclase activity in cultured neural cells

1985 • 22 citations

Receptor reserve in the calcium-dependent cyclic AMP response of astrocytoma cells to muscarinic receptor stimulation: demonstration by agonist-induced desensitization, receptor inactivation, and phorbol ester treatment.

1986 • 22 citations

Evolution of hormone‐receptor systems

1984 • 21 citations

Calmodulin activation and calcium regulation of parotid gland adenylate cyclase

1986 • 21 citations

Transport and metabolism of N6- and C8-substituted analogs of adenosine 3′,5′-cyclic monophosphate and adenosine 3′5′-cyclic phosphorothioate by the isolated perfused rat kidney

1983 • 21 citations

Effect of alamethicin, gramicidin S and melittin uppn the particulate guanylate cyclase from rat lung

1979 • 21 citations

Effect of Dexamethasone on Adenosine 3′,5′-Monophosphate Content and Phosphodiesterase Activities in 3T3-L1 Adipocytes*

1984 • 21 citations

Solubilization of rat heart sarcolemma 5′-nucleotidase by phosphatidylinositol-specific phospholipase C

1981 • 20 citations

Arachidonic acid activation of guinea pig lung guanylate cyclase by two independent mechanisms

1979 • 20 citations

Export of cyclic AMP from avian red cells. Independence from major membrane transporters and specific inhibition by prostaglandin A.

1985 • 20 citations

Guanylate cyclase from bovine adrenal medulla: Subcellular distribution and studies on the effect of lysolecithin on enzyme activity

1978 • 19 citations

Further observations on the increases in inositide phospholipids after stimulation by ACTH, cAMP and insulin, and on discrepancies in phosphatidylinositol mass and 32PO4-labeling during inhibition of hormonal effects by cycloheximide

1983 • 19 citations

Bee Venom Enhances Guanylate Cyclase Activity

1981 • 18 citations

Phosphoinositide phosphorylation and hydrolysis in pancreatic islet cell membrane

1986 • 18 citations

Cyclic AMP‐dependent protein kinase stimulates the formation of polyphosphoinositides in lymphocyte plasma membrane

1983 • 18 citations

O2-sensitivity of beta adrenergic responsiveness in isolated bovine and porcine coronary arteries.

1984 • 18 citations

Effect of membrane phospholipid composition changes on adenylate cyclase activity in normal and rous-sarcoma-transformed chicken embryo fibroblasts

1980 • 18 citations

Prostaglandin production in cultured gastric mucosal cells: Role of cAMP on its modulation

1986 • 17 citations

The Effect of Adrenocorticotropin and Nucleotides on Ca²⁺Uptake in Adrenal Cortical Microsomal Vesicles*

1978 • 17 citations

New developments concerning leukotriene antagonists: a review

1986 • 17 citations

Calcium-dependent modulation of guanosine 3′,5′-monophosphate in renal cortex

1980 • 17 citations

Role of lipoxygenase in the O2-dependent activation of soluble guanylate cyclase from rat lung

1982 • 17 citations

Stimulation of arachidonic acid release and prostaglandin production in 3T3 fibroblasts by adenosine 3':5'-monophosphate.

1978 • 17 citations

Binding and second messengers of prostaglandins F_2α and E₁ in primary cultures of rabbit endometrial cells

1986 • 16 citations

Phospholipase A2 modulation of cyclic GMP metabolism: Characteristics of guanylate cyclase activation

1985 • 16 citations

Blockade of N1E-115 murine neuroblastoma muscarinic receptor function by agents that affect the metabolism of arachidonic acid

1986 • 16 citations

Mechanism of action of prostaglandin F2α-induced luteolysis: evidence for a rapid effect on the guanine nucleotide binding regulatory component of adenylate cyclase in rat luteal tissue

1986 • 16 citations

Cyclic AMP-dependent protein kinase stimulates the phosphorylation of phosphatidylinositol to phosphatidylinositol-4-monophosphate in a plasma membrane preparation from pig granulocytes

1984 • 15 citations

Arachidonate metabolism in the mouse thyroid implication of the lipoxygenase pathway in thyrotropin action

1981 • 15 citations

Effects of Carbachol and Calcium on the Cyclic Guanosine‐3‘,5’‐Monophosphate (Cyclic GMP) Metabolism in Intestinal Smooth Muscle

1977 • 14 citations

Control of adenylate kinase by prostaglandins E2 and E3

1971 • 14 citations

Activation of the calcium/calmodulin-dependent guanylate cyclase from Paramecium by polypeptide antibiotics and melittin

1984 • 14 citations

Soluble bovine adrenal cortex guanylate cyclase: Effect of sodium nitroprusside, nitrosamines, and hydrophobic ligands on activity, substrate specificity and cation requirement

1978 • 14 citations

Phospholipid modulation of low-Km cyclic AMP phosphodiesterase activity on rat adipocyte microsomes

1983 • 13 citations

Phospholipase C digestion of rat liver plasma membrane stimulates adenylate cyclase

1981 • 13 citations

Cyclic AMP phosphodiesterase activity in mouse pancreatic islets Effects of calmodulin and phospholipids

1986 • 12 citations

Potentiation of prostaglandin E1-stimulated cAMP formation by 12-O-tetradecanoylphorbol-13-acetate in balb/C mouse 3T3 cells

1986 • 12 citations

Stimulation by cyclic GMP of prostaglandin E production in isolated graafian follicles

1977 • 12 citations

Cyclic AMP incudes synthesis of prostaglandin E1 in platelets

1983 • 12 citations

Effects of fatty acids on activity of cGMP-stimulated cyclic nucleotide phosphodiesterase from calf liver

1984 • 11 citations

Phospholipids and regulation of protein kinase reaction

1981 • 11 citations

Acidic phospholipid species inhibit adenylate cyclase activity in rat liver plasma membranes

1986 • 11 citations

Effects of Phospholipase A and Triton X-100 on Guanylate Cyclase Activity in Mammary Gland Homogenates from Mice

1978 • 10 citations

Acidic phospholipids may inhibit rat brain hexokinase by interaction at the nucleotide binding site

1985 • 10 citations

An analysis of inhibitory effect of cyclic GMP on arachidonic acid- or collagen-induced aggregation in rabbit platelets

1985 • 10 citations

Independent mechanisms for bradykinin-mediated prostaglandin E2 and cyclic GMP syntheses in rabbit renal inner medulla slices.

1982 • 10 citations

Differential regulation of the cyclooxygenase pathway in starch elicited rat peritoneal macrophages by prostaglandin E2, U-44069, a stable endoperoxide analogue and dibutyryl-cyclic AMP

1985 • 9 citations

Lipoxygenase inhibitors and cyclic AMP-mediated insulin secretion caused by forskolin, theophylline and dibutyryl cyclic AMP.

1985 • 9 citations

Phosphatidylethanolamine N-methylation and insulin release in isolated pancreatic islets of the rat.

1985 • 9 citations

Effects of Phosphatidylinositol-Specific Phospholipase C from Staphylococcus aureus on Plasma-Membrane Enzymes

1977 • 8 citations

Regulatory mechanisms of fatty acid isomers on adenylate cyclase activity from Ceratitis capitata brain

1984 • 8 citations

Probenecid Inhibits the Secretion of Nephrogenous Adenosine 3′,5′-Monophosphate in Normal Man*

1983 • 7 citations

Phosphatidylinositol Kinase in Rat Pancreatic Islets: Subcellular Distribution and Sensitivity to Calcium

1986 • 7 citations

Effects of phospholipases C on the β-receptor-adenylate cyclase system of chick erythrocyte membranes

1986 • 7 citations

Increasing membrane polyunsaturated fatty-acid content augments cyclic AMP formation and prostaglandin production in NIE-115 neuroblastoma

1984 • 6 citations

Modulation by cyclic AMP of arachidonic acid-induced platelet desensitization

1986 • 6 citations

Independent Effects of Bradykinin on Adenosine 3′,5′-Monophosphate and Prostaglandin E₂Metabolism by Rabbit Renal Medulla*

1984 • 6 citations

The incorporation of a purified, membrane-bound form of guanylate cyclase into phospholipid vesicles and erythrocytes

1985 • 6 citations

Kinase A does not activate phosphatidylinositol phosphorylation in rat lymphocyte membranes

1986 • 6 citations

Relationship of Cyclic Nucleotides and Calcium in Platelet Function

1982 • 5 citations

Modulation of rat myometrial guanylate cyclase activities by sodium nitroprusside and unsaturated fatty acids

1979 • 4 citations

Effects of nitroprusside on the bradykinin responsiveness of human fibroblasts.

1986 • 3 citations

Isoproterenol and nucleotide induced stimulation of Ca2+ uptake by microsomal fractions from kidney and isolated glomeruli

1979 • 3 citations

Ca2+-Activated, Fatty Acid-Dependent Guanylate Cyclase in Synaptic Plasma Membranes and Its Requirement for Ca2+ and Mg-GTP in the Activation

1984 • 2 citations

Effect of phosphodiesterase inhibitors on bradykinin-mediated prostaglandin E2 and cyclic amp synthesis in renal papillary collecting tubule cells

1985 • 2 citations

Stimulation of Brain Synaptosome - Associated Adenylate Cyclase by Acidic Phospholipids

1984 • 2 citations