Receptor regulation: evidence for a relationship between phospholipid metabolism and neurotransmitter receptor-mediated cAMP formation in brain

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Inositol trisphosphate and diacylglycerol as second messengers

1984 • 3,535 citations

Protein kinase C phosphorylates the inhibitory guanine‐nucleotide‐binding regulatory component and apparently suppresses its function in hormonal inhibition of adenylate cyclase

1985 • 736 citations

A Potential Second Messenger Role for Unsaturated Fatty Acids: Activation of Ca ²⁺ -Dependent Protein Kinase

1984 • 618 citations

Inositol Phospholipid Hydrolysis in Rat Cerebral Cortical Slices: I. Receptor Characterisation

1984 • 517 citations

Activation of protein kinase C potentiates isoprenaline-induced cyclic AMP accumulation in rat pinealocytes

1985 • 415 citations

Molecular mechanisms of transmembrane signalling

1985 • 352 citations

Direct activation of purified protein kinase C by unsaturated fatty acids (oleate and arachidonate) in the absence of phospholipids and Ca²⁺

1985 • 293 citations

Atypical Synergisticα₁- andβ-Adrenergic Regulation of Adenosine 3′,5′-Monophosphate and Guanosine 3′,5′- Monophosphate in Rat Pinealocytes

1985 • 256 citations

gamma-aminobutyric acid B receptors are negatively coupled to adenylate cyclase in brain, and in the cerebellum these receptors may be associated with granule cells.

1984 • 202 citations

Guanosine 5'-O-thiotriphosphate stimulates phospholipase C activity in plasma membranes of rat hepatocytes.

1985 • 154 citations

VASOPRESSIN POTENTIATES CYCLIC AMP ACCUMULATION AND ACTH RELEASE INDUCED BY CORTICOTROPIN-RELEASING FACTOR (CRF) IN RAT ANTERIOR PITUITARY CELLS IN CULTURE

1982 • 128 citations

Fluoronorepinephrines: specific agonists for the activation of alpha and beta adrenergic-sensitive cyclic AMP-generating systems in brain slices.

1980 • 125 citations

Characterization of the relationship between gamma-aminobutyric acid B agonists and transmitter-coupled cyclic nucleotide-generating systems in rat brain.

1985 • 113 citations

An activator of protein kinase C (phorbol‐12‐myristate‐13‐acetate) augments 2‐chloroadenosine‐elicited accumulation of cyclic AMP in guinea pig cerebral cortical particulate preparations

1985 • 102 citations

An Examination of the Involvement of Phospholipases A₂ and C in the α‐Adrenergic and γ‐Aminobutyric Acid Receptor Modulation of Cyclic AMP Accumulation in Rat Brain Slices

1986 • 97 citations

Accumulation of inositol phosphates and cyclic AMP in guinea-pig cerebral cortical preparations

1985 • 83 citations

Postsynaptic localization of the alpha receptor-mediated stimulation of phosphatidylinositol turnover in pineal gland

1979 • 82 citations

Norepinephrine and histamine potentiate the increases in cyclic adenosine 3':5'-monophosphate elicited by vasoactive intestinal polypeptide in mouse cerebral cortical slices: mediation by alpha 1- adrenergic and H1-histaminergic receptors

1985 • 80 citations

Possible Involvement of Inhibitory GTP Binding Regulatory Protein in α₂‐Adrenoceptor‐Mediated Inhibition of Adenylate Cyclase Activity in Cerebral Cortical Membranes of Rats

1985 • 38 citations