Cytotoxicity, Apoptosis, and Nitric Oxide

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

The L-Arginine-Nitric Oxide Pathway

1993 • 6,737 citations

Apoptosis by Death Factor

1997 • 5,038 citations

Nitric oxide as a secretory product of mammalian cells

1992 • 4,437 citations

A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

1998 • 3,169 citations

Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

1997 • 3,130 citations

A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds

1993 • 2,423 citations

Nitric oxide: A cytotoxic activated macrophage effector molecule

1988 • 2,050 citations

The proto-oncogene Bcl-2 and its role in regulating apoptosis

1997 • 1,768 citations

Mitochondrial control of apoptosis

1997 • 1,500 citations

Life, death, and the pursuit of apoptosis.

1996 • 1,333 citations

Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide.

1985 • 1,146 citations

DNA damage and mutation in human cells exposed to nitric oxide in vitro.

1992 • 980 citations

Inducible nitric oxide synthase: what difference does it make?

1997 • 964 citations

Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling.

1998 • 799 citations

Nitric oxide-mediated apoptosis in murine peritoneal macrophages

1993 • 782 citations

Cytochrome c: Can't Live with It—Can't Live without It

1997 • 768 citations

Human CD14 mediates recognition and phagocytosis of apoptotic cells

1998 • 685 citations

Stretch-induced programmed myocyte cell death.

1995 • 647 citations

Evidence for apoptosis in advanced human atheroma. Colocalization with interleukin-1 beta-converting enzyme.

1995 • 643 citations

Nitrogen Oxide Levels in Patients After Trauma and During Sepsis

1991 • 609 citations

Superoxide and peroxynitrite inactivate aconitases, but nitric oxide does not.

1994 • 585 citations

Nitric Oxide Reversibly Inhibits Seven Members of the Caspase Family via S-Nitrosylation

1997 • 530 citations

Nitric Oxide Protects Cultured Rat Hepatocytes from Tumor Necrosis Factor-α-induced Apoptosis by Inducing Heat Shock Protein 70 Expression

1997 • 527 citations

Nitric oxide produced by human B lymphocytes inhibits apoptosis and Epstein-Barr virus reactivation

1994 • 509 citations

Activated murine macrophages secrete a metabolite of arginine with the bioactivity of endothelium-derived relaxing factor and the chemical reactivity of nitric oxide.

1989 • 464 citations

Tissue injury caused by deposition of immune complexes is L-arginine dependent.

1991 • 436 citations

Apoptosis and Related Proteins in Different Stages of Human Atherosclerotic Plaques

1998 • 432 citations

Nitric Oxide Inhibits Caspase-3 by S-Nitrosationin Vivo

1999 • 427 citations

Apoptosis is abundant in human atherosclerotic lesions, especially in inflammatory cells (macrophages and T cells), and may contribute to the accumulation of gruel and plaque instability.

1996 • 420 citations

Inhibition of Neuronal Nitric Oxide Synthase by 7‐Nitroindazole Protects Against MPTP‐Induced Neurotoxicity in Mice

1995 • 416 citations

Effect of exogenous and endogenous nitric oxide on mitochondrial respiration of rat hepatocytes

1991 • 395 citations

Apoptosis: Cell death in tissue regulation

1987 • 393 citations

Increased endothelial cell turnover in areas of in vivo Evans Blue uptake in the pig aorta

1973 • 377 citations

Oxidized Low-Density Lipoprotein Induces Apoptosis of Human Endothelial Cells by Activation of CPP32-Like Proteases

1997 • 373 citations

Death by Design

1997 • 364 citations

Angiotensin II Induces Apoptosis of Human Endothelial Cells

1997 • 363 citations

Nitric Oxide Synthase Induces Macrophage Death by Apoptosis

1993 • 361 citations

Nitric oxide induces apoptosis in mouse thymocytes.

1995 • 356 citations

Apoptosis and necrosis. Basic types and mechanisms of cell death.

1993 • 353 citations

Vasoactive Substances Regulate Vascular Smooth Muscle Cell Apoptosis

1996 • 345 citations

Apoptotic Cell Death Triggered by Nitric Oxide in Pancreatic β-Cells

1995 • 343 citations

Nitric Oxide and Superoxide Contribute to Motor Neuron Apoptosis Induced by Trophic Factor Deprivation

1998 • 342 citations

Splenic B lymphocyte programmed cell death is prevented by nitric oxide release through mechanisms involving sustained Bcl-2 levels.

1995 • 340 citations

Interaction of genetic deficiency of endothelial nitric oxide, gender, and pregnancy in vascular response to injury in mice.

1998 • 339 citations

Differential Activation of Mitogen-activated Protein Kinases by Nitric Oxide-related Species

1996 • 332 citations

Shear stress inhibits apoptosis of human endothelial cells

1996 • 329 citations

NO-mediated activation of heme oxygenase: endogenous cytoprotection against oxidative stress to endothelium

1996 • 326 citations

Transfection with the inducible nitric oxide synthase gene suppresses tumorigenicity and abrogates metastasis by K-1735 murine melanoma cells.

1995 • 326 citations

Nitric oxide and peroxynitrite exert distinct effects on mitochondrial respiration which are differentially blocked by glutathione or glucose

1996 • 320 citations

Nitric Oxide Inhibits Fas-induced Apoptosis

1997 • 317 citations

Does Nitric Oxide Mediate Autoimmune Destruction of β-Cells?: Possible Therapeutic Interventions in IDDM

1992 • 299 citations

Peroxynitrite‐Induced Cytotoxicity in PC12 Cells: Evidence for an Apoptotic Mechanism Differentially Modulated by Neurotrophic Factors

1995 • 292 citations

Nitric oxide causes ADP-ribosylation and inhibition of glyceraldehyde-3-phosphate dehydrogenase.

1992 • 288 citations

Nitric oxide-induced apoptosis: p53-dependent and p53-independent signalling pathways

1996 • 284 citations

Interleukin 1 beta induces the formation of nitric oxide by beta-cells purified from rodent islets of Langerhans. Evidence for the beta-cell as a source and site of action of nitric oxide.

1992 • 283 citations

Targeting Nitric Oxide (NO) Deliveryin Vivo. Design of a Liver-Selective NO Donor Prodrug That Blocks Tumor Necrosis Factor-α-Induced Apoptosis and Toxicity in the Liver

1997 • 279 citations

Peroxynitrite Increases the Degradation of Aconitase and Other Cellular Proteins by Proteasome

1998 • 254 citations

Nitric Oxide Primes Pancreatic β Cells for Fas-mediated Destruction in Insulin-dependent Diabetes Mellitus

1997 • 242 citations

Nitric oxide induces apoptosis via triggering mitochondrial permeability transition

1997 • 238 citations

Nitric Oxide Sensitivity of the Aconitases

1997 • 234 citations

Bcl-2 Protects Macrophages from Nitric Oxide-induced Apoptosis

1996 • 224 citations

Nitrogen oxide‐induced autoprotection in isolated rat hepatocytes

1995 • 211 citations

The altered tumoricidal capacity of macrophages isolated from tumor-bearing mice is related to reduce expression of the inducible nitric oxide synthase gene.

1996 • 204 citations

Apoptosis of Cardiac Myocytes During Cardiac Allograft Rejection

1996 • 199 citations

Interleukin-1β-Induced Nitric Oxide Production Activates Apoptosis in Pancreatic RINm5F Cells

1994 • 194 citations

Shear Stress Inhibits H ₂ O ₂ -Induced Apoptosis of Human Endothelial Cells by Modulation of the Glutathione Redox Cycle and Nitric Oxide Synthase

1997 • 193 citations

Nitric Oxide Induces Upregulation of Fas and Apoptosis in Vascular Smooth Muscle

1996 • 186 citations

Disruption of Fas Receptor Signaling by Nitric Oxide in Eosinophils

1998 • 176 citations

Adenoviral transfer of the inducible nitric oxide synthase gene blocks endothelial cell apoptosis

1997 • 153 citations

Peroxynitrite and Nitric Oxide Donors Induce Neuronal Apoptosis by Eliciting Autocrine Excitotoxicity

1997 • 147 citations

The role of Fas/APO 1 and apoptosis in the development of human atherosclerotic lesions

1997 • 140 citations

APOPTOSIS AND INCREASED EXPRESSION OF INDUCIBLE NITRIC OXIDE SYNTHASE IN HUMAN ALLOGRAFT REJECTION1

1998 • 139 citations

Ferritin protects endothelial cells from oxidized low density lipoprotein in vitro.

1995 • 137 citations

Exacerbated Transplant Arteriosclerosis in Inducible Nitric Oxide–Deficient Mice

1998 • 135 citations

Cyclooxygenase‐2: an essential regulator of NO‐mediated apoptosis

1997 • 133 citations

DNA fragmentation in mouse organs during endotoxic shock.

1996 • 133 citations

Cytoskeletal Breakdown and Apoptosis Elicited by NO Donors in Cerebellar Granule Cells Require NMDA Receptor Activation

1996 • 130 citations

Interplay between NO and [Fe-S] Clusters: Relevance to Biological Systems

1997 • 128 citations

The nitric oxide donors, azide and hydroxylamine, inhibit the programmed cell death of cytokine‐deprived human eosinophils

1995 • 124 citations

Expression of cGMP-Dependent Protein Kinase I and Phosphorylation of Its Substrate, Vasodilator-Stimulated Phosphoprotein, in Human Endothelial Cells of Different Origin

1995 • 122 citations

Nitric oxide mediates cytotoxicity and basic fibroblast growth factor release in cultured vascular smooth muscle cells. A possible mechanism of neovascularization in atherosclerotic plaques.

1995 • 117 citations

Spontaneous cytotoxicity of macrophages against pancreatic islet cells.

1989 • 115 citations

Modulation of the Mitochondrial Permeability Transition by Nitric Oxide

1997 • 112 citations

Autocrine Nitric Oxide Modulates CD95-induced Apoptosis in γδ T Lymphocytes

1997 • 111 citations

Nitric oxide inhibition of cytochrome oxidase and mitochondrial respiration: Implications for inflammatory, neurodegenerative and ischaemic pathologies

1997 • 109 citations

The balance between nitric oxide and superoxide determines apoptotic and necrotic death of rat mesangial cells.

1997 • 105 citations

Nitric oxide induced poly(ADP‐ribose) polymerase cleavage in RAW 264.7 macrophage apoptosis is blocked by Bcl‐2

1996 • 103 citations

Transfection of Inducible Nitric Oxide Synthase Gene Causes Apoptosis in Vascular Smooth Muscle Cells

1998 • 103 citations

Effects of Redox-Related Congeners of NO on Apoptosis and Caspase-3 Activity

1997 • 101 citations

Nitric Oxide Donor SNAP Induces Apoptosis in Smooth Muscle Cells through cGMP-Independent Mechanism

1996 • 100 citations

Nitric oxide via an inducible isoform of nitric oxide synthase is a possible factor to eliminate inflammatory cells from the central nervous system of mice with experimental allergic encephalomyelitis

1997 • 99 citations

Nitric oxide donors induce apoptosis in glomerular mesangial cells, epithelial cells and endothelial cells

1996 • 96 citations

Nitric oxide inhibits APO-1/Fas-mediated cell death.

1998 • 90 citations

Striatal Malonate Lesions Are Attenuated in Neuronal Nitric Oxide Synthase Knockout Mice

1996 • 88 citations

Involvement of inducible nitric oxide synthase in the inflammatory process of myocardial infarction

1995 • 87 citations

Inhibition of endogenous nitric oxide synthase potentiates ischemia–reperfusion-induced myocardial apoptosis via a caspase-3 dependent pathway

2000 • 83 citations

Protein thiol modification and apoptotic cell death as cGMP-independent nitric oxide (NO) signaling pathways

1995 • 76 citations

Nitric Oxide and Apoptosis

1997 • 73 citations

Inducible Nitric Oxide Synthase Expression in Smooth Muscle Cells and Macrophages of Human Transplant Coronary Artery Disease

1998 • 70 citations

In Vivo Gene Transfection of Human Endothelial Cell Nitric Oxide Synthase in Cardiomyocytes Causes Apoptosis-Like Cell Death

1997 • 67 citations

Exogenous nitric oxide (NO) generation or IL-1 beta-induced intracellular NO production stimulates inhibitory auto-ADP-ribosylation of glyceraldehyde-3-phosphate dehydrogenase in RINm5F cells.

1993 • 66 citations

Neuronal Nitric Oxide Synthase Inhibition Reduces Neuronal Apoptosis After Hypothermic Circulatory Arrest

1997 • 62 citations

Neuroprotective and Neurodestructive Effects of Nitric Oxide and Redox Congeners

1994 • 61 citations

Induction of apoptosis in myocardial infarction and its possible relationship to nitric oxide synthase in macrophages

1996 • 51 citations

Nitrotyrosine formation, apoptosis, and oxidative damage: relationships to nitric oxide production in SJL mice bearing the RcsX tumor.

1997 • 49 citations

Nitrosative and oxidative stress induced heme oxygenase-1 accumulation in rat mesangial cells

1998 • 38 citations

Nitric oxide donor-induced apoptosis in smooth muscle cells is modulated by protein kinase C and protein kinase A

1997 • 32 citations

The Nitric Oxide Donor SIN-1 Protects Endothelial Cells from Tumor Necrosis Factor- -Mediated Cytotoxicity: Possible Role For Cyclic GMP and Heme Oxygenase

1997 • 32 citations

Potentiation of the Activity of Nitric Oxide by the Protein Kinase C Activator Phorbol Ester in Human Myeloid Leukemic HL-60 Cells: Association with Enhanced Fragmentation of Mature Genomic DNA

1997 • 31 citations

NO INDUCED APOPTOSIS ACCOMPANYING THE CHANGE OF ONCOPROTEIN EXPRESSION AND THE ACTIVATION OF CPP32 PROTEASE

1997 • 20 citations

High-output nitric oxide: Weapon against infection?

1996 • 16 citations