Protein thiol modification and apoptotic cell death as cGMP-independent nitric oxide (NO) signaling pathways

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

Oxidative stress: oxidants and antioxidants

1997 • 4,454 citations

Nitric oxide as a secretory product of mammalian cells

1992 • 4,437 citations

Nitric oxide synthases: Roles, tolls, and controls

1994 • 2,945 citations

Nitric oxide synthases in mammals

1994 • 2,762 citations

Biochemistry of Nitric Oxide and Its Redox-Activated Forms

1992 • 2,725 citations

Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain

1988 • 2,572 citations

Peroxynitrite oxidation of sulfhydryls.

1991 • 2,479 citations

A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds

1993 • 2,423 citations

Redox signaling: Nitrosylation and related target interactions of nitric oxide

1994 • 1,732 citations

Regulation of biosynthesis of nitric oxide.

1994 • 1,698 citations

Macrophage Cytotoxicity: Role for L-Arginine Deiminase and Imino Nitrogen Oxidation to Nitrite

1987 • 1,533 citations

Carbon Monoxide: a Putative Neural Messenger

1993 • 1,519 citations

NO at work

1994 • 1,493 citations

Nitric oxide activates guanylate cyclase and increases guanosine 3′:5′-cyclic monophosphate levels in various tissue preparations

1977 • 1,422 citations

Biosynthesis and Metabolism of Endothelium-Derived Nitric Oxide

1990 • 1,284 citations

DNA Deaminating Ability and Genotoxicity of Nitric Oxide and its Progenitors

1991 • 1,223 citations

Oxidative Stress: Oxidants and Antioxidants.

1992 • 1,193 citations

Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide.

1985 • 1,146 citations

Nitric Oxide Activation of Poly(ADP-Ribose) Synthetase in Neurotoxicity

1994 • 1,138 citations

Gases as biological messengers: nitric oxide and carbon monoxide in the brain

1994 • 1,052 citations

Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures

1993 • 1,024 citations

Apoptosis: The Biochemistry and Molecular Biology of Programmed Cell Death*

1993 • 1,005 citations

Nitric Oxide: First in a New Class of Neurotransmitters

1992 • 1,001 citations

Inflammation, immunoregulation, and inducible nitric oxide synthase

1993 • 877 citations

Cyclic GMP synthesis and function.

1987 • 871 citations

Nitric oxide synthase: Aspects concerning structure and catalysis

1994 • 865 citations

Nitric oxide-mediated apoptosis in murine peritoneal macrophages

1993 • 782 citations

Nitric oxide, a novel biologic messenger

1992 • 754 citations

Nitric oxide-mediated apoptosis in murine peritoneal macrophages.

1993 • 674 citations

Intracellular cyclic GMP receptor proteins

1993 • 655 citations

Induction and potential biological relevance of a Ca²⁺‐independent nitric oxide synthase in the myocardium

1992 • 623 citations

Nitric Oxide And Carbon Monoxide Produce Activity-Dependent Long-Term Synaptic Enhancement in Hippocampus

1993 • 562 citations

Nitrate Synthesis in the Germfree and Conventional Rat

1981 • 551 citations

The double-edged role of nitric oxide in brain function and superoxide-mediated injury.

1991 • 471 citations

Inhibition of platelet aggregation by carbon monoxide is mediated by activation of guanylate cyclase.

1987 • 466 citations

Internucleosomal DNA Cleavage Should not be the Sole Criterion for Identifying Apoptosis

1992 • 462 citations

Nitric oxide generation from nitroprusside by vascular tissue

1991 • 461 citations

Sodium nitroprusside and other smooth muscle-relaxants increase cyclic GMP levels in rat ductus deferens

1977 • 422 citations

p53 expression in nitric oxide‐induced apoptosis

1994 • 403 citations

Nitric oxide-induced S-nitrosylation of glyceraldehyde-3-phosphate dehydrogenase inhibits enzymatic activity and increases endogenous ADP-ribosylation.

1992 • 390 citations

The 46/50 kDa phosphoprotein VASP purified from human platelets is a novel protein associated with actin filaments and focal contacts.

1992 • 374 citations

ADP-ribosylation of proteins. Enzymology and biological significance.

1987 • 374 citations

EPR characterization of molecular targets for NO in mammalian cells and organelles

1993 • 373 citations

Nitric Oxide Synthase Induces Macrophage Death by Apoptosis

1993 • 361 citations

Activation of a Cytosolic ADP-ribosyltransferase by Nitric Oxide-generating Agents

1989 • 349 citations

Nitrite and Nitrate Are Formed by Endogenous Synthesis in the Human Intestine

1978 • 292 citations

Nitric oxide causes ADP-ribosylation and inhibition of glyceraldehyde-3-phosphate dehydrogenase.

1992 • 288 citations

Nitric oxide stimulates auto-ADP-ribosylation of glyceraldehyde-3-phosphate dehydrogenase.

1992 • 271 citations

Apoptosis: Molecular Control Point in Toxicity

1994 • 263 citations

Nitrite Inhibition of Clostridium botulinum : Electron Spin Resonance Detection of Iron-Nitric Oxide Complexes

1983 • 261 citations

Protein‐sulfenic acid stabilization and function in enzyme catalysis and gene regulation

1993 • 250 citations

Understanding the controversy over the identity of EDRF

1994 • 248 citations

Physiological role of cGMP and cGMP-dependent protein kinase in the cardiovascular system

2005 • 226 citations

Stimulation by nitric oxide of an NAD linkage to glyceraldehyde-3-phosphate dehydrogenase.

1993 • 225 citations

Apoptosis: the biochemistry and molecular biology of programmed cell death

1993 • 222 citations

Mechanism of covalent modification of glyceraldehyde‐3‐phosphate dehydrogenase at its active site thiol by nitric oxide, peroxynitrite and related nitrosating agents

1994 • 212 citations

Nitric oxide: foe or friend to the injured brain?

1993 • 212 citations

Interleukin-1β-Induced Nitric Oxide Production Activates Apoptosis in Pancreatic RINm5F Cells

1994 • 194 citations

NO^•, CO and ^•OH Endogenous soluble guanylyl cyclase‐activating factors

1992 • 192 citations

Nitric Oxide Toxicity in Islet Cells Involves Poly(ADP-Ribose) Polymerase Activation and Concomitant NAD+ Depletion

1994 • 188 citations

Glyceraldehyde-3-phosphate dehydrogenase on the surface of group A streptococci is also an ADP-ribosylating enzyme.

1993 • 185 citations

Activation of soluble guanylate cyclase by carbon monoxide and inhibition by superoxide anion

1990 • 183 citations

Islet Cell DNA Is a Target of Inflammatory Attack by Nitric Oxide

1993 • 180 citations

Epithelial autotoxicity of nitric oxide: role in the respiratory cytopathology of pertussis.

1994 • 171 citations

Ca2+ release from mitochondria induced by prooxidants

1988 • 166 citations

S‐Thiolation of human endothelial cell glyceraldehyde‐3‐phosphate dehydrogenase after hydrogen peroxide treatment

1994 • 164 citations

S-thiolation of glyceraldehyde-3-phosphate dehydrogenase induced by the phagocytosis-associated respiratory burst in blood monocytes.

1994 • 158 citations

Regulation of endothelial cell glyceraldehyde-3-phosphate dehydrogenase expression by hypoxia.

1994 • 151 citations

THE ORIGIN OF THE NITRATES IN THE URINE

1916 • 147 citations

Endogenous nitric oxide induced by interleukin‐1β in rat islets of Langerhans and HIT‐T15 cells causes significant DNA damage as measured by the ‘comet’ assay

1993 • 137 citations

Biotransformation of organic nitrates and vascular smooth muscle cell function

1994 • 132 citations

Nitric oxide: A signal for ADP-ribosylation of proteins

1994 • 132 citations

Cyclic nucleotide-gated channels: an expanding new family of ion channels.

1994 • 108 citations

ADP-ribose transfer reactions : mechanisms and biological significance

1989 • 103 citations

Pancreatic islet cells are highly susceptible towards the cytotoxic effects of chemically generated nitric oxide

1993 • 103 citations

Nitroprusside stimulates the cysteine‐specific mono(ADP‐ribosylation) of glyceraldehyde‐3‐phosphate dehydrogenase from human erythrocytes

1992 • 94 citations

Cyclic GMP in cell function.

1988 • 89 citations

Nonenzymic ADP-ribosylation of specific mitochondrial polypeptides.

1984 • 83 citations

Repair of Pancreatic β-cells: A Relevant Phenomenon in Early IDDM?

1993 • 78 citations

Stimulation of endogenous ADP-ribosylation by brefeldin A.

1994 • 75 citations

Nitric Oxide-Mediated Apoptosis in Murine Mastocytoma

1994 • 72 citations

Properties of a novel nitric oxide-stimulated ADP-ribosyltransferase

1990 • 71 citations

Nitric Oxide Stimulates the ADP-Ribosylation of Actin in Human Neutrophils

1993 • 68 citations

Nitric oxide signalling in the nervous system

1993 • 67 citations

Exogenous nitric oxide (NO) generation or IL-1 beta-induced intracellular NO production stimulates inhibitory auto-ADP-ribosylation of glyceraldehyde-3-phosphate dehydrogenase in RINm5F cells.

1993 • 66 citations

Cyclic ADP-ribose: A new member of a super family of signalling cyclic nucleotides

1994 • 65 citations

Characterization of a nitric‐oxide‐catalysed ADP‐ribosylation of glyceraldehyde‐3‐phosphate dehydrogenase

1992 • 58 citations

Ca2+-activated mechanisms in toxicity and programmed cell death

1988 • 46 citations

Modulation of endogenous ADP-ribosylation in rat brain

1992 • 45 citations

Glyceraldehyde-3-phosphate dehydrogenase is required for the transport of nitric oxide in platelets.

1993 • 40 citations

Cysteine‐specific ADP‐ribosylation of actin

1994 • 40 citations

Nitric oxide preferentially stimulates auto‐ADP‐ribosylation of glyceraldehyde‐3‐phosphate dehydrogenase compared to alcohol or lactate dehydrogenase

1993 • 36 citations

L-Arginine stimulates an endogenous ADP-ribosyltransferase

1991 • 35 citations

Free ADP-ribose in human erythrocytes: pathways of intra-erythrocytic conversion and non-enzymic binding to membrane proteins

1993 • 32 citations

Alterations in Nitric Oxide‐Stimulated Endogenous ADP‐Ribosylation Associated with Long‐Term Potentiation in Rat Hippocampus

1993 • 27 citations

Nitric Oxide Regulation of glyceraldehyde‐3‐phosphate Dehydrogenase Activity in Dictyostelium discoideum Cells and Lysates

1994 • 26 citations

Modualation of inducible nitric oxide synthase in RINm5F cells

1994 • 23 citations

Nitric oxide stimulates the ADP-ribosylation of a 41-kDa cytosolic protein in Dictyostelium discoideum.

1992 • 22 citations

NADPH: A stimulatory cofactor for nitric oxide-induced ADP-ribosylation reaction

1992 • 15 citations

Modulation of glyceraldehyde-3-phosphate dehydrogenase in Salmonella abortus equi lipopolysaccharide-treated mice

1994 • 10 citations

Inverse relationship of the dehydrogenase and ADP-ribosylation activities in sodium-nitroprusside-treated glyceraldehyde-3-phosphate dehydrogenase is coincidental

1993 • 7 citations

Changes in the ADP-ribosylation status of some hippocampal proteins are linked to kindling progression

1994 • 7 citations

Endogenous ADP-ribosylation of glyceraldehyde-3-phosphate dehydrogenase that is not regulated by nitric oxide in Dictyostelium discoideum

1993 • 5 citations

Sodium Nitroprusside Promotes NAD+ Labeling of a 116-kDa Protein in NG108-15 Cell Homogenates

1993 • 5 citations