Interplay between NO and [Fe-S] Clusters: Relevance to Biological Systems

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

1987 • 5,027 citations

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

Nitric oxide synthases: Roles, tolls, and controls

1994 • 2,945 citations

Biochemistry of Nitric Oxide and Its Redox-Activated Forms

1992 • 2,725 citations

Nitric oxide: A cytotoxic activated macrophage effector molecule

1988 • 2,050 citations

Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells.

1989 • 1,747 citations

Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate

1988 • 1,622 citations

THE MITOCHONDRIAL ELECTRON TRANSPORT AND OXIDATIVE PHOSPHORYLATION SYSTEM

1985 • 1,599 citations

Macrophage Cytotoxicity: Role for L-Arginine Deiminase and Imino Nitrogen Oxidation to Nitrite

1987 • 1,533 citations

Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide

1992 • 1,319 citations

Regulating the fate of mRNA: The control of cellular iron metabolism

1993 • 1,233 citations

Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide.

1985 • 1,146 citations

Peroxynitrite formation from macrophage-derived nitric oxide

1992 • 1,118 citations

L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells.

1987 • 958 citations

Correlation between nitric oxide formation during degradation of organic nitrates and activation of guanylate cyclase

1987 • 896 citations

Induction of nitrite/nitrate synthesis in murine macrophages by BCG infection, lymphokines, or interferon-gamma.

1987 • 722 citations

Evolution of the first metabolic cycles.

1990 • 705 citations

Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide

1992 • 702 citations

Inhibition of Mitochondrial Electron Transport by Peroxynitrite

1994 • 697 citations

Cytoplasmic protein binds in vitro to a highly conserved sequence in the 5' untranslated region of ferritin heavy- and light-subunit mRNAs.

1988 • 684 citations

Aconitase is readily inactivated by peroxynitrite, but not by its precursor, nitric oxide.

1994 • 596 citations

Differentiation of murine macrophages to express nonspecific cytotoxicity for tumor cells results in L-arginine-dependent inhibition of mitochondrial iron-sulfur enzymes in the macrophage effector cells.

1988 • 592 citations

Superoxide and peroxynitrite inactivate aconitases, but nitric oxide does not.

1994 • 585 citations

EPR demonstration of iron-nitrosyl complex formation by cytotoxic activated macrophages.

1990 • 512 citations

A specific mRNA binding factor regulates the iron-dependent stability of cytoplasmic transferrin receptor mRNA

1989 • 511 citations

Reactions of the bioregulatory agent nitric oxide in oxygenated aqueous media: Determination of the kinetics for oxidation and nitrosation by intermediates generated in the nitric oxide/oxygen reaction

1993 • 474 citations

Murine cytotoxic activated macrophages inhibit aconitase in tumor cells. Inhibition involves the iron-sulfur prosthetic group and is reversible.

1986 • 421 citations

Iron regulates nitric oxide synthase activity by controlling nuclear transcription.

1994 • 413 citations

Autoxidation kinetics of aqueous nitric oxide

1993 • 412 citations

Biosynthesis of nitric oxide activates iron regulatory factor in macrophages.

1993 • 409 citations

Effect of exogenous and endogenous nitric oxide on mitochondrial respiration of rat hepatocytes

1991 • 395 citations

Translational regulation via iron-responsive elements by the nitric oxide/NO-synthase pathway.

1993 • 393 citations

EPR characterization of molecular targets for NO in mammalian cells and organelles

1993 • 373 citations

Inhibition of Cytochromes P450 by Nitric Oxide and a Nitric Oxide-Releasing Agent

1993 • 358 citations

[24] Nitric oxide assay using hemoglobin method

1994 • 350 citations

Sites of inhibition of mitochondrial electron transport in macrophage-injured neoplastic cells.

1982 • 349 citations

Purification and characterization of cytosolic aconitase from beef liver and its relationship to the iron-responsive element binding protein.

1992 • 345 citations

An iron-sulfur center essential for transcriptional activation by the redox-sensing SoxR protein.

1994 • 331 citations

Cellular regulation of the iron-responsive element binding protein: disassembly of the cubane iron-sulfur cluster results in high-affinity RNA binding.

1992 • 324 citations

Activation by nitric oxide of an oxidative-stress response that defends Escherichia coli against activated macrophages.

1993 • 310 citations

Nitric oxide mediates iron release from ferritin

1990 • 290 citations

Evidence that the pathway of transferrin receptor mRNA degradation involves an endonucleolytic cleavage within the 3′ UTR and does not involve poly(A) tail shortening.

1994 • 290 citations

Generation of EPR-detectable nitrosyl-iron complexes in tumor target cells cocultured with activated macrophages

1991 • 280 citations

Iron regulatory protein prevents binding of the 43S translation pre-initiation complex to ferritin and eALAS mRNAs.

1994 • 273 citations

Reciprocal control of RNA-binding and aconitase activity in the regulation of the iron-responsive element binding protein: role of the iron-sulfur cluster.

1992 • 272 citations

Aconitase, a two‐faced protein: enzyme and iron regulatory factor ^{1 2}

1993 • 269 citations

Iron regulates cytoplasmic levels of a novel iron-responsive element-binding protein without aconitase activity.

1994 • 262 citations

Nitrite Inhibition of Clostridium botulinum : Electron Spin Resonance Detection of Iron-Nitric Oxide Complexes

1983 • 261 citations

Interleukin-1 beta-induced formation of EPR-detectable iron-nitrosyl complexes in islets of Langerhans. Role of nitric oxide in interleukin-1 beta-induced inhibition of insulin secretion.

1991 • 257 citations

Structure of activated aconitase: formation of the [4Fe-4S] cluster in the crystal.

1989 • 245 citations

Metallothionein protects against the cytotoxic and DNA-damaging effects of nitric oxide.

1995 • 243 citations

Loss and Degradation of Enzyme-bound Heme Induced by Cellular Nitric Oxide Synthesis

1995 • 237 citations

Paramagnetic Resonance Study of Nitric Oxide Hemoglobin

1968 • 231 citations

Haem‐Dependent Activation of Guanylate Cyclase and Cyclic GMP Formation by Endogenous Nitric Oxide: A Unique Transduction Mechanism for Transcellular Signaling

1990 • 230 citations

NITROGENASE: A Nucleotide-Dependent Molecular Switch

1994 • 228 citations

Nitric oxide signaling to iron-regulatory protein: direct control of ferritin mRNA translation and transferrin receptor mRNA stability in transfected fibroblasts.

1995 • 226 citations

Recent developments in the field of iron‐sulfur proteins

1990 • 223 citations

Molecular characterization of a second iron-responsive element binding protein, iron regulatory protein 2. Structure, function, and post-translational regulation.

1994 • 221 citations

Human ferrochelatase is an iron-sulfur protein

1994 • 208 citations

Nitric oxide, a biological effector

1991 • 203 citations

EPR detection of heme and nonheme iron-containing protein nitrosylation by nitric oxide during rejection of rat heart allograft.

1992 • 195 citations

An Electron Spin Resonance Study of Some Complexes of Iron, Nitric Oxide, and Anionic Ligands

1965 • 191 citations

Injury of neoplastic cells by murine macrophages leads to inhibition of mitochondrial respiration.

1980 • 186 citations

IFN-γ-activated macrophages: Detection by electron paramagnetic resonance of complexes between L-Arginine-derived nitric oxide and non-heme iron proteins

1990 • 185 citations

Mutational analysis of the [4Fe-4S]-cluster converting iron regulatory factor from its RNA-binding form to cytoplasmic aconitase.

1994 • 176 citations

Epithelial autotoxicity of nitric oxide: role in the respiratory cytopathology of pertussis.

1994 • 171 citations

Nitric oxide localized to spinal cords of mice with experimental allergic encephalomyelitis: an electron paramagnetic resonance study.

1993 • 153 citations

Optimal sequence and structure of iron-responsive elements. Selection of RNA stem-loops with high affinity for iron regulatory factor

1994 • 153 citations

SHORT COMMUNICATION: Cytokines Induce an L-Arginine-Dependent Effector System in Nonmacrophage Cells

1988 • 133 citations

Nitrosyl Complexes of Iron-Sulfur Clusters

1988 • 129 citations

Coordmation of cellular iron metabolism by post-transcriptional gene regulation

1992 • 121 citations

Nonheme Iron-Nitrosyl Complex Formation in Rat Hepatocytes: Detection by Electron Paramagnetic Resonance Spectroscopy

1993 • 120 citations

Identification of the EPR-Active Iron-Nitrosyl Complexes in Mammalian Ferritins

1994 • 117 citations

Effect of Endogenous Nitric Oxide on Mitochondrial Respiration of Rat Hepatocytes In Vitro and In Vivo

1991 • 114 citations

A double life: cytosolic aconitase as a regulatory RNA binding protein.

1993 • 108 citations

Potential ligands to the [2Fe-2S] Rieske cluster of the cytochrome bc1 complex of Rhodobacter capsulatus probed by site-directed mutagenesis

1992 • 107 citations

Iron‐sulphur cluster nitrosyls, a novel class of nitric oxide generator: mechanism of vasodilator action on rat isolated tail artery

1992 • 107 citations

Modification of a free Fe-S cluster cysteine residue in the active iron-responsive element-binding protein prevents RNA binding.

1993 • 103 citations

The nitric oxide complex of ferrous soybean lipoxygenase-1. Substrate, pH, and ethanol effects on the active-site iron.

1987 • 94 citations

Isolation and identification of a paramagnetic complex from the livers of carcinogen-treated rats

1970 • 92 citations

Interleukin-1β induces nitric oxide production and inhibits the activity of aconitase without decreasing glucose oxidation rates in isolated mouse pancreatic islets

1992 • 91 citations

Induction of iron-derived EPR signals in murine cancers by nitric oxide. Evidence for multiple intracellular targets.

1994 • 90 citations

Mitochondrial iron loss from leukemia cells injured by macrophages. A possible mechanism for electron transport chain defects.

1988 • 85 citations

Formation and Release of Dinitrosyl Iron Complexes by Endothelial Cells

1993 • 82 citations

Cytokine-Induced Expression of Nitric Oxide Synthase Results in Nitrosylation of Heme and Nonheme Iron Proteins in Vascular Smooth Muscle Cells

1994 • 82 citations

The iron-responsive element binding protein: a target for synaptic actions of nitric oxide.

1994 • 78 citations

Reaction of peroxynitrite with oxyhaemoglobin: interference with photometrical determination of nitric oxide

1994 • 71 citations

Comparison of carbon monoxide, nitric oxide, and nitrite as inhibitors of the nitrogenase from Clostridium pasteurianum

1981 • 70 citations

Differential regulation of two related RNA-binding proteins, iron regulatory protein (IRP) and IRPB.

1995 • 69 citations

Effect of nitric oxide on expression of transferrin receptor and ferritin and on cellular iron metabolism in K562 human erythroleukemia cells

1995 • 65 citations

Metallothionein Reacts with Fe2+ and NO to Form Products with a g=2.039 ESR Signal

1993 • 60 citations

Formation of paramagnetic mononuclear iron nitrosyl complexes from diamagnetic di- and tetranuclear iron-sulphur nitrosyls: characterisation by EPR spectroscopy and study of thiolate and nitrosyl ligand exchange reactions

1985 • 60 citations

The source of non-heme iron that binds nitric oxide in cultivated macrophages

1992 • 55 citations

Nitroglycerin metabolism by Phanerochaete chrysosporium: evidence for nitric oxide and nitrite formation

1991 • 51 citations

Does ferredoxin I (Azotobacter) represent a novel class of DNA‐binding proteins that regulate gene expression in response to cellular iron(II)?

1991 • 49 citations

Nitric oxide and the post-transcriptional control of cellular iron traffic

1994 • 46 citations

Nitrosyl cytochrome c oxidase. Formation and properties of mixed valence enzyme.

1988 • 36 citations

Localization of an RNA binding element of the iron responsive element binding protein within a proteolytic fragment containing iron coordination ligands

1994 • 33 citations

Electron paramagnetic resonance spectroscopic investigation of the inhibition of the phosphoroclastic system of Clostridium sporogenes by nitrite

1990 • 32 citations

Ferritin synthesis is controlled by iron-dependent translational derepression and by changes in synthesis/transport of nuclear ferritin RNAs.

1993 • 31 citations

Kinetic and spectroscopic analysis of the inactivating effects of nitric oxide on the individual components of Azotobacter vinelandii nitrogenase

1992 • 24 citations

Nitrosylation of 2Fe-2S and 4Fe-4S models for iron-sulphur redox proteins

1985 • 23 citations

Inhibition of nitrogenase by nitrite and nitric oxide in Rhodopseudomonas sphaeroides f. sp. denitrificans

1987 • 22 citations

Evidence that nitric oxide modulates IRP activities by targeting its [Fe_S] cluster

1994 • 3 citations

Deleted Work

1955 • 0 citations