Contributions of the Glial Injury Response to the Multifactorial Pathogenesis of Alzheimer’s Disease

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

1992 • 4,885 citations

Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease

1997 • 4,137 citations

Diffusible, nonfibrillar ligands derived from Aβ _1–42 are potent central nervous system neurotoxins

1998 • 3,404 citations

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1995 • 2,456 citations

Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

1990 • 1,975 citations

Control of Memory Formation Through Regulated Expression of a CaMKII Transgene

1996 • 1,525 citations

Molecular profile of reactive astrocytes—Implications for their role in neurologic disease

1993 • 1,436 citations

Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

1993 • 1,422 citations

Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease

1997 • 1,395 citations

The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases

1995 • 1,290 citations

Gene-targeting studies of mammalian behavior: is it the mutation or the background genotype?

1996 • 895 citations

Alzheimer's Disease--Genotypes, Phenotype, and Treatments

1997 • 884 citations

Apolipoprotein E allele–specific antioxidant activity and effects on cytotoxicity by oxidative insults and β–amyloid peptides

1996 • 876 citations

Differential Effects of Apolipoproteins E3 and E4 on Neuronal Growth in Vitro

1994 • 797 citations

APPSW Transgenic Mice Develop Age-related Aβ Deposits and Neuropil Abnormalities, but no Neuronal Loss in CA1

1997 • 640 citations

Aβ Deposition Is Associated with Neuropil Changes, but not with Overt Neuronal Loss in the Human Amyloid Precursor Protein V717F (PDAPP) Transgenic Mouse

1997 • 502 citations

Apolipoprotein E and Alzheimer's Disease

1996 • 457 citations

Incidence and Risk of Dementia: The Rotterdam study

1998 • 454 citations

Amyloidogenic role of cytokine TGF-β1 in transgenic mice and in Alzheimer's disease

1997 • 417 citations

Neurodegeneration in the Central Nervous System of apoE-Deficient Mice

1995 • 403 citations

Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease.

1996 • 373 citations

TRANSFORMING GROWTH FACTOR-βS IN NEURODEGENERATIVE DISEASE

1998 • 362 citations

Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: Increased susceptibility of females

1998 • 354 citations

Assessment of learning by the Morris water task and fear conditioning in inbred mouse strains and F1 hybrids: implications of genetic background for single gene mutations and quantitative trait loci analyses

1997 • 351 citations

Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: isoform-specific effects on neurodegeneration.

1999 • 340 citations

Human apolipoprotein E: the Alzheimer's disease connection

1996 • 325 citations

Stable Expression and Secretion of Apolipoproteins E3 and E4 in Mouse Neuroblastoma Cells Produces Differential Effects on Neurite Outgrowth

1995 • 321 citations

β-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease

1996 • 305 citations

Comparison of Neurodegenerative Pathology in Transgenic Mice Overexpressing V717F β-Amyloid Precursor Protein and Alzheimer’s Disease

1996 • 301 citations

Macrophage- and astrocyte-derived transforming growth factor beta as a mediator of central nervous system dysfunction in acquired immune deficiency syndrome.

1991 • 295 citations

The Pathogenesis of Alzheimer Disease: An Alternative to the Amyloid Hypothesis

1996 • 288 citations

Expression of Human Apolipoprotein E3 or E4 in the Brains ofApoe^−/−Mice: Isoform-Specific Effects on Neurodegeneration

1999 • 283 citations

Diagnosis of Cerebral Amyloid Angiopathy

1997 • 274 citations

Exploring the Etiology of Alzheimer Disease Using Molecular Genetics

1997 • 260 citations

Increased central nervous system production of extracellular matrix components and development of hydrocephalus in transgenic mice overexpressing transforming growth factor-beta 1.

1995 • 248 citations

Increased Synaptic Sprouting in Response to Estrogen via an Apolipoprotein E-Dependent Mechanism: Implications for Alzheimer’s Disease

1998 • 241 citations

Transforming growth factor-β1 is in plaques in Alzheimer and Down pathologies

1993 • 232 citations

Research advances in Alzheimer's disease and related disorders

1995 • 230 citations

Regulation of neuronal Bcl2 protein expression and calcium homeostasis by transforming growth factor type beta confers wide-ranging protection on rat hippocampal neurons.

1994 • 225 citations

Memory deficits and cholinergic impairments in apolipoprotein E-deficient mice

1995 • 218 citations

Astrocytes in infectious and immune‐mediated diseases of the central nervous system

1993 • 217 citations

Motor and cognitive deficits in apolipoprotein E-deficient mice after closed head injury

1997 • 215 citations

Glial Fibrillary Acidic Protein–Apolipoprotein E (apoE) Transgenic Mice: Astrocyte-Specific Expression and Differing Biological Effects of Astrocyte-Secreted apoE3 and apoE4 Lipoproteins

1998 • 213 citations

TGF‐β1 is an organizer of responses to neurodgeneration

1993 • 198 citations

Apolipoprotein E Is Localized to the Cytoplasm of Human Cortical Neurons: A Light and Electron Microscopic Study

1994 • 195 citations

Specific Regional Transcription of Apolipoprotein E in Human Brain Neurons

1999 • 172 citations

Amyloids and Are Generated Intracellularly in Cultured Human Neurons and Their Secretion Increases with Maturation

1996 • 167 citations

Apolipoprotein E-Deficient Mice Have Increased Susceptibility To Focal Cerebral Ischemia

1997 • 164 citations

Protective effect of transforming growth factor-beta 1 on beta-amyloid neurotoxicity in rat hippocampal neurons.

1996 • 163 citations

Astroglial overproduction of TGF-β1 enhances inflammatory central nervous system disease in transgenic mice

1997 • 152 citations

Neurodegeneration and cognitive impairment in apoE-deficient mice is ameliorated by infusion of recombinant apoE

1997 • 148 citations

Severe learning deficits in apolipoprotein E-knockout mice in a water maze task

1997 • 142 citations

Interaction of Nascent ApoE2, ApoE3, and ApoE4 Isoforms Expressed in Mammalian Cells with Amyloid Peptide β (1−40). Relevance to Alzheimer's Disease

1997 • 135 citations

Rodent models of Alzheimer's disease: Rat aβ infusion approaches to amyloid deposits

1996 • 131 citations

Conditional gene expression in secretory tissues and skin of transgenic mice using the MMTV‐LTR and the tetracycline responsive system

1995 • 129 citations

Behavioural, physiological and morphological analysis of a line of apolipoprotein E knockout mouse

1998 • 120 citations

Evidence for Normal Aging of the Septo-Hippocampal Cholinergic System in apoE (−/−) Mice but Impaired Clearance of Axonal Degeneration Products Following Injury

1998 • 117 citations

Transforming growth factor beta in Alzheimer's disease

1994 • 103 citations

Neurons of the Human Frontal Cortex Display Apolipoprotein E Immunoreactivity

1996 • 94 citations

The Use of Genetic “Knockout” Mice in Behavioral Endocrinology Research

1997 • 86 citations

Vascular dementia: a construct in evolution.

1996 • 75 citations

ApoE, Alzheimer's Disease, and Recovery from Brain Stress^a

1997 • 74 citations

Long-term treatment of chronic relapsing experimental allergic encephalomyelitis by transforming growth factor-β2

1993 • 74 citations

Reduced Levels of Antioxidants in Brains of Apolipoprotein E-Deficient Mice Following Closed Head Injury

1997 • 73 citations

Phosphorylation of tau in apolipoprotein E-deficient mice

1995 • 70 citations

Altered synaptic plasticity in hippocampal CA1 area of apolipoprotein E deficient mice

1997 • 69 citations

Epidemiological, Clinical, and Neuropathological Study of Apolipoprotein E Genotype in Alzheimer's Disease

1996 • 66 citations

Protection against developmental retardation in apolipoprotein E-deficient mice by a fatty neuropeptide: Implications for early treatment of Alzheimer's disease

1997 • 63 citations

Exploring the etiology of Alzheimer disease using molecular genetics

1997 • 58 citations

Absence of central cholinergic deficits in ApoE knockout mice

1997 • 53 citations

Specific Neurochemical Derangements of Brain Projecting Neurons in Apolipoprotein E‐Deficient Mice

1998 • 51 citations

Apolipoprotein-E deficiency results in an altered stress responsiveness in addition to an impaired spatial memory in young mice

1998 • 49 citations

Nerve Regeneration and Cholesterol Reutilization Occur in the Absence of Apolipoproteins E and A‐I in Mice

1995 • 49 citations

Expression of apolipoprotein E in normal and diverse neurodegenerative disease brain

1996 • 45 citations

Altered long-term potentiation in the hippocampus of apolipoprotein E-deficient mice

1998 • 44 citations

Peripheral Sensory Nerve Defects in Apolipoprotein E Knockout Mice

1998 • 43 citations

The Mean Aβ Load in the Hippocampus Correlates with Duration and Severity of Dementia in Subgroups of Alzheimer Disease

1997 • 38 citations

Cerebrovascular Pathology in Alzheimer's Disease

1999 • 31 citations

Phosphorylation of tau protein is not affected in mice lacking apolipoprotein E

1995 • 25 citations