Peripheral Sensory Nerve Defects in Apolipoprotein E Knockout Mice

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

1993 • 4,145 citations

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

1992 • 2,216 citations

ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree.

1994 • 1,646 citations

Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons

1994 • 1,065 citations

Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene

1994 • 978 citations

Nerve growth factor regulates expression of neuropeptide genes in adult sensory neurons

1989 • 934 citations

Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells.

1992 • 897 citations

Apolipoprotein E allele–specific antioxidant activity and effects on cytotoxicity by oxidative insults and β–amyloid peptides

1996 • 876 citations

Differential Effects of Apolipoproteins E3 and E4 on Neuronal Growth in Vitro

1994 • 797 citations

Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system.

1985 • 786 citations

Association of apolipoprotein E polymorphism with outcome after head injury

1997 • 703 citations

Apolipoprotein E and Alzheimer disease.

1995 • 697 citations

Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain.

1987 • 696 citations

Apolipoprotein E epsilon4 associated with chronic traumatic brain injury in boxing

1997 • 569 citations

Apolipoprotein E mRNA is abundant in the brain and adrenals, as well as in the liver, and is present in other peripheral tissues of rats and marmosets.

1985 • 500 citations

Apolipoprotein E ∈4 Associated With Chronic Traumatic Brain Injury in Boxing

1997 • 414 citations

Astrocytic apolipoprotein E mRNA and GFAP mRNA in hippocampus after entorhinal cortex lesioning

1991 • 386 citations

Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line.

1995 • 355 citations

Stable Expression and Secretion of Apolipoproteins E3 and E4 in Mouse Neuroblastoma Cells Produces Differential Effects on Neurite Outgrowth

1995 • 321 citations

Apolipoprotein E epsilon4 and the risk of dementia with stroke. A population-based investigation

1997 • 291 citations

The Inhibitory Effect of Apolipoprotein E4 on Neurite Outgrowth Is Associated with Microtubule Depolymerization

1995 • 277 citations

Preliminary Report of a Genetic Basis for Cognitive Decline After Cardiac Operations 11The members of the Neurologic Outcome Research Group of the Duke Heart Center are listed in Appendix A.

1997 • 264 citations

Accumulation of apolipoproteins in the regenerating and remyelinating mammalian peripheral nerve. Identification of apolipoprotein D, apolipoprotein A-IV, apolipoprotein E, and apolipoprotein A-I.

1990 • 243 citations

Role of neurotrophins and trk receptors in the development and maintenance of sensory neurons: an overview

1996 • 234 citations

Predictors of cognitive decline after cardiac operation

1995 • 208 citations

Effects of apolipoprotein E, beta-very low density lipoproteins, and cholesterol on the extension of neurites by rabbit dorsal root ganglion neurons in vitro.

1992 • 199 citations

Apolipoprotein E ϵ4 and the Risk of Dementia With Stroke<subtitle>A Population-Based Investigation</subtitle>

1997 • 195 citations

Apolipoprotein E Is Localized to the Cytoplasm of Human Cortical Neurons: A Light and Electron Microscopic Study

1994 • 195 citations

Denervated sheath cells secrete a new protein after nerve injury.

1983 • 181 citations

Increased Plasma and Lipoprotein Lipid Peroxidation in apo E-Deficient Mice

1994 • 172 citations

Atherosclerosis, Vascular Remodeling, and Impairment of Endothelium-Dependent Relaxation in Genetically Altered Hyperlipidemic Mice

1997 • 172 citations

Apolipoprotein E-Deficient Mice Have Increased Susceptibility To Focal Cerebral Ischemia

1997 • 164 citations

Apolipoprotein E Is Present in Hippocampal Neurons without Neurofibrillary Tangles in Alzheimer's Disease and in Age-Matched Controls

1994 • 153 citations

Apolipoprotein E and the Apolipoprotein E-Deficient Mouse

1995 • 142 citations

Regulation of axonal caliber, neurofilament content, and nuclear localization in mature sensory neurons by nerve growth factor

1991 • 136 citations

E-4-hydroxy-2-nonenal is cytotoxic and cross-links cytoskeletal proteins in P19 neuroglial cultures.

1996 • 132 citations

Macrophages in the peripheral nervous system and astroglia in the central nervous system of rat commonly express apolipoprotein E during development but differ in their response to injury

1986 • 108 citations

Apolipoprotein E Binds to and Potentiates the Biological Activity of Ciliary Neurotrophic Factor

1997 • 76 citations

Nerve Regeneration Occurs in the Absence of Apolipoprotein E in Mice

1993 • 76 citations

Oligodendrocytes but not astrocytes express apolipoprotein E after injury of rat optic nerve

1989 • 71 citations

Neurotrophins and peripheral neuropathy

1996 • 66 citations

Interaction of Apolipoprotein E with Laminin Increases Neuronal Adhesion and Alters Neurite Morphology

1995 • 59 citations

Oxygen toxicity in the nervous tissue: Comparison of the antioxidant defense of rat brain and sciatic nerve

1991 • 53 citations

(–)‐Deprenyl alters the survival of adult murine facial motoneurons after axotomy: Increases in vulnerable C57BL strain but decreases in motor neuron degeneration mutants

1994 • 50 citations

Synthesis and Secretion of Apolipoprotein E by Cultured Human Keratinocytes

1989 • 45 citations

A deficiency of axonal regeneration in C57BL/6J mice

1990 • 39 citations

Somatofugal axonal atrophy precedes development of axonal degeneration in acrylamide neuropathy

1992 • 32 citations

Studies of axonal regeneration in C57BL/6J and A/J mice

1994 • 22 citations

Regional CBF in apolipoprotein E-deficient and wild type mice during focal cerebral ischemia

1998 • 21 citations

Effects of Beraprost Sodium, a Prostacyclin Analogue, on Diabetic Neuropathy in Streptozotocin-Induced Diabetic Rats

1996 • 16 citations

Epidermal Keratinocytes Secrete Apolipoprotein E^a

1988 • 4 citations