Expression of Human Apolipoprotein E3 or E4 in the Brains ofApoe^−/−Mice: Isoform-Specific Effects on Neurodegeneration

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

1993 • 8,888 citations

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

1993 • 4,145 citations

Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease

1997 • 4,137 citations

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1991 • 4,120 citations

Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology

1988 • 3,984 citations

Excitatory Amino Acids as a Final Common Pathway for Neurologic Disorders

1994 • 2,668 citations

Excitatory amino acid neurotoxicity and neurodegenerative disease

1990 • 1,781 citations

Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease

1991 • 1,133 citations

Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells.

1992 • 897 citations

Apolipoprotein E allele–specific antioxidant activity and effects on cytotoxicity by oxidative insults and β–amyloid peptides

1996 • 876 citations

Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments

1994 • 866 citations

Apolipoprotein E: A pathological chaperone protein in patients with cerebral and systemic amyloid

1992 • 802 citations

Differential Effects of Apolipoproteins E3 and E4 on Neuronal Growth in Vitro

1994 • 797 citations

Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system.

1985 • 786 citations

Human E apoprotein heterogeneity. Cysteine-arginine interchanges in the amino acid sequence of the apo-E isoforms.

1981 • 760 citations

Human apolipoprotein E. The complete amino acid sequence.

1982 • 731 citations

Association of apolipoprotein E polymorphism with outcome after head injury

1997 • 703 citations

Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain.

1987 • 696 citations

Central nervous system damage produced by expression of the HIV-1 coat protein gpl20 in transgenic mice

1994 • 678 citations

Polymorphism of apolipoprotein E and occurrence of dysbetalipoproteinaemia in man

1977 • 654 citations

Synergistic Effects of Traumatic Head Injury and Apolipoprotein-epsilon4 in Patients With Alzheimer's Disease

1995 • 588 citations

Molecular biology of glutamate receptors in the central nervous system and their role in excitotoxicity, oxidative stress and aging

1998 • 575 citations

Expression of apolipoprotein E during nerve degeneration and regeneration.

1986 • 563 citations

Targeted Replacement of the Mouse Apolipoprotein E Gene with the Common Human APOE3 Allele Enhances Diet-induced Hypercholesterolemia and Atherosclerosis

1997 • 545 citations

Loss of the Presynaptic Vesicle Protein Synaptophysin in Hippocampus Correlates with Cognitive Decline in Alzheimer Disease

1997 • 535 citations

Genetic determinants of susceptibility to excitotoxic cell death: Implications for gene targeting approaches

1997 • 523 citations

Apolipoprotein E mRNA is abundant in the brain and adrenals, as well as in the liver, and is present in other peripheral tissues of rats and marmosets.

1985 • 500 citations

Hypothesis: Microtubule Instability and Paired Helical Filament Formation in the Alzheimer Disease Brain Are Related to Apolipoprotein E Genotype

1994 • 427 citations

High and Low Annealing Temperatures Increase Both Specificity and Yield in Touchdown and Stepdown PCR

1996 • 409 citations

Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3.

1994 • 407 citations

Correlations of synaptic and pathological markers with cognition of the elderly

1995 • 405 citations

Neurodegeneration in the Central Nervous System of apoE-Deficient Mice

1995 • 403 citations

Spectrum of human immunodeficiency virus–associated neocortical damage

1992 • 369 citations

Transgenic mice expressing β-galactosidase in mature neurons under neuron-specific enolase promoter control

1990 • 360 citations

Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: Increased susceptibility of females

1998 • 354 citations

Axonal disruption and aberrant localization of tau protein characterize the neuropil pathology of Alzheimer's disease

1987 • 348 citations

Phenotypes of apolipoprotein B and apolipoprotein E after liver transplantation.

1991 • 334 citations

Human apolipoprotein E: the Alzheimer's disease connection

1996 • 325 citations

Stable Expression and Secretion of Apolipoproteins E3 and E4 in Mouse Neuroblastoma Cells Produces Differential Effects on Neurite Outgrowth

1995 • 321 citations

Plastic Neuronal Remodeling Is Impaired in Patients with Alzheimer’s Disease Carrying Apolipoprotein ε4 Allele

1997 • 321 citations

Neuropathological changes in scrapie and Alzheimer's disease are associated with increased expression of apolipoprotein E and cathepsin D in astrocytes

1991 • 297 citations

Macrophage-specific expression of human apolipoprotein E reduces atherosclerosis in hypercholesterolemic apolipoprotein E-null mice.

1995 • 279 citations

Synaptotrophic effects of human amyloid β protein precursors in the cortex of transgenic mice

1994 • 278 citations

The Inhibitory Effect of Apolipoprotein E4 on Neurite Outgrowth Is Associated with Microtubule Depolymerization

1995 • 277 citations

Levels and Alternative Splicing of Amyloid β Protein Precursor (APP) Transcripts in Brains of APP Transgenic Mice and Humans with Alzheimer's Disease

1995 • 250 citations

Motor and cognitive deficits in apolipoprotein E-deficient mice after closed head injury

1997 • 215 citations

Glial Fibrillary Acidic Protein–Apolipoprotein E (apoE) Transgenic Mice: Astrocyte-Specific Expression and Differing Biological Effects of Astrocyte-Secreted apoE3 and apoE4 Lipoproteins

1998 • 213 citations

Apolipoprotein E Is Localized to the Cytoplasm of Human Cortical Neurons: A Light and Electron Microscopic Study

1994 • 195 citations

Apolipoprotein E ϵ4 and the Risk of Dementia With Stroke<subtitle>A Population-Based Investigation</subtitle>

1997 • 195 citations

Human Apolipoprotein E2, E3, and E4 Isoform-Specific Transgenic Mice: Human-like Pattern of GlialandNeuronal Immunoreactivity in Central Nervous System Not Observed in Wild-Type Mice

1996 • 178 citations

Specific Regional Transcription of Apolipoprotein E in Human Brain Neurons

1999 • 172 citations

[13] Isolation and characterization of apolipoprotein E

1986 • 155 citations

Apolipoprotein E Isoform-Specific Differences in Outcome from Focal Ischemia in Transgenic Mice

1998 • 145 citations

Hippocampal damage produced by systemic injections of domoic acid in mice

1991 • 135 citations

Differential Cellular Accumulation/Retention of Apolipoprotein E Mediated by Cell Surface Heparan Sulfate Proteoglycans

1998 • 134 citations

Behavioural, physiological and morphological analysis of a line of apolipoprotein E knockout mouse

1998 • 120 citations

Evidence for Normal Aging of the Septo-Hippocampal Cholinergic System in apoE (−/−) Mice but Impaired Clearance of Axonal Degeneration Products Following Injury

1998 • 117 citations

Amyloid precursor proteins protect neurons of transgenic mice against acute and chronic excitotoxic injuries in vivo

1997 • 116 citations

Quantitative Assessment of the Synaptophysin Immuno-Reactivity of the Cortical Neuropil in Various Neurodegenerative Disorderswith Dementia

1993 • 106 citations

An antibody against phosphorylated neurofilaments identifies a subset of damaged association axons in Alzheimer's disease.

1993 • 103 citations

Amyloid β‐Protein, APOE Genotype and Head Injury

1996 • 100 citations

Neurons of the Human Frontal Cortex Display Apolipoprotein E Immunoreactivity

1996 • 94 citations

Selective alterations in the cellular distribution of apolipoprotein E immunoreactivity following transient cerebral ischaemia in the rat

1996 • 86 citations

Indicator expression directed by regulatory sequences of the glial fibrillary acidic protein (GFAP) gene: In vivo comparison of distinct GFAP‐lacZ transgenes

1995 • 83 citations

Complete cerebral ischemia with short-term survival in rat induced by cardiac arrest. II. Extracellular and intracellular accumulation of apolipoproteins E and J in the brain

1995 • 74 citations

Apolipoprotein E: impact of cytoskeletal stability in neurons and the relationship to Alzheimerʼs disease

1995 • 71 citations

A Method for Obtaining Cerebrospinal Fluid from Mice

1971 • 59 citations

Expression of apolipoprotein E in normal and diverse neurodegenerative disease brain

1996 • 45 citations

An improved T1/A ribonuclease protection assay.

1994 • 43 citations

Novel role of human CD4 molecule identified in neurodegeneration

1998 • 29 citations