β-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease

“Mini-mental state”

1975 • 82,784 citations

Neuropathological stageing of Alzheimer-related changes

1991 • 14,533 citations

The Clinical Dementia Rating (CDR)

1993 • 8,861 citations

Applied Multiple Regression/Correlation Analysis for the Behavioral Sciences.

1979 • 5,283 citations

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD)

1991 • 4,669 citations

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1991 • 4,120 citations

The Association Between Quantitative Measures of Dementia and of Senile Change in the Cerebral Grey Matter of Elderly Subjects

1968 • 4,041 citations

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

1992 • 2,520 citations

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1995 • 2,456 citations

Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity

1990 • 2,131 citations

Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production

1992 • 1,723 citations

Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease

1994 • 1,213 citations

Clinical, pathological, and neurochemical changes in dementia: A subgroup with preserved mental status and numerous neocortical plaques

1988 • 1,186 citations

Consortium to establish a registry for Alzheimer's disease (CERAD) clinical and neuropsychological assessment of Alzheimer's disease.

1988 • 1,118 citations

The Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE): socio-demographic correlates, reliability, validity and some norms

1989 • 1,071 citations

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons.

1993 • 1,035 citations

Neuron numbers and dendritic extent in normal aging and Alzheimer's disease

1987 • 769 citations

A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis.

1990 • 715 citations

Identification of normal and pathological aging in prospectively studied nondemented elderly humans

1992 • 625 citations

β-Amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage

1990 • 620 citations

Plaques, tangles and dementia

1982 • 603 citations

Synergistic Effects of Traumatic Head Injury and Apolipoprotein-epsilon4 in Patients With Alzheimer's Disease

1995 • 588 citations

β-Amyloid fibrils induce tau phosphorylation and loss of microtubule binding

1995 • 580 citations

Amyloid beta-peptide impairs ion-motive ATPase activities: evidence for a role in loss of neuronal Ca2+ homeostasis and cell death

1995 • 559 citations

The Alzheimer's Aβ peptide induces neurodegeneration and apoptotic cell death in transgenic mice

1995 • 517 citations

Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau.

1992 • 509 citations

Neocortical Neurofibrillary Tangles Correlate With Dementia Severity in Alzheimer's Disease

1995 • 488 citations

Formic acid pretreatment enhances immunostaining of cerebral and systemic amyloids.

1987 • 469 citations

The toxicity in vitro of β-amyloid protein

1995 • 427 citations

A NEW DEFINITION OF ALZHEIMER'S DISEASE: A HIPPOCAMPAL DEMENTIA

1985 • 422 citations

A rapid method for isolation of synaptosomes on Percoll gradients

1986 • 421 citations

Correlations of synaptic and pathological markers with cognition of the elderly

1995 • 405 citations

Neuritic pathology and dementia in alzheimer's disease

1991 • 362 citations

A4POE*4-associated Alzheimer's disease risk is modified by α1–antichymotrypsin polymorphism

1995 • 337 citations

Relative Roles of Plaques and Tangles in the Dementia of Alzheimer's Disease: Correlations Using Three Sets of Neuropathological Criteria

1995 • 281 citations

Longitudinal evaluation of dementia of the Alzheimer type

1990 • 273 citations

The canine as an animal model of human aging and dementia

1996 • 269 citations

The Lack of Accumulation of Senile Plaques or Amyloid Burden in Alzheimerʼs Disease Suggests a Dynamic Balance Between Amyloid Deposition and Resolution

1993 • 269 citations

Image analysis of β-amyloid load in Alzheimer's disease and relation to dementia severity

1995 • 265 citations

Neuropathological Indexes of Alzheimer's Disease in Demented and Nondemented Persons Aged 80 Years and Older

1993 • 254 citations

Cognitive functions and aging in the dog: Acquisition of nonspatial visual tasks.

1994 • 224 citations

β-Amyloid Accumulation Correlates with Cognitive Dysfunction in the Aged Canine

1996 • 217 citations

Diffuse plaques do not accentuate synapse loss in Alzheimer's disease.

1990 • 209 citations

Quantitative analysis of senile plaques in Alzheimer disease: observation of log-normal size distribution and molecular epidemiology of differences associated with apolipoprotein E genotype and trisomy 21 (Down syndrome).

1995 • 207 citations

Cognitive functions and aging in the dog: Acquisition of nonspatial visual tasks.

1994 • 196 citations

β-Amyloid accumulation in aged canine brain: A model of early plaque formation in Alzheimer's disease

1993 • 185 citations

Loss of synaptophysin-like immunoreactivity in the hippocampal formation is an early phenomenon in alzheimer's disease

1995 • 183 citations

Large amounts of neocortical βA4 deposits without neuritic plaques nor tangles in a psychometrically assessed, non-demented person

1990 • 174 citations

Genetic association of the very low density lipoprotein (VLDL) receptor gene with sporadic Alzheimer's disease

1995 • 171 citations

A comparative study of histological and immunohistochemical methods for neurofibrillary tangles and senile plaques in Alzheimer's disease

1992 • 164 citations

Senile plaques as aberrant sprout-stimulating structures

1986 • 161 citations

Alzheimer's disease: A correlational analysis of the Blessed Information-Memory-Concentration Test and the Mini-Mental State Exam

1986 • 159 citations

THE TOPOGRAPHY OF PLAQUES AND TANGLES IN DOWN'S SYNDROME PATIENTS OF DIFFERENT AGES

1986 • 159 citations

β-Amyloid-induced changes in cultured astrocytes parallel reactive astrocytosis associated with senile plaques in Alzheimer's disease

1994 • 151 citations

Interlaboratory Comparison of Neuropathology Assessments in Alzheimerʼs Disease

1994 • 149 citations

Tau, paired helical filaments and amyloid in the neocortex: a morphometric study of 15 cases with graded intellectual status in aging and senile dementia of Alzheimer type

1989 • 136 citations

β-Amyloid induces neuritic dystrophy in vitro

1992 • 132 citations

Spatial learning and memory as a function of age in the dog.

1995 • 131 citations

Spatial learning and memory as a function of age in the dog.

1995 • 129 citations

Intracellular Aβ1-42 Aggregates Stimulate the Accumulation of Stable, Insoluble Amyloidogenic Fragments of the Amyloid Precursor Protein in Transfected Cells

1995 • 126 citations

The Ca²⁺ influx induced by β‐amyloid peptide 25–35 in cultured hippocampal neurons results from network excitation

1995 • 123 citations

Comparison of four staining methods on the detection of neuritic plaques

1989 • 120 citations

β-amyloid peptide decreases membrane fluidity

1995 • 120 citations

Aggregation of the amyloid precursor protein within degenerating neurons and dystrophic neurites in alzheimer's disease

1992 • 120 citations

Clinicopathologic Correlates in Alzheimer Disease

1993 • 113 citations

Quantitative Assessment of the Synaptophysin Immuno-Reactivity of the Cortical Neuropil in Various Neurodegenerative Disorderswith Dementia

1993 • 106 citations

Rating of the lesions in senile dementia of the Alzheimer type: concordance between laboratories A European multicenter study under the auspices of EURAGE

1990 • 98 citations

Quantitative Assessment of Synaptic Density in the Outer Molecular Layer of the Hippocampal Dentate Gyrus in Alzheimer's Disease

1996 • 97 citations

Synaptophysin gene expression in human brain: A quantitative in situ hybridization and immunocytochemical study

1994 • 93 citations

Synaptic Pathology of Alzheimer's Diseasea

1993 • 86 citations

Differential correlation between neurochemical deficits, neuropathology, and cognitive status in Alzheimer's disease

1995 • 84 citations

COMPARISON OF SEVEN STAINING METHODS FOR SENILE PLAQUES AND NEUROFIBRILLARY TANGLES IN A PROSPECTIVE SERIES OF 15 ELDERLY PATIENTS

1989 • 81 citations

Quantitative assessment of synaptic density in the entorhinal cortex in Alzheimer's disease

1993 • 80 citations

Induction of β-Amyloid-Containing Polypeptides in Hippocampus: Evidence for a Concomitant Loss of Synaptic Proteins and Interactions with an Excitotoxin

1994 • 72 citations

Amyloid β protein-induced irreversible current in rat cortical neurones

1994 • 68 citations

Topographical relationship between beta-amyloid and tau protein epitopes in tangle-bearing cells in Alzheimer disease.

1990 • 64 citations

A simple dot-immunobinding assay for quantification of synaptophysin-like immunoreactivity in human brain.

1994 • 63 citations

Does amyloid precede paired helical filaments in the senile plaque? A study of 15 cases with graded intellectual status in aging and Alzheimer disease

1988 • 62 citations

Topographical distribution of synaptic-associated proteins in the neuritic plaques of Alzheimer's disease hippocampus

1994 • 56 citations

Amyloid beta-protein activates tachykinin receptors and inositol trisphosphate accumulation by synergy with glutamate.

1993 • 55 citations

Ageing in higher functioning adults with Down's syndrome: an interim report in a longitudinal study

1992 • 54 citations

β-amyloid increases choline conductance of PC12 cells: possible mechanism of toxicity in Alzheimer's disease

1994 • 53 citations

Microwave antigen retrieval for immunocytochemistry on formalin‐fixed, paraffin‐embedded post‐mortem CNS tissue

1995 • 53 citations

Alzheimer disease A68 proteins injected into rat brain induce codeposits of beta-amyloid, ubiquitin, and alpha 1-antichymotrypsin.

1993 • 45 citations

Constructional apraxia in Alzheimer's disease correlates with neuritic neuropathology in occipital cortex

1996 • 41 citations

Tissue fixation methods alter the immunhistochemical demonstrability of neurofilament proteins, synpatophysin, and glial fibrillary acidic protein in human cerebellum

1993 • 33 citations

Two distinct ubiquitin immunoreactive senile plaques in Alzheimer's disease: relationship with the intellectual status in 29 cases

1993 • 32 citations

Clinical and Neuropathological Correlates of Apolipoprotein E Genotype in Alzheimer's Disease ‐ Window on Molecular Epidemiologya

1996 • 31 citations

Alzheimer's lesions labelled by anti‐ubiquitin antibodies: comparison with other staining techniques. A study of 15 cases with graded intellectual status in ageing and Alzheimer's disease

1993 • 28 citations

Color image analysis in neuroanatomical research: Application to senile plaque subtype quantification in Alzheimer's disease

1995 • 22 citations

The Amyloid .BETA. Protein Precursor Mutations Linked to Familial Alzheimer's Disease Alter Processing in a Way That Fosters Amyloid Deposition.

1994 • 20 citations

Subpopulations of dystrophic neuritis in Alzheimer's brain with distinct immunocytochemical and argentophilic characteristics

1994 • 14 citations

Flow cytometric analysis on cytotoxic action of amyloid β protein fragment 25–35 on brain neurons dissociated from the rats

1994 • 10 citations

Alzheimer’s Disease, a Cerebral Form of Amyloidosis

1988 • 8 citations

Behavioral, cellular, and molecular biological studies of aged nonhuman primates.

1990 • 7 citations

Deleted Work

1955 • 0 citations