Human astrocytomas co-expressing Fas and Fas ligand also produce TGFbeta2 and Bcl-2.

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family

1993 • 2,546 citations

Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege

1995 • 2,028 citations

Involvement of the bcl -2 Gene in Human Follicular Lymphoma

1985 • 1,797 citations

Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth.

1986 • 1,617 citations

Fas and Perforin Pathways as Major Mechanisms of T Cell-Mediated Cytotoxicity

1994 • 1,558 citations

BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death.

1991 • 1,301 citations

Protection from Fas-Mediated Apoptosis by a Soluble Form of the Fas Molecule

1994 • 1,120 citations

Transforming growth factor beta is an important immunomodulatory protein for human B lymphocytes.

1986 • 777 citations

Involvement of an ICE-like protease in Fas-mediated apoptosis

1995 • 757 citations

The TGF-β family of growth and differentiation factors

1987 • 675 citations

Expression of the functional soluble form of human fas ligand in activated lymphocytes.

1995 • 656 citations

Constitutive and induced expression of APO-1, a new member of the nerve growth factor/tumor necrosis factor receptor superfamily, in normal and neoplastic cells.

1993 • 643 citations

Effects of transforming growth factor beta on the functions of natural killer cells: depressed cytolytic activity and blunting of interferon responsiveness.

1986 • 579 citations

Inhibition of cytokine production by cyclosporin A and transforming growth factor beta.

1987 • 466 citations

Fas ligand expression by astrocytoma in vivo: maintaining immune privilege in the brain?

1997 • 403 citations

Immunosuppression and transforming growth factor-beta in glioblastoma. Preferential production of transforming growth factor-beta 2.

1989 • 391 citations

Fas-mediated cytotoxicity by freshly isolated natural killer cells.

1995 • 372 citations

Anti-Fas/APO-1 antibody-mediated apoptosis of cultured human glioma cells. Induction and modulation of sensitivity by cytokines.

1994 • 361 citations

Role of Fas ligand (CD95L) in immune escape: the tumor cell strikes back.

1997 • 342 citations

Protooncogene bcl-2 gene transfer abrogates Fas/APO-1 antibody-mediated apoptosis of human malignant glioma cells and confers resistance to chemotherapeutic drugs and therapeutic irradiation.

1995 • 258 citations

Activated B cells express functional Fas ligand

1996 • 202 citations

Immunohistological study of mononuclear cell infiltrate in malignant gliomas

1987 • 192 citations

Fas Ligand Expression in Glioblastoma Cell Lines and Primary Astrocytic Brain Tumors

1997 • 153 citations

Immunohistochemical analysis of Bcl-2, Bcl-X, Mcl-1, and Bax in tumors of central and peripheral nervous system origin.

1997 • 145 citations

Elevated soluble Fas (sFas) levels in nonhematopoietic human malignancy.

1996 • 142 citations

The glioblastoma‐derived T‐cell suppressor factor/transforming growth factor beta₂ inhibits the generation of lymphokineactivated killer (LAK) cells

1988 • 131 citations

Fas/APO-1 gene transfer for human malignant glioma.

1995 • 127 citations

Enhanced expression of transforming growth factor‐β and its type‐I and type‐II receptors in human glioblastoma

1995 • 127 citations

Transforming growth factor‐β2 down‐regulates HLA‐DR antigen expression on human malignant glioma cells.

1988 • 110 citations

Effect of the expression of transforming growth factor-β2 in primary human glioblastomas on immunosuppression and loss of immune surveillance

1992 • 109 citations

Apoptosis and cell proliferation in human neuroepithelial tumors

1995 • 96 citations

Expression of Fas/APO-1 during the progression of astrocytomas.

1995 • 96 citations

bcl-2 protein expression in tumors of the central nervous system

1994 • 76 citations

Preferential expression of Fas/APO1 (CD95) and apoptotic cell death in perinecrotic cells of glioblastoma multiforme

1996 • 65 citations

Co-expression of Fas and Fas ligand in malignant glial tumors and cell lines

1998 • 60 citations

Apoptosis in cerebral astrocytic tumours and its relationship to expression of the bcl‐2 and p53 proteins

1995 • 60 citations

bcl-2 protein expression in astrocytomas in relation to patient survival and p53 gene status

1997 • 47 citations

Expression of bcl-2 in reactive and neoplastic astrocytes: lack of correlation with presence or degree of malignancy

1995 • 47 citations

Immunotherapy of malignant gliomas.

1994 • 38 citations

The Cytocidal Activity of OK‐432‐activated Mononuclear Cells against Human Glioma Cells is Partly Mediated through the Fas Ligand/Fas System

1996 • 22 citations