Enhanced expression of transforming growth factor‐β and its type‐I and type‐II receptors in human glioblastoma

Mechanism of activation of the TGF-β receptor

1994 • 2,298 citations

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.

1994 • 1,970 citations

The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.

1994 • 1,950 citations

pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest

1994 • 1,932 citations

Histological Typing of Tumours of the Central Nervous System

1993 • 1,493 citations

Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase

1992 • 1,071 citations

Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification.

1987 • 843 citations

Cloning of a TGF$beta; type I receptor that forms a heteromeric complex with the TGF$beta; type II receptor

1993 • 779 citations

The Transforming Growth Factor-βs

1990 • 741 citations

Platelet-derived growth factor and its receptors in human glioma tissue: expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops.

1992 • 689 citations

TGFβ inhibition of Cdk4 synthesis is linked to cell cycle arrest

1993 • 544 citations

Latent transforming growth factor-beta 1 associates to fibroblast extracellular matrix via latent TGF-beta binding protein

1994 • 450 citations

Immunosuppression and transforming growth factor-beta in glioblastoma. Preferential production of transforming growth factor-beta 2.

1989 • 391 citations

Immunohistochemical staining for transforming growth factor beta 1 associates with disease progression in human breast cancer.

1992 • 346 citations

Transforming growth factor beta isoforms in the adult rat central and peripheral nervous system

1991 • 303 citations

p53 mutation and loss of heterozygosity on chromosomes 17 and 10 during human astrocytoma progression.

1992 • 297 citations

Endoglin forms a heteromeric complex with the signaling receptors for transforming growth factor-beta.

1994 • 193 citations

Transforming growth factor-beta 1, -beta 2, and -beta 3 secreted by a human glioblastoma cell line. Identification of small and different forms of large latent complexes.

1992 • 181 citations

Receptors for Transforming Growth Factor-β

1993 • 181 citations

Involvement of transforming growth factor-beta in the formation of fibrotic lesions in carcinoid heart disease.

1993 • 160 citations

Altered metabolic and adhesive properties and increased tumorigenesis associated with increased expression of transforming growth factor beta 1.

1992 • 155 citations

The ins and outs of RB: coupling gene expression to the cell cycle clock

1994 • 137 citations

Factor-binding element in the human c-myc promoter involved in transcriptional regulation by transforming growth factor beta 1 and by the retinoblastoma gene product.

1991 • 120 citations

Immunocytochemical study of transforming growth factor expression in benign and malignant gliomas.

1989 • 108 citations

Retinoblastoma gene deletions in human glioblastomas.

1991 • 89 citations

Effects of Transforming Growth Factor β1 on Astroglial Cells in Culture

1990 • 85 citations

Expression and prognostic significance of TGF-beta isotypes, latent TGF-beta 1 binding protein, TGF-beta type I and type II receptors, and endoglin in normal ovary and ovarian neoplasms.

1995 • 85 citations

Effects of Transforming Growth Factor-beta on Human Pulmonary Adenocarcinoma Cell Adhesion, Motility, and Invasion In Vitro

1992 • 73 citations

Mutant p53 tumor suppressor gene causes resistance to transforming growth factor beta 1 in murine keratinocytes.

1993 • 68 citations

Effects of type beta transforming growth factor in combination with retinoic acid or tumor necrosis factor on proliferation of a human glioblastoma cell line and clonogenic cells from freshly resected human brain tumors

1988 • 30 citations