Apoptosis in cerebral astrocytic tumours and its relationship to expression of the bcl‐2 and p53 proteins

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1988 • 3,194 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

Apoptosis. Its significance in cancer and cancer Therapy

1994 • 2,148 citations

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo.

1994 • 2,141 citations

Histological Typing of Tumours of the Central Nervous System

1993 • 1,493 citations

BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death.

1991 • 1,301 citations

Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma.

1986 • 1,118 citations

Bcl-2 initiates a new category of oncogenes: regulators of cell death

1992 • 1,078 citations

Expression of the protooncogene bcl-2 in the prostate and its association with emergence of androgen-independent prostate cancer.

1992 • 1,063 citations

Apoptosis

1993 • 972 citations

Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)

1991 • 876 citations

Bcl-2 initiates a new category of oncogenes: regulators of cell death

1992 • 860 citations

Programmed cell death: Apoptosis and oncogenesis

1991 • 856 citations

Prevention of Programmed Cell Death of Sympathetic Neurons by the bcl-2 Proto-Oncogene

1992 • 724 citations

Apoptosis and disease

1993 • 684 citations

bcl-2 Protein in Non-Small-Cell Lung Carcinoma

1993 • 684 citations

Expression of the bcl-2 oncogene protein is not specific for the 14;18 chromosomal translocation.

1990 • 622 citations

In situ end‐labelling detects DNA strand breaks in apoptosis and other physiological and pathological states

1993 • 584 citations

Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations.

1993 • 565 citations

The Bcl-2 Protein: a Prognostic Indicator Strongly Related to p53 Protein in Lymph Node-Negative Breast Cancer Patients

1994 • 461 citations

Apoptosis (the 1992 Frank Rose Memorial Lecture)

1993 • 447 citations

bcl-2 protein expression is widespread in the developing nervous system and retained in the adult PNS

1994 • 432 citations

Bcl-2 blocks p53-dependent apoptosis.

1994 • 371 citations

The clinical assessment of proliferation and growth in human tumours: Evaluation of methods and applications as prognostic variables

1990 • 341 citations

Expression of bcl-2 in fetal tissues suggests a role in morphogenesis.

1993 • 320 citations

Mechanisms of Apoptosis: Integration of Genetic, Biochemical, and Cellular Indicators

1994 • 320 citations

The p53 Gene and Protein in Human Brain Tumors

1994 • 303 citations

Multiple subcellular localization of bcl-2: detection in nuclear outer membrane, endoplasmic reticulum membrane, and mitochondrial membranes.

1994 • 290 citations

Oncogenes and cell death

1994 • 266 citations

BCL‐2 expression in adult and embryonic non‐haematopoietic tissues

1993 • 265 citations

Expression of the apoptosis-suppressing protein bcl-2, in neuroblastoma is associated with unfavorable histology and N-myc amplification.

1993 • 262 citations

Correlations between apoptotic and proliferative indices in malignant non-Hodgkin's lymphomas.

1993 • 222 citations

Differential expression of bcl2 protooncogene in neuroblastoma and other human tumor cell lines of neural origin.

1991 • 222 citations

A Study of Apoptosis in Normal and Pathologic Nervous Tissue After In situ End-Labeling of DNA Strand Breaks

1994 • 205 citations

The bcl-2 gene is rearranged in many diffuse B-cell lymphomas

1988 • 173 citations

The regulation of p53 function: Steiner award lecture

1994 • 145 citations

Apoptosis is inversely related to necrosis and determines net growth in tumors bearing constitutively expressed myc, ras, and HPV oncogenes.

1994 • 140 citations

Accumulation of wild type p53 protein in human astrocytomas.

1993 • 127 citations

Bcl‐2 protein expression in carcinomas originating from the follicular epithelium of the thyroid gland

1994 • 126 citations

Actual growth rate and tumour cell proliferation in human pulmonary neoplasms

1984 • 96 citations

Human gliomas with wild-type p53 express bcl-2.

1995 • 94 citations

bcl-2 protein expression in tumors of the central nervous system

1994 • 76 citations

Tumor cell proliferation and apoptosis in medulloblastoma

1994 • 67 citations

Expression of the p53 protein in a spectrum of astrocytic tumours

1992 • 47 citations

Expression of bcl‐2 gene product in neuroblastoma

1994 • 44 citations