Roles of phospholipid signaling in chemoattractant-induced responses

Inositol phosphates and cell signalling

1989 • 4,058 citations

Chemokines

2000 • 3,773 citations

Human Chemokines: An Update

1997 • 2,235 citations

NADPH Oxidase: An Update

1999 • 2,134 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1995 • 1,499 citations

The Molecular Biology of Leukocyte Chemoattractant Receptors

1994 • 1,224 citations

Central Role for G Protein-Coupled Phosphoinositide 3-Kinase γ in Inflammation

2000 • 1,209 citations

Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration

2000 • 1,031 citations

Polarization of Chemoattractant Receptor Signaling During Neutrophil Chemotaxis

2000 • 892 citations

Regulation of Phosphoinositide-specific Phospholipase C Isozymes

1997 • 866 citations

Roles of PLC-β2 and -β3 and PI3Kγ in Chemoattractant-Mediated Signal Transduction

2000 • 825 citations

Characterization of Rac and Cdc42 Activation in Chemoattractant-stimulated Human Neutrophils Using a Novel Assay for Active GTPases

1999 • 765 citations

Regulation of Phagocyte Oxygen Radical Production by the GTP-Binding Protein Rac 2

1991 • 669 citations

Isozyme-selective stimulation of phospholipase C-β2 by G protein βγ-subunits

1992 • 630 citations

G Protein Signaling Events Are Activated at the Leading Edge of Chemotactic Cells

1998 • 626 citations

Deficiency of the Hematopoietic Cell-Specific Rho Family GTPase Rac2 Is Characterized by Abnormalities in Neutrophil Function and Host Defense

1999 • 568 citations

The Gβγ Sensitivity of a PI3K Is Dependent upon a Tightly Associated Adaptor, p101

1997 • 549 citations

Chemoattractant signaling and leukocyte activation

1995 • 510 citations

Subunits βγ of heterotrimeric G protein activate β2 isoform of phospholipase C

1992 • 506 citations

Regulation of purified subtypes of phosphatidylinositol-specific phospholipase C beta by G protein alpha and beta gamma subunits

1993 • 444 citations

G protein-coupled signal transduction pathways for interleukin-8

1993 • 385 citations

Activation of phospholipase C by the alpha subunits of the Gq and G11 proteins in transfected Cos-7 cells.

1992 • 321 citations

Interleukin 8-stimulated phosphatidylinositol-3-kinase activity regulates the migration of human neutrophils independent of extracellular signal-regulated kinase and p38 mitogen-activated protein kinases

1997 • 314 citations

Chemokines and tissue injury.

1995 • 303 citations

Localization of the G Protein βγ Complex in Living Cells During Chemotaxis

2000 • 284 citations

Receptors induce chemotaxis by releasing the βγ subunit of G _i , not by activating G _q or G _s

1997 • 276 citations

Chemoattractant Receptor Cross-desensitization

1999 • 275 citations

Wortmannin binds specifically to 1-phosphatidylinositol 3-kinase while inhibiting guanine nucleotide-binding protein-coupled receptor signaling in neutrophil leukocytes.

1994 • 212 citations

Selective G Protein Coupling by C-C Chemokine Receptors

1996 • 191 citations

Phospholipase Cβ4 is specifically involved in climbing fiber synapse elimination in the developing cerebellum

1998 • 186 citations

Activation of neutrophil leukocytes: chemoattractant receptors and respiratory burst ¹

1993 • 184 citations

Investigation of neutrophil signal transduction using a specific inhibitor of phosphatidylinositol 3-kinase.

1995 • 184 citations

Comparison of the roles of mitogen-activated protein kinase kinase and phosphatidylinositol 3-kinase signal transduction in neutrophil effector function

1998 • 173 citations

Phosphoinositide 3-Kinase-dependent and -independent Activation of the Small GTPase Rac2 in Human Neutrophils

1999 • 172 citations

Chemotaxis in a lymphocyte cell line transfected with C-C chemokine receptor 2B: Evidence that directed migration is mediated by βγ dimers released by activation of G_αi-coupled receptors

1997 • 158 citations

Genetic alteration of phospholipase C β3 expression modulates behavioral and cellular responses to μ opioids

1999 • 148 citations

Roles of phospholipase C β2 in chemoattractant-elicited responses

1997 • 143 citations

Pertussis Toxin-sensitive Activation of Phospholipase C by the C5a and fMet-Leu-Phe Receptors

1996 • 139 citations

Phospholipase C β4 is involved in modulating the visual response in mice

1996 • 127 citations

A Tyrosine Kinase Signaling Pathway Accounts for the Majority of Phosphatidylinositol 3,4,5-Trisphosphate Formation in Chemoattractant-stimulated Human Neutrophils

1996 • 115 citations

Attachment to fibronectin or vitronectin makes human neutrophil migration sensitive to alterations in cytosolic free calcium concentration.

1991 • 113 citations

PI 3-Kinase-Dependent and Independent Chemotaxis of Human Neutrophil Leukocytes

1995 • 99 citations

Activation of phosphatidylinositol lipid‐specific phospholipase C‐β₃ by G‐protein βγ subunits

1993 • 81 citations

The translocation of respiratory burst oxidase components from cytosol to plasma membrane is regulated by guanine nucleotides and diacylglycerol.

1992 • 61 citations

Neutrophil migration across monolayers of resting or cytokine-activated endothelial cells. Role of intracellular calcium changes and fusion of specific granules with the plasma membrane.

1992 • 54 citations

Intracellular Signalling: PI 3-kinase puts GTP on the Rac

1995 • 53 citations

Effects of buffering intracellular free calcium on neutrophil migration through three-dimensional matrices

1997 • 45 citations

Receptors and Intracellular Signaling in Human Neutrophils

1990 • 44 citations

G‐Protein Coupled Receptor‐Mediated Activation of PI 3‐Kinase in Neutrophils^a

1997 • 34 citations

Small G proteins and the neutrophil NADPH oxidase

1995 • 33 citations

Activation factors of neutrophil NADPH oxidase complex

1994 • 33 citations

Two For-Met–Leu–Phe-OMe analogues trigger selective neutrophil responses

1997 • 30 citations

Transient increase of free cytosolic calcium during neutrophil motility responses

1997 • 28 citations

The role of calcium in neutrophil migration: The effect of calcium and calcium-antagonists in electroporated neutrophils

1992 • 27 citations

Neutrophil F-actin and myosin but not microtubules functionally regulate transepithelial migration induced by interleukin 8 across a cultured intestinal epithelial monolayer.

1999 • 23 citations

Random migration of polymorphonuclear leukocytes induced by GM-CSF involving a signal transduction pathway different from that of fMLP

1997 • 22 citations

Deleted Work

1955 • 0 citations