Cell senescence and cancer

The Hallmarks of Cancer

2000 • 27,569 citations

Oxidants, oxidative stress and the biology of ageing

2000 • 8,990 citations

The serial cultivation of human diploid cell strains

1961 • 7,886 citations

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

1994 • 7,043 citations

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

1995 • 6,950 citations

Oxidants, antioxidants, and the degenerative diseases of aging.

1993 • 6,011 citations

The limited in vitro lifetime of human diploid cell strains

1965 • 5,595 citations

Telomeres shorten during ageing of human fibroblasts

1990 • 5,530 citations

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

1997 • 4,870 citations

Extension of Life-Span by Introduction of Telomerase into Normal Human Cells

1998 • 4,845 citations

Mammalian Telomeres End in a Large Duplex Loop

1999 • 2,372 citations

Creation of human tumour cells with defined genetic elements

1999 • 2,333 citations

Telomere length predicts replicative capacity of human fibroblasts.

1992 • 2,209 citations

Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.

1992 • 2,096 citations

Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA

1997 • 2,086 citations

TRF2 Protects Human Telomeres from End-to-End Fusions

1998 • 1,679 citations

Telomere reduction in human colorectal carcinoma and with ageing

1990 • 1,672 citations

Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging

2001 • 1,584 citations

Role of the INK4a Locus in Tumor Suppression and Cell Mortality

1996 • 1,580 citations

Multiple Intestinal Neoplasia Caused by a Mutation in the Murine Homolog of the APC Gene

1992 • 1,510 citations

Carcinoma-associated fibroblasts stimulate tumor progression of initiated human epithelium

2000 • 1,445 citations

Telomere states and cell fates

2000 • 1,359 citations

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

1999 • 1,326 citations

Essential role of mouse telomerase in highly proliferative organs

1998 • 1,256 citations

Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines

1997 • 1,244 citations

Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells

1998 • 1,206 citations

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.

1994 • 1,165 citations

The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability

2001 • 1,161 citations

Somatic activation of the K-ras oncogene causes early onset lung cancer in mice

2001 • 1,145 citations

A telomerase component is defective in the human disease dyskeratosis congenita

1999 • 1,135 citations

Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age.

1994 • 1,133 citations

Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

2000 • 1,077 citations

p53- and ATM-Dependent Apoptosis Induced by Telomeres Lacking TRF2

1999 • 1,076 citations

Inhibition of telomerase limits the growth of human cancer cells

1999 • 1,032 citations

Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span

1998 • 1,001 citations

p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis

1999 • 969 citations

Oncogenes, antioncogenes, and the molecular bases of multistep carcinogenesis.

1989 • 961 citations

The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita

2001 • 955 citations

The age of cancer

2000 • 949 citations

Molecular Biology of Aging

1999 • 877 citations

Direct activation of TERT transcription by c-MYC

1999 • 871 citations

Telomerase activation by the E6 gene product of human papillomavirus type 16

1996 • 825 citations

Pharmacological Rescue of Mutant p53 Conformation and Function

1999 • 794 citations

Control of Human Telomere Length by TRF1 and TRF2

2000 • 753 citations

Cellular Senescence

2000 • 743 citations

Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes.

1993 • 743 citations

Correlation Between Deoxyribonucleic Acid Excision-Repair and Life-Span in a Number of Mammalian Species

1974 • 738 citations

A role for both RB and p53 in the regulation of human cellular senescence*1

1991 • 737 citations

Developmental and tissue-specific regulation of mouse telomerase and telomere length.

1995 • 686 citations

Myc activates telomerase

1998 • 650 citations

Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells.

1994 • 617 citations

Rescuing the function of mutant p53

2001 • 563 citations

The relationship between in vitro cellular aging and in vivo human age.

1976 • 559 citations

Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes

2001 • 552 citations

Relationship between donor age and the replicative lifespan of human cells in culture: A reevaluation

1998 • 547 citations

Telomere dysfunction and evolution of intestinal carcinoma in mice and humans

2001 • 525 citations

Telomerase activity in the regenerative basal layer of the epidermis inhuman skin and in immortal and carcinoma-derived skin keratinocytes.

1996 • 494 citations

Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts

1998 • 481 citations

Disease states associated with telomerase deficiency appear earlier in mice with short telomeres

1999 • 462 citations

Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions

2001 • 448 citations

Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation

1999 • 404 citations

Telomerase activity: a prevalent marker of malignant human prostate tissue.

1996 • 394 citations

Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology

2000 • 393 citations

Expression of TERT in early premalignant lesions and a subset of cells in normal tissues

1998 • 386 citations

Telomere Dysfunction Increases Mutation Rate and Genomic Instability

2001 • 377 citations

Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes

2001 • 374 citations

Short Dysfunctional Telomeres Impair Tumorigenesis in the INK4aΔ2/3 Cancer-Prone Mouse

1999 • 373 citations

Functional Characterization and Developmental Regulation of Mouse Telomerase RNA

1995 • 366 citations

Regulation of Telomerase Activity in Immortal Cell Lines

1996 • 360 citations

Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis

2000 • 346 citations

Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation

1998 • 332 citations

Telomere Length Dynamics and Chromosomal Instability in Cells Derived from Telomerase Null Mice

1999 • 322 citations

A critical role for telomeres in suppressing and facilitating carcinogenesis

2000 • 314 citations

Expression of human telomerase subunits and correlation with telomerase activity in cervical cancer.

1998 • 301 citations

Differential regulation of telomerase activity and telomerase RNA during multi-stage tumorigenesis

1996 • 291 citations

Mechanism of Telomerase Induction during T Cell Activation

1996 • 291 citations

Transgenic Models of Tumor Development

1991 • 289 citations

Telomerase reverse transcriptase promotes cardiac muscle cell proliferation, hypertrophy, and survival

2001 • 285 citations

Differentiation of immortal cells inhibits telomerase activity.

1995 • 269 citations

Cytotoxic T cell immunity against telomerase reverse transcriptase in humans

2000 • 259 citations

Telomeres Do D-Loop–T-Loop

1999 • 258 citations

Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1

1991 • 257 citations

Replicative senescence of human skin fibroblasts correlates with a loss of regulation and overexpression of collagenase activity

1989 • 237 citations

The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo

2000 • 235 citations

Telomerase Activation by Human Papillomavirus Type 16 E6 Protein: Induction of Human Telomerase Reverse Transcriptase Expression through Myc and GC-Rich Sp1 Binding Sites

2001 • 234 citations

Inactivation of p16 in Human Mammary Epithelial Cells by CpG Island Methylation

1998 • 231 citations

Lack of Replicative Senescence in Cultured Rat Oligodendrocyte Precursor Cells

2001 • 229 citations

Cooperating oncogenes converge to regulate cyclin/cdk complexes.

1997 • 229 citations

Mammalian telomeres and telomerase

2000 • 227 citations

Expression of mouse telomerase catalytic subunit in embryos and adult tissues

1998 • 216 citations

Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation

2001 • 210 citations

Lack of Replicative Senescence in Normal Rodent Glia

2001 • 182 citations

Cellular delivery of peptide nucleic acids and inhibition of human telomerase

1999 • 171 citations

Severe growth defect in mouse cells lacking the telomerase RNA component

1998 • 159 citations

Frequent amplification of the telomerase reverse transcriptase gene in human tumors.

2000 • 157 citations

Impaired germinal center reaction in mice with short telomeres

2000 • 149 citations

Telomerase inhibition by peptide nucleic acids reverses `immortality' of transformed human cells

1999 • 137 citations

Telomerase activity in normal and malignant murine tissues.

1995 • 126 citations

Mice without telomerase: what can they teach us about human cancer?

2000 • 125 citations

INK4a gene expression and methylation in primary breast cancer: overexpression of p16INK4a messenger RNA is a marker of poor prognosis.

2000 • 119 citations

Telomere biology in human aging and aging syndromes

2001 • 112 citations

Presence of telomeric G‐strand tails in the telomerase catalytic subunit TERT knockout mice

1999 • 105 citations

Isothiazolone Derivatives Selectively Inhibit Telomerase from Human and Rat Cancer Cells in Vitro

1999 • 87 citations

Telomerase activity in benign endometrium and endometrial carcinoma.

1997 • 74 citations

Dyskeratosis congenita, telomeres and human ageing

2000 • 73 citations

Detection of human telomerase reverse transcriptase messenger RNA in voided urine samples as a useful diagnostic tool for bladder cancer.

1998 • 69 citations

Modeling chromosomal instability and epithelial carcinogenesis in the telomerase-deficient mouse

2001 • 62 citations

p19^ARF‐independent induction of p53 and cell cycle arrest by Raf in murine keratinocytes

2001 • 59 citations

Ras versus cyclin-dependent kinase inhibitors

1998 • 55 citations

Partial transformation of human thyroid epithelial cells by mutant Ha-ras oncogene.

1990 • 41 citations

Ageing hard or hardly ageing?

1999 • 35 citations