THE MECHANISMS BY WHICH GROWTH HORMONE BRINGS ABOUT GROWTH

Insulin-Like Growth Factors and Their Binding Proteins: Biological Actions*

1995 • 4,419 citations

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

1993 • 2,880 citations

Role of insulin-like growth factors in embryonic and postnatal growth

1993 • 2,349 citations

Insulin-like growth factors and their binding proteins: biological actions

1995 • 1,976 citations

Insulin-Like Growth Factors I and II. Peptide, Messenger Ribonucleic Acid and Gene Structures, Serum, and Tissue Concentrations*

1989 • 1,796 citations

Parental imprinting of the mouse insulin-like growth factor II gene

1991 • 1,773 citations

The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin.

1978 • 1,530 citations

Dramatic growth of mice that develop from eggs microinjected with metallothionein–growth hormone fusion genes

1982 • 1,338 citations

Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1

1990 • 1,211 citations

A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro. 1956.

1990 • 1,075 citations

Insulin-like growth factor II receptor as a multifunctional binding protein

1987 • 858 citations

Somatomedin: Proposed Designation for Sulphation Factor

1972 • 840 citations

Primary structure of human insulin‐like growth factor II

1978 • 776 citations

Insulin-like Growth Factor Binding Proteins

1993 • 754 citations

Introns increase transcriptional efficiency in transgenic mice.

1988 • 733 citations

Metallothionein-Human GH Fusion Genes Stimulate Growth of Mice

1983 • 699 citations

Role of insulin-like growth factors in embryonic and postnatal growth

1993 • 644 citations

Insulin-like growth factor I stimulates growth in hypophysectomized rats

1982 • 605 citations

Mechanism of the Stimulatory Effect of Growth Hormone on Longitudinal Bone Growth*

1987 • 580 citations

Binding proteins for the insulin-like growth factors: Structure, regulation and function

1989 • 565 citations

Growth Hormone Stimulates Longitudinal Bone Growth Directly

1982 • 524 citations

A dual effector theory of growth-hormone action

1985 • 512 citations

Growth Enhancement of Transgenic Mice Expressing Human Insulin-Like Growth Factor I*

1988 • 481 citations

Growth Hormone (GH) Insensitivity Due to Primary GH Receptor Deficiency

1994 • 466 citations

A Specific Radioimmunoassay for the Growth Hormone (GH)-Dependent Somatomedin-Binding Protein: Its Use for Diagnosis of GH Deficiency

1990 • 460 citations

Serum levels of insulin-like growth factor I (IGF-I) and IGF binding protein 3 reflect spontaneous growth hormone secretion.

1993 • 391 citations

Reduction of Plasma Immunoreactive Somatomedin C during Fasting in Humans*

1981 • 369 citations

Insulin-Like Growth Factor Binding Proteins in Maternal Serum Throughout Gestation and in the Puerperium: Effects of a Pregnancy-Associated Serum Protease Activity*

1990 • 368 citations

Insulin-like growth factor-binding protein from human plasma. Purification and characterization.

1986 • 343 citations

Enhancement of the anabolic effects of growth hormone and insulin-like growth factor I by use of both agents simultaneously.

1993 • 336 citations

Demonstration of receptors for insulin-like growth factor binding protein-3 on Hs578T human breast cancer cells.

1993 • 317 citations

High molecular weight insulin-like growth factor binding protein complex

1989 • 315 citations

Regulation by Growth Hormone of Number of Chondrocytes Containing IGF-I in Rat Growth Plate

1986 • 314 citations

Evidence suggesting that the direct growth-promoting effect of growth hormone on cartilage in vivo is mediated by local production of somatomedin.

1986 • 310 citations

CELL DIVISION IN ENDOCHONDRAL OSSIFICATION

1960 • 270 citations

Expression of human growth hormone-releasing factor in transgenic mice results in increased somatic growth

1985 • 260 citations

Serum levels of insulin-like growth factor I (IGF-I) and IGF binding protein 3 reflect spontaneous growth hormone secretion

1993 • 223 citations

Recombinant human insulin-like growth factor I induces its own specific carrier protein in hypophysectomized and diabetic rats.

1989 • 221 citations

Insulin-like growth factors I and II in evaluation of growth retardation

1986 • 220 citations

Dramatic Pituitary Hyperplasia in Transgenic Mice Expressing a Human Growth Hormone-Releasing Factor Gene

1988 • 220 citations

Differential effects of insulin-like growth factor I and growth hormone on developmental stages of rat growth plate chondrocytes in vivo.

1994 • 205 citations

The induction of a specific protease for insulin-like growth factor binding protein-3 in the circulation during severe illness

1991 • 199 citations

Administration of Growth Hormone to Patients with Familial Dwarfism with High Plasma Immunoreactive Growth Hormone: Measurement of Sulfation Factor, Metabolic and Linear Growth Responses

1971 • 197 citations

SULFATION FACTOR ACTIVITY OF SERA FROM PATIENTS WITH PITUITARY DISORDERS*

1959 • 196 citations

Clinical features and endocrine status in patients with growth hormone insensitivity (Laron syndrome).

1993 • 196 citations

Expression of Insulin-Like Growth Factor I Stimulates Normal Somatic Growth in Growth Hormone-Deficient Transgenic Mice

1990 • 195 citations

The Generation of Insulin-Like Growth Factor-1—Sensitive Cells by Growth Hormone Action

1986 • 192 citations

Molecular Forms of Serum Insulin-Like Growth Factor (IGF)-Binding Proteins in Man: Relationships with Growth Hormone and IGFs and Physiological Significance*

1989 • 190 citations

Serum Immunoreactive Somatomedin Levels in Normal Adults, Pregnant Women at Term, Children at Various Ages, and Children with Constitutionally Delayed Growth*

1981 • 181 citations

Insulin-like growth factor-binding protein-3 proteolysis is induced after elective surgery.

1992 • 172 citations

Local Injections of Human or Rat Growth Hormone or of Purified Human Somatomedin-C Stimulate Unilateral Tibial Epiphyseal Growth in Hypophysectomized Rats*

1985 • 170 citations

Cellular localization and regulation of gene expression for components of the insulin-like growth factor ternary binding protein complex.

1994 • 166 citations

Growth hormone induces multiplication of the slowly cycling germinal cells of the rat tibial growth plate.

1992 • 150 citations

Insulin-Like Growth Factor-I (IGF-I) Infusion into Hypophysectomized or Protein-Deprived Rats Induces Specific IGF-Binding Proteins in Serum*

1989 • 143 citations

Effects of Prolonged Dopamine Infusion on Anterior Pituitary Function in Normal Males*

1981 • 142 citations

Prenatal expression of the growth hormone (GH) receptor/binding protein in the rat: a role for GH in embryonic and fetal development?

1992 • 141 citations

Synchronous activation of DNA synthesis in hypophysectomized rat cartilage by growth hormone.

1966 • 138 citations

Mutation creating a new splice site in the growth hormone receptor genes of 37 Ecuadorean patients with Laron syndrome

1992 • 134 citations

Hormonal and metabolic effects and pharmacokinetics of recombinant insulin-like growth factor-I in growth hormone receptor deficiency/Laron syndrome.

1993 • 126 citations

A randomized, double blind, placebo-controlled trial on safety and efficacy of recombinant human insulin-like growth factor-I in children with growth hormone receptor deficiency.

1995 • 126 citations

Plasma Somatomedin-Binding Proteins in Hypopituitarism: Changes during Growth Hormone Therapy*

1981 • 123 citations

The Ontogeny of Growth Hormone Receptors in the Rabbit Tibia*

1988 • 121 citations

Recombinant human insulin-like growth factor: testing the somatomedin hypothesis in hypophysectomized rats

1987 • 115 citations

Differential Effects of Growth Hormone and Insulin-Like Growth Factor I on Colony Formation of Epiphyseal Chondrocytes in Suspension Culture in Rats of Different Ages*

1987 • 112 citations

QUANTATIVE DETERMINATION OF THE SULPHATION FACTOR ACTIVITY IN HUMAN SERUM

1970 • 112 citations

Consequences of postnatally elevated insulin-like growth factor-II in transgenic mice: endocrine changes and effects on body and organ growth.

1994 • 108 citations

Regulation by GH of insulin-like growth factor-I mRNA expression in rat epiphyseal growth plate as studied with in-situ hybridization

1990 • 107 citations

Clinical features and endocrine status in patients with growth hormone insensitivity (Laron syndrome)

1993 • 106 citations

The Stimulatory Effect of Growth Hormone, Prolactin, and Placental Lactogen on β-Cell Proliferation Is not Mediated by Insulin-Like Growth Factor-I

1991 • 105 citations

Growth hormone receptor deficiency in Ecuador: clinical and biochemical phenotype in two populations.

1993 • 100 citations

Differential cellular synthesis of insulin-like growth factor binding protein-1 (IGFBP-1) and IGFBP-3 within human liver.

1994 • 98 citations

Cell Kinetics and the Control of Growth In Long Bones

1978 • 95 citations

Insulin-Like Growth Factor I Improves Height in Growth Hormone Insensitivity: Two Years’ Results

1995 • 94 citations

Effects of growth hormone and insulin-like growth factor-I on colony formation of rabbit epiphyseal chondrocytes at different stages of maturation

1987 • 87 citations

Biosynthetic Somatomedin C (SM-C/IGF-I) Increases the Length and Weight of Snell Dwarf Mice

1986 • 83 citations

Regulation of Insulin-Like Growth Factor (IGF) Binding Proteins in Transgenic Mice with Altered Expression of Growth Hormone and IGF-I

1991 • 81 citations

Insulin-like growth factor I stimulates growth in normal growing rats

1986 • 79 citations

Effect of growth hormone and insulin-like growth factor-I on DNA synthesis and matrix production in rat epiphyseal chondrocytes in monolayer culture

1992 • 79 citations

Insulin-like growth factor-binding protein-3 proteolysis is induced after elective surgery

1992 • 78 citations

Growth hormone promotes the differentiation of myoblasts and preadipocytes generated by azacytidine treatment of 10T1/2 cells.

1984 • 72 citations

AN IMPROVED TECHNIQUE FOR MEASURING SOMATOMEDIN ACTIVITY IN VITRO

1974 • 72 citations

Is IGF binding protein‐3 assessment helpful for the diagnosis of GH deficiency?

1995 • 70 citations

Report On The Nomenclature Of The IGF Binding Proteins

1990 • 70 citations

Effects of tri-iodothyronine and insulin-like growth factor-I (IGF-I) on alkaline phosphatase activity, [3H]thymidine incorporation and IGF-I receptor mRNA in cultured rat epiphyseal chondrocytes

1992 • 64 citations

Pharmacokinetics of recombinant human insulin‐like growth factor I given subcutaneously to healthy volunteers and to patients with growth hormone receptor deficiency

1993 • 64 citations

Visual Demonstration of Growth Hormone Receptors on Human Growth Plate Chondrocytes*

1990 • 62 citations

The composition and distribution of insulin-like growth factors (IGFs) and IGF-binding proteins (IGFBPs) in the serum of growth hormone receptor-deficient patients: effects of IGF-I therapy on IGFBP-3.

1993 • 62 citations

Insulin‐Like Growth Factor Binding Proteins (IGFBPs) with Special Reference to IGFBPS

1990 • 57 citations

Cellular localization and regulation of gene expression for components of the insulin-like growth factor ternary binding protein complex

1994 • 57 citations

Consequences of postnatally elevated insulin-like growth factor-II in transgenic mice: endocrine changes and effects on body and organ growth

1994 • 55 citations

A randomized, double blind, placebo-controlled trial on safety and efficacy of recombinant human insulin-like growth factor-I in children with growth hormone receptor deficiency

1995 • 55 citations

The insulin-like growth factor (IGF)-binding proteins and IGF bioactivity in Laron-type dwarfism.

1992 • 53 citations

Hormonal and metabolic effects and pharmacokinetics of recombinant insulin-like growth factor-I in growth hormone receptor deficiency/Laron syndrome

1993 • 50 citations

Growth hormone (GH) receptors are expressed on human fetal mesenchymal tissues--identification of messenger ribonucleic acid and GH-binding protein.

1993 • 50 citations

Growth hormone receptor deficiency in Ecuador: clinical and biochemical phenotype in two populations

1993 • 49 citations

Insulin‐Like Growth Factor Receptors

1991 • 48 citations

Hormonal and other inherited growth disturbances in mice with special reference to the Snell dwarf mouse. A review.

1983 • 41 citations

Effects of continuous infusion of insulin-like growth factor I and II, alone and in combination with thyroxine or growth hormone, on the neonatal hypophysectomized rat.

1992 • 40 citations

Effect of dihydroergocristine administration on serum prolactin and growth hormone levels in normal, hyperprolactinaemic, and acromegalic subjects: further evidence for pituitary dopamine deficiency in these conditions

1983 • 39 citations

Differential cellular synthesis of insulin-like growth factor binding protein-1 (IGFBP-1) and IGFBP-3 within human liver

1994 • 37 citations

Expression of serum insulin-like growth factors, insulin-like growth factor-binding proteins, and the growth hormone-binding protein in heterozygote relatives of Ecuadorian growth hormone receptor deficient patients

1992 • 35 citations

Identification of growth hormone receptors on human growth plate chondrocytes

1993 • 31 citations

Growth hormone insensitivity syndromes: a preliminary report on changes in insulin-like growth factors and their binding proteins during treatment with recombinant insulin-like growth factor I

1993 • 30 citations

Long‐term effects of insulin‐like growth factor (IGF)‐I treatment on serum IGFs and IGF binding proteins in adolescent patients with growth hormone receptor deficiency

1995 • 28 citations

The composition and distribution of insulin-like growth factors (IGFs) and IGF-binding proteins (IGFBPs) in the serum of growth hormone receptor-deficient patients: effects of IGF-I therapy on IGFBP-3

1993 • 27 citations

Expression of serum insulin-like growth factors, insulin-like growth factor-binding proteins, and the growth hormone-binding protein in heterozygote relatives of Ecuadorian growth hormone receptor deficient patients

1992 • 26 citations

Characterization of specific insulin-like growth factor (IGF)-I and IGF-II receptors on cultured rabbit articular chondrocyte membranes

1989 • 24 citations

Effects of continuous infusion of insulin-like growth factor I and II, alone and in combination with thyroxine or growth hormone, on the neonatal hypophysectomized rat

1992 • 22 citations

A double-staining technique for detection of growth hormone and insulin-like growth factor-I binding to rat tibial epiphyseal chondrocytes

1993 • 22 citations

Growth hormone (GH) receptors are expressed on human fetal mesenchymal tissues--identification of messenger ribonucleic acid and GH-binding protein

1993 • 21 citations

Report on the nomenclature of the IGF binding proteins

1992 • 20 citations