Growth hormone insensitivity syndromes: a preliminary report on changes in insulin-like growth factors and their binding proteins during treatment with recombinant insulin-like growth factor I

Characterization of the human growth hormone receptor gene and demonstration of a partial gene deletion in two patients with Laron-type dwarfism.

1989 • 586 citations

Radioimmunoassay of growth hormone-dependent insulinlike growth factor binding protein in human plasma.

1986 • 524 citations

Insulin-like growth factors I and II in healthy man.

1989 • 513 citations

A Specific Radioimmunoassay for the Growth Hormone (GH)-Dependent Somatomedin-Binding Protein: Its Use for Diagnosis of GH Deficiency

1990 • 460 citations

Synthesis and Secretion of Insulin-Like Growth Factor and Its Binding Protein by the Perfused Rat Liver: Dependence on Growth Hormone Status^*

1983 • 447 citations

Serum levels of insulin-like growth factor I (IGF-I) and IGF binding protein 3 reflect spontaneous growth hormone secretion.

1993 • 391 citations

Insulin‐Like Growth Factors I and II: Some Biological Actions and Receptor Binding Characteristics of Two Purified Constituents of Nonsuppressible Insulin‐Like Activity of Human Serum

1978 • 384 citations

Structure of the Mr 140,000 growth hormone-dependent insulin-like growth factor binding protein complex: determination by reconstitution and affinity-labeling.

1989 • 308 citations

Circulating Levels and Molecular Distribution of the Acid-Labile (α) Subunit of the High Molecular Weight Insulin-Like Growth Factor-Binding Protein Complex*

1990 • 259 citations

Serum levels of insulin-like growth factor I (IGF-I) and IGF binding protein 3 reflect spontaneous growth hormone secretion

1993 • 223 citations

Growth hormone resistance and inhibition of somatomedin activity by excess of insulin-like growth factor binding protein in uraemia

1991 • 212 citations

Clinical features and endocrine status in patients with growth hormone insensitivity (Laron syndrome).

1993 • 196 citations

Molecular Forms of Serum Insulin-Like Growth Factor (IGF)-Binding Proteins in Man: Relationships with Growth Hormone and IGFs and Physiological Significance*

1989 • 190 citations

Regulation of binding proteins for insulin-like growth factors (IGF) in humans. Increased expression of IGF binding protein 2 during IGF I treatment of healthy adults and in patients with extrapancreatic tumor hypoglycemia.

1990 • 148 citations

A specific radioimmunoassay for insulin-like growth factor II: the interference of IGF binding proteins can be blocked by excess IGF-I

1988 • 147 citations

Insulin-Like Growth Factor-I (IGF-I) Infusion into Hypophysectomized or Protein-Deprived Rats Induces Specific IGF-Binding Proteins in Serum*

1989 • 143 citations

Clinical studies of IGFBP-2 by radioimmunoassay.

1993 • 138 citations

Clinical features and endocrine status in patients with growth hormone insensitivity (Laron syndrome)

1993 • 106 citations

Evaluation of the Growth Hormone-Binding Proteins in Human Plasma Using High Pressure Liquid Chromatography Gel Filtration*

1990 • 97 citations

Recurrent nonsense mutations in the growth hormone receptor from patients with Laron dwarfism.

1991 • 97 citations

Serum levels of the low molecular weight form of insulin-like growth factor binding protein in healthy subjects and patients with growth hormone deficiency, acromegaly and anorexia nervosa

1988 • 86 citations

Regulation of Insulin-Like Growth Factor (IGF) Binding Proteins in Transgenic Mice with Altered Expression of Growth Hormone and IGF-I

1991 • 81 citations

Insulin-like growth factor-binding protein-3 is functionally normal in pregnancy serum.

1992 • 73 citations

Long-term treatment of Laron type dwarfs with insulin-like growth factor-1 increases serum insulin-like growth factor-binding protein-3 in the absence of growth hormone activity

1993 • 59 citations

The insulin-like growth factor (IGF)-binding proteins and IGF bioactivity in Laron-type dwarfism.

1992 • 53 citations

IGF binding protein 3 in patients with Laron type dwarfism: effect of exogenous rIGF‐I

1992 • 51 citations

INSULIN-LIKE GROWTH FACTOR (IGF) BINDING PROTEIN-3 IN PREGNANCY SERUM BINDS NATIVE IGF-I BUT NOT IODO-IGF-L

1991 • 50 citations

Insulin-like growth factor-binding protein-3 is functionally normal in pregnancy serum

1992 • 45 citations

Hormonal regulation of growth

1990 • 44 citations

Responses of insulin-like growth factor binding protein-1 (IGFBP-1) and the IGFBP-3 complex to administration of insulin-like growth factor-I

1993 • 41 citations

The insulin-like growth factor (IGF)-binding proteins and IGF bioactivity in Laron-type dwarfism

1992 • 33 citations

Report on the nomenclature of the IGF binding proteins

1991 • 18 citations

Effects of recombinant insulin-like growth factor I on IGF binding proteins and the acid-labile subunit in growth hormone insensitivity syndrome.

1993 • 16 citations