Evidence suggesting that the direct growth-promoting effect of growth hormone on cartilage in vivo is mediated by local production of somatomedin.

Tissue concentrations of somatomedin C: further evidence for multiple sites of synthesis and paracrine or autocrine mechanisms of action.

1984 • 1,171 citations

A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro. 1956.

1990 • 1,075 citations

Insulin-like growth factor I stimulates growth in hypophysectomized rats

1982 • 605 citations

Growth Hormone Stimulates Longitudinal Bone Growth Directly

1982 • 524 citations

A dual effector theory of growth-hormone action

1985 • 512 citations

Mode of Action of Pituitary Growth Hormone on Target Cells

1985 • 452 citations

Evidence that somatomedin is synthesized by multiple tissues in the fetus

1980 • 434 citations

Hormonal Control of Immunoreactive Somatomedin Production by Cultured Human Fibroblasts

1981 • 323 citations

Evidence for a functional role of endogenously produced somatomedinlike peptides in the regulation of DNA synthesis in cultured human fibroblasts and porcine smooth muscle cells.

1985 • 257 citations

Growth hormone and the adipose conversion of 3T3 cells

1982 • 254 citations

Somatomedins

1980 • 247 citations

Effect of growth hormone on osteoblasts and demonstration of somatomedin-C/IGF I in bone organ culture

1984 • 178 citations

Local Injections of Human or Rat Growth Hormone or of Purified Human Somatomedin-C Stimulate Unilateral Tibial Epiphyseal Growth in Hypophysectomized Rats*

1985 • 170 citations

Relationship of somatomedin-C concentrations to pubertal changes

1983 • 167 citations

Release of Somatomedin-Like Activity by Cultured WI-38 Human Fibroblasts*

1980 • 162 citations

Growth hormone stimulates the proliferation of cultured chondrocytes from rabbit ear and rat rib growth cartilage

1983 • 150 citations

[1] Production of antibodies by inoculation into lymph nodes

1983 • 148 citations

Effects of Prolonged Dopamine Infusion on Anterior Pituitary Function in Normal Males*

1981 • 142 citations

Rate of normal longitudinal bone growth in the rat

1972 • 137 citations

Effects of local administration of GH and IGF-1 on longitudinal bone growth in rats

1986 • 136 citations

Contribution of Growth Hormone to the Adipogenic Activity of Serum*

1984 • 112 citations

Insulin - Like Growth Factors. Somatomedins

1983 • 86 citations

Variables controlling the secretion of a somatomedin-like peptide by cultured porcine smooth muscle cells.

1985 • 81 citations

A direct growth effect of growth hormone in rat hindlimb shown by arterial infusion

1986 • 70 citations

SPECIFIC BINDING OF GROWTH HORMONE TO ISOLATED CHONDROCYTES FROM RABBIT EAR AND EPIPHYSEAL PLATE

1983 • 69 citations

Activity of Human Growth Hormone and Related Polypeptides on the Adipose Conversion of 3T3 Cells

1984 • 67 citations

Identification and Characterization of Specific Growth Hormone Receptors in Cultured Human Fibroblasts*

1983 • 66 citations

Neonatal Rat Islet Cell Cultures Synthesize Insulin-like Growth Factor I

1985 • 65 citations

Recent advances in the biochemistry and physiology of the insulin-like growth factor/somatomedin family

1983 • 56 citations

Localizator! of IGF‐I in adult rats. Immunohistochemical studies

1986 • 55 citations

Growth hormone modulation of murine erythroleukemia cell growth in vitro.

1978 • 46 citations

GROWTH HORMONE POLYPEPTIDES STIMULATE PROLIFERATION OF K562 HUMAN ERYTHROLEUKEMIA CELLS

1980 • 25 citations

A Stereotaxic Approach to Transauricular Hypophysectomy in the Rat

1967 • 24 citations

Receptors for insulin-like growth factors in rabbit articular and growth plate chondrocytes in culture

1983 • 17 citations