A randomized, double blind, placebo-controlled trial on safety and efficacy of recombinant human insulin-like growth factor-I in children with growth hormone receptor deficiency.

RADIOGRAPHIC ATLAS OF SKELETAL DEVELOPMENT OF THE HAND AND WRIST

1959 • 5,245 citations

Growth hormone receptor and serum binding protein: purification, cloning and expression

1987 • 1,540 citations

Characterization of the human growth hormone receptor gene and demonstration of a partial gene deletion in two patients with Laron-type dwarfism.

1989 • 586 citations

Sequence of cDNA encoding human insulin-like growth factor I precursor

1983 • 401 citations

Genetic pituitary dwarfism with high serum concentation of growth hormone--a new inborn error of metabolism?

1966 • 342 citations

Effects of recombinant insulin-like growth factor I on insulin secretion and renal function in normal human subjects.

1989 • 320 citations

Laron Dwarfism and Mutations of the Growth Hormone–Receptor Gene

1989 • 304 citations

Insulinlike Growth Factor-Binding Proteins

1990 • 291 citations

Recombinant human insulin-like growth factor I induces its own specific carrier protein in hypophysectomized and diabetic rats.

1989 • 221 citations

Insulin-like growth factors I and II in evaluation of growth retardation

1986 • 220 citations

Effects of insulin-like growth factor on linear growth, head circumference, and body fat in patients with Laron-type dwarfism

1992 • 206 citations

The Little Women of Loja — Growth Hormone–Receptor Deficiency in an Inbred Population of Southern Ecuador

1990 • 158 citations

Insulin-Like Growth Factor-I (IGF-I) Infusion into Hypophysectomized or Protein-Deprived Rats Induces Specific IGF-Binding Proteins in Serum*

1989 • 143 citations

Effects of the Infusion of Insulin-like Growth Factor I in a Child with Growth Hormone Insensitivity Syndrome (Laron Dwarfism)

1991 • 141 citations

Measurement and characterization of insulin-like growth factor binding protein-3 in human biological fluids: discrepancies between radioimmunoassay and ligand blotting.

1992 • 139 citations

Mutation creating a new splice site in the growth hormone receptor genes of 37 Ecuadorean patients with Laron syndrome

1992 • 134 citations

Hormonal and metabolic effects and pharmacokinetics of recombinant insulin-like growth factor-I in growth hormone receptor deficiency/Laron syndrome.

1993 • 126 citations

Diverse growth hormone receptor gene mutations in Laron syndrome.

1993 • 125 citations

Insulin-Like Growth Factor Binding Proteins: Structural and Molecular Relationships

1991 • 120 citations

Growth hormone receptor deficiency in Ecuador: clinical and biochemical phenotype in two populations.

1993 • 100 citations

Recurrent nonsense mutations in the growth hormone receptor from patients with Laron dwarfism.

1991 • 97 citations

Stimulation of statural growth by recombinant insulin-like growth factor I in a child with growth hormone insensitivity syndrome (Laron type)

1992 • 85 citations

Chemical Synthesis, Cloning, and Expression of Genes for Human Somatomedin C (Insulin‐like Growth Factor I) and ⁵⁹Val‐Somatomedin C

1986 • 67 citations

Pharmacokinetics of recombinant human insulin‐like growth factor I given subcutaneously to healthy volunteers and to patients with growth hormone receptor deficiency

1993 • 64 citations

IGF binding protein 3 in patients with Laron type dwarfism: effect of exogenous rIGF‐I

1992 • 51 citations

Treatment with recombinant human insulin-like growth factor I of children with growth hormone receptor deficiency (Laron syndrome). Kabi Pharmacia Study Group on Insulin-like Growth Factor I Treatment in Growth Hormone Insensitivity Syndromes.

1992 • 45 citations

Effects of continuous infusion of insulin-like growth factor I and II, alone and in combination with thyroxine or growth hormone, on the neonatal hypophysectomized rat.

1992 • 40 citations

Long‐term effects of insulin‐like growth factor (IGF)‐I treatment on serum IGFs and IGF binding proteins in adolescent patients with growth hormone receptor deficiency

1995 • 28 citations

Repeated sc administration of recombinant human insulin-like growth factor I (IGF-I) to human subjects for 7 days.

1991 • 24 citations