Regulation of parathyroid hormone-related protein (PTHrP) gene expression. Sp1 binds through an inverted CACCC motif and regulates promoter activity in cooperation with Ets1.

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

A Parathyroid Hormone-Related Protein Implicated in Malignant Hypercalcemia: Cloning and Expression

1987 • 1,293 citations

A G Protein-Linked Receptor for Parathyroid Hormone and Parathyroid Hormone-Related Peptide

1991 • 1,230 citations

A cooperative interaction between NF-kappa B and Sp1 is required for HIV-1 enhancer activation.

1993 • 480 citations

Different activation domains of Sp1 govern formation of multimers and mediate transcriptional synergism.

1991 • 437 citations

Interaction of murine ets-1 with GGA-binding sites establishes the ETS domain as a new DNA-binding motif.

1992 • 381 citations

Humoral Hypercalcemia of Cancer

1988 • 362 citations

Similarity of Synthetic Peptide from Human Tumor to Parathyroid Hormone in Vivo and in Vitro

1987 • 357 citations

The ets gene family

1992 • 308 citations

The beta-globin dominant control region: hypersensitive site 2.

1990 • 295 citations

Expression of Messenger Ribonucleic Acids Encoding a Parathyroid Hormone-Like Peptide in Normal Human and Animal Tissues with Abnormal Expression in Human Parathyroid Adenomas

1988 • 217 citations

Constitutive expression of parathyroid hormone-related protein gene in human T cell leukemia virus type 1 (HTLV-1) carriers and adult T cell leukemia patients that can be trans-activated by HTLV-1 tax gene.

1990 • 211 citations

Sp-1 binds promoter elements regulated by the RB protein and Sp-1-mediated transcription is stimulated by RB coexpression.

1993 • 203 citations

Transactivation of interleukin 2 and its receptor induces immune activation in human T-cell lymphotropic virus type I-associated myelopathy: pathogenic implications and a rationale for immunotherapy.

1990 • 194 citations

Temporal and tissue-specific expression of mouse ets genes.

1987 • 191 citations

The product of the c-ets-1 proto-oncogene and the related Ets2 protein act as transcriptional activators of the long terminal repeat of human T cell leukemia virus HTLV-1.

1990 • 189 citations

Characterization of the human parathyroid hormone-like peptide gene

1989 • 180 citations

Synergistic activation of the HTLV1 LTR Ets-responsive region by transcription factors Ets1 and Sp1.

1993 • 180 citations

Isolation and characterization of the human parathyroid hormone-like peptide gene.

1989 • 175 citations

Induction of Sp1-p53 DNA-binding heterocomplexes during granulocyte/macrophage colony-stimulating factor-dependent proliferation in human erythroleukemia cell line TF-1.

1993 • 151 citations

Enhanced growth of a human keratinocyte cell line induced by antisense RNA for parathyroid hormone-related peptide.

1992 • 133 citations

Expression of ets genes in mouse thymocyte subsets and T cells.

1989 • 128 citations

A novel cis-acting element controlling the rat CYP2D5 gene and requiring cooperativity between C/EBP beta and an Sp1 factor.

1994 • 117 citations

Cooperation of GATA-1 and Sp1 can result in synergistic transcriptional activation or interference.

1993 • 116 citations

Identification and preferential expression in thymic and bursal lymphocytes of a c-ets oncogene-encoded Mr 54,000 cytoplasmic protein.

1986 • 114 citations

Structure of the 5' flanking region of the gene encoding human parathyroid-hormone-related protein (PTHrP)

1989 • 110 citations

The proto-oncogene c-ets is preferentially expressed in lymphoid cells.

1985 • 98 citations

Identification and analysis of all components of a gel retardation assay by combination with immunoblotting.

1993 • 94 citations

Native and a synthetic analogue of the malignancy-associated parathyroid hormone-like protein have in vitro transforming growth factor-like properties.

1989 • 91 citations

Transforming growth factor β stimulation of parathyroid hormone-related protein (PTHrP): A paracrine regulator?

1993 • 90 citations

Evidence that the transcription factor USF is a component of the human beta-globin locus control region heteromeric protein complex.

1993 • 88 citations

Indirect binding of human T-cell leukemia virus type I tax1 to a responsive element in the viral long terminal repeat.

1989 • 85 citations

A 36-kilodalton cellular transcription factor mediates an indirect interaction of human T-cell leukemia/lymphoma virus type I TAX1 with a responsive element in the viral long terminal repeat.

1990 • 81 citations

High-affinity DNA-protein interactions of the cellular ETS1 protein: the determination of the ETS binding motif.

1991 • 78 citations

Sequence-specific interaction of the Ets1 protein with the long terminal repeat of the human T-lymphotropic virus type I

1991 • 75 citations

Discrimination Among Potential Activators of the β-Globin CACCC Element by Correlation of Binding and Transcriptional Properties

1993 • 74 citations

Transactivation of the P2 promoter of parathyroid hormone-related protein by human T-cell lymphotropic virus type I Tax1: evidence for the involvement of transcription factor Ets1

1993 • 72 citations

Parathyroid hormone-related protein a peptide of diverse physiologic functions

1993 • 68 citations

The htβ Gene Encodes a Novel CACCC Box-Binding Protein That Regulates T-Cell Receptor Gene Expression

1993 • 66 citations

Parathyroid hormone-related protein is a possible autocrine growth inhibitor for lymphocytes

1990 • 63 citations

Parathyroid hormone-related peptide is a downstream target for ras and src activation.

1994 • 59 citations

Cell-type-specific transactivation of the parathyroid hormone-related protein gene promoter by the human T-cell leukemia virus type I (HTLV- I) tax and HTLV-II tax proteins

1993 • 53 citations

22-Oxacalcitriol, a noncalcemic analogue of calcitriol, suppresses both cell proliferation and parathyroid hormone-related peptide gene expression in human T cell lymphotrophic virus, type I-infected T cells

1993 • 51 citations

A new regulatory element that augments the Tax-dependent enhancer of human T-cell leukemia virus type 1 and cloning of cDNAs encoding its binding proteins

1993 • 47 citations

Activation of the human T-cell leukemia virus type I enhancer is mediated by binding sites for Elf-1 and the pets factor

1993 • 41 citations

Parathyroid hormone‐related peptide can regulate the growth of human lung cancer cells, and may form part of an autocrine TGF‐α loop

1992 • 36 citations

Anomalous interaction of Sp1 and specific binding of an E‐box‐binding protein with the regulatory elements of the Na,K‐ATPase α2 subunit gene promoter

1993 • 35 citations

High expression of ets-1 gene in human thymocytes and immature T leukemic cells.

1988 • 33 citations

Transcriptional activation of the human T-lymphotropic virus type I long terminal repeat by functional interaction of Tax1 and Ets1

1993 • 33 citations

Interleukin-2 increases production and secretion of parathyroid hormone-related peptide by human T cell leukemia virus type I-infected T cells: possible role in hypercalcemia associated with adult T cell leukemia.

1993 • 31 citations

Parathyroid hormone-related peptide.

1993 • 28 citations

Growth factor-like properties of parathyroid hormone-related peptide in transfected rodent cell line.

1993 • 21 citations

Enhancing Effect of Interleukin‐2 on Production of Parathyroid Hormone‐related Protein by Adult T‐Cell Leukemia Cells

1993 • 9 citations