Hodgkin disease: pharmacologic intervention of the CD40-NFκB pathway by a protease inhibitor

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

1997 • 2,137 citations

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

1994 • 2,124 citations

Activation of interleukin-6 gene expression through the NF-kappa B transcription factor.

1990 • 1,377 citations

MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1

1997 • 1,294 citations

The CD40 Antigen and its Ligand

1994 • 1,259 citations

The Tumor Necrosis Factor Ligand and Receptor Families

1996 • 1,239 citations

TRAF2-Mediated Activation of NF-κB by TNF Receptor 2 and CD40

1995 • 1,046 citations

The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family

1995 • 990 citations

IκB-β regulates the persistent response in a biphasic activation of NF-κB

1995 • 780 citations

Tumor necrosis factor (TNF)-mediated kinase cascades: Bifurcation of Nuclear Factor-κB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2

1997 • 552 citations

Association of TRAF1, TRAF2, and TRAF3 with an Epstein-Barr Virus LMP1 Domain Important for B-Lymphocyte Transformation: Role in NF-κB Activation

1996 • 491 citations

Tumor necrosis factor ligand superfamily: involvement in the pathology of malignant lymphomas

1995 • 462 citations

Involvement of CRAF1, a relative of TRAF, in CD40 signaling

1995 • 454 citations

Fas ligation induces apoptosis of CD40-activated human B lymphocytes.

1995 • 402 citations

Cross-linking CD40 on B cells rapidly activates nuclear factor-kappa B.

1994 • 358 citations

TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling.

1996 • 339 citations

High-level nuclear NF-kappa B and Oct-2 is a common feature of cultured Hodgkin/Reed-Sternberg cells

1996 • 328 citations

CD40 ligation induces Apo-1/Fas expression on human B lymphocytes and facilitates apoptosis through the Apo-1/Fas pathway.

1995 • 285 citations

TANK, a co-inducer with TRAF2 of TNF- and CD 40L-mediated NF-kappaB activation.

1996 • 283 citations

Overexpression of I Kappa B Alpha Without Inhibition of NF-κB Activity and Mutations in the I Kappa B Alpha Gene in Reed-Sternberg Cells

1999 • 267 citations

Mode of inhibition of acid proteases by pepstatin.

1976 • 235 citations

Long-term inhibition of murine lupus by brief simultaneous blockade of the B7/CD28 and CD40/gp39 costimulation pathways.

1997 • 219 citations

Expression of functional CD40 antigen on Reed-Sternberg cells and Hodgkin's disease cell lines

1995 • 212 citations

I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction.

1996 • 210 citations

Cytochemical, immunologic, chromosomal, and molecular genetic analysis of a novel cell line derived from Hodgkin's disease

1986 • 171 citations

Defective IκBα in Hodgkin cell lines with constitutively active NF-κB

1998 • 129 citations

Human B cell precursors proliferate and express CD23 after CD40 ligation.

1993 • 123 citations

Reed-Sternberg Cell Genome Expression Supports a B-Cell Lineage

1999 • 114 citations

Assembly and Regulation of the CD40 Receptor Complex in Human B Cells

1997 • 101 citations

Specific association of activated MAP kinase kinase kinase (Raf) with the plasma membranes of ras-transformed retinal cells.

1993 • 98 citations

Differential Requirements for Tumor Necrosis Factor Receptor-associated Factor Family Proteins in CD40-mediated Induction of NF-κB and Jun N-terminal Kinase Activation

1999 • 98 citations

Expression and function of CD40 on Hodgkin and Reed-Sternberg cells and the possible relevance for Hodgkin's disease

1994 • 96 citations

Expression and function of Fas antigen on activated murine B cells

1996 • 81 citations

Gene Expression by Single Reed-Sternberg Cells: Pathways of Apoptosis and Activation

1998 • 64 citations

CD40L blockade prevents autoimmune encephalomyelitis and hampers TH1 but not TH2 pathway of T cell differentiation

1997 • 61 citations

Clonality and germinal centre B-cell derivation of Hodgkin/Reed–Sternberg cells in Hodgkin’s disease

1998 • 54 citations

CD40/CD40 Ligand Interactions in Normal, Reactive and Malignant Lympho-Hematopoietic Tissues

1997 • 46 citations

Reed-Sternberg cell: survival in a hostile sea.

1998 • 44 citations

The selectivity of statine-based inhibitors against various human aspartic proteinases

1990 • 41 citations

CD40-mediated signals inhibit the binding of TNF receptor-associated factor 2 to the CD40 cytoplasmic domain.

1997 • 24 citations