Clonality and germinal centre B-cell derivation of Hodgkin/Reed–Sternberg cells in Hodgkin’s disease

Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells.

1996 • 749 citations

Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections.

1993 • 691 citations

Hodgkin disease: Hodgkin and Reed-Sternberg cells picked from histological sections show clonal immunoglobulin gene rearrangements and appear to be derived from B cells at various stages of development.

1994 • 691 citations

Somatic hypermutation in normal and transformed human B cells

1998 • 351 citations

Origin of Nodular Lymphocyte-Predominant Hodgkin's Disease from a Clonal Expansion of Highly Mutated Germinal-Center B Cells

1997 • 335 citations

THE ORIGIN OF HODGKIN AND REED/STERNBERG CELLS IN HODGKIN'S DISEASE

1998 • 314 citations

Hodgkin and Reed–Sternberg cells in lymphocyte predominant Hodgkin disease represent clonal populations of germinal center-derived tumor B cells

1997 • 276 citations

Hodgkin's Disease with Monoclonal and Polyclonal Populations of Reed–Sternberg Cells

1995 • 200 citations

Peripheral blood mononuclear cells of a patient with advanced Hodgkin's lymphoma give rise to permanently growing Hodgkin-Reed Sternberg cells

1996 • 194 citations

Molecular single cell analysis demonstrates the derivation of a peripheral blood-derived cell line (L1236) from the Hodgkin/Reed- Sternberg cells of a Hodgkin's lymphoma patient

1996 • 170 citations

Clonality in Nodular Lymphocyte-Predominant Hodgkin's Disease

1997 • 157 citations

Recent Results on the Biology of Hodgkin and Reed-Sternberg Cells. I. Biopsy Material

1992 • 145 citations

The interrelationship between Hodgkin's disease and non-Hodgkin's lymphomas

1994 • 122 citations

Lymphocyte predominance Hodgkin's disease: lineage and clonality determination using a single-cell assay

1994 • 117 citations

Composite Lymphoma and Related Disorders

1993 • 110 citations

Clonal relationship between lymphocytic predominance Hodgkin's disease and concurrent or subsequent large-cell lymphoma of B lineage

1995 • 92 citations

Nodular lymphocyte-predominant Hodgkin's disease associated with large- cell lymphoma: analysis of Ig gene rearrangements by V-J polymerase chain reaction

1996 • 77 citations

Detection of immunoglobulin heavy‐chain gene rearrangement at the single‐cell level in malignant lymphomas: No rearrangement is found in hodgkin and reed‐sternberg cells

1994 • 76 citations

Granzyme B expression in Reed-Sternberg cells of Hodgkin's disease.

1996 • 74 citations

Detection of Clonal Hodgkin and Reed-Sternberg Cells With Identical Somatically Mutated and Rearranged VH Genes in Different Biopsies in Relapsed Hodgkin’s Disease

1998 • 56 citations

Amplification of TCRβ gene rearrangements from micromanipulated single cells: T cells rosetting around Hodgkin and Reed-Sternberg cells in Hodgkin's disease are polyclonal

1998 • 50 citations

Isolation of viable Hodgkin and Reed-Sternberg cells from Hodgkin disease tissues

1998 • 38 citations

Hodgkin and Reed-Sternberg cells do not carry T-cell receptor gamma gene rearrangements: evidence from single-cell polymerase chain reaction examination

1995 • 35 citations

Nodular lymphocyte predominance Hodgkin's disease: a monoclonal or polyclonal B-cell disorder?

1996 • 29 citations

The clonal relationship between nodular sclerosis Hodgkin's disease with a clonal Reed-Sternberg cell population and a subsequent B-cell small noncleaved cell lymphoma.

1998 • 27 citations

Detection of identical Hodgkin–Reed Sternberg cell specific immunoglobulin gene rearrangements in a patient with Hodgkin’s disease of mixed cellularity subtype at primary diagnosis and in relapse two and a half years later

1998 • 25 citations

Poor correlation between clonal immunoglobulin gene rearrangement and immunoglobulin gene transcription in Hodgkin's disease.

1996 • 23 citations

Immunoglobulin V Genes in Reed–Sternberg Cells

1996 • 23 citations

Molecular single-cell analysis of Hodgkin and Reed-Sternberg cells

1995 • 14 citations

CLASSICAL HODGKIN AND REED-STERNBERG CELLS DEMONSTRATE A NON-CLONAL IMMATURE B LYMPHOID LINEAGE: EVIDENCE FROM A SINGLE CELL ASSAY ANDIN SITU HYBRIDIZATION

1996 • 14 citations

Molecular biology of Hodgkin's disease.

1997 • 12 citations

Clonal identification of Burkitt's Lymphoma Arising from Lymphocyte‐Predominant Hodgkin's Disease

1996 • 12 citations

IMMUNOGLOBULIN V GENES IN REED-STEMBERG CELLS

1996 • 10 citations