Mode of inhibition of acid proteases by pepstatin.

The determination of enzyme inhibitor constants

1953 • 4,050 citations

Enzyme and metabolic inhibitors

1963 • 1,529 citations

Separation of dansyl-amino acids by polyamide layer chromatography

1967 • 1,482 citations

PEPSTATIN, A NEW PEPSIN INHIBITOR PRODUCED BY AGTINOMYGETES

1970 • 653 citations

Analog approaches to the structure of the transition state in enzyme reactions

1972 • 599 citations

THE ESTIMATION OF PEPSIN WITH HEMOGLOBIN

1932 • 512 citations

[52] Sequential degradation plus dansylation

1967 • 459 citations

Enzyme inhibitors of microbial origin

1972 • 314 citations

Pancreatic trypsin inhibitor. 2. Reaction with trypsin

1953 • 292 citations

Pepsin from Pepsinogen

1966 • 189 citations

Use of peptide aldehydes to generate transition-state analogs of elastase

1973 • 181 citations

EFFECT OF PEPSTATIN ON ACID PROTEASES

1971 • 160 citations

Specific and Irreversible Inactivation of Pepsin by Substrate-like Epoxides

1971 • 149 citations

The inhibition of tissue acid proteinases by pepstatin

1972 • 141 citations

Kinetics and Mechanism of Pepsinogen Activation

1972 • 123 citations

THE STRUCTURE OF PEPSTATIN

1970 • 107 citations

BIOLOGICAL ACTIVITY OF PEPSTATINS, PEPSTANONE A AND PARTIAL PEPTIDES ON PEPSIN, CATHEPSIN D AND RENIN

1972 • 104 citations

[41] Acetylation

1972 • 95 citations

An aspartic acid residue at the active site of pepsin. The isolation and sequence of the heptapeptide

1969 • 95 citations

On the Reaction of Diazoacetyl Compounds with Pepsin

1969 • 82 citations

Amino Acid Sequence around the Epoxide-reactive Residues in Pepsin

1972 • 77 citations

MECHANISM OF INHIBITION OF PEPSIN BY PEPSTATIN

1972 • 69 citations

The Carboxylate Ion in the Active Center of Pepsin

1972 • 67 citations

Pepstatin, an inhibitor for renin purification by affinity chromatography

1973 • 63 citations

Renin inhibition by pepstatin

1972 • 62 citations

Kinetics of the Pepsin-catalyzed Hydrolysis of N-Acetyl-L-phenylalanyl-L-diiodotyrosine^*

1965 • 61 citations

Inactivation of Acid Proteases from Rhizopus chinensis, Aspergillus saitoi and Mucor pusillus, and Calf Rennin by Diazoacetylnorleucine Methyl Ester*

1972 • 59 citations

[27] Gastricsin and Pepsin

1970 • 56 citations

Pyridyl esters of peptides as synthetic substrates of pepsin

1969 • 48 citations

Pepstatin Inhibition of Human Renin

1974 • 42 citations

Inhibition of cathepsin D by diazoacetylnorleucine methyl ester

1970 • 41 citations

Inhibition of pepsin action

1968 • 39 citations

The amino terminal sequences of acid proteases - human pepsin and gastricsin and the protease of Rhizopus chinensis

1975 • 38 citations

Amino acid sequence around the active site aspartic acid in penicillopepsin

1970 • 36 citations

MECHANISM OF INHIBITION OF PEPSIN BY PEPSTATIN. II

1974 • 34 citations

Carboxyl-terminal Sequence of Human Gastricsin and Pepsin

1970 • 33 citations

An affinity column for renin

1973 • 33 citations

Thyroid acid proteinase Properties and inactivation by diazoacetyl-norleucine methyl ester

1969 • 33 citations

N-Methyl-2-anilinonaphthalene-6-sulfonyl Peptides as Fluorescent Probes for Pepsin-Substrate Interaction

1973 • 30 citations

Mechanism of Enzyme Action

1973 • 29 citations

Specific Chemical Modifications of Acid Proteases in the Presence and Absence of Pepstatin*

1973 • 26 citations

The crystal structure at 5.5Å resolution of an acid-protease from Rhizopus chinensis

1976 • 23 citations

The site of diazoacetyl inhibitor attachment to acid proteinase of Aspergilius awamori — An analog of penicillopepsin and pepsin

1972 • 18 citations

Effects of the renin inhibitor pepstatin on the blood pressure on intact and nephrectomized rats

1972 • 16 citations

Inhibition of cathepsin E by diazoacetyl‐norleucine methyl ester

1970 • 16 citations