Expression and Regulation of c-kit Receptor and Proliferative Response to Stem Cell Factor in Childhood Lymphoma and Leukemia Cells

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand.

1987 • 1,627 citations

Identification, purification, and biological characterization of hematopoietic stem cell factor from buffalo rat liver-conditioned medium

1990 • 837 citations

Expression and function of c-kit in hemopoietic progenitor cells.

1991 • 756 citations

The kit Ligand, Stem Cell Factor

1993 • 653 citations

Ex vivo expansion and maturation of peripheral blood CD34+ cells into the myeloid lineage

1992 • 365 citations

Recombinant human stem cell factor enhances the formation of colonies by CD34+ and CD34+lin- cells, and the generation of colony-forming cell progeny from CD34+lin- cells cultured with interleukin-3, granulocyte colony-stimulating factor, or granulocyte-macrophage colony-stimulating factor

1991 • 341 citations

Ex vivo expansion of enriched peripheral blood CD34+ progenitor cells by stem cell factor, interleukin-1 beta (IL-1 beta), IL-6, IL-3, interferon-gamma, and erythropoietin

1993 • 334 citations

Non-Hodgkin's lymphomas of childhood and adolescence: results of a treatment stratified for biologic subtypes and stage--a report of the Berlin-Frankfurt-Münster Group.

1995 • 319 citations

Ex vivo expansion and maturation of peripheral blood CD34+ cells into the myeloid lineage

1992 • 291 citations

Epstein-Barr virus (EBV) induces expression of B-cell activation markers on in vitro infection of EBV-negative B-lymphoma cells.

1987 • 254 citations

The role of recombinant stem cell factor in early B cell development. Synergistic interaction with IL-7.

1991 • 222 citations

Role of c-kit ligand in the expansion of human hematopoietic progenitor cells

1992 • 218 citations

Phenotypic and functional characterization of c-kit expression during intrathymic T cell development.

1992 • 194 citations

Soluble interleukin-2 receptor levels in patients with undifferentiated and lymphoblastic lymphomas: correlation with survival.

1987 • 171 citations

Distinctive sequence of human mitochondrial ribosomal RNA genes

1980 • 169 citations

Enhancement of murine hematopoiesis by synergistic interactions between steel factor (ligand for c-kit), interleukin-11, and other early acting factors in culture

1992 • 167 citations

Nonhematopoietic tumor cell lines express stem cell factor and display c-kit receptors

1992 • 160 citations

Role of the KIT protooncogene in normal and malignant human hematopoiesis.

1992 • 138 citations

Changes in frequencies of clonable pre B cells during life in different lymphoid organs of mice

1993 • 138 citations

Cytokines in malignant lymphomas: Review and prospective evaluation

1993 • 135 citations

Transplantation potential of hematopoietic cells released into the circulation during routine chemotherapy for non-Hodgkin's lymphoma [see comments]

1993 • 134 citations

Effects of human stem cell factor (c-kit ligand) on proliferation of myeloid leukemia cells: heterogeneity in response and synergy with other hematopoietic growth factors

1992 • 133 citations

Nonhematopoietic tumor cell lines express stem cell factor and display c-kit receptors

1992 • 131 citations

The use of lymphomatous and lymphoblastoid cell lines in the study of Burkitt's lymphoma.

1985 • 125 citations

Differential roles of stromal cells, interleukin-7, and kit-ligand in the regulation of B lymphopoiesis

1992 • 120 citations

Endemic Burkitt's Lymphoma: Phenotypic Analysis of Tumor Biopsy Cells and of Derived Tumor Cell Lines2

1986 • 110 citations

Transforming growth factor-beta regulates c-kit message stability and cell-surface protein expression in hematopoietic progenitors

1994 • 107 citations

B-cell lymphoma after angioimmunoblastic lymphadenopathy: a case with oligoclonal gene rearrangements associated with Epstein-Barr virus

1993 • 100 citations

The ligand for c-kit, stem cell factor, stimulates the circulation of cells that engraft lethally irradiated baboons

1992 • 95 citations

A c-kit ligand, recombinant human stem cell factor, mediates reversible expansion of multiple CD34+ colony-forming cell types in blood and marrow of baboons

1992 • 90 citations

Synergistic interaction between interleukin-12 and steel factor in support of proliferation of murine lymphohematopoietic progenitors in culture

1994 • 86 citations

T lymphocyte differentiation in vitro from adult human prethymic CD34+ bone marrow cells.

1993 • 83 citations

AML: immunophenotypic heterogeneity and prognostic significance of c-kit expression.

1994 • 82 citations

B cell IL-7. Human B cell lines constitutively secrete IL-7 and express IL-7 receptors.

1994 • 77 citations

Identification and expression of a nuclear antigen from the genomic region of the Jijoye strain of Epstein-Barr virus that is missing in its nonimmortalizing deletion mutant, P3HR-1.

1985 • 69 citations

Interferon-gamma gene expression in human B-cell lines: induction by interleukin-2, protein kinase C activators, and possible effect of hypomethylation on gene regulation

1992 • 63 citations

Hematopoietic colony-stimulating factors.

1989 • 62 citations

Activity of stem cell factor and IL-7 in combination on normal bone marrow B lineage cells.

1993 • 57 citations

Cytokine regulation of early human lymphopoiesis.

1994 • 56 citations

Activation of lymphocytes induced by recombinant human granulocyte- macrophage colony-stimulating factor in patients with malignant lymphoma

1990 • 54 citations

Tumor necrosis factor/cachectin and lymphotoxin gene expression in lymph nodes from lymphoma patients

1990 • 53 citations

Expression of the c-kit proto-oncogene in myeloproliferative disorders and myelodysplastic syndromes.

1994 • 47 citations

B lymphocyte precursors in embryonic and adult W anemic mice.

1984 • 46 citations

c-kit expression by B cell precursors in mouse bone marrow. Stimulation of B cell genesis by in vivo treatment with anti-c-kit antibody.

1994 • 42 citations

Heterogeneity in interleukin (IL)-1 receptors expressed on human B cell lines. Differences in the molecular properties of IL-1 alpha and IL-1 beta binding sites.

1990 • 40 citations

Establishment of Lymphomatous Cell Lines From Bone Marrow Samples From Patients With Burkitt's Lymphoma<xref ref-type="fn" rid="FN2">2</xref>

1984 • 37 citations

Tumor necrosis factor/cachectin and lymphotoxin gene expression in lymph nodes from lymphoma patients

1990 • 37 citations

Status of kappa L chain gene rearrangements and c-kit and IL-7 receptor expression in stromal cell-dependent pre-B cells.

1992 • 32 citations

Functional expression of c-kit by acute myelogenous leukemia blasts is enhanced by tumor necrosis factor-alpha through posttranscriptional mRNA stabilization by a labile protein

1992 • 27 citations

Absence of G‐CSF receptors and absent response to G‐CSF in childhood Burkitt's lymphoma and B‐ALL cells

1995 • 26 citations

A Phase II Study of Recombinant Interleukin-2 With or Without Recombinant Interferon-?? in Non-Hodgkin??s Lymphoma. A Study of the Cancer and Leukemia Group B

1992 • 23 citations

The c-kit Molecule and the Surface Immunophenotype of Human Acute Leukemia

1994 • 20 citations

Biological Activities and Potential Therapeutic Uses of Steel Factor; A New Growth Factor Active on Multiple Hematopoietic Lineages

1992 • 18 citations

The use of colony stimulating factors in marrow transplantation

1993 • 18 citations

Non-Hodgkin's lymphoma in children.

1990 • 17 citations

Soluble factors and cell-surface molecules involved in human B lymphocyte activation, growth and differentiation

1989 • 15 citations

Establishment of a murine pre-B cell clone dependent on interleukin-7 and stem cell factor

1992 • 14 citations

Biologic and clinical significance of cytokine production in B‐cell malignancies

1989 • 9 citations

Differential effects of teleocidin on TNFα receptor regulation in human B cell lines: Relationship to coexpression of IL-2 and IL-1 receptors and to lymphokine secretion

1990 • 8 citations

Rat Stem‐Cell Factor Induces Splenocytes Capable Of Regenerating The Thymus

1992 • 6 citations

Haematopoietic growth factors in clinical medicine

1994 • 4 citations

U.S. Mammography Capacity Exceeding Usage and Need

1991 • 3 citations