Changes in frequencies of clonable pre B cells during life in different lymphoid organs of mice

Somatic generation of antibody diversity

1983 • 3,275 citations

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene

1991 • 1,783 citations

Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow.

1991 • 1,622 citations

The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus

1988 • 1,390 citations

The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene

1988 • 1,336 citations

The hematopoietic growth factor KL is encoded by the SI locus and is the ligand of the c-kit receptor, the gene product of the W locus

1990 • 1,208 citations

Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors

1988 • 1,086 citations

A plaque assay for all cells secreting Ig of a given type or class

1976 • 1,034 citations

Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms

1990 • 870 citations

Identification, purification, and biological characterization of hematopoietic stem cell factor from buffalo rat liver-conditioned medium

1990 • 837 citations

Stimulation of B-cell progenitors by cloned murine interleukin-7

1988 • 826 citations

Expression and function of c-kit in hemopoietic progenitor cells.

1991 • 756 citations

Mast cell growth factor maps near the steel locus on mouse chromosome 10 and is deleted in a number of steel alleles

1990 • 632 citations

Regulation of Hemopoiesis by Bone Marrow Stromal Cells and Their Products

1990 • 546 citations

Complete replacement of serum by albumin, transferrin, and soybean lipid in cultures of lipopolysaccharide-reactive B lymphocytes.

1978 • 535 citations

Lack of N regions in fetal and neonatal mouse immunoglobulin V-D-J junctional sequences.

1990 • 414 citations

Molecular and cellular origins of B lymphocyte diversity

1991 • 346 citations

Long-term proliferating early pre B cell lines and clones with the potential to develop to surface Ig-positive, mitogen reactive B cells in vitro and in vivo.

1991 • 335 citations

A second gene, VpreB in the lambda 5 locus of the mouse, which appears to be selectively expressed in pre-B lymphocytes.

1987 • 306 citations

λ5, a new light-chain-related locus selectively expressed in pre-B lymphocytes

1986 • 302 citations

Cells and Molecules that Regulate B Lymphopoiesis in Bone Marrow

1989 • 272 citations

A developmental switch in B lymphopoiesis.

1991 • 270 citations

The evolution and involution of Peyer's patches in fetal and postnatal sheep

1983 • 266 citations

The bulk of the peripheral B-cell pool in mice is stable and not rapidly renewed from the bone marrow.

1990 • 239 citations

B cell development regulated by gene rearrangement: Arrest of maturation by membrane-bound Dμ protein and selection of DH element reading frames

1991 • 203 citations

Insulin-like growth factor-I regulates pro-B cell differentiation

1992 • 190 citations

Stepwise progression of B lineage differentiation supported by interleukin 7 and other stromal cell molecules.

1990 • 158 citations

Flow cytometric analysis of cell proliferation dynamics in the B cell compartment of the mouse

1989 • 157 citations

Proliferation kinetics and the lifespan of B cells in central and peripheral lymphoid organs

1991 • 156 citations

Ontogeny of terminal deoxynucleotidyl transferase-positive cells in lymphohemopoietic tissues of rat and mouse.

1979 • 137 citations

The c‐kit‐encoded tyrosine kinase regulates the proliferation of early pre‐B cells

1991 • 113 citations

Analysis of Junctional Diversity During B Lymphocyte Development

1990 • 107 citations

Differentiation of growth signal requirement of B lymphocyte precursor is directed by expression of immunoglobulin.

1991 • 92 citations

Enrichment and characterization of uncommitted B-cell precursors from fetal liver at day 12 of gestation.

1992 • 86 citations

In Vitro Analysis of Murine B-Cell Development

1985 • 80 citations

One synchronous wave of B cell development in mouse fetal liver changes at day 16 of gestation from dependence to independence of a stromal cell environment.

1989 • 75 citations

In vitro proliferation of primitive hemopoietic stem cells supported by stromal cells: evidence for the presence of a mechanism(s) other than that involving c-kit receptor and its ligand.

1992 • 69 citations

Establishment and Functional Implications of B‐cell Connectivity

1989 • 60 citations

A novel regulatory myosin light chain gene distinguishes pre-B cell subsets and is IL-7 inducible.

1992 • 45 citations

The λ/λ ratio in surface immunoglobulin molecules on B lymphocytes differentiating from D_HJ_H‐rearranged murine pre‐B cell clones in vitro

1991 • 41 citations

B lymphocyte development in fetal liver

1977 • 41 citations

Allelic polymorphism of mouse Igh-J locus, which encodes immunoglobulin heavy chain joining (JH) segments

1992 • 25 citations

Long-Term Lymphoid Cultures in the Study of B-Cell Differentiation

1989 • 8 citations