Biologic and clinical significance of cytokine production in B‐cell malignancies

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas

1988 • 1,698 citations

Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells.

1987 • 1,667 citations

Cachectin and tumour necrosis factor as two sides of the same biological coin

1986 • 1,659 citations

Autocrine growth factors and cancer

1985 • 1,462 citations

Stimulation of bone resorption and inhibition of bone formation in vitro by human tumour necrosis factors

1986 • 1,433 citations

Endothelial cell-derived basic fibroblast growth factor: synthesis and deposition into subendothelial extracellular matrix.

1987 • 1,045 citations

Characterization of receptors for human tumour necrosis factor and their regulation by γ-interferon

1985 • 896 citations

The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells.

1988 • 791 citations

Paracrine rather than autocrine regulation of myeloma-cell growth and differentiation by interleukin-6

1989 • 775 citations

Tumor necrosis factor/cachectin interacts with endothelial cell receptors to induce release of interleukin 1.

1986 • 709 citations

B-Cell Stimulatory Factor-1/Interleukin 4

1987 • 602 citations

Induction of β2-interferon by tumor necrosis factor: A homeostatic mechanism in the control of cell proliferation

1986 • 577 citations

Synergistic interactions between interleukin 1, tumor necrosis factor, and lymphotoxin in bone resorption.

1987 • 527 citations

Triggering of the T3-Ti antigen-receptor complex results in clonal T-cell proliferation through an interleukin 2-dependent autocrine pathway.

1984 • 506 citations

Purification and partial sequence of human osteoclast-activating factor: identity with interleukin 1 beta.

1985 • 505 citations

Lymphokine-activated killer cell phenomenon. II. Precursor phenotype is serologically distinct from peripheral T lymphocytes, memory cytotoxic thymus-derived lymphocytes, and natural killer cells

1983 • 477 citations

Lymphokines

1987 • 459 citations

Homozygous deletion of the alpha- and beta 1-interferon genes in human leukemia and derived cell lines.

1988 • 407 citations

Osteoblasts mediate interleukin 1 stimulation of bone resorption by rat osteoclasts.

1986 • 392 citations

Production of Lymphotoxin, a Bone-Resorbing Cytokine, by Cultured Human Myeloma Cells

1987 • 386 citations

Synergy of interleukin 1 and granulocyte colony-stimulating factor: in vivo stimulation of stem-cell recovery and hematopoietic regeneration following 5-fluorouracil treatment of mice.

1987 • 380 citations

Human interleukin-2 promotes proliferation of activated B cells via surface receptors similar to those of activated T cells

1984 • 375 citations

Independent regulation of tumor necrosis factor and lymphotoxin production by human peripheral blood lymphocytes.

1987 • 372 citations

Factors Affecting B-Cell Growth and Differentiation

1985 • 354 citations

Recombinant interleukin-2 directly augments the cytotoxicity of human monocytes

1987 • 301 citations

TUMOUR NECROSIS FACTOR AS AN AUTOCRINE TUMOUR GROWTH FACTOR FOR CHRONIC B-CELL MALIGNANCIES

1988 • 282 citations

Autocrine secretion of GM-CSF in acute myeloblastic leukemia

1986 • 280 citations

A human inhibitor of tumor necrosis factor alpha.

1988 • 264 citations

Synthesis and secretion of multiple forms of beta 2-interferon/B-cell differentiation factor 2/hepatocyte-stimulating factor by human fibroblasts and monocytes.

1988 • 254 citations

Regulation of cell proliferation and differentiation by interferons

1985 • 241 citations

The role of IL-5 in IgA B cell differentiation.

1988 • 240 citations

Role of interleukin 1 in the activation of T lymphocytes.

1988 • 231 citations

Oncogenes and Tumor-Suppressing Genes

1988 • 222 citations

Identification of a common class of high affinity receptors for both types of porcine interleukin-1 on connective tissue cells

1986 • 219 citations

Interleukin 1 induces cultured human endothelial cell production of granulocyte-macrophage colony-stimulating factor.

1987 • 212 citations

Human β ₂ Interferon and B-Cell Differentiation Factor BSF-2 Are Identical

1987 • 204 citations

Production of interleukin-1 by bone marrow myeloma cells

1989 • 191 citations

Production of tumor necrosis factor/cachectin by human B cell lines and tonsillar B cells.

1988 • 173 citations

Interleukin 1 gene expression in adult T cell leukemia.

1987 • 161 citations

Interleukin 1 and interleukin 1 inhibitor production by human macrophages exposed to influenza virus or respiratory syncytial virus. Respiratory syncytial virus is a potent inducer of inhibitor activity.

1986 • 161 citations

Lymphotoxin Is an Important T Cell-Derived Growth Factor for Human B Cells

1987 • 151 citations

Interleukin 1 as an autocrine growth factor for acute myeloid leukemia cells.

1989 • 149 citations

A urine inhibitor of interleukin 1 activity affects both interleukin 1 alpha and 1 beta but not tumor necrosis factor alpha.

1987 • 142 citations

Separation and comparison of two monokines with lymphocyte-activating factor activity: IL-1 beta and hybridoma growth factor (HGF). Identification of leukocyte-derived HGF as IL-6.

1988 • 133 citations

Interleukin-6 gene expression in human endothelial cells: RNA start sites, multiple IL-6 proteins and inhibition of proliferation

1989 • 131 citations

Constitutive expression of the interleukin-6 gene in chronic lymphocytic leukemia

1989 • 126 citations

A possible subgroup of ALL with 9p−

1983 • 125 citations

Interleukin-1 gene (IL1) assigned to long arm of human chromosome 2.

1986 • 118 citations

Interferon and c- ets -1 Genes in the Translocation (9;11)(p22;q23) in Human Acute Monocytic Leukemia

1986 • 103 citations

In vitro production of interleukin 1 by normal and malignant human B lymphocytes.

1986 • 90 citations

Receptors for T cell-replacing factor/interleukin 5. Specificity, quantitation, and its implication.

1988 • 79 citations

Autocrine growth function of human interleukin 1 molecules on ROHA-9, an EBV-transformed human B cell line.

1987 • 58 citations

The human interleukin-1 alpha gene is located on the long arm of chromosome 2 at band q13

1989 • 56 citations

T cell-derived B cell growth factor(s) can induce stimulation of both resting and activated B cells.

1985 • 53 citations

Production of growth factors by human myeloma cells.

1987 • 29 citations

Cytotoxic effector function of B lymphoblasts.

1987 • 18 citations

Burkitt's cells can be triggered by teleocidin to secrete interferon-γ

1986 • 13 citations

Current Studies Examining Regulation of the Human B Cell Cycle

1987 • 6 citations

Regulation of Human B Cell Proliferation and Differentiation by Interleukin 2

1986 • 2 citations

Antigen Processing and Presentation by B Cells

1986 • 1 citations