A c-kit ligand, recombinant human stem cell factor, mediates reversible expansion of multiple CD34+ colony-forming cell types in blood and marrow of baboons

Stem cell factor is encoded at the SI locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor

1990 • 1,448 citations

The hematopoietic growth factor KL is encoded by the SI locus and is the ligand of the c-kit receptor, the gene product of the W locus

1990 • 1,208 citations

Isolation of a candidate human hematopoietic stem-cell population.

1992 • 1,098 citations

Identification of a ligand for the c-kit proto-oncogene

1990 • 970 citations

Effect of peripheral-blood progenitor cells mobilised by filgrastim (G-CSF) on platelet recovery after high-dose chemotherapy

1992 • 900 citations

Sequential generations of hematopoietic colonies derived from single nonlineage-committed CD34+CD38- progenitor cells

1991 • 869 citations

Identification, purification, and biological characterization of hematopoietic stem cell factor from buffalo rat liver-conditioned medium

1990 • 837 citations

Primary structure and functional expression of rat and human stem cell factor DNAs

1990 • 779 citations

Characterization and partial purification of human marrow cells capable of initiating long-term hematopoiesis in vitro

1989 • 699 citations

Effects of recombinant human granulocyte colony-stimulating factor on hematopoietic progenitor cells in cancer patients

1988 • 600 citations

Circulation of CD34+ hematopoietic stem cells in the peripheral blood of high-dose cyclophosphamide-treated patients: enhancement by intravenous recombinant human granulocyte-macrophage colony-stimulating factor

1989 • 549 citations

Recombinant human stem cell factor synergises with GM-CSF, G-CSF, IL-3 and epo to stimulate human progenitor cells of the myeloid and erythroid lineages.

1991 • 454 citations

Precursors of colony-forming cells in humans can be distinguished from colony-forming cells by expression of the CD33 and CD34 antigens and light scatter properties.

1989 • 453 citations

Recombinant human stem cell factor enhances the formation of colonies by CD34+ and CD34+lin- cells, and the generation of colony-forming cell progeny from CD34+lin- cells cultured with interleukin-3, granulocyte colony-stimulating factor, or granulocyte-macrophage colony-stimulating factor

1991 • 341 citations

Transplantation potential of peripheral blood stem cells induced by granulocyte colony-stimulating factor

1990 • 301 citations

Purified primitive human hematopoietic progenitor cells with long-term in vitro repopulating capacity adhere selectively to irradiated bone marrow stroma.

1990 • 275 citations

Selective expression of CD45 isoforms on functional subpopulations of CD34+ hemopoietic cells from human bone marrow.

1990 • 259 citations

Characterization of a human hematopoietic progenitor cell capable of forming blast cell containing colonies in vitro.

1988 • 213 citations

The effects on hematopoiesis of recombinant stem cell factor (ligand for c-kit) administered in vivo to mice either alone or in combination with granulocyte colony-stimulating factor

1991 • 169 citations

A comparison of hematopoiesis in normal and splenectomized mice treated with granulocyte colony-stimulating factor

1990 • 155 citations

Human hematopoietic precursors in long-term culture: single CD34+ cells that lack detectable T cell, B cell, and myeloid cell antigens produce multiple colony-forming cells when cultured with marrow stromal cells.

1990 • 149 citations

Mast cell growth factor (c-kit ligand) supports the growth of human multipotential progenitor cells with a high replating potential

1991 • 144 citations

Detection of a human CFC with a high proliferative potential

1989 • 135 citations

Recombinant human stem cell factor, a c-kit ligand, stimulates hematopoiesis in primates

1991 • 133 citations

In vitro growth and regulation of bone marrow enriched CD34+ hematopoietic progenitors in Diamond-Blackfan anemia

1991 • 88 citations

Diamond-blackfan anemia: in vitro response of erythroid progenitors to the ligand for c-kit

1991 • 77 citations

Durable and complete hematopoietic reconstitution after autografting of rhGM-CSF exposed peripheral blood progenitor cells.

1990 • 73 citations

Diamond-Blackfan anemia: heterogenous response of hematopoietic progenitor cells in vitro to the protein product of the steel locus

1991 • 70 citations

Alternatives to chronic restraint of nonhuman primates.

1987 • 44 citations

Utilization of recombinant human GM-CSF to enhance peripheral progenitor cell yield for autologous transplantation.

1991 • 28 citations