TRAIL and inhibitors of apoptosis are opposing determinants for NF-κB-dependent, genotoxin-induced apoptosis of cancer cells

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

1999 • 6,443 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

1998 • 4,383 citations

Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

1998 • 3,603 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

NF-κB: Ten Years After

1996 • 3,008 citations

NF-κB Antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to Suppress Caspase-8 Activation

1998 • 2,698 citations

Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL

1996 • 2,627 citations

An APAF-1·Cytochrome c Multimeric Complex Is a Functional Apoptosome That Activates Procaspase-9

1999 • 2,088 citations

Control of TRAIL-Induced Apoptosis by a Family of Signaling and Decoy Receptors

1997 • 1,694 citations

Bax directly induces release of cytochrome c from isolated mitochondria

1998 • 1,514 citations

Apoptosis control by death and decoy receptors

1999 • 1,296 citations

Induction of Apoptosis by Cancer Chemotherapy

2000 • 1,239 citations

Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-κB control

1997 • 875 citations

Distinct Caspase Cascades Are Initiated in Receptor-mediated and Chemical-induced Apoptosis

1999 • 829 citations

DNA Damaging Agents Induce Expression of Fas Ligand and Subsequent Apoptosis in T Lymphocytes via the Activation of NF-κB and AP-1

1998 • 726 citations

Death Receptor 5, a New Member of the TNFR Family, and DR4 Induce FADD-Dependent Apoptosis and Activate the NF-κB Pathway

1997 • 685 citations

The alpha 5 beta 1 integrin supports survival of cells on fibronectin and up-regulates Bcl-2 expression.

1995 • 627 citations

Transcriptional activation of the tumor necrosis factor alpha-inducible zinc finger protein, A20, is mediated by kappa B elements.

1992 • 449 citations

The A20 zinc finger protein protects cells from tumor necrosis factor cytotoxicity.

1992 • 446 citations

Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3

2001 • 445 citations

Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending.

1994 • 430 citations

Plasma fibronectin supports neuronal survival and reduces brain injury following transient focal cerebral ischemia but is not essential for skin-wound healing and hemostasis.

2001 • 353 citations

Retinoic acid-induced apoptosis in leukemia cells is mediated by paracrine action of tumor-selective death ligand TRAIL

2001 • 344 citations

Deletion of the loop region of Bcl-2 completely blocks paclitaxel-induced apoptosis

1999 • 338 citations

Regulation of death receptor expression and TRAIL/Apo2L-induced apoptosis by NF-κB

2001 • 316 citations

Characterization of two receptors for TRAIL¹

1997 • 293 citations

Intestinal trefoil factor confers colonic epithelial resistance to apoptosis

2000 • 275 citations

Identification and characterization of rat intestinal trefoil factor: tissue- and cell-specific member of the trefoil protein family.

1991 • 272 citations

Increased Expression of Death Receptors 4 and 5 Synergizes the Apoptosis Response to Combined Treatment with Etoposide and TRAIL

2000 • 259 citations

A20 Blocks Endothelial Cell Activation through a NF-κB-dependent Mechanism

1996 • 248 citations

A new family of growth factor‐like peptides ‘Trefoil’ disulphide loop structures as a common feature in breast cancer associated peptide (pS2), pancreatic spasmolytic polypeptide (PSP), and frog skin peptides (spasmolysins)

1989 • 236 citations

Tumor Necrosis Factor Alpha and Interleukin-1β Regulate the Murine Manganese Superoxide Dismutase Gene Through a Complex Intronic Enhancer Involving C/EBP-β and NF-κB

1997 • 231 citations

IFN-γ Mediates a Novel Antiviral Activity Through Dynamic Modulation of TRAIL and TRAIL Receptor Expression

1999 • 220 citations

BAX enhances paclitaxel-induced apoptosis through a p53-independent pathway

1996 • 217 citations

Reovirus-Induced Apoptosis Is Mediated by TRAIL

2000 • 190 citations

Inhibition of apoptosis by antioxidants in the human HL-60 leukemia cell line

1995 • 177 citations

Somatic mutations of TRAIL-receptor 1 and TRAIL-receptor 2 genes in non-Hodgkin's lymphoma

2001 • 162 citations

Rare loss-of-function mutation of a death receptor gene in head and neck cancer.

1998 • 160 citations

The DNA-Dependent Protein Kinase Participates in the Activation of NFκB Following DNA Damage

1998 • 113 citations

Differential Activation of Lung-specific Genes by Two Forkhead Proteins, FREAC-1 and FREAC-2

1996 • 103 citations

Suppression of Steady-state, but not Stimulus-induced NF-κB Activity Inhibits Alphavirus-induced Apoptosis

1998 • 86 citations

FREAC-1 Contains a Cell-Type-Specific Transcriptional Activation Domain and Is Expressed in Epithelial–Mesenchymal Interfaces

1998 • 82 citations

Transcription Factor NF-κB Signals Antianoikic Function of Trefoil Factor 3 on Intestinal Epithelial Cells

2000 • 81 citations

The role of superoxide radical in TNF-alpha induced NF-kappaB activation.

1999 • 55 citations

TRAIL-R2 is not correlated with p53 status and is rarely mutated in non-small cell lung cancer.

2001 • 34 citations

APO2L/TRAIL expression in human brain tumors

2000 • 32 citations