Correlation of Bcl-2 with P-Glycoprotein Expression in Chronic Lymphocytic Leukaemia and Other Haematological Neoplasms but of Neither Marker withEx VivoChemosensitivity or Patient Survival

Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.

1995 • 2,877 citations

Involvement of the bcl -2 Gene in Human Follicular Lymphoma

1985 • 1,797 citations

Apoptosis induced by anticancer drugs

1992 • 861 citations

Checkpoints of dueling dimers foil death wishes

1994 • 806 citations

Inactivation of Bcl-2 by phosphorylation.

1995 • 744 citations

High expression of bcl-2 protein in acute myeloid leukemia cells is associated with poor response to chemotherapy

1993 • 738 citations

Detection of P-glycoprotein isoforms by gene-specific monoclonal antibodies.

1990 • 386 citations

p53 gene mutation in B-cell chronic lymphocytic leukemia is associated with drug resistance and is independent of MDR1/MDR3 gene expression

1993 • 372 citations

Bcl-x and Bcl-2 inhibit TNF and Fas-induced apoptosis and activation of phospholipase A2 in breast carcinoma cells.

1995 • 293 citations

Phase I/II trial of cyclosporine as a chemotherapy-resistance modifier in acute leukemia.

1993 • 284 citations

bcl-2 proto-oncogene expression in normal and neoplastic human myeloid cells

1992 • 276 citations

Structure/function relationship of proteins belonging to the family of receptors coupled to GTP‐binding proteins

1991 • 241 citations

Distribution of multi-drug resistance-associated P-glycoprotein in normal and neoplastic human tissues

1990 • 240 citations

Correlations between apoptotic and proliferative indices in malignant non-Hodgkin's lymphomas.

1993 • 222 citations

Regulation of bcl-2 Proto-Oncogene Expression During Normal Human Lymphocyte Proliferation

1987 • 202 citations

Immunohistochemical detection of p53 and bcl‐2 proteins in non‐Hodgkin's lymphoma

1993 • 101 citations

The bcl-2 gene encodes a novel G protein

1989 • 61 citations

An overview of membrane, cytosolic and nuclear proteins associated with the expression of resistance to multiple drugs in vitro

1992 • 58 citations

Chlorambucil induced apoptosis in chronic lymphocytic leukemia (CLL) and its relationship to clinical efficacy.

1994 • 49 citations

Enhanced Ex vivo drug sensitivity testing of chronic lymphocytic leukaemia using refined DiSC assay methodology

1996 • 44 citations

Novel ex vivo analysis of nonclassical, pleiotropic drug resistance and collateral sensitivity induced by therapy provides a rationale for treatment strategies in chronic lymphocytic leukemia

1996 • 40 citations

The clinical relevance of t(14; 18)/BCL-2 rearrangement and DEL 6q in diffuse large cell lymphoma and immunoblastic lymphoma

1993 • 28 citations

Expression of bcl-2 gene confers multidrug resistance to chemotherapy- induced cell death

1994 • 16 citations

Evaluation of the Clinical Relevance of the Anionic Glutathione-S-Transferase (GSTπ) and Multidrug Resistance (mdr-1) Gene Coexpression in Leukemias and Lymphomas

1994 • 16 citations

BCL-2α encodes a novel small molecular weight GTP binding protein

1990 • 3 citations