Analysis of chromosome 21 yeast artificial chromosome (YAC) clones.

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1991 • 4,533 citations

CpG-rich islands and the function of DNA methylation

1986 • 3,760 citations

CpG Islands in vertebrate genomes

1987 • 3,315 citations

Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer Locus

1987 • 1,589 citations

Cloning of Large Segments of Exogenous DNA into Yeast by Means of Artificial Chromosome Vectors

1987 • 1,517 citations

The Genetic Defect Causing Familial Alzheimer's Disease Maps on Chromosome 21

1987 • 1,149 citations

t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1.

1991 • 897 citations

A novel, rapid method for the isolation of terminal sequences from yeast artificial chromosome (YAC) clones

1990 • 650 citations

Radiation Hybrid Mapping: A Somatic Cell Genetic Method for Constructing High-Resolution Maps of Mammalian Chromosomes

1990 • 630 citations

Alu polymerase chain reaction: a method for rapid isolation of human-specific sequences from complex DNA sources.

1989 • 578 citations

Systematic screening of yeast artificial-chromosome libraries by use of the polymerase chain reaction.

1990 • 454 citations

Linkage of a Gene Causing Familial Amyotrophic Lateral Sclerosis to Chromosome 21 and Evidence of Genetic-Locus Heterogeneity

1991 • 373 citations

Isolation of Single-Copy Human Genes from a Library of Yeast Artificial Chromosome Clones

1989 • 316 citations

The promoter of Alzheimer's disease amyloid A4 precursor gene.

1988 • 309 citations

Critical role of the D21S55 region on chromosome 21 in the pathogenesis of Down syndrome.

1989 • 261 citations

Molecular definition of a region of chromosome 21 that causes features of the Down syndrome phenotype.

1990 • 241 citations

The proximity of DNA sequences in interphase cell nuclei is correlated to genomic distance and permits ordering of cosmids spanning 250 kilobase pairs

1989 • 230 citations

Molecular genetic approach to the characterization of the ?Down syndrome region? of chromosome 21

1989 • 195 citations

Analysis of human chromosome 21: correlation of physical and cytogenetic maps; gene and CpG island distributions.

1990 • 187 citations

Down syndrome: molecular mapping of the congenital heart disease and duodenal stenosis.

1992 • 173 citations

Localization of a gene for progressive myoclonus epilepsy to chromosome 21q22.

1991 • 154 citations

A map of the distal region of the long arm of human chromosome 21 constructed by radiation hybrid mapping and pulsed-field gel electrophoresis

1991 • 124 citations

The PreA4₆₉₅precursor protein of Alzheimer's disease A4 amyloid is encoded by 16 exons

1989 • 123 citations

The structure of the human interferon alpha/beta receptor gene.

1992 • 100 citations

Second-generation approach to the construction of yeast artificial-chromosome libraries

1990 • 94 citations

APP717, APP693, and PRIP gene mutations are rare in Alzheimer disease.

1991 • 89 citations

Isolation of a yeast artificial chromosome spanning the 8;21 translocation breakpoint t(8;21)(q22;q22.3) in acute myelogenous leukemia.

1991 • 70 citations

A compositional map of human chromosome 21.

1990 • 69 citations

Cloning and in vivo expression of the human GART gene using yeast artificial chromosomes.

1991 • 58 citations

Physical mapping around the Alzheimer disease locus on the proximal long arm of chromosome 21.

1990 • 41 citations

Holoprosencephaly in an infant with a minute deletion of chromosome 21(q22.3)

1990 • 41 citations

Human chromosome 21-encoded cDNA clones

1986 • 38 citations

Report of the Second International Workshop on Human Chromosome 21 Mapping (1991)

1991 • 29 citations

Rapid screening of a YAC library by pulsed-field gel Southern blot analysis of pooled YAC clones

1991 • 24 citations

Expression of chromosome 21 specific sequences in normal and Down's syndrome tissues

1988 • 18 citations

[Decoding of the primary structure of the son3 region in human genome: identification of a new protein with unusual structure and homology with DNA-binding proteins].

1988 • 14 citations

Isolation and regional mapping of NotI and EagI clones from human chromosome 21

1991 • 13 citations

Walking, cloning, and mapping with yeast artificial chromosomes: A contig encompassing D21S13 and D21S16

1992 • 13 citations

Unique sequence homology in the pericentromeric regions of the long arms of chromosomes 13 and 21

1992 • 11 citations

Physical mapping of the long arm of chromosome 21.

1990 • 8 citations

Potential gene sequence isolation and regional mapping in human chromosome 21

2005 • 7 citations

Expression of Genes on Human Chromosome 21a

1985 • 7 citations