Analysis of human chromosome 21: correlation of physical and cytogenetic maps; gene and CpG island distributions.

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

A RAPID BANDING TECHNIQUE FOR HUMAN CHROMOSOMES

1971 • 5,049 citations

CpG-rich islands and the function of DNA methylation

1986 • 3,760 citations

CpG Islands in vertebrate genomes

1987 • 3,315 citations

DNA Methylation and Gene Function

1980 • 2,069 citations

The Mosaic Genome of Warm-Blooded Vertebrates

1985 • 887 citations

A fraction of the mouse genome that is derived from islands of nonmethylated, CpG-rich DNA

1985 • 668 citations

Human genome organization: Alu, LINES, and the molecular structure of metaphase chromosome bands

1988 • 563 citations

Replication Timing of Genes and Middle Repetitive Sequences

1984 • 561 citations

Cloning of the $beta; subunit of the leukocyte adhesion proteins: Homology to an extracellular matrix receptor defines a novel supergene family

1987 • 520 citations

Use of restriction enzymes to detect potential gene sequences in mammalian DNA

1987 • 387 citations

MECHANISMS OF CHROMOSOME BANDING AND IMPLICATIONS FOR CHROMOSOME STRUCTURE

1978 • 319 citations

Fractionation of large mammalian DNA restriction fragments using vertical pulsed-field gradient gel electrophoresis

1986 • 290 citations

PREDISPOSING LOCUS FOR ALZHEIMER'S DISEASE ON CHROMOSOME 21

1989 • 271 citations

Critical role of the D21S55 region on chromosome 21 in the pathogenesis of Down syndrome.

1989 • 261 citations

Rapid detection of human chromosome 21 aberrations by in situ hybridization.

1988 • 251 citations

Gene Encoding the β Subunit of S100 Protein Is on Chromosome 21: Implications for Down Syndrome

1988 • 222 citations

Mid-prophase human chromosomes. The attainment of 2000 bands

1981 • 198 citations

Molecular genetic approach to the characterization of the ?Down syndrome region? of chromosome 21

1989 • 195 citations

Nucleotide sequence and expression of human chromosome 21-encoded superoxide dismutase mRNA.

1983 • 193 citations

Hu- ets -1 and Hu- ets -2 Genes Are Transposed in Acute Leukemias with (4;11) and (8;21) Translocations

1986 • 191 citations

erg , a Human ets -Related Gene on Chromosome 21: Alternative Splicing, Polyadenylation, and Translation

1987 • 178 citations

The Fourth International Workshop on Chromosomes in Leukemia

1984 • 178 citations

Trisomie 21 et superoxyde dismutase-1 (IPO-A)

1976 • 175 citations

Unmethlated domains in vertebrate DNA

1983 • 173 citations

Preferential location of X-ray induced chromosome breakage in the R-bands of human chromosomes

2009 • 136 citations

Cloning and chromosomal localization of human genes encoding the three chains of type VI collagen.

1988 • 134 citations

Genetic linkage map of human chromosome 21

1988 • 125 citations

Global variation in G + C content along vertebrate genome DNA

1988 • 104 citations

Isolation of polymorphic DNA fragments from human chromosome 4

1987 • 100 citations

Differential staining of interspecific chromosomes in somatic cell hybrids by alkaline Giemsa stain

1976 • 98 citations

Variability of DNA methylation patterns during serial passage of human diploid fibroblasts

1982 • 97 citations

Gene distribution and nucleotide sequence organization in the mouse genome

1986 • 96 citations

The effect of site-specific methylation on restriction-modification enzymes

1987 • 95 citations

Cloned DNA probes regionally mapped to human Chromosome 21 and their use in determining the origin of nondisjunction

1985 • 93 citations

Searching for coding sequences in the mammalian genome: the H-2K region of the mouse MHC is replete with genes expressed in embryos.

1988 • 89 citations

Partial physical map of human chromosome 21

1988 • 87 citations

Synteny between glycinamide ribonucleotide synthetase and superoxide dismutase (soluble).

1977 • 83 citations

Regional localization of DNA sequences on chromosome 21 using somatic cell hybrids.

1986 • 82 citations

A genetic linkage map of 17 markers on human chromosome 21

1989 • 74 citations

Base ratio, DNA content, and quinacrine-brightness of human chromosomes.

1978 • 67 citations

cDNA cloning and assignment to chromosome 21 ofIFI-78K gene, the human equivalent of murineMx gene

1988 • 62 citations

Report of the committee on the genetic constitution of chromosomes 20 and 21

1988 • 61 citations

Consistent involvement of only 71 of the 329 chromosomal bands of the human genome in primary neoplasia-associated rearrangements.

1988 • 54 citations

Genetic linkage in the mouse of genes involved in down syndrome and Alzheimer's disease in man

1987 • 52 citations

Molecular mechanism in the formation of a human ring chromosome 21.

1989 • 51 citations

Isolation and regional mapping of DNA sequences unique to human chromosome 21.

1987 • 45 citations

Moderate Down's syndrome in three siblings having partial trisomy 21q22.2?qter and therefore no SOD-1 excess

1982 • 43 citations

Confirmation of assignment of the human α1-crystallin gene (CRYA1) to chromosome 21 with regional localization to q22.3

1987 • 42 citations

Human chromosome 21-encoded cDNA clones

1986 • 38 citations

Assignment of human phosphoribosylglycinamide synthetase locus to region 21q221

1984 • 35 citations

Mitotic chiasmata, gene density, and oncogenes

1985 • 34 citations

Transverse alternating field electrophoresis and applications to mammalian genome mapping

1989 • 30 citations

De novo 21q interstitial deletion in a retarded boy with ulno‐fibular dysostosis

1985 • 27 citations

Giemsa-11 technique. Applications in the chromosomal characterization of hematologic specimens

1982 • 21 citations

Construction of a cDNA clone containing the entire coding region of the human liver-type phosphofructokinase

1987 • 19 citations

Isolation of DNA sequences on human chromosome 21 by application of a recombination-based assay to DNA from flow-sorted chromosomes

1988 • 19 citations

Atypical Down syndrome and partial trisomy 21

2008 • 18 citations

Expression of chromosome 21 specific sequences in normal and Down's syndrome tissues

1988 • 18 citations

RFLPs at the D21S19 locus of human chromosome 21

1985 • 11 citations

The persistence of chromosomes in somatic cell hybrids correlates with the enzymatic hypermethylation of their dna

1981 • 9 citations

Characterization of an unusual and complex chromosome 21 rearrangement using somatic cell genetics and cloned DNA probes

1989 • 8 citations

Three interesting cases of Down's syndrome.

1983 • 4 citations