Human airway mucin glycosylation: a combinatory of carbohydrate determinants which vary in cystic fibrosis.

Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis

2016 • 4,824 citations

Molecular genetic basis of the histo-blood group ABO system

1990 • 1,142 citations

Human β-Defensin-1 Is a Salt-Sensitive Antibiotic in Lung That Is Inactivated in Cystic Fibrosis

1997 • 1,069 citations

Cystic Fibrosis Airway Epithelia Fail to Kill Bacteria Because of Abnormal Airway Surface Fluid

1996 • 1,042 citations

Structures and Immunochemical Properties of Oligosaccharides Isolated from Pig Submaxillary Mucins

1968 • 976 citations

Receptor determinants of human and animal influenza virus isolates: Differences in receptor specificity of the H3 hemagglutinin based on species of origin

1983 • 908 citations

Inflammatory cytokines in cystic fibrosis lungs.

1995 • 702 citations

CYSTIC FIBROSIS: GENOTYPIC AND PHENOTYPIC VARIATIONS

1995 • 613 citations

Pathways of O-glycan biosynthesis in cancer cells

1999 • 545 citations

Sequence and Expression of a Candidate for the Human Secretor Blood Group α(1,2)Fucosyltransferase Gene (FUT2)

1995 • 541 citations

The human sialyltransferase family

2001 • 528 citations

Bronchoalveolar lavage findings in cystic fibrosis patients with stable, clinically mild lung disease suggest ongoing infection and inflammation.

1994 • 525 citations

The Structure and Assembly of Secreted Mucins

1999 • 523 citations

A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group alpha(1,3/1,4)fucosyltransferase.

1990 • 504 citations

Defective acidification of intracellular organelles in cystic fibrosis

1991 • 490 citations

Role of Flagella in Pathogenesis ofPseudomonas aeruginosaPulmonary Infection

1998 • 467 citations

IL-4 Induces Mucin Gene Expression and Goblet Cell Metaplasia In Vitro and In Vivo

1999 • 453 citations

Human airway ion transport. Part one.

1994 • 446 citations

Influenza virus strains selectively recognize sialyloligosaccharides on human respiratory epithelium; the role of the host cell in selection of hemagglutinin receptor specificity

1993 • 441 citations

Protease-antiprotease imbalance in the lungs of children with cystic fibrosis.

1994 • 381 citations

Platelet-activating factor receptor and ADAM10 mediate responses to Staphylococcus aureus in epithelial cells

2002 • 354 citations

Normal bronchial epithelial cells constitutively produce the anti-inflammatory cytokine interleukin-10, which is downregulated in cystic fibrosis.

1995 • 354 citations

Molecular cloning, sequence, and expression of a human GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase cDNA that can form the H blood group antigen.

1990 • 339 citations

Antigen structure and genetic basis of histo-blood groups A, B and O: their changes associated with human cancer

1999 • 332 citations

Expression cloning of a novel alpha 1,3-fucosyltransferase that is involved in biosynthesis of the sialyl Lewis x carbohydrate determinants in leukocytes.

1994 • 329 citations

Isolation of a novel human alpha (1,3)fucosyltransferase gene and molecular comparison to the human Lewis blood group alpha (1,3/1,4)fucosyltransferase gene. Syntenic, homologous, nonallelic genes encoding enzymes with distinct acceptor substrate specificities.

1992 • 321 citations

Expression cloning of a cDNA encoding UDP-GlcNAc:Gal beta 1-3-GalNAc-R (GlcNAc to GalNAc) beta 1-6GlcNAc transferase by gene transfer into CHO cells expressing polyoma large tumor antigen.

1992 • 312 citations

Receptor binding properties of human and animal H1 influenza virus isolates

1989 • 305 citations

Influenza C virus uses 9-O-acetyl-N-acetylneuraminic acid as a high affinity receptor determinant for attachment to cells.

1986 • 298 citations

Molecular cloning of a fourth member of a human alpha (1,3)fucosyltransferase gene family. Multiple homologous sequences that determine expression of the Lewis x, sialyl Lewis x, and difucosyl sialyl Lewis x epitopes.

1992 • 295 citations

TNF-alpha mediates recruitment of neutrophils and eosinophils during airway inflammation.

1995 • 293 citations

Ion composition of airway surface liquid of patients with cystic fibrosis as compared with normal and disease-control subjects.

1997 • 293 citations

Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions

1999 • 291 citations

Allergen-induced IL-9 directly stimulates mucin transcription in respiratory epithelial cells

1999 • 286 citations

Transcriptional activation of mucin by Pseudomonas aeruginosa lipopolysaccharide in the pathogenesis of cystic fibrosis lung disease

1997 • 284 citations

Molecular cloning of a human fucosyltransferase gene that determines expression of the Lewis x and VIM-2 epitopes but not ELAM-1-dependent cell adhesion.

1991 • 281 citations

Purification and properties of sialoadhesin, a sialic acid-binding receptor of murine tissue macrophages.

1991 • 280 citations

Cloning and Expression of Human Core 1 β1,3-Galactosyltransferase

2002 • 278 citations

Interleukin-9 Upregulates Mucus Expression in the Airways

2000 • 275 citations

Excessive inflammatory response of cystic fibrosis mice to bronchopulmonary infection with Pseudomonas aeruginosa.

1997 • 265 citations

Sulfotransferases of Two Specificities Function in the Reconstitution of High Endothelial Cell Ligands for L-selectin

1999 • 260 citations

Expression of the cystic fibrosis gene in adult human lung.

1994 • 248 citations

Differential expression of five sialyltransferase genes in human tissues.

1994 • 246 citations

The Pseudomonas aeruginosa Flagellar Cap Protein, FliD, Is Responsible for Mucin Adhesion

1998 • 236 citations

MUC5AC, but not MUC2, is a prominent mucin in respiratory secretions

1996 • 232 citations

Mucin gene (MUC 2 and MUC 5AC) upregulation by Gram-positive and Gram-negative bacteria

1998 • 228 citations

Human Mucin Genes Assigned to 11p15.5: Identification and Organization of a Cluster of Genes

1996 • 225 citations

Tumor necrosis factor-alpha induces mucin hypersecretion and MUC-2 gene expression by human airway epithelial cells.

1995 • 223 citations

Cloning of a novel alpha 2,3-sialyltransferase that sialylates glycoprotein and glycolipid carbohydrate groups.

1994 • 223 citations

Inflammation-induced expression of sialyl Lewis X-containing glycan structures on alpha 1-acid glycoprotein (orosomucoid) in human sera.

1993 • 221 citations

A Novel, High Endothelial Venule–Specific Sulfotransferase Expresses 6-Sulfo Sialyl Lewisx, an L-Selectin Ligand Displayed by CD34

1999 • 221 citations

Increased sulfation of glycoconjugates by cultured nasal epithelial cells from patients with cystic fibrosis.

1989 • 216 citations

Molecular Cloning and Expression of a Novel β-1,6-N-Acetylglucosaminyltransferase That Forms Core 2, Core 4, and I Branches

1999 • 216 citations

cDNA Cloning and Expression of a Novel Human UDP- -acetyl-α-D-galactosamine

1996 • 212 citations

Cloning of a Human UDP-N-Acetyl-α-d-Galactosamine:PolypeptideN-Acetylgalactosaminyltransferase That Complements Other GalNAc-Transferases in Complete O-Glycosylation of the MUC1 Tandem Repeat

1998 • 209 citations

Purification and cDNA Cloning of a Human UDP-N-acetyl-α- D-galactosamine:polypeptide N-Acetylgalactosaminyltransferase

1995 • 199 citations

A Family of Human β4-Galactosyltransferases

1997 • 190 citations

Developmental Mucin Gene Expression in the Human Respiratory Tract

1999 • 189 citations

Osmotic water permeabilities of cultured, well-differentiated normal and cystic fibrosis airway epithelia

2000 • 183 citations

Cloning and Characterization of a Close Homologue of Human UDP-N-acetyl-α-d-galactosamine:Polypeptide N-Acetylgalactosaminyltransferase-T3, Designated GalNAc-T6

1999 • 182 citations

The expanding beta 4-galactosyltransferase gene family: messages from the databanks

1998 • 182 citations

A Family of Human β3-Galactosyltransferases

1998 • 180 citations

Electron microscopy of cervical, gastric and bronchial mucus glycoproteins

1986 • 169 citations

Sialoadhesin on macrophages: its identification as a lymphocyte adhesion molecule.

1992 • 168 citations

Human respiratory tract secretions

1976 • 167 citations

Molecular Cloning and Characterization of a Novel UDP-GlcNAc:GalNAc-peptide β1,3-N-Acetylglucosaminyltransferase (β3Gn-T6), an Enzyme Synthesizing the Core 3 Structure of O-Glycans

2002 • 165 citations

Selectins and other mammalian sialic acid-binding lectins

1992 • 162 citations

Molecular Cloning of a Novel α2,3-Sialyltransferase (ST3Gal VI) That Sialylates Type II Lactosamine Structures on Glycoproteins and Glycolipids

1999 • 160 citations

Mouse β-galactoside α2,3-sialyltransferases: comparison of in vitro substrate specificities and tissue specific expression

1997 • 159 citations

Expression cloning of cDNA encoding a human β-1,3-N-acetylglucosaminyltransferase that is essential for poly-N-acetyllactosamine synthesis

1997 • 153 citations

The oligosaccharide binding specificities of CD22 beta, a sialic acid-specific lectin of B cells.

1994 • 153 citations

Identification of the full-length coding sequence for human galactosyltransferase (β-N-acetylglucosaminide: β1,4-galactosyltransferase)

1988 • 152 citations

Chromosomal localization of a human mucin gene (MUC8) and cloning of the cDNA corresponding to the carboxy terminus.

1997 • 151 citations

Expression Cloning and Functional Characterization of Human cDNA for Ganglioside GM3 Synthase

1998 • 150 citations

MUC5B and MUC7 Are Differentially Expressed in Mucous and Serous Cells of Submucosal Glands in Human Bronchial Airways

1998 • 148 citations

Airway mucosa: secretory cells, mucus and mucin genes

1997 • 148 citations

Developmental Expression of Mucin Genes in the Human Respiratory Tract

1997 • 147 citations

Heterogeneity of the carbohydrate chains of sulfated bronchial glycoproteins isolated from a patient suffering from cystic fibrosis.

1975 • 144 citations

Expression of the developmental I antigen by a cloned human cDNA encoding a member of a beta-1,6-N-acetylglucosaminyltransferase gene family.

1993 • 144 citations

Sialylation and sulfation of the carbohydrate chains in respiratory mucins from a patient with cystic fibrosis.

1994 • 144 citations

Cloning, Expression, and Characterization of a Novel UDP-galactose:β-N-Acetylglucosamine β1,3-Galactosyltransferase (β3Gal-T5) Responsible for Synthesis of Type 1 Chain in Colorectal and Pancreatic Epithelia and Tumor Cells Derived Therefrom

1999 • 141 citations

Distinct sputum cytokine profiles in cystic fibrosis and other chronic inflammatory airway disease

1999 • 140 citations

Complete cDNA sequence encoding human β-galactoside α-2, 6-sialyltransferase

1990 • 140 citations

Goblet Cell Increase in Rat Bronchial Epithelium after Exposure to Cigarette and Cigar Tobacco Smoke

1969 • 136 citations

Subcellular localization of the UDP-N-acetyl-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase-mediated O-glycosylation reaction in the submaxillary gland.

1994 • 136 citations

Pseudomonas aeruginosa recognizes carbohydrate chains containing type 1 (Gal beta 1-3GlcNAc) or type 2 (Gal beta 1-4GlcNAc) disaccharide units

1991 • 135 citations

Cloning and Expression of Human Galβ1,3(4)GlcNAc α2,3-Sialyltransferase

1993 • 133 citations

O‐glycan biosynthesis in human colorectal adenoma cells during progression to cancer

1994 • 132 citations

Primary-Structure Determination of Fourteen Neutral Oligosaccharides Derived from Bronchial-Mucus Glycoproteins of Patients Suffering from Cystic Fibrosis, Employing 500-MHz 1H-NMR Spectroscopy

1982 • 132 citations

Identification and Characterization of Three Novel β1,3-N-Acetylglucosaminyltransferases Structurally Related to the β1,3-Galactosyltransferase Family

2001 • 131 citations

Pili and lipopolysaccharide of Pseudomonas aeruginosa bind to the glycolipid asialo GM1

1994 • 130 citations

Control of O-Glycan Branch Formation

2000 • 130 citations

Tumor Necrosis Factor α Increases the Expression of Glycosyltransferases and Sulfotransferases Responsible for the Biosynthesis of Sialylated and/or Sulfated Lewis x Epitopes in the Human Bronchial Mucosa

2002 • 128 citations

Cloning and expression of a human gene encoding an N-acetylgalactosamine- 2,6-sialyltransferase (ST6GalNAc I): a candidate for synthesis of cancer-associated sialyl-Tn antigens

1999 • 127 citations

Control of Mucin Transcription by Diverse Injury-induced Signaling Pathways

1999 • 127 citations

Adherence of Pseudomonas aeruginosa to human tracheobronchial mucin

1984 • 126 citations

The pili of Pseudomonas aeruginosa strains PAK and PAO bind specifically to the carbohydrate sequence βGalNAc(1–4)βGal found in glycosphingolipids asialo‐GM₁ and asialo‐GM₂

1994 • 125 citations

A novel human UDP‐N‐acetyl‐<scp>D</scp>‐galactosamine:polypeptide N‐acetylgalactosaminyltransferase, GalNAc‐T7, with specificity for partial GalNAc‐glycosylated acceptor substrates

1999 • 125 citations

α1,3‐Fucoslytransferase IX (Fuc‐TIX) is very highly conserved between human and mouse; molecular cloning, characterization and tissue distribution of human Fuc‐TIX

1999 • 123 citations

Novel Cytoplasmic Proteins of Nontypeable Haemophilus influenzae Up-regulate Human MUC5AC Mucin Transcription via a Positive p38 Mitogen-activated Protein Kinase Pathway and a Negative Phosphoinositide 3-Kinase-Akt Pathway

2002 • 123 citations

Regulation of human airway mucins by acrolein and inflammatory mediators

1999 • 122 citations

Molecular cloning of a human cDNA encoding β-1,4-galactosyltransferase with 37% identity to mammalian UDP-Gal:GlcNAc β-1,4-galactosyltransferase

1998 • 121 citations

Isolation and structural characterization of low‐molecular‐mass monosialyl oligosaccharides derived from respiratory‐mucus glycoproteins of a patient suffering from bronchiectasis

1988 • 121 citations

The Carbohydrate Diversity of Human Respiratory Mucins: A Protection of the Underlying Mucosa?

1991 • 120 citations

The sialylation of bronchial mucins secreted by patients suffering from cystic fibrosis or from chronic bronchitis is related to the severity of airway infection

1999 • 120 citations

Different cell-surface receptor determinants of antigenically similar influenza virus hemagglutinins.

1981 • 120 citations

Binding of Pseudomonas cepacia to normal human intestinal mucin and respiratory mucin from patients with cystic fibrosis.

1992 • 119 citations

Localization of the cystic fibrosis transmembrane conductance regulator in airway secretory glands

1993 • 118 citations

New sialic acids from biological sources identified by a comprehensive and sensitive approach: liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS) of SIA quinoxalinones

1997 • 117 citations

Control of O-Glycan Branch Formation

1999 • 114 citations

Respiratory Carcinoma Cell Lines

1999 • 109 citations

Characterization of Human Mucin 5B Gene Expression in Airway Epithelium and the Genomic Clone of the Amino-Terminal and 5 ′ -Flanking Region

2001 • 109 citations

Human Mucin Genes MUC2, MUC3,MUC4, MUC5AC, MUC5B, andMUC6 Express Stable and Extremely Large mRNAs and Exhibit a Variable Length Polymorphism

1998 • 108 citations

Cystic Fibrosis as a Disease of Misprocessing of the Cystic Fibrosis Transmembrane Conductance Regulator Glycoprotein

1999 • 107 citations

Genotypic analysis of respiratory mucous sulfation defects in cystic fibrosis.

1995 • 106 citations

Primary structure determination of five sialylated oligosaccharides derived from bronchial mucus glycoproteins of patients suffering from cystic fibrosis. The occurrence of the NeuAc alpha(2----3)Gal beta(1----4)[Fuc alpha(1----3)] GlcNAc beta(1----.) structural element revealed by 500-MHz 1H NMR spectroscopy.

1984 • 106 citations

Terminal glycosylation in cystic fibrosis

1999 • 102 citations

Light microscopic histochemical detection of sugar residues in secretory glycoproteins of rodent and human tracheal glands with lectin-horseradish peroxidase conjugates and the galactose oxidase-Schiff sequence.

1983 • 99 citations

Heterologous expression of delta F508 CFTR results in decreased sialylation of membrane glycoconjugates

1994 • 98 citations

Recognition of Lewis x Derivatives Present on Mucins by Flagellar Components of Pseudomonas aeruginosa

2001 • 95 citations

Evidence against Defective -Golgi Acidification in Cystic Fibrosis

1996 • 94 citations

Expression and function of α2,3‐sialyl‐ and α,3/l,4‐fucosyltransferases in colon adenocarcinoma cell lines: Role in synthesis of E‐selectin counter‐receptors

1995 • 93 citations

Human airway secretory cells during development and in mature airway epithelium

1992 • 90 citations

Use of lectins for detection of glycoconjugates in the glandular cells of the human bronchial mucosa.

1982 • 90 citations

Complex structure of human bronchial mucus glycoprotein

1984 • 90 citations

Human N-Acetylglucosamine-6-O-Sulfotransferase Involved in the Biosynthesis of 6-Sulfo Sialyl Lewis X: Molecular Cloning, Chromosomal Mapping, and Expression in Various Organs and Tumor Cells

1998 • 90 citations

Cystic Fibrosis Transmembrane Conductance Regulator-associated ATP and Adenosine 3′-Phosphate 5′-Phosphosulfate Channels in Endoplasmic Reticulum and Plasma Membranes

1997 • 90 citations

Dexamethasone suppresses mucus production and MUC-2 and MUC-5AC gene expression by NCI-H292 cells

1996 • 89 citations

Tracheobronchial mucin receptor for Pseudomonas aeruginosa: predominance of amino sugars in binding sites

1985 • 89 citations

Primary structure of neutral oligosaccharides derived from respiratory‐mucus glycoproteins of a patient suffering from bronchiectasis, determined by combination of 500‐MHz ¹H‐NMR spectroscopy and quantitative sugar analysis

1988 • 88 citations

Molecular basis for defective glycosylation and Pseudomonas pathogenesis in cystic fibrosis lung

2001 • 85 citations

Evolutionary History of the 11p15 Human Mucin Gene Family

1998 • 81 citations

Molecular Cloning and Expression of Human Galβ1,3GalNAc α2,3-Sialyltransferase (hST3Gal II)

1996 • 81 citations

Altered Carbohydrate Composition of Salivary Mucins from Patients with Cystic Fibrosis and the Adhesion of Pseudomonas aeruginosa

1993 • 80 citations

The binding of anti-pseudomonal antibiotics to macromolecules from cystic fibrosis sputum

1988 • 79 citations

FUT4 and FUT9 genes are expressed early in human embryogenesis

2000 • 79 citations

Localization of O-glycan initiation, sphingomyelin synthesis, and glucosylceramide synthesis in Vero cells with respect to the endoplasmic reticulum-Golgi intermediate compartment.

1994 • 79 citations

Comparison of physicochemical properties of purified mucus glycoproteins isolated from respiratory secretions of cystic fibrosis and asthmatic patients

1985 • 78 citations

Defective acidification of the biosynthetic pathway in cystic fibrosis

1993 • 78 citations

Structure of sialyl-oligosaccharides isolated from bronchial mucus glycoproteins of patients (blood group O) suffering from cystic fibrosis

1987 • 77 citations

Molecular cloning of a novel human UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase, GalNAc-T8, and analysis as a candidate autosomal dominant hypophosphatemic rickets (ADHR) gene

2000 • 76 citations

Mucus Glycoproteins Secreted by Respiratory Epithelial Tissue from Cystic Fibrosis Patients

1983 • 75 citations

Pseudomonas aeruginosa outer membrane adhesins for human respiratory mucus glycoproteins

1994 • 75 citations

Histochemical properties of the respiratory tract epithelium in different species.

1983 • 73 citations

Structure determination of five sulfated oligosaccharides derived from tracheobronchial mucus glycoproteins.

1987 • 72 citations

Enhanced Susceptibility to Pulmonary Infection withBurkholderia cepaciainCftr^−/−Mice

2001 • 70 citations

Mucus glycoproteins from cystic fibrotic sputum. Macromolecular properties and structural ‘architecture’

1991 • 69 citations

UDPgalactose:glycoprotein–N‐acetyl‐<scp>d</scp>‐galactosamine 3‐β‐<scp>d</scp>‐galactosyltransferase activity synthesizing O‐glycan core 1 is controlled by the amino acid sequence and glycosylation of glycopeptide substrates

1994 • 68 citations

Further characterization, by a combined high-performance liquid chromatography/1H-NMR approach, of the heterogeneity displayed by the neutral carbohydrate chains of human bronchial mucins

1984 • 68 citations

Differences in adhesion of Pseudomonas aeruginosa to mucin glycopeptides from sputa of patients with cystic fibrosis and chronic bronchitis

1989 • 68 citations

Structural features of human tracheobronchial mucus glycoprotein

1984 • 68 citations

Gastrointestinal mucins. Structures and antigenicities of their carbohydrate chains in health and disease.

1982 • 67 citations

Genomic Organization and Chromosomal Mapping of the Galβ1,3GalNAc/Galβ1,4GlcNAc α2,3-Sialyltransferase

1996 • 67 citations

Brain-specific expression of a novel human UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T9)

2000 • 64 citations

Pseudomonas aeruginosa binds to neoglycoconjugates bearing mucin carbohydrate determinants and predominantly to sialyl-Lewis x conjugates

1999 • 63 citations

Ion Composition and Rheology of Airway Liquid from Cystic Fibrosis Fetal Tracheal Xenografts

1999 • 62 citations

Specificities ofN-Acetylglucosamine-6-O-sulfotransferases in Relation to L-selectin Ligand Synthesis and Tumor-associated Enzyme Expression

2002 • 61 citations

Sulfated sialyl-oligosaccharides derived from tracheobronchial mucous glycoproteins of a patient suffering from cystic fibrosis.

1992 • 60 citations

Identification of a nonmucin glycoprotein (gp-340) from a purified respiratory mucin preparation: evidence for an association involving the MUC5B mucin

2001 • 58 citations

TNF-A and IL-8 in Consecutive Sputum Samples from Cystic Fibrosis Patients During Antibiotic Treatment

2000 • 58 citations

DIRECT INFLUENCES OF PRO-INFLAMMATORY CYTOKINES (IL-1β, TNF-α, IL-6) ON THE PROLIFERATION AND CELL-SURFACE ANTIGEN EXPRESSION OF CANCER CELLS

2000 • 58 citations

Cloning, expression and gene organization of a human Neu5Acα2–3Galβ1–3GalNAc α2,6-sialyltransferase: hST6GalNAc IV

2000 • 57 citations

Oligosaccharides of human bronchial glycoproteins. Neutral di- and trisaccharides isolated from a patient suffering from chronic bronchitis.

1980 • 57 citations

Molecular cloning and functional expression of human ST6GalNAc II. Molecular expression in various human cultured cells

2000 • 57 citations

Molecular Cloning and Characterization of a Human β-Gal-3′-sulfotransferase That Acts on Both Type 1 and Type 2 (Galβ1–3/1–4GlcNAc-R) Oligosaccharides

2001 • 56 citations

Subsets of sialylated, sulfated mucins of diverse origins are recognized by L-selectin. Lack of evidence for unique oligosaccharide sequences mediating binding

1996 • 55 citations

Structures of monosialyl oligosaccharides isolated from the respiratory mucins of a non-secretor (O, Le^a+b−) patient suffering from chronic bronchitis. Characterization of a novel type of mucin carbohydrate core structure

1994 • 53 citations

The acceptor specificity of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases.

1999 • 52 citations

Cloning and expression of human NF-YC

1997 • 52 citations

Human tracheobronchial mucin: purification and binding to Pseudomonas aeruginosa

1992 • 51 citations

CFTR: domains, structure, and function.

1997 • 50 citations

Activity of fucosyltransferases and altered glycosylation in cystic fibrosis airway epithelial cells

2001 • 49 citations

An interaction between lysozyme and mucus glycoproteins. Implications for density-gradient separations

1979 • 49 citations

Characterization of anN-Acetylglucosamine-6-O-sulfotransferase from Human Respiratory Mucosa Active on Mucin Carbohydrate Chains

1997 • 48 citations

The high lipid content of respiratory mucins in cystic fibrosis is related to infection

1986 • 48 citations

Differential binding of Pseudomonas aeruginosa to normal and cystic fibrosis tracheobronchial mucins

1994 • 47 citations

Structure of two sulphated oligosaccharides from respiratory mucins of a patient suffering from cystic fibrosis. A fast-atom-bombardment m.s. and 1H-n.m.r. spectroscopic study

1991 • 47 citations

Identification of Two Distinct Types of Flagellar Cap Proteins, FliD, in Pseudomonas aeruginosa

2000 • 47 citations

Interactions between Glycoconjugates from Human Respiratory Airways and Pseudomonas aeruginosa

1996 • 46 citations

Molecular Cloning and Characterization of a Novel Human Galactose 3-O-Sulfotransferase That Transfers Sulfate to Galβ1→3GalNAc Residue in O-Glycans

2001 • 45 citations

Isolation and structural characterization of novel sialylated oligosaccharide‐alditols from respiratory‐mucus glycoproteins of a patient suffering from bronchiectasis

1993 • 44 citations

Adhesion of Pseudomonas aeruginosa to respiratory mucins and expression of mucin-binding proteins are increased by limiting iron during growth

1996 • 42 citations

Chromosomal localization and genomic organization for the galactose/ N-acetylgalactosamine/N-acetylglucosamine 6-O-sulfotransferase gene family

2001 • 42 citations

Characterization of a Sulfotransferase from Human Airways Responsible for the 3-O-Sulfation of Terminal Galactose in N-Acetyllactosamine-containing Mucin Carbohydrate Chains

1995 • 41 citations

Determination of the Site-specific Oligosaccharide Distribution of the O-Glycans Attached to the Porcine Submaxillary Mucin Tandem Repeat

2002 • 40 citations

Molecular Cloning and Expression of a Novel Human β-Gal-3-O-sulfotransferase That Acts Preferentially onN-Acetyllactosamine in N- andO-Glycans

2001 • 38 citations

Structural analysis of monosulfated side-chain oligosaccharides isolated from human tracheobronchial mucous glycoproteins

1992 • 37 citations

Structures of sulfated oligosaccharides isolated from the respiratory mucins of a non-secretor (O, Le(a + b -)) patient suffering from chronic bronchitis.

1997 • 37 citations

Sialyl-Le(x) and sulfo-sialyl-Le(x) determinants are receptors for P. aeruginosa.

2000 • 34 citations

Adhesion of nontypeable Haemophilus influenzae from blood and sputum to human tracheobronchial mucins and lactoferrin

1995 • 34 citations

Inhibition of neutrophil elastase by mucus glycoprotein.

1994 • 32 citations

Alteration of Sulfation of Glycoconjugates, but Not Sulfate Transport and Intracellular Inorganic Sulfate Content in Cystic Fibrosis Airway Epithelial Cells

1995 • 32 citations

Mucins from cystic fibrosis sputum.

1976 • 32 citations

Limulus polyphemus lectin sites in human bronchial mucosa.

1977 • 31 citations

Role of sialic acid in saliva-mediated aggregation of Pseudomonas aeruginosa isolated from cystic fibrosis patients

1987 • 30 citations

Glycopeptide N-acetylgalactosaminyltransferase specificities for O-glycosylated sites on MUC5AC mucin motif peptides

2001 • 30 citations

Molecular mechanisms of expression of Lewis b antigen and other Type I Lewis antigens in human colorectal cancer

1999 • 30 citations

Isolation and structural characterization of novel neutral oligosaccharide‐alditols from respiratory‐mucus glycoproteins of a patient suffering from bronchiectasis

1991 • 29 citations

Structures of sulfated oligosaccharides in human trachea mucin glycoproteins

1993 • 28 citations

Strong ionic interactions between mucins and two basic proteins, mucus proteinase inhibitor and lysozyme, in human bronchial secretions

1992 • 28 citations

Differences in the binding specificities of Pseudomonas aeruginosa M35 and Escherichia coli C600 for lipid-linked oligosaccharides with lactose-related core regions

1992 • 28 citations

Sequential biosynthesis of sulfated and/or sialylated Lewis x determinants by transferases of the human bronchial mucosa

1999 • 27 citations

Elevated Serum Level and Altered Glycosylation of α1-Acid Glycoprotein in Hyperimmunoglobulinemia D and Periodic Fever Syndrome: Evidence for Persistent Inflammation

1995 • 26 citations

Interaction of fimbriated and nonfimbriated strains of unencapsulated Haemophilus influenzae with human respiratory tract mucus in vitro

1995 • 25 citations

Airway surface fluid volume and Cl content in cystic fibrosis and normal bronchial xenografts

1999 • 25 citations

Mucous and serous secretions of human bronchial epithelial cells in secondary culture.

1995 • 25 citations

Terminal glycosylation of cystic fibrosis airway epithelial cells.

2000 • 25 citations

Isolation and structural characterization of novel neutral oligosaccharide‐alditols from respiratory‐mucus glycoproteins of a patient suffering from bronchiectasis

1991 • 22 citations

Quantitation and structures of oligosaccharide chains in human trachea mucin glycoproteins

1992 • 20 citations

Different O-glycosylation of respiratory mucin glycopeptides from a patient with cystic fibrosis.

1998 • 20 citations

The binding of surface proteins from Staphylococcus aureus to human bronchial mucins

1997 • 19 citations

Mucins secreted by a transformed cell line derived from human tracheal gland cells

1997 • 19 citations

Structures of neutral oligosaccharides isolated from the respiratory mucins of a non-secretor (O, Le^a+b−) patient suffering from chronic bronchitis

1991 • 19 citations

The role of bacterial adhesion in cystic fibrosis including the Staphylococcal aspect

1990 • 17 citations

Synthesis of sulfated oligosaccharides by cystic fibrosis trachea epithelial cells.

1999 • 15 citations

The fucosylation and secretion of mucins synthesized in human bronchial cells vary according to growth conditions

1997 • 11 citations

Human, bronchial-mucus glycoproteins: a comparison between chemical properties and affinity for lectins

1981 • 9 citations

A new monoclonal antibody (3D3) generated with human respiratory mucins and directed against Lewis determinants

1995 • 8 citations

Influence of culture conditions on the α1,2-fucosyltransferase and gene expression of a transformed cell line MM-39 derived from human tracheal gland cells

2001 • 7 citations

Binding between Pseudomonas aeruginosa adhesins and human salivary, tracheobronchial and nasopharyngeal mucins

1996 • 7 citations

Deleted Work

1955 • 0 citations