Pathways of O-glycan biosynthesis in cancer cells

Biological roles of oligosaccharides: all of the theories are correct

1993 • 5,121 citations

Molecular genetic basis of the histo-blood group ABO system

1990 • 1,142 citations

Aberrant Glycosylation In Tumors And Tumor-Associated Carbohydrate Antigens

1989 • 1,083 citations

The α(1,3)Fucosyltransferase Fuc-TVII Controls Leukocyte Trafficking through an Essential Role in L-, E-, and P-selectin Ligand Biosynthesis

1996 • 723 citations

Diversity in the sialic acids

1992 • 590 citations

Contribution of carbohydrate antigens sialyl Lewis A and sialyl Lewis X to adhesion of human cancer cells to vascular endothelium.

1993 • 547 citations

Sequence and Expression of a Candidate for the Human Secretor Blood Group α(1,2)Fucosyltransferase Gene (FUT2)

1995 • 541 citations

Perspectives on the significance of altered glycosylation of glycoproteins in cancer.

1997 • 532 citations

Expression of Tn, sialosyl-Tn, and T antigens in human colon cancer.

1989 • 510 citations

A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group alpha(1,3/1,4)fucosyltransferase.

1990 • 504 citations

Cell membrane-associated mucins and their adhesion-modulating property

1992 • 472 citations

Photolabeling of Prostaglandin Endoperoxide H Synthase-1 with 3-Trifluoro-3-(m-[125I]iodophenyl)diazirine as a Probe of Membrane Association and the Cyclooxygenase Active Site

1996 • 460 citations

Distribution of oncofetal antigen tumor-associated glycoprotein-72 defined by monoclonal antibody B72.3.

1986 • 456 citations

Metastatic Potential Is Positively Correlated with Cell Surface Sialylation of Cultured Murine Tumor Cell Lines

1981 • 445 citations

Increased expression of sialyl Lewisx antigen correlates with poor survival in patients with colorectal carcinoma: clinicopathological and immunohistochemical study.

1993 • 417 citations

Sialosyl-Tn. A novel mucin antigen associated with prognosis in colorectal cancer patients

1990 • 380 citations

Comparison of O-Linked Carbohydrate Chains in MUC-1 Mucin from Normal Breast Epithelial Cell Lines and Breast Carcinoma Cell Lines:

1996 • 354 citations

Mechanisms Underlying Aberrant Glycosylation of MUC1 Mucin in Breast Cancer Cells

1995 • 347 citations

Post-translational Modifications of Recombinant P-selectin Glycoprotein Ligand-1 Required for Binding to P- and E-selectin

1996 • 340 citations

A core protein epitope of the polymorphic epithelial mucin detected by the monoclonal antibody SM‐3 is selectively exposed in a range of primary carcinomas

1989 • 339 citations

Molecular cloning, sequence, and expression of a human GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase cDNA that can form the H blood group antigen.

1990 • 339 citations

ELFT: A gene that directs the expression of an ELAM-1 ligand

1990 • 338 citations

Expression cloning of a novel alpha 1,3-fucosyltransferase that is involved in biosynthesis of the sialyl Lewis x carbohydrate determinants in leukocytes.

1994 • 329 citations

Isolation of a novel human alpha (1,3)fucosyltransferase gene and molecular comparison to the human Lewis blood group alpha (1,3/1,4)fucosyltransferase gene. Syntenic, homologous, nonallelic genes encoding enzymes with distinct acceptor substrate specificities.

1992 • 321 citations

Expression cloning of a cDNA encoding UDP-GlcNAc:Gal beta 1-3-GalNAc-R (GlcNAc to GalNAc) beta 1-6GlcNAc transferase by gene transfer into CHO cells expressing polyoma large tumor antigen.

1992 • 312 citations

Sugar-nucleotide donor specificity of histo-blood group A and B transferases is based on amino acid substitutions.

1990 • 311 citations

Humoral immunity against a tandem repeat epitope of human mucin MUC-1 in sera from breast, pancreatic, and colon cancer patients.

1994 • 307 citations

Mucin glycoproteins in neoplasia

1996 • 299 citations

Molecular cloning of a fourth member of a human alpha (1,3)fucosyltransferase gene family. Multiple homologous sequences that determine expression of the Lewis x, sialyl Lewis x, and difucosyl sialyl Lewis x epitopes.

1992 • 295 citations

Structure of the O-Glycans in GlyCAM-1, an Endothelial-derived Ligand for L-selectin

1995 • 291 citations

Human T-lymphocyte activation is associated with changes in O-glycan biosynthesis.

1988 • 287 citations

Molecular cloning of a human fucosyltransferase gene that determines expression of the Lewis x and VIM-2 epitopes but not ELAM-1-dependent cell adhesion.

1991 • 281 citations

MUC‐1 Epithelial Tumor Mucin‐Based Immunity and Cancer Vaccines

1995 • 267 citations

T-cell-specific deletion of a polypeptide N-acetylgalactosaminyl-transferase gene by site-directed recombination.

1995 • 266 citations

Mucin degradation in the human colon: production of sialidase, sialate O-acetylesterase, N-acetylneuraminate lyase, arylesterase, and glycosulfatase activities by strains of fecal bacteria

1992 • 261 citations

Inhibition of mucin glycosylation by aryl-N-acetyl-α-galactosaminides in human colon cancer cells

1989 • 260 citations

Oligosaccharide structures of human colonic mucin.

1985 • 253 citations

Differential colon cancer cell adhesion to E-, P-, and L-selectin: role of mucin-type glycoproteins.

1995 • 250 citations

A family of UDP-GalNAc: polypeptide N-acetylgalactosaminyl-transferases control the initiation of mucin-type O-linked glycosylation

1996 • 248 citations

Localization of three human polypeptide GalNAc-transferases in HeLa cells suggests initiation of O-linked glycosylation throughout the Golgi apparatus

1998 • 236 citations

Correlation of Expression of H/Le^Y/Le^BAntigens with Survival in Patients with Carcinoma of the Lung

1992 • 235 citations

Expression of Blood-Group Antigen A — A Favorable Prognostic Factor in Non-Small-Cell Lung Cancer

1991 • 221 citations

Differential E-selectin-dependent adhesion efficiency in sublines of a human colon cancer exhibiting distinct metastatic potentials.

1994 • 218 citations

Molecular Cloning and Expression of a Novel β-1,6-N-Acetylglucosaminyltransferase That Forms Core 2, Core 4, and I Branches

1999 • 216 citations

Surface sialic acid reduces attachment of metastatic tumour cells to collagen type IV and fibronectin

1982 • 215 citations

Cytotoxic T cells from ovarian malignant tumors can recognize polymorphic epithelial mucin core peptides.

1993 • 213 citations

cDNA Cloning and Expression of a Novel Human UDP- -acetyl-α-D-galactosamine

1996 • 212 citations

Cloning of a Human UDP-N-Acetyl-α-d-Galactosamine:PolypeptideN-Acetylgalactosaminyltransferase That Complements Other GalNAc-Transferases in Complete O-Glycosylation of the MUC1 Tandem Repeat

1998 • 209 citations

1994, the year of sialyltransferases

1995 • 205 citations

Purification and cDNA Cloning of a Human UDP-N-acetyl-α- D-galactosamine:polypeptide N-Acetylgalactosaminyltransferase

1995 • 199 citations

Incomplete sulphomucin-secreting intestinal metaplasia for gastric cancer. Preliminary data from a prospective study from three centres.

1985 • 199 citations

Structures of O-linked oligosaccharides isolated from normal granulocytes, chronic myelogenous leukemia cells, and acute myelogenous leukemia cells.

1986 • 196 citations

Mucin production by human colonic carcinoma cells correlates with their metastatic potential in animal models of colon cancer metastasis.

1991 • 193 citations

Increased expression of sialyl-dimeric LeX antigen in liver metastases of human colorectal carcinoma.

1989 • 191 citations

6'-Sulfated Sialyl Lewis x Is a Major Capping Group of GlyCAM-1

1994 • 191 citations

A Family of Human β4-Galactosyltransferases

1997 • 190 citations

The Sialyltransferase “Sialylmotif” Participates in Binding the Donor Substrate CMP-NeuAc

1995 • 190 citations

Bovine galactosyltransferase: identification of a clone by direct immunological screening of a cDNA expression library.

1986 • 189 citations

Molecular basis for H blood group deficiency in Bombay (Oh) and para-Bombay individuals.

1994 • 186 citations

Glycoproteins and Their Relationship to Human Disease

1998 • 182 citations

The expanding beta 4-galactosyltransferase gene family: messages from the databanks

1998 • 182 citations

Co-purification of the Lewis blood group N-acetylglucosaminide alpha 1 goes to 4 fucosyltransferase and an N-acetylglucosaminide alpha 1 goes to 3 fucosyltransferase from human milk.

1981 • 180 citations

A Family of Human β3-Galactosyltransferases

1998 • 180 citations

Tumor-specific cytotoxic T cell clones from patients with breast and pancreatic adenocarcinoma recognize EBV-immortalized B cells transfected with polymorphic epithelial mucin complementary DNA.

1993 • 180 citations

High affinity binding of the leucocyte adhesion molecule L-selectin to 3′-sulphated-Lea and -Lex oligosaccharides and the predominance of sulphate in this interaction demonstrated by binding studies with a series of lipid-linked oligosaccharides

1992 • 173 citations

Enhanced sialylation of mucin-associated carbohydrate structures in human colon cancer metastasis

1996 • 169 citations

Cloning and expression of the Gal beta 1, 3GalNAc alpha 2,3-sialyltransferase.

1992 • 163 citations

Alterations of O-glycan biosynthesis in human colon cancer tissues

1994 • 162 citations

Carcinoma-associated expression of core 2 beta-1,6-N-acetylglucosaminyltransferase gene in human colorectal cancer: role of O-glycans in tumor progression.

1997 • 159 citations

Isolation and expression of a cDNA clone encoding a bovine UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase

1993 • 157 citations

Molecular Cloning and Characterization of anN-Acetylglucosamine-6-O-sulfotransferase

1998 • 157 citations

Expression cloning of cDNA encoding a human β-1,3-N-acetylglucosaminyltransferase that is essential for poly-N-acetyllactosamine synthesis

1997 • 153 citations

Identification of the full-length coding sequence for human galactosyltransferase (β-N-acetylglucosaminide: β1,4-galactosyltransferase)

1988 • 152 citations

Cell surface sialylation and tumor metastasis. Metastatic potential of B16 melanoma variants correlates with their relative numbers of specific penultimate oligosaccharide structures.

1988 • 148 citations

Molecular Cloning and Characterization of Human Keratan Sulfate Gal-6-Sulfotransferase

1997 • 147 citations

Serum sialyl Tn as an independent predictor of poor prognosis in patients with epithelial ovarian cancer.

1992 • 147 citations

Expression of the α(1,3)Fucosyltransferase Fuc-TVII in Lymphoid Aggregate High Endothelial Venules Correlates with Expression of L-Selectin Ligands

1996 • 146 citations

Expression of the developmental I antigen by a cloned human cDNA encoding a member of a beta-1,6-N-acetylglucosaminyltransferase gene family.

1993 • 144 citations

Detection of a pancreatic cancer-associated antigen (DU-PAN-2 antigen) in serum and ascites of patients with adenocarcinoma.

1984 • 142 citations

Regulation of alpha 2,3-sialyltransferase expression correlates with conversion of peanut agglutinin (PNA)+ to PNA- phenotype in developing thymocytes.

1993 • 142 citations

Up-regulation of a set of glycosyltransferase genes in human colorectal cancer.

1998 • 140 citations

Enzymatic Synthesis of the Protein-Hexosamine Linkage in Sheep Submaxillary Mucin

1967 • 136 citations

Subcellular localization of the UDP-N-acetyl-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase-mediated O-glycosylation reaction in the submaxillary gland.

1994 • 136 citations

In situ hybridization shows distinct patterns of mucin gene expression in normal, benign, and malignant pancreas tissues

1995 • 135 citations

O‐glycan biosynthesis in human colorectal adenoma cells during progression to cancer

1994 • 132 citations

Purification, cDNA Cloning, and Expression of UDP-Gal: Glucosylceramide β-1,4-Galactosyltransferase from Rat Brain

1998 • 131 citations

Up-regulation of the oligosaccharide sialyl LewisX: a new prognostic parameter in metastatic prostate cancer.

1995 • 128 citations

Sialic Acids

1971 • 124 citations

Mucin synthesis. UDP-GlcNAc:GalNAc-R .beta.3-N-acetylglucosaminyltransferase and UDP-GlcNAc:GlcNAc.beta.1-3GalNAc-R (GlcNAc to GalNAc) .beta.6-N-acetylglucosaminyltransferase from pig and rat colon mucosa

1985 • 122 citations

Inhibition of selectin-dependent tumor cell adhesion to endothelial cells and platelets by blocking O-glycosylation of these cells

1992 • 122 citations

A Transfected Sialyltransferase That Is Elevated in Breast Cancer and Localizes to the medial/trans-Golgi Apparatus Inhibits the Development of core-2–based O-Glycans

1997 • 121 citations

Molecular cloning of a human cDNA encoding β-1,4-galactosyltransferase with 37% identity to mammalian UDP-Gal:GlcNAc β-1,4-galactosyltransferase

1998 • 121 citations

O‐linked mucin‐type glycoproteins in normal and malignant colon mucosa: Lack of T‐antigen expression and accumulation of tn and sialosyl‐Tn antigens in carcinomas

1990 • 120 citations

Core2 beta-1,6-N-acetylglucosaminyltransferase enzyme activity is critical for P-selectin glycoprotein ligand-1 binding to P-selectin

1996 • 118 citations

Prediction of lymph node involvement in breast cancer by detection of altered glycosylation in the primary tumour

1991 • 118 citations

Structural analysis of the O‐glycosidically linked core‐region oligosaccharides of human meconium glycoproteins which express oncofoetal antigens

1985 • 115 citations

Bovine beta 1----4-galactosyltransferase: two sets of mRNA transcripts encode two forms of the protein with different amino-terminal domains. In vitro translation experiments demonstrate that both the short and the long forms of the enzyme are type II membrane-bound glycoproteins.

1990 • 114 citations

Immunogenicity of synthetic peptides related to the core peptide sequence encoded by the human MUC1 mucin gene: Effect of immunization on the growth of murine mammary adenocarcinoma cells transfected with the human MUC1 gene

1993 • 114 citations

Control of O-Glycan Branch Formation

1999 • 114 citations

Altered mRNA expression of specific molecular species of fucosyl- and sialyl-transferases in human colorectal cancer tissues

1997 • 112 citations

The influence of flanking sequence on the O-glycosylation of threonine in vitro.

1992 • 110 citations

Colorectal mucin histochemistry in health and disease: A critical review

1994 • 110 citations

Inhibition of experimental pulmonary metastasis of mouse colon adenocarcinoma 26 sublines by a sialic acid:nucleoside conjugate having sialyltransferase inhibiting activity.

1986 • 109 citations

Human B-cell immune response to the polymorphic epithelial mucin.

1993 • 109 citations

Molecular Cloning, Expression, Chromosomal Assignment, and Tissue-specific Expression of a Murine α-(1,3)-Fucosyltransferase Locus Corresponding to the Human ELAM-1 Ligand Fucosyl Transferase

1995 • 108 citations

Sequential Interchange of Four Amino Acids from Blood Group B to Blood Group A Glycosyltransferase Boosts Catalytic Activity and Progressively Modifies Substrate Recognition in Human Recombinant Enzymes

1997 • 107 citations

Simple mucin-type carbohydrate antigens (Tn, sialosyl-Tn and T) in gastric mucosa, carcinomas and metastases.

1992 • 107 citations

Effect of O-Glycosylated Mucin on Invasion and Metastasis of HM7 Human Colon Cancer Cells

1996 • 105 citations

Structures of the major oligosaccharides from a human rectal adenocarcinoma glycoprotein.

1983 • 105 citations

Purification to homogeneity and enzymatic characterization of an alpha-N-acetylgalactosaminide alpha 2 leads to 6 sialyltransferase from porcine submaxillary glands.

1979 • 103 citations

Demonstration of T‐Transferase Deficiency in Tn‐Polyagglutinable Blood Samples

1978 • 103 citations

Molecular cloning and expression of GalNAc alpha 2,6-sialyltransferase.

1994 • 101 citations

Mucin associated Tn and sialosyl-Tn antigen expression in colorectal polyps.

1992 • 101 citations

Molecular cloning of eukaryotic glycoprotein and glycolipid glycosyltransferases: a survey

1995 • 99 citations

Molecular cloning and expression of Galβ1,3GalNAcα2,3‐sialyltransferase from mouse brain

1993 • 98 citations

Isolation and characterization of ovarian cancer antigen CA 125 using a new monoclonal antibody (VK-8): identification as a mucin-type molecule

1997 • 98 citations

Golgi and Secreted Galactosyltransferas

1986 • 98 citations

Effect of modification of carbohydrate side chains on the reactivity of antibodies with core-protein epitopes of the MUC1 gene product.

1993 • 97 citations

Genomic Cloning and Expression of Three Murine UDP-galactose: β-N-Acetylglucosamine β1,3-Galactosyltransferase Genes

1998 • 97 citations

Fucosyltransferase activities in human pancreatic tissue: comparative study between cancer tissues and established tumoral cell lines

1998 • 95 citations

Cloning of a Novel Member of the UDP-Galactose:β-N-Acetylglucosamine β1,4-Galactosyltransferase Family, β4Gal-T4, Involved in Glycosphingolipid Biosynthesis

1998 • 94 citations

T and Tn Pancarcinoma Markers: Autoantigenic Adhesion Molecules in Pathogenesis, Prebiopsy Carcinoma-Detection, and Long-Term Breast Carcinoma Immunotherapy

1995 • 93 citations

Polylactosamine glycosylation on human fetal placental fibronectin weakens the binding affinity of fibronectin to gelatin.

1985 • 93 citations

Characterization of two cis-regulatory regions in the murine beta 1,4-galactosyltransferase gene. Evidence for a negative regulatory element that controls initiation at the proximal site

1993 • 92 citations

Branched O-linked oligosaccharides ectopically expressed in transgenic mice reduce primary T-cell immune responses

1997 • 92 citations

Stage-specific expression of SSEA-1-related antigens in the developing lung of human embryos and its relation to the distribution of these antigens in lung cancers.

1988 • 91 citations

Lex and Ley antigen expression in human pancreatic cancer.

1988 • 91 citations

Transcription of Human ABO Histo-blood Group Genes Is Dependent upon Binding of Transcription Factor CBF/NF-Y to Minisatellite Sequence

1997 • 90 citations

Tumor sialomucin complexes as tumor antigens and modulators of cellular interactions and proliferation

1992 • 90 citations

Biosynthesis and turnover of O-acetyl and N-acetyl groups in the gangliosides of human melanoma cells.

1990 • 89 citations

Tumor-associated sialylated antigens are constitutively expressed in normal human colonic mucosa.

1995 • 89 citations

Biosynthesis of O-glycans in leukocytes from normal donors and from patients with leukemia: increase in O-glycan core 2 UDP-GlcNAc:Gal beta 3 GalNAc alpha-R (GlcNAc to GalNAc) beta(1-6)-N-acetylglucosaminyltransferase in leukemic cells.

1991 • 89 citations

Human colon carcinoma cells with increased invasive capacity obtained by selection for sialyl-dimeric Lex antigen*1

1991 • 88 citations

6′-Sulfo Sialyl Lex but Not 6-Sulfo Sialyl Lex Expressed on the Cell Surface Supports L-selectin-mediated Adhesion

1996 • 88 citations

Cloning and expression of Gal beta 1,3GalNAc-specific GalNAc alpha 2,6-sialyltransferase.

1994 • 85 citations

Altered Golgi Localization of Core 2 β-1,6-N-Acetylglucosaminyltransferase Leads to Decreased Synthesis of Branched O-Glycans

1997 • 85 citations

Molecular Cloning of a Developmentally Regulated N-Acetylgalactosamine α2,6-Sialyltransferase Specific for Sialylated Glycoconjugates

1996 • 82 citations

Comparative study of the mucin-type sugar chains of human chorionic gonadotropin present in the urine of patients with trophoblastic diseases and healthy pregnant women.

1988 • 82 citations

Molecular Cloning and Expression of Human Galβ1,3GalNAc α2,3-Sialyltransferase (hST3Gal II)

1996 • 81 citations

Molecular Cloning and Functional Expression of Two Members of Mouse NeuAcα2,3Galβ1,3GalNAc GalNAcα2,6-Sialyltransferase Family, ST6GalNAc III and IV

1999 • 81 citations

T/Tn Antigen Vaccine is Effective and Safe in Preventing Recurrence of Advanced Human Breast Carcinoma

1994 • 79 citations

Sialylation and malignant potential in tumour cell glycosylation mutants

1994 • 79 citations

Characterization of quantitative mucin variants from a human colon cancer cell line.

1987 • 79 citations

T-lymphocytic leukemia expresses complex, branched O-linked oligosaccharides on a major sialoglycoprotein, leukosialin

1991 • 79 citations

The polymorphic epithelial mucin: potential as an immunogen for a cancer vaccine

1996 • 78 citations

Sulfated Lewis X Determinants as a Major Structural Motif in Glycans from LS174T-HM7 Human Colon Carcinoma Mucin

1997 • 77 citations

Expression of a carbohydrate differentiation antigen, stage-specific embryonic antigen 1, in human colonic adenocarcinoma.

1984 • 77 citations

Synthesis of O-glycan core 3: Characterization of UDP-GlcNAc: GalNAc-R β3-N-acetyl-glucosaminyltransferase activity from colonic mucosal tissues and lack of the activity in human cancer cell lines

1995 • 77 citations

Increase of rat colon carcinoma cells tumorigenicity by α(l–2) fucosyltransferase gene transfection

1997 • 76 citations

Neutral oligosaccharides of bovine submaxillary mucin

1992 • 75 citations

Oligosaccharide structures of mucins secreted by the human colonic cancer cell line CL.16E.

1992 • 75 citations

CHANGES IN CELL SURFACE GLYCOSYLATION IN ??1,3-GALACTOSYLTRANSFERASE KNOCKOUT AND ??1,2-FUCOSYLTRANSFERASE TRANSGENIC MICE

1997 • 74 citations

Persistent repression of a functional allele can be responsible for galactosyltransferase deficiency in Tn syndrome.

1993 • 74 citations

Enzymatic basis for sialyl-Tn expression in human colon cancer cells.

1998 • 74 citations

Expression of alpha-1,3-fucosyltransferase type IV and VII genes is related to poor prognosis in lung cancer.

1996 • 73 citations

Remodeling of Mouse Milk Glycoconjugates by Transgenic Expression of a Human Glycosyltransferase

1995 • 72 citations

Mucin synthesis. I. Detection in canine submaxillary glands of an N-acetylglucosaminyltransferase which acts on mucin substrates.

1980 • 72 citations

Influence of acceptor substrate primary amino acid sequence on the activity of human UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase. Studies with the MUC1 tandem repeat.

1994 • 71 citations

cis-Golgi resident proteins and O-glycans are abnormally compartmentalized in the RER of colon cancer cells

1993 • 70 citations

[30] High-performance liquid chromatography assays for N-acetylglucosaminyltransferases involved in N- and O-glycan synthesis

1989 • 69 citations

Regulation of the oncodevelopmental expression of type 1 chain ABH and Lewis(b) blood group antigens in human colon by alpha-2-L-fucosylation.

1991 • 69 citations

UDPgalactose:glycoprotein–N‐acetyl‐<scp>d</scp>‐galactosamine 3‐β‐<scp>d</scp>‐galactosyltransferase activity synthesizing O‐glycan core 1 is controlled by the amino acid sequence and glycosylation of glycopeptide substrates

1994 • 68 citations

Control of mucin synthesis: the peptide portion of synthetic O-glycopeptide substrates influences the activity of O-glycan core 1 uridine 5'-diphospho-galactose:N-acetyl-.alpha.-galactosaminyl-.alpha.-R .beta.3-galactosyltransferase

1990 • 68 citations

Molecular Cloning and Genomic Analysis of Mouse Galβ1,3GalNAc-specific GalNAc α2,6-Sialyltransferase

1996 • 67 citations

Effect of benzyl-alpha-GalNAc, an inhibitor of mucin glycosylation, on cancer-associated antigens in human colon cancer cells.

1992 • 67 citations

Sialyl Lewis(x) antigen as defined by monoclonal antibody AM-3 is a marker of dysplasia in the colonic adenoma-carcinoma sequence.

1992 • 67 citations

Elevated expression of H type GDP-L-fucose:beta-D-galactoside alpha-2-L-fucosyltransferase is associated with human colon adenocarcinoma progression.

1995 • 67 citations

Expression of Tn and Sialyl-Tn Antigens in Tumor Tissues of the Ovary

1991 • 65 citations

Glycoproteins and Human Disease

1997 • 64 citations

E‐selectin binding by pancreatic tumor cells is inhibited by cancer sera

1994 • 64 citations

Expression of three UDP-N-acetyl-alpha-D-galactosamine:polypeptide GalNAc N-acetylgalactosaminyltransferases in adenocarcinoma cell lines.

1997 • 62 citations

Differential production of high molecular weight sulfated glycoproteins in normal colonic mucosa, primary colon carcinoma, and metastases.

1987 • 61 citations

Enzymatic sulfation of mucus glycoprotein in gastric mucosa. Effect of ethanol.

1988 • 61 citations

Developmental regulation of sialic acid modifications in rat and human colon

1987 • 59 citations

Histo-blood group A/B versus H status of human carcinoma cells as correlated with haptotactic cell motility: approach with A and B gene transfection.

1997 • 58 citations

Expression of Lewis&lt;sup&gt;X&lt;/sup&gt; and Sialylated Lewis&lt;sup&gt;X&lt;/sup&gt; Antigens in Human Colorectal Polyps&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;

1987 • 58 citations

Pancarcinoma T and Tn epitopes: autoimmunogens and diagnostic markers that reveal incipient carcinomas and help establish prognosis.

1990 • 58 citations

Branching beta 1-6N-acetylglucosaminetransferases and polylactosamine expression in mouse F9 teratocarcinoma cells and differentiated counterparts.

1993 • 58 citations

ProcessingO-glycan core 1, Gal?1-3GalNAc?-R. Specificities of core 2, UDP-GlcNAc: Gal?1-3GalNAc-R(GlcNAc to GalNAc) ?6-N-acetylglucosaminyltransferase and CMP-sialic acid:Gal?1-3GalNAc-R ?3-sialyltransferase

1993 • 58 citations

Biosynthesis of polylactosaminoglycans. Novikoff ascites tumor cells contain two UDP-GleNAc:beta-galactoside beta1 6-N-acetylglucosaminyltransferase activities

1987 • 57 citations

Linkage-specific Action of Endogenous Sialic Acid -Acetyltransferase in Chinese Hamster Ovary Cells

1996 • 56 citations

Distribution of sialosyl Tn and Tn antigens within normal and malignant colorectal epithelium

1995 • 56 citations

Clinical value of sialyl Tn antigen in patients with gynecologic tumors.

1990 • 56 citations

Expression of the gene coding for a human mucin in mouse mammary tumor cells can affect their tumorigenicity

1991 • 56 citations

Glycosyltransferase changes upon differentiation of CaCo-2 human colonic adenocarcinoma cells.

1991 • 56 citations

The blood group ABO gene transcript is down-regulated in human bladder tumors and growth-stimulated urothelial cell lines.

1996 • 55 citations

Expression of stable human O-glycan core 2 β-1,6-N-acetylglucosaminyltransferase in Sf9 insect cells

1997 • 54 citations

Gene expression of fucosyl- and sialyl-transferases which synthesize sialyl Lewisx, the carbohydrate ligands for E-selectin, in human breast cancer.

1998 • 54 citations

Expression of MUC2 epithelial mucin in breast carcinoma.

1993 • 54 citations

Specificity of O-glycosylation by bovine colostrum UDP-GalNAc: polypeptide ?-N-acetylgalactosaminyltransferase using synthetic glycopeptide substrates

1996 • 54 citations

Structures of monosialyl oligosaccharides isolated from the respiratory mucins of a non-secretor (O, Le^a+b−) patient suffering from chronic bronchitis. Characterization of a novel type of mucin carbohydrate core structure

1994 • 53 citations

Association of sialyl-Lewis(a) and sialyl-Lewis(x) with MUC-1 apomucin ina pancreatic cancer cell line.

1995 • 52 citations

Targeting of proteins to the Golgi apparatus

1994 • 52 citations

Clinical Aspects of Glycoprotein Biosynthesis

1993 • 51 citations

Characterization of a novel mucin sulphotransferase activity synthesizing sulphated O-glycan core 1, 3-sulphate-Galβ1-3GalNAcα-R

1995 • 50 citations

Mucin synthesis. III. UDP-GlcNAc:Galβ1-3(GlcNAcβ1-6)GalNAc-R (GlcNAc to Gal) β3-N-acetylglucosaminyltransferase, an enzyme in porcine gastric mucosa involved in the elongation of mucin-type oligosaccharides

1983 • 50 citations

?-2,3-sialyltransferase type 3N and ?-1,3-fucosyltransferase type VII are related to sialyl Lewisx synthesis and patient survival from lung carcinoma

1997 • 49 citations

Aberrant α1→2Fucosyltransferases Found in Human Colorectal Carcinoma Involved in the Accumulation of Le^b and Y Antigens in Colorectal Tumors

1993 • 49 citations

The broad diversity of neutral and sialylated oligosaccharides derived from human salivary mucins

1992 • 49 citations

Sialylmotifs of sialyltransferases.

1997 • 48 citations

Isolation of a cDNA coding for human galactosyltransferase

1986 • 47 citations

Activity of the human blood group ABO, Se, H, Le, and X gene-encoded glycosyltransferases in normal and malignant bladder urothelium.

1988 • 46 citations

Elevation of alpha2-->6 sialyltransferase and alpha1-->2 fucosyltransferase activities in human choriocarcinoma.

1998 • 46 citations

Molecular Cloning and Expression of a Third Type of Rabbit GDP-L-Fucose:β-D-Galactoside 2-α-L-Fucosyltransferase

1996 • 44 citations

Ovarian cancer alpha 1,3-L-fucosyltransferase. Differentiation of distinct catalytic species with the unique substrate, 3'-sulfo-N-acetyllactosamine in conjunction with other synthetic acceptors.

1992 • 44 citations

Induction of sialic acid 9-O-acetylation by diverse gene products: Implications for the expression cloning of sialic acid O-acetyltransferases

1998 • 44 citations

The Chicken Genome Contains Two Functional Nonallelic β1,4-Galactosyltransferase Genes

1997 • 43 citations

Quantitative differences in GlcNAc:beta1-->3 and GlcNAc:beta1-->4 galactosyltransferase activities between human colonic adenocarcinomas and normal colonic mucosa.

1996 • 43 citations

The Polymorphic Epithelial Mucin as a Target for Immunotherapya

1993 • 42 citations

Distribution of Blood Group Antigens A, B, H, and I(Ma) in Mucus-Producing Adenocarcinoma of Human Lung&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;

1984 • 41 citations

Characterization of a Sulfotransferase from Human Airways Responsible for the 3-O-Sulfation of Terminal Galactose in N-Acetyllactosamine-containing Mucin Carbohydrate Chains

1995 • 41 citations

Predictive value of preoperative serum sialyl tn antigen levels in prognosis of patients with gastric cancer

1993 • 41 citations

Cloning and sequence homology of a rat UDP-GalNAc:polypeptideN-acetylgalactosaminyltransferase

1995 • 39 citations

Biosynthetic basis of incompatible histo-blood group A antigen expression: anti-A transferase antibodies reactive with gastric cancer tissue of type O individuals.

1993 • 38 citations

Parallel changes in the blood levels of abnormally-fucosylated haptoglobin and alpha 1,3 fucosyltransferase in relationship to tumour burden: more evidence for a disturbance of fucose metabolism in cancer

1992 • 38 citations

Correlation between sialyl Tn antigen and lymphatic metastasis in patients with Borrmann type IV gastric carcinoma

1995 • 37 citations

Monoclonal antibody LU-BCRU-G7 against a breast tumour-associated glycoprotein recognizes the disaccharide Galβ1-3GlcNAc

1995 • 37 citations

Sialyltransferase activity in FR3T3 cells transformed withras oncogene: decreased CMP-Neu5Ac:Gal?1-3GalNAc ?-2,3-sialyltransferase

1993 • 36 citations

Single Glycosyltransferase, Core 2 β1→6-N-acetylglucosaminyltransferase, Regulates Cell Surface Sialyl-Lex Expression Level in Human Pre-B Lymphocytic Leukemia Cell Line KM3 Treated with Phorbolester

1998 • 36 citations

Characteristics of colorectal carcinoma cells with high metastatic potential

1984 • 35 citations

Sialyltransferase, sialic acid and sialoglycoconjugates in metastatic tumor and human liver tissue

1982 • 34 citations

Fucosyltransferase III and sialyl-Lex expression correlate in cultured colon carcinoma cells but not in colon carcinoma tissue

1996 • 33 citations

N-acetyl-β-d-glucosaminyltransferases related to the synthesis of mucin-type glycoproteins in human ovarian tissue

1986 • 33 citations

Role and Metabolism of Glycoconjugate Sulfation.

1997 • 33 citations

Biosynthesis of galactosyl-beta 1,3-N-acetylglucosamine.

1982 • 32 citations

Molecular cloning of glycosyltransferase genes

1994 • 32 citations

Benzyl-alpha-GalNAc inhibits sialylation of O-glycosidic sugar chains on CD44 and enhances experimental metastatic capacity in B16BL6 melanoma cells.

1996 • 32 citations

Charge distribution of flanking amino acids inhibits O-glycosylation of several single-site acceptors in vivo

1997 • 31 citations

Increased activity of a specific sialyltransferase in chronic myelogenous leukemia

1985 • 31 citations

Two different glycosyltransferase defects that result in GalNAcα-O-peptide (Tn) expression

1994 • 31 citations

Differential Effect of α-Lactalbumin on β-1,4-Galactosyltransferase IV Activities

1998 • 30 citations

T cell clones with normal or defective O‐galactosylation from a patient with permanent mixed‐field polyagglutinability

1992 • 30 citations

Molecular cloning and expression of chick Gal, β1,3GalNAc α2,3-sialyltransferase

1995 • 30 citations

Enzymatic sulfation of mucus glycoprotein in gastric mucosa

1986 • 30 citations

The Centrally Acting β1,6N-Acetylglucosaminyltransferase (GlcNAc to Gal)

1998 • 29 citations

Aberrant sialylation of granulocyte membranes in chronic myelogenous leukemia

1984 • 27 citations

Role of sialosyl Lewis^a in adhesion of colon cancer cells

1998 • 27 citations

Biosynthesis of Branched Polylactosaminoglycans

1998 • 27 citations

The Distribution of Type 1 Chain ABH and Related Histo-Blood Group Antigens in Normal Cycling Human Endometrium

1993 • 26 citations

Changes of Le^xand Dimeric Le^xHaptens and their Sialylated Antigens During Development of Human Kidney and Kidney Tumors

1986 • 26 citations

A NEW SALMONELLA TYPE (S. SIMI) FROM THE BELGIAN CONGO

1950 • 25 citations

Altered expression of sialyl-Tn, Lewis antigens and carcinoembryonic antigen between primary and metastatic lesions of uterine cervical cancers

1992 • 25 citations

Serum α(1 → 3)-L-fucosyltransferase, carcinoembryonic antigen, and sialyl lewis X-i antigen levels in lung cancer

1989 • 25 citations

The Gene Encoding Murine α1,3-Galactosyltransferase Is Expressed in Female Germ Cells but Not in Male Germ Cells

1995 • 22 citations

Lewis blood group antigens (a and b) in human breast tissues. Loss of lewis-b in breast cancer cells and correlation with tumor grade

1991 • 21 citations

Predominance of sialomucin secretion in malignant and premalignant pancreatic lesions

1990 • 21 citations

Carbohydrate antigens in human lung carcinomas.

1992 • 20 citations

The aberrant expression of Lewis a antigen in intestinal metaplastic cells of gastric mucosa is caused by augmentation of Lewis enzyme expression.

1998 • 20 citations

Mucin Biosynthesis: Molecular Cloning and Expression of Bovine Lung Mucin Core 2 N-Acetylglucosaminyltransferase cDNA

1998 • 19 citations

Leukaemia and anaemia in AKR/O mice

1992 • 19 citations

Induction of antibody responses to breast carcinoma associated mucins using synthetic peptide constructs as immunogens

1993 • 18 citations

cDNA Cloning, Expression, and Chromosomal Localization of a Human UDP-GalNAc: Polypeptide, N-Acetylgalactosaminyltransferase

1995 • 18 citations

Purification and Characterization of UDP-GlcNAc:Galβ1–4GlcNAcβ1–3*Galβ1–4Glc(NAc)-R(GlcNAc to *Gal) β1,6N-Acetylglucosaminyltransferase from Hog Small Intestine

1998 • 18 citations

A transfected human fucosyltransferase cDNA determines biosynthesis of oligosaccharide ligand(s) for endothelial-leukocyte adhesion molecule I

1991 • 17 citations

A single human colonic adenoma cell line can be converted IN VITRO to both A colorectal adenocarcinoma and A mucinous carcinoma

1992 • 15 citations

UDP‐GalNAc : GalNAc‐mucin α‐N‐acetylgalactosamine transferase activity in human intestinal cancerous tissues

1985 • 15 citations

Enzymatic Basis for the Accumulation of Lewis^b Antigen in Uterine Endometrial Cancer

1995 • 15 citations

Human leukemic myeloblasts and myeloblastoid cells contain the enzyme cytidine 5'-monophosphate-N-acetylneuraminic acid:Gal beta 1-3GalNAc alpha (2-3)-sialyltransferase.

1990 • 15 citations

Differential gene expression of a human α2,3‐sialyltransferase in leukaemic cell lines and leucocytes

1998 • 14 citations

Chapter 5 Biosynthesis 4c. Compartmentation of Glycoprotein Biosynthesis

1995 • 14 citations

Transporters of nucleotide sugars, nucleotide sulfate and ATP in the Golgi apparatus membrane: Where next?

1997 • 13 citations

Glycosyltransferases Involved in the Biosynthesis of Protein-Bound Oligosaccharides of the Asparagine-N-Acetyl-D-Glucosamine and Serine(Threonine)-N-Acetyl-D-Galactosamine Types

1985 • 10 citations

Glycosyltransferase levels in familial polyposis coli

1986 • 8 citations

Artificial Neural Network Method for Predicting the Specificity of GalNAc-transferase

1997 • 8 citations

Cloning and Expression of the Catalytic Domain from Rat Hepatoma H35 Cell GDP-Fucose:GM1α1→2Fucosyltransferase, an Enzyme Which Is Activated during Early Stages of Chemical Carcinogenesis in Rat Liver

1998 • 6 citations

Localization of Golgi Glycosyltransferases.

1997 • 4 citations

In vivo overexpression of Core2 N-Acetylglucosaminyltransferase prevents repopulation of the bone marrow with colony forming cells but fails to affect normal T cell development

1998 • 2 citations